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The map label for this gene is mdtD [H]

Identifier: 161523939

GI number: 161523939

Start: 830889

End: 832325

Strand: Reverse

Name: mdtD [H]

Synonym: Bmul_0759

Alternate gene names: 161523939

Gene position: 832325-830889 (Counterclockwise)

Preceding gene: 161523941

Following gene: 161523938

Centisome position: 24.14

GC content: 66.95

Gene sequence:

>1437_bases
ATGTCCGACCGCTCGTCTGCCGCCGCTCCCGGCGAAAAGAACCTCACCGTCATGCTCTGGCTCGTCGCCACGGGCTTCTT
CATGCAGACGCTCGATTCGACGATCGTGAACACCGCGCTGCCGTCGATGGCCGCGAGCCTCGGCGAATCGCCGTTGCGCA
TGCAATCGGTCGTGATCGCGTATTCGCTGACGATGGCCGTGATGATTCCGGTGTCCGGCTGGCTCGCCGACACGTTCGGC
ACGCGGCGCGTCTTCCTCAGCGCGATCCTCGTGTTTTCGCTCGGCTCGCTGCTGTGCGCGAACGCACATACGCTGCCGCA
ACTGGTCGCGTTCCGCATCGTGCAGGGCGTCGGCGGCGCGATGCTGCTGCCGGTCGGGCGGCTCGCGGTGCTGCGCACGT
TTCCGGCCGAGCGCTATCTGCCCGCGCTGTCGTTCGTCGCGATTCCGGGGCTGATCGGCCCGCTGATCGGGCCGACGCTC
GGCGGCTGGCTCGTGAAGATCGCGTCGTGGCACTGGATCTTCCTGATCAACGTGCCGGTCGGCATCGTCGGCTGCGTCGC
GACGTTCTTCTCGATGCCCGACGCGCGCAACGCGGCCGTCGGCCGCTTCGACGTGAAGGGCTATCTGCTGCTGACGATCG
GCATGGTCGCGATCTCGCTGTCGCTCGACGGGCTCGCCGATCTCGGGATGCAGCACGCGGCCGTGCTCGTGCTGCTGATC
CTGAGCCTCGCCTGCTTCGTCGCATACGGGCTGTACGCCGTGCGCGCGCCGCAGCCGATCTTCTCGCTCGAACTGTTCAA
GATCCATACGTTCAGCGTCGGCCTGCTCGGCAATCTGTTCGCGCGGATCGGCAGCGGCGCGATGCCGTACCTGATCCCGC
TGCTGCTGCAGGTGAGCCTCGGCTATTCGGCGTTCGAGGCCGGGCTCATGATGCTGCCCGTCGCGGCGGCCGGCATGTTC
TCGAAGCGGCTCATCACGCGGCTGATCATGAAGTACGGCTACCGCAAGGTGCTGCTCGCGAACACGATCATGGTCGGCGT
GATGATGGCGAGCTTCGCGCTGATGCGCGACACGATGCCCGTCTGGCTGAAGGTCGTGCAGCTCGCGCTGTTCGGCGGCT
TCAACTCGATGCAGTTCACCGCGATGAACACGCTGACGCTGAAGGATCTCGGCACGGGCGGCGCGAGCAGCGGCAACAGC
CTGTTCTCGCTCGTGCAGATGCTGTCGATGAGCCTCGGCGTGACCGTCGCGGGCGCGCTGCTCGCGACCTTCACCGGGAT
GCTGCGCACCGTGACGCCGAGCAACACGCTGCCCGCGTTCCACGCGACCTTCATCTGCGTCGGGCTGATCACGGCCGCGT
CGGCGTGGATTTTCGGCCAGCTCGCGCCCGAGGTACGCGGCCGCGCGCACAAGACCGATCCGTCCGAGCGCACATGA

Upstream 100 bases:

>100_bases
GCCGCACGCACGAGACAGCGCCGCGCGAGGTGACGCCCTTCTGCACGGCGCGAGCGCTTTCCCTACAATGTCGGGTGTCC
TGCGCCCCCGCCCTCGCCTC

Downstream 100 bases:

>100_bases
CGCGCGGCGCGCACCAGCGCGGTGCGCTCGGGCGCGTCCTGTGCCCGCGCAGCGCGCCCGCGCCGGGGTCGCAACCGCGC
ATGCTTCTTGCTGGCCTATT

Product: EmrB/QacA family drug resistance transporter

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 478; Mature: 477

Protein sequence:

>478_residues
MSDRSSAAAPGEKNLTVMLWLVATGFFMQTLDSTIVNTALPSMAASLGESPLRMQSVVIAYSLTMAVMIPVSGWLADTFG
TRRVFLSAILVFSLGSLLCANAHTLPQLVAFRIVQGVGGAMLLPVGRLAVLRTFPAERYLPALSFVAIPGLIGPLIGPTL
GGWLVKIASWHWIFLINVPVGIVGCVATFFSMPDARNAAVGRFDVKGYLLLTIGMVAISLSLDGLADLGMQHAAVLVLLI
LSLACFVAYGLYAVRAPQPIFSLELFKIHTFSVGLLGNLFARIGSGAMPYLIPLLLQVSLGYSAFEAGLMMLPVAAAGMF
SKRLITRLIMKYGYRKVLLANTIMVGVMMASFALMRDTMPVWLKVVQLALFGGFNSMQFTAMNTLTLKDLGTGGASSGNS
LFSLVQMLSMSLGVTVAGALLATFTGMLRTVTPSNTLPAFHATFICVGLITAASAWIFGQLAPEVRGRAHKTDPSERT

Sequences:

>Translated_478_residues
MSDRSSAAAPGEKNLTVMLWLVATGFFMQTLDSTIVNTALPSMAASLGESPLRMQSVVIAYSLTMAVMIPVSGWLADTFG
TRRVFLSAILVFSLGSLLCANAHTLPQLVAFRIVQGVGGAMLLPVGRLAVLRTFPAERYLPALSFVAIPGLIGPLIGPTL
GGWLVKIASWHWIFLINVPVGIVGCVATFFSMPDARNAAVGRFDVKGYLLLTIGMVAISLSLDGLADLGMQHAAVLVLLI
LSLACFVAYGLYAVRAPQPIFSLELFKIHTFSVGLLGNLFARIGSGAMPYLIPLLLQVSLGYSAFEAGLMMLPVAAAGMF
SKRLITRLIMKYGYRKVLLANTIMVGVMMASFALMRDTMPVWLKVVQLALFGGFNSMQFTAMNTLTLKDLGTGGASSGNS
LFSLVQMLSMSLGVTVAGALLATFTGMLRTVTPSNTLPAFHATFICVGLITAASAWIFGQLAPEVRGRAHKTDPSERT
>Mature_477_residues
SDRSSAAAPGEKNLTVMLWLVATGFFMQTLDSTIVNTALPSMAASLGESPLRMQSVVIAYSLTMAVMIPVSGWLADTFGT
RRVFLSAILVFSLGSLLCANAHTLPQLVAFRIVQGVGGAMLLPVGRLAVLRTFPAERYLPALSFVAIPGLIGPLIGPTLG
GWLVKIASWHWIFLINVPVGIVGCVATFFSMPDARNAAVGRFDVKGYLLLTIGMVAISLSLDGLADLGMQHAAVLVLLIL
SLACFVAYGLYAVRAPQPIFSLELFKIHTFSVGLLGNLFARIGSGAMPYLIPLLLQVSLGYSAFEAGLMMLPVAAAGMFS
KRLITRLIMKYGYRKVLLANTIMVGVMMASFALMRDTMPVWLKVVQLALFGGFNSMQFTAMNTLTLKDLGTGGASSGNSL
FSLVQMLSMSLGVTVAGALLATFTGMLRTVTPSNTLPAFHATFICVGLITAASAWIFGQLAPEVRGRAHKTDPSERT

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=480, Percent_Identity=46.25, Blast_Score=429, Evalue=1e-121,
Organism=Escherichia coli, GI1788392, Length=450, Percent_Identity=48.4444444444444, Blast_Score=388, Evalue=1e-109,
Organism=Escherichia coli, GI1789042, Length=454, Percent_Identity=27.9735682819383, Blast_Score=155, Evalue=6e-39,
Organism=Escherichia coli, GI1788710, Length=324, Percent_Identity=33.3333333333333, Blast_Score=155, Evalue=8e-39,
Organism=Escherichia coli, GI87081983, Length=318, Percent_Identity=31.1320754716981, Blast_Score=128, Evalue=8e-31,
Organism=Escherichia coli, GI1788509, Length=136, Percent_Identity=33.8235294117647, Blast_Score=66, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6322958, Length=465, Percent_Identity=23.8709677419355, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6325455, Length=125, Percent_Identity=29.6, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323735, Length=162, Percent_Identity=30.8641975308642, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 50859; Mature: 50727

Theoretical pI: Translated: 10.30; Mature: 10.30

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDRSSAAAPGEKNLTVMLWLVATGFFMQTLDSTIVNTALPSMAASLGESPLRMQSVVIA
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
YSLTMAVMIPVSGWLADTFGTRRVFLSAILVFSLGSLLCANAHTLPQLVAFRIVQGVGGA
HHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCH
MLLPVGRLAVLRTFPAERYLPALSFVAIPGLIGPLIGPTLGGWLVKIASWHWIFLINVPV
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCH
GIVGCVATFFSMPDARNAAVGRFDVKGYLLLTIGMVAISLSLDGLADLGMQHAAVLVLLI
HHHHHHHHHHCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSLACFVAYGLYAVRAPQPIFSLELFKIHTFSVGLLGNLFARIGSGAMPYLIPLLLQVSL
HHHHHHHHHHHHHHCCCCCCCEEEEEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHC
GYSAFEAGLMMLPVAAAGMFSKRLITRLIMKYGYRKVLLANTIMVGVMMASFALMRDTMP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHH
VWLKVVQLALFGGFNSMQFTAMNTLTLKDLGTGGASSGNSLFSLVQMLSMSLGVTVAGAL
HHHHHHHHHHHCCCCCCEEEEEEEEEEHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LATFTGMLRTVTPSNTLPAFHATFICVGLITAASAWIFGQLAPEVRGRAHKTDPSERT
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SDRSSAAAPGEKNLTVMLWLVATGFFMQTLDSTIVNTALPSMAASLGESPLRMQSVVIA
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
YSLTMAVMIPVSGWLADTFGTRRVFLSAILVFSLGSLLCANAHTLPQLVAFRIVQGVGGA
HHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCH
MLLPVGRLAVLRTFPAERYLPALSFVAIPGLIGPLIGPTLGGWLVKIASWHWIFLINVPV
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCH
GIVGCVATFFSMPDARNAAVGRFDVKGYLLLTIGMVAISLSLDGLADLGMQHAAVLVLLI
HHHHHHHHHHCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSLACFVAYGLYAVRAPQPIFSLELFKIHTFSVGLLGNLFARIGSGAMPYLIPLLLQVSL
HHHHHHHHHHHHHHCCCCCCCEEEEEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHC
GYSAFEAGLMMLPVAAAGMFSKRLITRLIMKYGYRKVLLANTIMVGVMMASFALMRDTMP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHH
VWLKVVQLALFGGFNSMQFTAMNTLTLKDLGTGGASSGNSLFSLVQMLSMSLGVTVAGAL
HHHHHHHHHHHCCCCCCEEEEEEEEEEHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LATFTGMLRTVTPSNTLPAFHATFICVGLITAASAWIFGQLAPEVRGRAHKTDPSERT
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA