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The map label for this gene is arpR [H]

Identifier: 161523867

GI number: 161523867

Start: 751456

End: 752241

Strand: Reverse

Name: arpR [H]

Synonym: Bmul_0687

Alternate gene names: 161523867

Gene position: 752241-751456 (Counterclockwise)

Preceding gene: 161523871

Following gene: 161523866

Centisome position: 21.81

GC content: 64.25

Gene sequence:

>786_bases
ATGGATGTATGTAAAAAGACCGTCCGCGCCGTGCCAAGCGCGAAGTCTTACGAATTGTTACCAGTCGCAAGCATAGCCCG
TTCGGGCGCGCGCGACGAGGGGCCCGGCCCCGGTTTATCACTCATCGAATCAGATTCAGGCCTGCACATGGTCAGACGCA
CCAAGGAGGAGGCGCTCGAGACGCGCAACCGCATTCTCGATGCCGCCGAGCACGTGTTCTTCGAGAAGGGCGTGTCGCAT
ACGTCGCTGGCGGACATCGCGCAGCACGCCGGCGTGACGCGCGGTGCGATCTACTGGCACTTCGCAAACAAGAGCGACCT
GTTCGACGCGATGTTCGACCGCGTGCTGCTGCCGATCGACGAGTTGAAGCGGATGCCGGCGGACGCGCCGGGCAGCAATC
CGCTCGAGAAGGTGCGCAAGATCCTGATCTGGTGCCTGCTCGGCGTGCAGCGCGATTCGCAGCTGCGCCGCGTGTTCAGC
ATCCTGTTCATGAAGTGCGAGTACGTGGCCGACATGGAGCCGCTGCTGCTGCGCAACCGCGCGGGGATGAGCGAGGCGCT
GCACGCGATCGACGCCGATCTCGCAATGGCCGTGCGGCTCGAGCTGCTGCCCGAGCGGCTCGACACGTGGCGCGCGACGC
TGATGCTGCATACGCTCGTCAGCGGCTTCGTGCGCGACATGCTGATGCTGCCGGACGAGATCGATGCGGAAAAGCATGCG
GAGAAGCTGGTCGACGGCTGCTTCGACATGCTGCGCTGCAGCCCGGCGATGCTGAAGGACGACTGA

Upstream 100 bases:

>100_bases
CAAACTGCGGACTGGTACTTTGGCGGGAATCAGCAGAGTGGGATATTAACTGATTGCCACTTTGGTCATTCGATCGTAGG
GTGGTATTGTATATACATTC

Downstream 100 bases:

>100_bases
GGGGCGAGGCTACAGGTCAGTCGTGCGGCCGGCTGGCATGCTGCAGCCGTCGGTGCTCGTCGCGCGGCTGGTCTCGGTTT
CGGTCTCCGTTTCGGTCTCG

Product: TetR family transcriptional regulator

Products: NA

Alternate protein names: Antibiotic efflux pump ArpABC operon regulator [H]

Number of amino acids: Translated: 261; Mature: 261

Protein sequence:

>261_residues
MDVCKKTVRAVPSAKSYELLPVASIARSGARDEGPGPGLSLIESDSGLHMVRRTKEEALETRNRILDAAEHVFFEKGVSH
TSLADIAQHAGVTRGAIYWHFANKSDLFDAMFDRVLLPIDELKRMPADAPGSNPLEKVRKILIWCLLGVQRDSQLRRVFS
ILFMKCEYVADMEPLLLRNRAGMSEALHAIDADLAMAVRLELLPERLDTWRATLMLHTLVSGFVRDMLMLPDEIDAEKHA
EKLVDGCFDMLRCSPAMLKDD

Sequences:

>Translated_261_residues
MDVCKKTVRAVPSAKSYELLPVASIARSGARDEGPGPGLSLIESDSGLHMVRRTKEEALETRNRILDAAEHVFFEKGVSH
TSLADIAQHAGVTRGAIYWHFANKSDLFDAMFDRVLLPIDELKRMPADAPGSNPLEKVRKILIWCLLGVQRDSQLRRVFS
ILFMKCEYVADMEPLLLRNRAGMSEALHAIDADLAMAVRLELLPERLDTWRATLMLHTLVSGFVRDMLMLPDEIDAEKHA
EKLVDGCFDMLRCSPAMLKDD
>Mature_261_residues
MDVCKKTVRAVPSAKSYELLPVASIARSGARDEGPGPGLSLIESDSGLHMVRRTKEEALETRNRILDAAEHVFFEKGVSH
TSLADIAQHAGVTRGAIYWHFANKSDLFDAMFDRVLLPIDELKRMPADAPGSNPLEKVRKILIWCLLGVQRDSQLRRVFS
ILFMKCEYVADMEPLLLRNRAGMSEALHAIDADLAMAVRLELLPERLDTWRATLMLHTLVSGFVRDMLMLPDEIDAEKHA
EKLVDGCFDMLRCSPAMLKDD

Specific function: Probable regulatory protein for the antibiotic efflux pump arpABC operon. May function as a repressor [H]

COG id: COG1309

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786669, Length=209, Percent_Identity=38.2775119617225, Blast_Score=134, Evalue=5e-33,
Organism=Escherichia coli, GI1789664, Length=208, Percent_Identity=32.2115384615385, Blast_Score=92, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR013572
- InterPro:   IPR001647 [H]

Pfam domain/function: PF08361 TetR_C_2; PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 29271; Mature: 29271

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS01081 HTH_TETR_1 ; PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVCKKTVRAVPSAKSYELLPVASIARSGARDEGPGPGLSLIESDSGLHMVRRTKEEALE
CCHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHH
TRNRILDAAEHVFFEKGVSHTSLADIAQHAGVTRGAIYWHFANKSDLFDAMFDRVLLPID
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHCCHH
ELKRMPADAPGSNPLEKVRKILIWCLLGVQRDSQLRRVFSILFMKCEYVADMEPLLLRNR
HHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
AGMSEALHAIDADLAMAVRLELLPERLDTWRATLMLHTLVSGFVRDMLMLPDEIDAEKHA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
EKLVDGCFDMLRCSPAMLKDD
HHHHHHHHHHHHCCCHHHCCC
>Mature Secondary Structure
MDVCKKTVRAVPSAKSYELLPVASIARSGARDEGPGPGLSLIESDSGLHMVRRTKEEALE
CCHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHH
TRNRILDAAEHVFFEKGVSHTSLADIAQHAGVTRGAIYWHFANKSDLFDAMFDRVLLPID
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHCCHH
ELKRMPADAPGSNPLEKVRKILIWCLLGVQRDSQLRRVFSILFMKCEYVADMEPLLLRNR
HHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
AGMSEALHAIDADLAMAVRLELLPERLDTWRATLMLHTLVSGFVRDMLMLPDEIDAEKHA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
EKLVDGCFDMLRCSPAMLKDD
HHHHHHHHHHHHCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11160799 [H]