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The map label for this gene is pth [H]

Identifier: 161523691

GI number: 161523691

Start: 560288

End: 560887

Strand: Reverse

Name: pth [H]

Synonym: Bmul_0511

Alternate gene names: 161523691

Gene position: 560887-560288 (Counterclockwise)

Preceding gene: 161523692

Following gene: 161523690

Centisome position: 16.26

GC content: 65.83

Gene sequence:

>600_bases
ATGATCAAACTGATCGTCGGCCTCGGCAATCCCGGGGCGGAATACACCGCGACGCGTCACAATGCCGGCTTCTGGCTGAT
CGACCAGCTCGCCCGCGAAGCCGGTGCGACGCTGCGCGACGAGCGCCGCTTCCACGGCTTCTATGCGAAAGCGCGCCTCT
ACGGCGAAGAAGTGCATCTGCTCGAGCCGCAAACCTACATGAACCGCTCCGGCCAGTCAGTCGTCGCGCTCGCCCATTTC
TTCAAGATCCTGCCCGACCAGATCCTCGTCGCGCACGACGAGCTCGACCTGCCGCCCGGCACCGTGAAGCTGAAGCTCGG
CGGCGGCAGCGGCGGCCACAACGGGCTGAAGGACATCTCCGCGCATCTGTCGTCGCAGCAGTACTGGCGTCTGCGGATCG
GCATCGGCCATCCGCGCGACCTGATTCCGGAAAGCGCGCGCGCCGGCGCGAAGCCCGACGTCGCGAACTTCGTGCTGAAG
CCGCCGCGTCGCGAAGAACAGGACGTGATCGACGCGGCAATCGAGCGCGCGCTCGCCGTGATGCCAATGGTCGTCAAGGG
CGAACTCGATCGCGCGACGATGCAGTTGCATCGCAACTGA

Upstream 100 bases:

>100_bases
TCGATCCGTTTCGCGAAACGGTCGACGCAACCCGCCGCGGCATGCCCGGCGGGTTTTTCTTTTTCTGCGCCCAGGCGGCC
GACGCCGCCTTCGAAACGTC

Downstream 100 bases:

>100_bases
CGCACGGCCGCGCACCGGCATGGCGCACGGCGGCCGCCGCGCCGGCTGCCGACATGCGCGGCCGCACTGGCGCGACGCGC
GCCGCGGCGTGCAACATGCG

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 199; Mature: 199

Protein sequence:

>199_residues
MIKLIVGLGNPGAEYTATRHNAGFWLIDQLAREAGATLRDERRFHGFYAKARLYGEEVHLLEPQTYMNRSGQSVVALAHF
FKILPDQILVAHDELDLPPGTVKLKLGGGSGGHNGLKDISAHLSSQQYWRLRIGIGHPRDLIPESARAGAKPDVANFVLK
PPRREEQDVIDAAIERALAVMPMVVKGELDRATMQLHRN

Sequences:

>Translated_199_residues
MIKLIVGLGNPGAEYTATRHNAGFWLIDQLAREAGATLRDERRFHGFYAKARLYGEEVHLLEPQTYMNRSGQSVVALAHF
FKILPDQILVAHDELDLPPGTVKLKLGGGSGGHNGLKDISAHLSSQQYWRLRIGIGHPRDLIPESARAGAKPDVANFVLK
PPRREEQDVIDAAIERALAVMPMVVKGELDRATMQLHRN
>Mature_199_residues
MIKLIVGLGNPGAEYTATRHNAGFWLIDQLAREAGATLRDERRFHGFYAKARLYGEEVHLLEPQTYMNRSGQSVVALAHF
FKILPDQILVAHDELDLPPGTVKLKLGGGSGGHNGLKDISAHLSSQQYWRLRIGIGHPRDLIPESARAGAKPDVANFVLK
PPRREEQDVIDAAIERALAVMPMVVKGELDRATMQLHRN

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Homo sapiens, GI50897284, Length=147, Percent_Identity=38.7755102040816, Blast_Score=95, Evalue=4e-20,
Organism=Escherichia coli, GI1787455, Length=197, Percent_Identity=54.8223350253807, Blast_Score=179, Evalue=1e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328
- InterPro:   IPR018171 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 22056; Mature: 22056

Theoretical pI: Translated: 9.38; Mature: 9.38

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1 ; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKLIVGLGNPGAEYTATRHNAGFWLIDQLAREAGATLRDERRFHGFYAKARLYGEEVHL
CEEEEEECCCCCCCCEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEE
LEPQTYMNRSGQSVVALAHFFKILPDQILVAHDELDLPPGTVKLKLGGGSGGHNGLKDIS
ECCHHHHCCCCCHHHHHHHHHHHCCHHEEEECCCCCCCCCEEEEEECCCCCCCCHHHHHH
AHLSSQQYWRLRIGIGHPRDLIPESARAGAKPDVANFVLKPPRREEQDVIDAAIERALAV
HHCCCCCEEEEEEECCCCHHHCCCCCCCCCCCCHHHHEECCCCCCHHHHHHHHHHHHHHH
MPMVVKGELDRATMQLHRN
HHHHHCCCCCHHHHHHCCC
>Mature Secondary Structure
MIKLIVGLGNPGAEYTATRHNAGFWLIDQLAREAGATLRDERRFHGFYAKARLYGEEVHL
CEEEEEECCCCCCCCEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEE
LEPQTYMNRSGQSVVALAHFFKILPDQILVAHDELDLPPGTVKLKLGGGSGGHNGLKDIS
ECCHHHHCCCCCHHHHHHHHHHHCCHHEEEECCCCCCCCCEEEEEECCCCCCCCHHHHHH
AHLSSQQYWRLRIGIGHPRDLIPESARAGAKPDVANFVLKPPRREEQDVIDAAIERALAV
HHCCCCCEEEEEEECCCCHHHCCCCCCCCCCCCHHHHEECCCCCCHHHHHHHHHHHHHHH
MPMVVKGELDRATMQLHRN
HHHHHCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA