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The map label for this gene is moeB [H]

Identifier: 161523624

GI number: 161523624

Start: 489143

End: 489895

Strand: Reverse

Name: moeB [H]

Synonym: Bmul_0444

Alternate gene names: 161523624

Gene position: 489895-489143 (Counterclockwise)

Preceding gene: 161523625

Following gene: 161523616

Centisome position: 14.21

GC content: 69.06

Gene sequence:

>753_bases
ATGAACGACGATCAACTCCTTCGCTATTCCCGCCACATCCTCGTCGACGAAATCGGCATCGAGGCGCAGCAGCGCTTTCT
CGACGCGCACGCGATCGTCGTGGGCGCCGGCGGCCTCGGCTCGCCCGCGGCGATGTATCTGGCGGCGTCGGGCGTCGGCA
CGATCACGCTCGTCGACGCCGACACGGTCGATCTGACGAACCTGCAGCGGCAGATCCTGCACGCTACCGCGTCGGTGGGC
CGCAGCAAGGTCGAATCGGGACGCGACACGCTCGCGCGGCTGAACCCGGACGTCGTCGTGCAGGCGGTCGCGCAGCGCGT
CGACGACGCATGGCTCGACGCACACGTGCCGAACGCGACGGTCGTGCTCGACTGCACCGACAACTTCGCGACGCGCCATG
CGATCAACCGCGCCTGCGTCGCGCACGGCGTGCCGCTCGTATCGGGCGCCGCGCTGCGCTTCGACGGGCAGATCAGCACG
TTCGACTTCCGCGACGCGGCCGCGCCCTGCTACGCGTGCGTGTTTCCGGAGGATCAGCCGTTCGAGGAAGTCGCGTGCGC
GACGATGGGCGTGTTCGCGCCGACGGTCGGCATCATCGGCGCGATGCAGGCCGCCGAAGCGCTACGCGTGATCGGCGCGA
TCGGCACGACGCTGAACGGCCGGCTGATGATGCTCGACTCGCTGCGCATGGAATGGACGACGATGAAGATCGCGCGCCAG
CCCGACTGCCCGGTGTGCGGCAAGCGGCACTGA

Upstream 100 bases:

>100_bases
GCCATCGCGGGAAGACCGCGATGGCCCGTTTTTCATGCGCGCCTAGAATAGACCGGTACGCCCGCGCCCGTTCGCGCGGC
GGCATCGCTGACGACACACC

Downstream 100 bases:

>100_bases
CGCGCATGCGCGCGCAACGATCGTCATGATCGTCGAGGACTCGTCGCTGACGCCTATGCGGCGGCGTCCGCACGCGGTTC
GGCGACTGCGAGGCGCTTCA

Product: UBA/THIF-type NAD/FAD binding protein

Products: NA

Alternate protein names: MoaD protein adenylase; Molybdopterin-converting factor subunit 1 adenylase [H]

Number of amino acids: Translated: 250; Mature: 250

Protein sequence:

>250_residues
MNDDQLLRYSRHILVDEIGIEAQQRFLDAHAIVVGAGGLGSPAAMYLAASGVGTITLVDADTVDLTNLQRQILHATASVG
RSKVESGRDTLARLNPDVVVQAVAQRVDDAWLDAHVPNATVVLDCTDNFATRHAINRACVAHGVPLVSGAALRFDGQIST
FDFRDAAAPCYACVFPEDQPFEEVACATMGVFAPTVGIIGAMQAAEALRVIGAIGTTLNGRLMMLDSLRMEWTTMKIARQ
PDCPVCGKRH

Sequences:

>Translated_250_residues
MNDDQLLRYSRHILVDEIGIEAQQRFLDAHAIVVGAGGLGSPAAMYLAASGVGTITLVDADTVDLTNLQRQILHATASVG
RSKVESGRDTLARLNPDVVVQAVAQRVDDAWLDAHVPNATVVLDCTDNFATRHAINRACVAHGVPLVSGAALRFDGQIST
FDFRDAAAPCYACVFPEDQPFEEVACATMGVFAPTVGIIGAMQAAEALRVIGAIGTTLNGRLMMLDSLRMEWTTMKIARQ
PDCPVCGKRH
>Mature_250_residues
MNDDQLLRYSRHILVDEIGIEAQQRFLDAHAIVVGAGGLGSPAAMYLAASGVGTITLVDADTVDLTNLQRQILHATASVG
RSKVESGRDTLARLNPDVVVQAVAQRVDDAWLDAHVPNATVVLDCTDNFATRHAINRACVAHGVPLVSGAALRFDGQIST
FDFRDAAAPCYACVFPEDQPFEEVACATMGVFAPTVGIIGAMQAAEALRVIGAIGTTLNGRLMMLDSLRMEWTTMKIARQ
PDCPVCGKRH

Specific function: Catalyzes the adenylation by ATP of the carboxyl group of the C-terminal glycine of sulfur carrier protein moaD [H]

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hesA/moeB/thiF family [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=251, Percent_Identity=41.4342629482072, Blast_Score=181, Evalue=6e-46,
Organism=Homo sapiens, GI4885649, Length=167, Percent_Identity=29.940119760479, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI13376212, Length=259, Percent_Identity=25.4826254826255, Blast_Score=64, Evalue=9e-11,
Organism=Escherichia coli, GI1787048, Length=251, Percent_Identity=43.8247011952191, Blast_Score=229, Evalue=1e-61,
Organism=Escherichia coli, GI87082356, Length=247, Percent_Identity=44.1295546558704, Blast_Score=197, Evalue=4e-52,
Organism=Escherichia coli, GI1789177, Length=131, Percent_Identity=36.6412213740458, Blast_Score=71, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17540406, Length=258, Percent_Identity=41.0852713178295, Blast_Score=206, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI193203301, Length=164, Percent_Identity=27.4390243902439, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6321903, Length=251, Percent_Identity=36.6533864541833, Blast_Score=160, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6320598, Length=165, Percent_Identity=25.4545454545455, Blast_Score=66, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6322639, Length=160, Percent_Identity=25.625, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24582879, Length=248, Percent_Identity=40.7258064516129, Blast_Score=193, Evalue=9e-50,
Organism=Drosophila melanogaster, GI24660640, Length=158, Percent_Identity=32.2784810126582, Blast_Score=86, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR012730
- InterPro:   IPR016040
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 26713; Mature: 26713

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDDQLLRYSRHILVDEIGIEAQQRFLDAHAIVVGAGGLGSPAAMYLAASGVGTITLVDA
CCCHHHHHHHHHHHHHHHCHHHHHHHHHHEEEEEECCCCCCHHHHHEEECCCCEEEEEEC
DTVDLTNLQRQILHATASVGRSKVESGRDTLARLNPDVVVQAVAQRVDDAWLDAHVPNAT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCE
VVLDCTDNFATRHAINRACVAHGVPLVSGAALRFDGQISTFDFRDAAAPCYACVFPEDQP
EEEECCCCHHHHHHHHHHHHHCCCCHHCCCEEEECCCEEEECCCCCCCCEEEEECCCCCC
FEEVACATMGVFAPTVGIIGAMQAAEALRVIGAIGTTLNGRLMMLDSLRMEWTTMKIARQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHEEEEEECC
PDCPVCGKRH
CCCCCCCCCC
>Mature Secondary Structure
MNDDQLLRYSRHILVDEIGIEAQQRFLDAHAIVVGAGGLGSPAAMYLAASGVGTITLVDA
CCCHHHHHHHHHHHHHHHCHHHHHHHHHHEEEEEECCCCCCHHHHHEEECCCCEEEEEEC
DTVDLTNLQRQILHATASVGRSKVESGRDTLARLNPDVVVQAVAQRVDDAWLDAHVPNAT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCE
VVLDCTDNFATRHAINRACVAHGVPLVSGAALRFDGQISTFDFRDAAAPCYACVFPEDQP
EEEECCCCHHHHHHHHHHHHHCCCCHHCCCEEEECCCEEEECCCCCCCCEEEEECCCCCC
FEEVACATMGVFAPTVGIIGAMQAAEALRVIGAIGTTLNGRLMMLDSLRMEWTTMKIARQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHEEEEEECC
PDCPVCGKRH
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503 [H]