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The map label for this gene is bioA [H]

Identifier: 161523554

GI number: 161523554

Start: 410853

End: 412199

Strand: Reverse

Name: bioA [H]

Synonym: Bmul_0374

Alternate gene names: 161523554

Gene position: 412199-410853 (Counterclockwise)

Preceding gene: 161523555

Following gene: 161523553

Centisome position: 11.95

GC content: 70.68

Gene sequence:

>1347_bases
TTGAGTACGTCAGCCCCCGACGACTGGGTCGCGCGCAGCCTGCGCGCGGTCTGGCATCCCTGCACCCAGATGAAGCACCA
CGAGCGCCTGCCGCTCGTTCCCGTCGCGCGCGGCGCGGGCGTATGGCTGTACGACCGCGACGGGCGCCGCTACTTCGACG
CGATCAGCTCGTGGTGGGTCAATCTATTCGGCCATGCGAATCCCGACATCAACGCCGCGCTGAAGGACCAGCTCGATACG
CTCGAACACGCGATGCTCGCCGGCTGCACGCACGAGCCCGCAATCGAGCTCGCCGAGCGGCTGCATGCGCTGACCGCGAA
CACGCTCGGCCATGCATTCTTCGCGTCGGACGGCGCATCGGCCGTCGAGATCGCGCTGAAGATGAGCTTTCACGCGTGGC
GCAATCGCGGCCGCGCCGACAAGCGCGAATTCGCGTGCGTCGCGAACGGCTACCACGGCGAAACGATCGGCGCGCTCGGC
GTGACCGACGTCGCGCTGTTCAAGGACGCGTACGATCCGCTGATCCGCCACGCGCACGTCGTCGCGTCGCCCGACGCGCG
CGGCGCGCTGCCCGGCGAAACGGCCGCCGACGTCGCGGGCCGTGCGCTCGCCGACGTGCGCCGCCTGTTCGTCGAACGCG
GCGAACGGATCGCCGCGCTGATCGTCGAGCCGCTCGTGCAGTGCGCGGCCGGCATGGCGATGCACGATCCGTCGTACGTG
CGCGGCCTGCGCGCGCTCTGCGACGAATTCGACGTGCATCTGATCGCCGACGAGATCGCGGTCGGCTGCGGCCGCACCGG
CACGTTCTTCGCCTCCGAGCAGGCCGGCGTGTGGCCCGACTTCCTGTGCCTATCGAAAGGCATCAGCGGCGGCTATCTGC
CGTTGTCGCTCGTGCTGACGCGCGACGACGTGTTCGCCGCGTTCTACGACGACGACACGACGCGCGGCTTCCTGCACTCG
CACTCGTACACCGGCAATCCGCTCGCCTGCCGCGCGGCGGTCGCGACGCTCGACCTGTTCGCGCGCGACGACGTGCTCGC
GAGCAACGCGCGCAAGTCGGCCGCGCTGCGCGCCGCGCTCGCGCCGCTCGCCGCCCATCCGGACGTGCGCCACCTGCGCG
AGCGCGGCACGCTGTTCGCGTTCGACGTCGCGCTCGACGGCGACGCGGCACGCGGCTTCTCGCGGCGCTTCTTCGAGCGC
GCGCTCGAGCGCGAACTGCTGCTGCGGCCGATCGGCACGACCGTCTACCTGATGCCGCCGTACGTGATGAGCGACGACGA
CATCGCCTGGCTCGCGCAGCGCACGCGCGACACGCTCGAGGCCACGCTCGCGGAGATTGCACGATGA

Upstream 100 bases:

>100_bases
GTTTTCGTGTCGTGCGCGCCGTCGGCCGCACGATGGCTGTCCCCGTGTGCGCGCCGCGTCCGACGATGCCGCGCGCCGCC
GTTTTACCCCCGGAGTCGCC

Downstream 100 bases:

>100_bases
ACCTGCTCGATACGCTGCAGCGCGGCCTCGCCGATCTCGACGCGCAAGGGCTGCGCCGTGTGCGCCGCACGGCCGACAGC
GCCTGCGACGCGCACATGAC

Product: adenosylmethionine--8-amino-7-oxononanoate transaminase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MSTSAPDDWVARSLRAVWHPCTQMKHHERLPLVPVARGAGVWLYDRDGRRYFDAISSWWVNLFGHANPDINAALKDQLDT
LEHAMLAGCTHEPAIELAERLHALTANTLGHAFFASDGASAVEIALKMSFHAWRNRGRADKREFACVANGYHGETIGALG
VTDVALFKDAYDPLIRHAHVVASPDARGALPGETAADVAGRALADVRRLFVERGERIAALIVEPLVQCAAGMAMHDPSYV
RGLRALCDEFDVHLIADEIAVGCGRTGTFFASEQAGVWPDFLCLSKGISGGYLPLSLVLTRDDVFAAFYDDDTTRGFLHS
HSYTGNPLACRAAVATLDLFARDDVLASNARKSAALRAALAPLAAHPDVRHLRERGTLFAFDVALDGDAARGFSRRFFER
ALERELLLRPIGTTVYLMPPYVMSDDDIAWLAQRTRDTLEATLAEIAR

Sequences:

>Translated_448_residues
MSTSAPDDWVARSLRAVWHPCTQMKHHERLPLVPVARGAGVWLYDRDGRRYFDAISSWWVNLFGHANPDINAALKDQLDT
LEHAMLAGCTHEPAIELAERLHALTANTLGHAFFASDGASAVEIALKMSFHAWRNRGRADKREFACVANGYHGETIGALG
VTDVALFKDAYDPLIRHAHVVASPDARGALPGETAADVAGRALADVRRLFVERGERIAALIVEPLVQCAAGMAMHDPSYV
RGLRALCDEFDVHLIADEIAVGCGRTGTFFASEQAGVWPDFLCLSKGISGGYLPLSLVLTRDDVFAAFYDDDTTRGFLHS
HSYTGNPLACRAAVATLDLFARDDVLASNARKSAALRAALAPLAAHPDVRHLRERGTLFAFDVALDGDAARGFSRRFFER
ALERELLLRPIGTTVYLMPPYVMSDDDIAWLAQRTRDTLEATLAEIAR
>Mature_447_residues
STSAPDDWVARSLRAVWHPCTQMKHHERLPLVPVARGAGVWLYDRDGRRYFDAISSWWVNLFGHANPDINAALKDQLDTL
EHAMLAGCTHEPAIELAERLHALTANTLGHAFFASDGASAVEIALKMSFHAWRNRGRADKREFACVANGYHGETIGALGV
TDVALFKDAYDPLIRHAHVVASPDARGALPGETAADVAGRALADVRRLFVERGERIAALIVEPLVQCAAGMAMHDPSYVR
GLRALCDEFDVHLIADEIAVGCGRTGTFFASEQAGVWPDFLCLSKGISGGYLPLSLVLTRDDVFAAFYDDDTTRGFLHSH
SYTGNPLACRAAVATLDLFARDDVLASNARKSAALRAALAPLAAHPDVRHLRERGTLFAFDVALDGDAARGFSRRFFERA
LERELLLRPIGTTVYLMPPYVMSDDDIAWLAQRTRDTLEATLAEIAR

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=411, Percent_Identity=31.3868613138686, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI37574042, Length=421, Percent_Identity=24.4655581947743, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI284507298, Length=313, Percent_Identity=30.6709265175719, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI226442705, Length=421, Percent_Identity=24.4655581947743, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI226442709, Length=391, Percent_Identity=24.5524296675192, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI24119277, Length=429, Percent_Identity=23.7762237762238, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1786991, Length=415, Percent_Identity=38.5542168674699, Blast_Score=251, Evalue=5e-68,
Organism=Escherichia coli, GI145693181, Length=403, Percent_Identity=30.5210918114144, Blast_Score=180, Evalue=1e-46,
Organism=Escherichia coli, GI1789016, Length=403, Percent_Identity=30.5210918114144, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1789759, Length=405, Percent_Identity=28.1481481481481, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1788044, Length=319, Percent_Identity=30.4075235109718, Blast_Score=129, Evalue=5e-31,
Organism=Escherichia coli, GI1787560, Length=407, Percent_Identity=29.2383292383292, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1786349, Length=317, Percent_Identity=29.3375394321767, Blast_Score=99, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI25144271, Length=433, Percent_Identity=25.8660508083141, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI25144274, Length=236, Percent_Identity=28.3898305084746, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI32564660, Length=427, Percent_Identity=25.0585480093677, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71992977, Length=371, Percent_Identity=23.4501347708895, Blast_Score=81, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6324386, Length=460, Percent_Identity=28.695652173913, Blast_Score=207, Evalue=4e-54,
Organism=Saccharomyces cerevisiae, GI6323470, Length=442, Percent_Identity=28.0542986425339, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6324432, Length=436, Percent_Identity=25.4587155963303, Blast_Score=117, Evalue=3e-27,
Organism=Drosophila melanogaster, GI21357415, Length=422, Percent_Identity=27.9620853080569, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI161085790, Length=452, Percent_Identity=23.4513274336283, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI28574759, Length=380, Percent_Identity=25.5263157894737, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI21356575, Length=316, Percent_Identity=24.0506329113924, Blast_Score=102, Evalue=7e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 49056; Mature: 48925

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00436 PEROXIDASE_2 ; PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTSAPDDWVARSLRAVWHPCTQMKHHERLPLVPVARGAGVWLYDRDGRRYFDAISSWWV
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEEEECCCHHHHHHHHHHHH
NLFGHANPDINAALKDQLDTLEHAMLAGCTHEPAIELAERLHALTANTLGHAFFASDGAS
HHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCH
AVEIALKMSFHAWRNRGRADKREFACVANGYHGETIGALGVTDVALFKDAYDPLIRHAHV
HHHHHHHHHHHHHHCCCCCCHHHEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHEE
VASPDARGALPGETAADVAGRALADVRRLFVERGERIAALIVEPLVQCAAGMAMHDPSYV
EECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHH
RGLRALCDEFDVHLIADEIAVGCGRTGTFFASEQAGVWPDFLCLSKGISGGYLPLSLVLT
HHHHHHHHHCCCEEEHHHHHHCCCCCCCEEECCCCCCCHHHHHHHCCCCCCCEEEEEEEE
RDDVFAAFYDDDTTRGFLHSHSYTGNPLACRAAVATLDLFARDDVLASNARKSAALRAAL
CCCEEEEEECCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHCHHHHHCHHHHHHHHHHH
APLAAHPDVRHLRERGTLFAFDVALDGDAARGFSRRFFERALERELLLRPIGTTVYLMPP
HHHHCCCCHHHHHHCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
YVMSDDDIAWLAQRTRDTLEATLAEIAR
EEECCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
STSAPDDWVARSLRAVWHPCTQMKHHERLPLVPVARGAGVWLYDRDGRRYFDAISSWWV
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEEEECCCHHHHHHHHHHHH
NLFGHANPDINAALKDQLDTLEHAMLAGCTHEPAIELAERLHALTANTLGHAFFASDGAS
HHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCH
AVEIALKMSFHAWRNRGRADKREFACVANGYHGETIGALGVTDVALFKDAYDPLIRHAHV
HHHHHHHHHHHHHHCCCCCCHHHEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHEE
VASPDARGALPGETAADVAGRALADVRRLFVERGERIAALIVEPLVQCAAGMAMHDPSYV
EECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHH
RGLRALCDEFDVHLIADEIAVGCGRTGTFFASEQAGVWPDFLCLSKGISGGYLPLSLVLT
HHHHHHHHHCCCEEEHHHHHHCCCCCCCEEECCCCCCCHHHHHHHCCCCCCCEEEEEEEE
RDDVFAAFYDDDTTRGFLHSHSYTGNPLACRAAVATLDLFARDDVLASNARKSAALRAAL
CCCEEEEEECCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHCHHHHHCHHHHHHHHHHH
APLAAHPDVRHLRERGTLFAFDVALDGDAARGFSRRFFERALERELLLRPIGTTVYLMPP
HHHHCCCCHHHHHHCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
YVMSDDDIAWLAQRTRDTLEATLAEIAR
EEECCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2110099 [H]