Click here to switch to the map view.

The map label for this gene is ilvA1

Identifier: 161509605

GI number: 161509605

Start: 1505322

End: 1506362

Strand: Reverse

Name: ilvA1

Synonym: USA300HOU_1375

Alternate gene names: 161509605

Gene position: 1506362-1505322 (Counterclockwise)

Preceding gene: 161509606

Following gene: 161509604

Centisome position: 52.43

GC content: 35.06

Gene sequence:

>1041_bases
ATGACAACCAACACAGTTACATTACAAACAGCACATATTGTAAGTTTAGGAGATATCGAAGAAGCTAAAGCAAGCATTAA
ACCATTTATTCGTCGAACACCTCTAATTAAATCAATGTATTTAAGCCAAAGTATAACTAAAGGGAATGTATTTCTAAAAT
TAGAAAATATGCAATTCACAGGATCTTTTAAATTTAGAGGCGCTAGCAATAAAATTAATCACTTAACAGATGAACAAAAA
GAAAAAGGCATTATCGCAGCATCTGCTGGGAACCATGCACAAGGTGTTGCTTTAACAGCTAAATTATTAGGCATTGATGC
AACGATTGTAATGCCTGAAACAGCACCACAAGCGAAACAACAAGCAACAAAAGGCTATGGGGCAAAGGTTATTTTAAAAG
GTAAAAACTTTAACGAAACTAGACTTTATATGGAAGAATTAGCGAAAGAAAATGGCATGACAATCGTTCATCCATATGAC
GATAAGTTTGTAATGGCAGGCCAAGGAACAATTGGTTTAGAAATTTTAGATGATATTTGGAATGTGAATACAGTCATCGT
ACCAGTTGGCGGTGGAGGATTAATTGCAGGTATTGCCACCGCATTAAAATCATTTAACCCTTCAATTCATATTATCGGTG
TTCAATCTGAGAATGTTCATGGTATGGCTGAGTCTTTCTATAAGAGAGATTTAACTGAACATCGAGTGGATAGCACAATA
GCAGATGGTTGTGATGTAAAAGTTCCTGGTGAACAAACATATGAAGTAGTTAAACATTTAGTAGATGAATTTATTCTTGT
TACTGAAGAAGAAATTGAACATGCTATGAAAGATTTAATGCAGCGTGCCAAAATTATTACTGAAGGTGCAGGCGCATTAC
CAACAGCTGCAATTTTAAGTGGAAAAATAAACAATAAATGGCTTGAAGATAAAAATGTTGTTGCATTAGTTTCAGGCGGG
AATGTTGACTTAACTAGAGTTTCAGGTGTCATTGAACATGGACTGAATATTGCAGATACAAGCAAGGGTGTGGTAGGTTA
A

Upstream 100 bases:

>100_bases
GAATAGATAGTAATTTAAATGAAATTGAGTGAAATGAATATTTTAAATATAGCATTATAGTTTGGACTAAAAATTTACAA
AACGGAAGGATGTAATTATT

Downstream 100 bases:

>100_bases
AACATTTAATCTTAAAAATGAGGTGTAATTATGTCAAATGGTAAAGAATTACAAAAAAATATAGGTTTCTTCTCAGCGTT
TGCTATTGTTATGGGGACAG

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase

Number of amino acids: Translated: 346; Mature: 345

Protein sequence:

>346_residues
MTTNTVTLQTAHIVSLGDIEEAKASIKPFIRRTPLIKSMYLSQSITKGNVFLKLENMQFTGSFKFRGASNKINHLTDEQK
EKGIIAASAGNHAQGVALTAKLLGIDATIVMPETAPQAKQQATKGYGAKVILKGKNFNETRLYMEELAKENGMTIVHPYD
DKFVMAGQGTIGLEILDDIWNVNTVIVPVGGGGLIAGIATALKSFNPSIHIIGVQSENVHGMAESFYKRDLTEHRVDSTI
ADGCDVKVPGEQTYEVVKHLVDEFILVTEEEIEHAMKDLMQRAKIITEGAGALPTAAILSGKINNKWLEDKNVVALVSGG
NVDLTRVSGVIEHGLNIADTSKGVVG

Sequences:

>Translated_346_residues
MTTNTVTLQTAHIVSLGDIEEAKASIKPFIRRTPLIKSMYLSQSITKGNVFLKLENMQFTGSFKFRGASNKINHLTDEQK
EKGIIAASAGNHAQGVALTAKLLGIDATIVMPETAPQAKQQATKGYGAKVILKGKNFNETRLYMEELAKENGMTIVHPYD
DKFVMAGQGTIGLEILDDIWNVNTVIVPVGGGGLIAGIATALKSFNPSIHIIGVQSENVHGMAESFYKRDLTEHRVDSTI
ADGCDVKVPGEQTYEVVKHLVDEFILVTEEEIEHAMKDLMQRAKIITEGAGALPTAAILSGKINNKWLEDKNVVALVSGG
NVDLTRVSGVIEHGLNIADTSKGVVG
>Mature_345_residues
TTNTVTLQTAHIVSLGDIEEAKASIKPFIRRTPLIKSMYLSQSITKGNVFLKLENMQFTGSFKFRGASNKINHLTDEQKE
KGIIAASAGNHAQGVALTAKLLGIDATIVMPETAPQAKQQATKGYGAKVILKGKNFNETRLYMEELAKENGMTIVHPYDD
KFVMAGQGTIGLEILDDIWNVNTVIVPVGGGGLIAGIATALKSFNPSIHIIGVQSENVHGMAESFYKRDLTEHRVDSTIA
DGCDVKVPGEQTYEVVKHLVDEFILVTEEEIEHAMKDLMQRAKIITEGAGALPTAAILSGKINNKWLEDKNVVALVSGGN
VDLTRVSGVIEHGLNIADTSKGVVG

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family

Homologues:

Organism=Homo sapiens, GI11345492, Length=318, Percent_Identity=37.4213836477987, Blast_Score=208, Evalue=5e-54,
Organism=Homo sapiens, GI19923959, Length=155, Percent_Identity=40, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI33469958, Length=320, Percent_Identity=26.5625, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1789505, Length=317, Percent_Identity=54.5741324921136, Blast_Score=314, Evalue=4e-87,
Organism=Escherichia coli, GI1790207, Length=297, Percent_Identity=38.7205387205387, Blast_Score=164, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI71991565, Length=324, Percent_Identity=41.358024691358, Blast_Score=214, Evalue=4e-56,
Organism=Caenorhabditis elegans, GI17537387, Length=327, Percent_Identity=39.1437308868502, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17508781, Length=320, Percent_Identity=30, Blast_Score=131, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6322631, Length=319, Percent_Identity=37.9310344827586, Blast_Score=206, Evalue=5e-54,
Organism=Saccharomyces cerevisiae, GI6320930, Length=319, Percent_Identity=40.1253918495298, Blast_Score=196, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6319788, Length=282, Percent_Identity=25.177304964539, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21355833, Length=322, Percent_Identity=40.3726708074534, Blast_Score=175, Evalue=5e-44,
Organism=Drosophila melanogaster, GI24645328, Length=225, Percent_Identity=40.4444444444444, Blast_Score=109, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): THD2_STAA3 (Q2FH01)

Other databases:

- EMBL:   CP000255
- RefSeq:   YP_494027.1
- ProteinModelPortal:   Q2FH01
- SMR:   Q2FH01
- STRING:   Q2FH01
- EnsemblBacteria:   EBSTAT00000037917
- GeneID:   3913061
- GenomeReviews:   CP000255_GR
- KEGG:   saa:SAUSA300_1330
- eggNOG:   COG1171
- GeneTree:   EBGT00050000024421
- HOGENOM:   HBG714501
- OMA:   DIECEAR
- ProtClustDB:   PRK08638
- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789
- TIGRFAMs:   TIGR01127

Pfam domain/function: PF00291 PALP; SSF53686 PyrdxlP-dep_enz_bsu

EC number: =4.3.1.19

Molecular weight: Translated: 37306; Mature: 37175

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTNTVTLQTAHIVSLGDIEEAKASIKPFIRRTPLIKSMYLSQSITKGNVFLKLENMQFT
CCCCEEEEEEEEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCEEEEEEECEEEE
GSFKFRGASNKINHLTDEQKEKGIIAASAGNHAQGVALTAKLLGIDATIVMPETAPQAKQ
EEEEECCCCCCHHHCCCHHHHCCEEEECCCCCCCCCEEEEEEECCCEEEEECCCCCHHHH
QATKGYGAKVILKGKNFNETRLYMEELAKENGMTIVHPYDDKFVMAGQGTIGLEILDDIW
HHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCCEEEEECCCCEEEECCCCCHHHHHHHHC
NVNTVIVPVGGGGLIAGIATALKSFNPSIHIIGVQSENVHGMAESFYKRDLTEHRVDSTI
CCCEEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
ADGCDVKVPGEQTYEVVKHLVDEFILVTEEEIEHAMKDLMQRAKIITEGAGALPTAAILS
CCCCCEECCCHHHHHHHHHHHHHHHEECHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHC
GKINNKWLEDKNVVALVSGGNVDLTRVSGVIEHGLNIADTSKGVVG
CCCCCCEECCCCEEEEEECCCEEHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
TTNTVTLQTAHIVSLGDIEEAKASIKPFIRRTPLIKSMYLSQSITKGNVFLKLENMQFT
CCCEEEEEEEEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCEEEEEEECEEEE
GSFKFRGASNKINHLTDEQKEKGIIAASAGNHAQGVALTAKLLGIDATIVMPETAPQAKQ
EEEEECCCCCCHHHCCCHHHHCCEEEECCCCCCCCCEEEEEEECCCEEEEECCCCCHHHH
QATKGYGAKVILKGKNFNETRLYMEELAKENGMTIVHPYDDKFVMAGQGTIGLEILDDIW
HHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCCEEEEECCCCEEEECCCCCHHHHHHHHC
NVNTVIVPVGGGGLIAGIATALKSFNPSIHIIGVQSENVHGMAESFYKRDLTEHRVDSTI
CCCEEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
ADGCDVKVPGEQTYEVVKHLVDEFILVTEEEIEHAMKDLMQRAKIITEGAGALPTAAILS
CCCCCEECCCHHHHHHHHHHHHHHHEECHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHC
GKINNKWLEDKNVVALVSGGNVDLTRVSGVIEHGLNIADTSKGVVG
CCCCCCEECCCCEEEEEECCCEEHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA