Click here to switch to the map view.

The map label for this gene is apt

Identifier: 160902526

GI number: 160902526

Start: 1134575

End: 1135096

Strand: Direct

Name: apt

Synonym: Pmob_1065

Alternate gene names: 160902526

Gene position: 1134575-1135096 (Clockwise)

Preceding gene: 160902525

Following gene: 160902527

Centisome position: 52.3

GC content: 37.36

Gene sequence:

>522_bases
ATGGAGATAGTAGACCTAAAAAAATGGATAAGAGATATACCAGATTTTCCAGAAAAAGGAGTTATATTTAGAGATATCAC
ACCACTTTTGAAAAACCCTGAAGTTTTTAAGTATTCGGTCGAAAAAATCGCTGAATTGATAAAAGAGTGGGATTTCGATT
GTATCGTATCCCCCGAGTCAAGGGGGTTTATATTTGCTACACCTTTAGCTTACCTCATGAATAAAGAATTCGTTCCCATA
AGAAAACCAGGAAAACTGCCTTACAAAACCTATTCGATCTCTTATGAACTGGAATATGGTCAAACATCCCTGGAAATGCA
TGTTGACGCGATAGATAAAGGAGAAAAGGTGATAGTCGTTGATGATGTGTTAGCCACCGGAGGTACTACAAAAGCGATAA
AAGAATTAGTAGACAGAGCCGGAGGCAAAACCGTTGGAGTTGTCTGCCTTGCTGAATTAACCTATCTAAATCCAAGAGAA
AATTTAAAAGATTTGGAAATTGCCAGCTTGATACGATATTGA

Upstream 100 bases:

>100_bases
TTTAAACTGGCACCCTCAAAATAAAGAATTAGAAAAGATAATATCTGATGCATGGAAATGGCATAAAAATAAAGACAAAA
ATGTTTTAGGAGGATAACTC

Downstream 100 bases:

>100_bases
AAGTTTAATTTAAACGTAAGAAGGGGGAAAAAAGATGAATGGTATAAAATTTGATTTTTCAAATGTTTTCCATCCCAATA
TTGAAAATGGCTTAACGGAA

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 173; Mature: 173

Protein sequence:

>173_residues
MEIVDLKKWIRDIPDFPEKGVIFRDITPLLKNPEVFKYSVEKIAELIKEWDFDCIVSPESRGFIFATPLAYLMNKEFVPI
RKPGKLPYKTYSISYELEYGQTSLEMHVDAIDKGEKVIVVDDVLATGGTTKAIKELVDRAGGKTVGVVCLAELTYLNPRE
NLKDLEIASLIRY

Sequences:

>Translated_173_residues
MEIVDLKKWIRDIPDFPEKGVIFRDITPLLKNPEVFKYSVEKIAELIKEWDFDCIVSPESRGFIFATPLAYLMNKEFVPI
RKPGKLPYKTYSISYELEYGQTSLEMHVDAIDKGEKVIVVDDVLATGGTTKAIKELVDRAGGKTVGVVCLAELTYLNPRE
NLKDLEIASLIRY
>Mature_173_residues
MEIVDLKKWIRDIPDFPEKGVIFRDITPLLKNPEVFKYSVEKIAELIKEWDFDCIVSPESRGFIFATPLAYLMNKEFVPI
RKPGKLPYKTYSISYELEYGQTSLEMHVDAIDKGEKVIVVDDVLATGGTTKAIKELVDRAGGKTVGVVCLAELTYLNPRE
NLKDLEIASLIRY

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=175, Percent_Identity=43.4285714285714, Blast_Score=137, Evalue=6e-33,
Organism=Homo sapiens, GI71773201, Length=129, Percent_Identity=44.9612403100775, Blast_Score=110, Evalue=7e-25,
Organism=Escherichia coli, GI1786675, Length=164, Percent_Identity=43.9024390243902, Blast_Score=144, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17509087, Length=170, Percent_Identity=41.7647058823529, Blast_Score=133, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6323619, Length=163, Percent_Identity=37.4233128834356, Blast_Score=103, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6320649, Length=163, Percent_Identity=34.9693251533742, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17136334, Length=170, Percent_Identity=39.4117647058824, Blast_Score=115, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_PETMO (A9BG28)

Other databases:

- EMBL:   CP000879
- RefSeq:   YP_001568107.1
- ProteinModelPortal:   A9BG28
- SMR:   A9BG28
- GeneID:   5758198
- GenomeReviews:   CP000879_GR
- KEGG:   pmo:Pmob_1065
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- BioCyc:   PMOB403833:PMOB_1065-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 19689; Mature: 19689

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIVDLKKWIRDIPDFPEKGVIFRDITPLLKNPEVFKYSVEKIAELIKEWDFDCIVSPES
CCCHHHHHHHHHCCCCCCCCEEHHCCHHHHCCCHHHHHHHHHHHHHHHHCCCCEEECCCC
RGFIFATPLAYLMNKEFVPIRKPGKLPYKTYSISYELEYGQTSLEMHVDAIDKGEKVIVV
CCEEEECHHHHHHCCCCCCCCCCCCCCEEEEEEEEEEECCCCEEEEEEEECCCCCEEEEE
DDVLATGGTTKAIKELVDRAGGKTVGVVCLAELTYLNPRENLKDLEIASLIRY
ECCHHCCCCHHHHHHHHHHCCCCEEEHHEEEHHHHCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MEIVDLKKWIRDIPDFPEKGVIFRDITPLLKNPEVFKYSVEKIAELIKEWDFDCIVSPES
CCCHHHHHHHHHCCCCCCCCEEHHCCHHHHCCCHHHHHHHHHHHHHHHHCCCCEEECCCC
RGFIFATPLAYLMNKEFVPIRKPGKLPYKTYSISYELEYGQTSLEMHVDAIDKGEKVIVV
CCEEEECHHHHHHCCCCCCCCCCCCCCEEEEEEEEEEECCCCEEEEEEEECCCCCEEEEE
DDVLATGGTTKAIKELVDRAGGKTVGVVCLAELTYLNPRENLKDLEIASLIRY
ECCHHCCCCHHHHHHHHHHCCCCEEEHHEEEHHHHCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA