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The map label for this gene is mazG [H]

Identifier: 160902523

GI number: 160902523

Start: 1132089

End: 1132478

Strand: Direct

Name: mazG [H]

Synonym: Pmob_1062

Alternate gene names: 160902523

Gene position: 1132089-1132478 (Clockwise)

Preceding gene: 160902522

Following gene: 160902524

Centisome position: 52.18

GC content: 36.67

Gene sequence:

>390_bases
ATGAAAAGATTGAGGGGACCAAAAGGTTGCGATCCTGCACTCTCTTTAGCAAGAAGAATTCAAGAAAATGCTGCTGCGGT
AGGGTTTGACTGGGTAGAAGTTAAAGATGTGCTCGATAAAGTAAAAGAAGAAGTGGAAGAACTTAATGAAGCAAAAACCC
AAGCAGAAGTAGAAGAAGAGTTTGGGGATTTGTTGTTTGCGCTGGTTAACTTGGCTCGTTTTTTAAAGATAGATCCGGAA
GTATCTTTAAGAAAGGCAAGTGAGAAGTTTATAGAACGGTTCACTCAGATGGAAAAAGCGATTGAAAAAGATGGAAAGGA
ATTTGAAGCTTTAAATTTAGAAGAGTTAGATAAATATTGGGAATTAATTAAAAAAGAGGAAAAGAGGTGA

Upstream 100 bases:

>100_bases
AACTCTATTATGGGAAAGGAGGGAAAATTCTGCATTCCTCTCACCACTTCCTTATCTGCCGTAAGGCTGTTCTCTGGTGA
GTCTCCTGCAGATATTTTTC

Downstream 100 bases:

>100_bases
AAATTAGGTGGAAATAGGCATATTCGGCCTTCCGTTAACGGGTAAAACTACTATTTTTTCCCTTTTAACTGATTATAAAA
TAGAGGATAGTTATAAAAGA

Product: MazG nucleotide pyrophosphohydrolase

Products: NA

Alternate protein names: NTP-PPase [H]

Number of amino acids: Translated: 129; Mature: 129

Protein sequence:

>129_residues
MKRLRGPKGCDPALSLARRIQENAAAVGFDWVEVKDVLDKVKEEVEELNEAKTQAEVEEEFGDLLFALVNLARFLKIDPE
VSLRKASEKFIERFTQMEKAIEKDGKEFEALNLEELDKYWELIKKEEKR

Sequences:

>Translated_129_residues
MKRLRGPKGCDPALSLARRIQENAAAVGFDWVEVKDVLDKVKEEVEELNEAKTQAEVEEEFGDLLFALVNLARFLKIDPE
VSLRKASEKFIERFTQMEKAIEKDGKEFEALNLEELDKYWELIKKEEKR
>Mature_129_residues
MKRLRGPKGCDPALSLARRIQENAAAVGFDWVEVKDVLDKVKEEVEELNEAKTQAEVEEEFGDLLFALVNLARFLKIDPE
VSLRKASEKFIERFTQMEKAIEKDGKEFEALNLEELDKYWELIKKEEKR

Specific function: Involved in the regulation of bacterial cell survival under conditions of nutritional stress. Regulates the MazEF toxin- antitoxin (TA) module that mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp p

COG id: COG1694

COG function: function code R; Predicted pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nucleoside triphosphate pyrophosphohydrolase family [H]

Homologues:

Organism=Escherichia coli, GI1789144, Length=121, Percent_Identity=45.4545454545455, Blast_Score=101, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004518
- InterPro:   IPR011551 [H]

Pfam domain/function: PF03819 MazG [H]

EC number: =3.6.1.8 [H]

Molecular weight: Translated: 15029; Mature: 15029

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRLRGPKGCDPALSLARRIQENAAAVGFDWVEVKDVLDKVKEEVEELNEAKTQAEVEEE
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FGDLLFALVNLARFLKIDPEVSLRKASEKFIERFTQMEKAIEKDGKEFEALNLEELDKYW
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHH
ELIKKEEKR
HHHHHHCCC
>Mature Secondary Structure
MKRLRGPKGCDPALSLARRIQENAAAVGFDWVEVKDVLDKVKEEVEELNEAKTQAEVEEE
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FGDLLFALVNLARFLKIDPEVSLRKASEKFIERFTQMEKAIEKDGKEFEALNLEELDKYW
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHH
ELIKKEEKR
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]