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The map label for this gene is hisG

Identifier: 160902479

GI number: 160902479

Start: 1083999

End: 1084631

Strand: Direct

Name: hisG

Synonym: Pmob_1016

Alternate gene names: 160902479

Gene position: 1083999-1084631 (Clockwise)

Preceding gene: 160902478

Following gene: 160902480

Centisome position: 49.96

GC content: 34.28

Gene sequence:

>633_bases
ATGACAACAATATCAGCCGCATTGCCATCAGGAAGATTGCTGGAAGACAGTAAGGCTTTTCTAAAAAAGATAGGTATAAA
TGTTAAAGAACCTGCGAAGAGAGAGCTTATATCATATGAAAATGGTTATGCCTTTTATTTTCCAAGAGCTTTTGATGTTC
CTGTATACGTAGAAAATGGAGTAGACATTGGGATATGCGGAAGTGATGTTGTCCTTGAAAGAAACAATGAAGTGTATATT
CCATTAGAACTACCTTTTGGTAAATGTAGAATGAGTATCATCTTACCAGAAAACAGAGAAATATCTTTTCAAAATATGGA
AGGATACAAAATAGCGACCAAATACCCTGAAATTACAAAAAATTTCTTTTCTGAAAAGGGTTTAAAGGTGAAGATACTCA
AGTTAAATGGAGCGGTAGAATTGGCAGCAAAAACCGGTATAGCGGATGCCATAGTAGATATTGTTGACACCGGGAACACT
ATAAAAGCAAACAATTTAAAAGAAGCTTACAAGATAATGGATATCTCTGCAGTACTCTTGGTAAACAGGATAACCCAAAA
GACGAAGTTCGATTTTATAAACGATTTAATAAATAAAGCAAAGAATTATAAAAATGGGGTGAAAGGGCACTAA

Upstream 100 bases:

>100_bases
ATAATGGTTACCTTTTAGGCAACGGTGGCCAATACAAGATAAACGGCAAATATTCGTGTGGAATGGCTTTAAATTTGGAT
ATTATAGGGGAGATGATGAG

Downstream 100 bases:

>100_bases
AGCAAATCCTACAGTTGCTAAGGTCAGTGCCAAAAATCGAAGGAGGGAAAAATAATGGAATTACAGAGCTACGTTTCACA
GATATTAAACGACATTAAAA

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 210; Mature: 209

Protein sequence:

>210_residues
MTTISAALPSGRLLEDSKAFLKKIGINVKEPAKRELISYENGYAFYFPRAFDVPVYVENGVDIGICGSDVVLERNNEVYI
PLELPFGKCRMSIILPENREISFQNMEGYKIATKYPEITKNFFSEKGLKVKILKLNGAVELAAKTGIADAIVDIVDTGNT
IKANNLKEAYKIMDISAVLLVNRITQKTKFDFINDLINKAKNYKNGVKGH

Sequences:

>Translated_210_residues
MTTISAALPSGRLLEDSKAFLKKIGINVKEPAKRELISYENGYAFYFPRAFDVPVYVENGVDIGICGSDVVLERNNEVYI
PLELPFGKCRMSIILPENREISFQNMEGYKIATKYPEITKNFFSEKGLKVKILKLNGAVELAAKTGIADAIVDIVDTGNT
IKANNLKEAYKIMDISAVLLVNRITQKTKFDFINDLINKAKNYKNGVKGH
>Mature_209_residues
TTISAALPSGRLLEDSKAFLKKIGINVKEPAKRELISYENGYAFYFPRAFDVPVYVENGVDIGICGSDVVLERNNEVYIP
LELPFGKCRMSIILPENREISFQNMEGYKIATKYPEITKNFFSEKGLKVKILKLNGAVELAAKTGIADAIVDIVDTGNTI
KANNLKEAYKIMDISAVLLVNRITQKTKFDFINDLINKAKNYKNGVKGH

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=203, Percent_Identity=33.9901477832512, Blast_Score=100, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6320896, Length=184, Percent_Identity=29.8913043478261, Blast_Score=82, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_PETMO (A9BJZ4)

Other databases:

- EMBL:   CP000879
- RefSeq:   YP_001568060.1
- ProteinModelPortal:   A9BJZ4
- SMR:   A9BJZ4
- GeneID:   5756565
- GenomeReviews:   CP000879_GR
- KEGG:   pmo:Pmob_1016
- HOGENOM:   HBG391868
- OMA:   GCAREYF
- ProtClustDB:   PRK01686
- BioCyc:   PMOB403833:PMOB_1016-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01018
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070

Pfam domain/function: PF01634 HisG

EC number: =2.4.2.17

Molecular weight: Translated: 23459; Mature: 23327

Theoretical pI: Translated: 9.40; Mature: 9.40

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTISAALPSGRLLEDSKAFLKKIGINVKEPAKRELISYENGYAFYFPRAFDVPVYVENG
CCEECCCCCCCCEEHHHHHHHHHHCCCCCCCHHHHHHCCCCCEEEECCCCCCCCEEEECC
VDIGICGSDVVLERNNEVYIPLELPFGKCRMSIILPENREISFQNMEGYKIATKYPEITK
CEEEEECCCEEEECCCCEEEEEECCCCCEEEEEEECCCCCEEEECCCCEEEEECCCHHHH
NFFSEKGLKVKILKLNGAVELAAKTGIADAIVDIVDTGNTIKANNLKEAYKIMDISAVLL
HHHHCCCCEEEEEEECCEEEEEECCCHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHH
VNRITQKTKFDFINDLINKAKNYKNGVKGH
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TTISAALPSGRLLEDSKAFLKKIGINVKEPAKRELISYENGYAFYFPRAFDVPVYVENG
CEECCCCCCCCEEHHHHHHHHHHCCCCCCCHHHHHHCCCCCEEEECCCCCCCCEEEECC
VDIGICGSDVVLERNNEVYIPLELPFGKCRMSIILPENREISFQNMEGYKIATKYPEITK
CEEEEECCCEEEECCCCEEEEEECCCCCEEEEEEECCCCCEEEECCCCEEEEECCCHHHH
NFFSEKGLKVKILKLNGAVELAAKTGIADAIVDIVDTGNTIKANNLKEAYKIMDISAVLL
HHHHCCCCEEEEEEECCEEEEEECCCHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHH
VNRITQKTKFDFINDLINKAKNYKNGVKGH
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA