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The map label for this gene is vipA [H]

Identifier: 160902425

GI number: 160902425

Start: 1020566

End: 1021873

Strand: Direct

Name: vipA [H]

Synonym: Pmob_0961

Alternate gene names: 160902425

Gene position: 1020566-1021873 (Clockwise)

Preceding gene: 160902424

Following gene: 160902426

Centisome position: 47.04

GC content: 35.63

Gene sequence:

>1308_bases
ATGGCATTATTGGATAAAATAAAAGATAAAACTGCAAAGATAGGGGTAATAGGTTTGGGTTATGTTGGTTTACCTCTTGC
GGTGGAAAAGGCGAAGGCAGGGTACAACGTTTTAGGGTTCGATATTCAAAAAGAAAAAGTAGAAAAGGTCAACAAAGGGA
TAAATTATATCGGAGATGTTGTAAATTCAGAGTTAGAAAAGCTGGTTGACGATGGTTATCTAAGCGCTACAGGCGATTAT
GATAGAATAAAGGAGTGCGATTGTGTAACAATATGTGTTCCAACTCCTTTGGATAAATACAAACAACCTGATTTAAGTTT
TGTTGTTGATTCAACCAAAGAGGTAGCCAAAAGGCTTCATCCAGAAATGTTGATTGTTTTAGAAAGCACTACTTATCCGG
GAACTACCGAAGAAGTAATTCTGCCGTTATTACAAGAGTATGGGTTCAAGGTTGGAAAAGATTTTTATTTAGCTTTTAGC
CCAGAAAGGGTGGATCCGGGAAATTTGATTTACAAGACGAAAAATACTCCAAAAGTAGTCGGTGGAGTTACCGAAAAATG
CACTTTACATGCAAAAACCCTCTATGAAAACGTATTAAACGCAGAAGTTTTCACCGTTTCATCCCCTAAGGAAGCAGAAA
TGTCAAAAATTTTGGAAAATACCTTTAGAATAGTCAATATTGGTCTCATAAATGAAATGGCTATCTTAGCAAAGAAAATG
GGAATAAATATCTGGCAGGTCATAGATGCAGCTGCTACAAAGCCTTTTGGATTCATGCCCTTTTATCCAGGACCAGGTGT
GGGCGGGCATTGTATTCCAATAGATCCTTTTTATTTAACGTATAAAGCTAGAGAGTTTGACTATCACACAAGGATAATAG
AATTGGCTGGGGAAATAAACGATTATATGCCTGAGTATGTAATTGAAAGACTAATGGACATTTTAAACGAAAATAAAAAG
TGTTTGAACGGTTCCAAAATATTGATGTTAGGGGTGACTTATAAAAACGATATAGACGATTTAAGAGAGTCTCCTGCTTT
GAAAGTTTTGGAGCTTTTGGAAAGAAAGGGTGCAGAAGTTAGGATTCATGACCCTTATATAAAAAGTTTTTCTCACAAAG
GAATAGCGTATAAAACGGTAGACTTAACAAAAGAATTGTTAGAGGGATCAGATGCTGTCTTAATTACTACGGGGCACAAA
AAGGTGGATTACAATTTCGTTTTGGAAAATGCCAATATAGTTTTTGATACAAAAAATGTCACAAAAGGACTTAGAGAGAA
GTATCCAGAAAAAGTTTCTTTATTATGA

Upstream 100 bases:

>100_bases
AGGAGCTGGAATACGTAGTTAAAAGTATTAAAGAGTTTTTTTCAAAATAGTTTTAGAGTTTCTAAAGATAGCGATATTTT
AGAAAGAGGAGGACTAAAAA

Downstream 100 bases:

>100_bases
AAAGTTTAAAAGTAGGTGATATTCTTTGCTTAAATTGGCTGTAATAGGTTGTGGAAGAATTGCTCAAACAAAACACTCAG
AAGCAATTATAAAAAATTCT

Product: nucleotide sugar dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: NA

Number of amino acids: Translated: 435; Mature: 434

Protein sequence:

>435_residues
MALLDKIKDKTAKIGVIGLGYVGLPLAVEKAKAGYNVLGFDIQKEKVEKVNKGINYIGDVVNSELEKLVDDGYLSATGDY
DRIKECDCVTICVPTPLDKYKQPDLSFVVDSTKEVAKRLHPEMLIVLESTTYPGTTEEVILPLLQEYGFKVGKDFYLAFS
PERVDPGNLIYKTKNTPKVVGGVTEKCTLHAKTLYENVLNAEVFTVSSPKEAEMSKILENTFRIVNIGLINEMAILAKKM
GINIWQVIDAAATKPFGFMPFYPGPGVGGHCIPIDPFYLTYKAREFDYHTRIIELAGEINDYMPEYVIERLMDILNENKK
CLNGSKILMLGVTYKNDIDDLRESPALKVLELLERKGAEVRIHDPYIKSFSHKGIAYKTVDLTKELLEGSDAVLITTGHK
KVDYNFVLENANIVFDTKNVTKGLREKYPEKVSLL

Sequences:

>Translated_435_residues
MALLDKIKDKTAKIGVIGLGYVGLPLAVEKAKAGYNVLGFDIQKEKVEKVNKGINYIGDVVNSELEKLVDDGYLSATGDY
DRIKECDCVTICVPTPLDKYKQPDLSFVVDSTKEVAKRLHPEMLIVLESTTYPGTTEEVILPLLQEYGFKVGKDFYLAFS
PERVDPGNLIYKTKNTPKVVGGVTEKCTLHAKTLYENVLNAEVFTVSSPKEAEMSKILENTFRIVNIGLINEMAILAKKM
GINIWQVIDAAATKPFGFMPFYPGPGVGGHCIPIDPFYLTYKAREFDYHTRIIELAGEINDYMPEYVIERLMDILNENKK
CLNGSKILMLGVTYKNDIDDLRESPALKVLELLERKGAEVRIHDPYIKSFSHKGIAYKTVDLTKELLEGSDAVLITTGHK
KVDYNFVLENANIVFDTKNVTKGLREKYPEKVSLL
>Mature_434_residues
ALLDKIKDKTAKIGVIGLGYVGLPLAVEKAKAGYNVLGFDIQKEKVEKVNKGINYIGDVVNSELEKLVDDGYLSATGDYD
RIKECDCVTICVPTPLDKYKQPDLSFVVDSTKEVAKRLHPEMLIVLESTTYPGTTEEVILPLLQEYGFKVGKDFYLAFSP
ERVDPGNLIYKTKNTPKVVGGVTEKCTLHAKTLYENVLNAEVFTVSSPKEAEMSKILENTFRIVNIGLINEMAILAKKMG
INIWQVIDAAATKPFGFMPFYPGPGVGGHCIPIDPFYLTYKAREFDYHTRIIELAGEINDYMPEYVIERLMDILNENKKC
LNGSKILMLGVTYKNDIDDLRESPALKVLELLERKGAEVRIHDPYIKSFSHKGIAYKTVDLTKELLEGSDAVLITTGHKK
VDYNFVLENANIVFDTKNVTKGLREKYPEKVSLL

Specific function: Catalyzes The Oxidation Of Udp-Mannac To Udp-N- Acetylmannosaminuronic Acid (Udp-Mannaca). [C]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=448, Percent_Identity=25, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI296040438, Length=328, Percent_Identity=25.3048780487805, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI296040443, Length=294, Percent_Identity=25.5102040816327, Blast_Score=75, Evalue=8e-14,
Organism=Escherichia coli, GI48994968, Length=403, Percent_Identity=33.7468982630273, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI1788340, Length=367, Percent_Identity=25.3405994550409, Blast_Score=86, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17560350, Length=384, Percent_Identity=25, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17136908, Length=376, Percent_Identity=24.7340425531915, Blast_Score=82, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 48754; Mature: 48623

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALLDKIKDKTAKIGVIGLGYVGLPLAVEKAKAGYNVLGFDIQKEKVEKVNKGINYIGDV
CCHHHHHHCCHHEEEEEEECCCCCCCEEHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHH
VNSELEKLVDDGYLSATGDYDRIKECDCVTICVPTPLDKYKQPDLSFVVDSTKEVAKRLH
HHHHHHHHHCCCCEECCCCHHHHCCCCEEEEEECCCHHHHCCCCCEEEECCHHHHHHHCC
PEMLIVLESTTYPGTTEEVILPLLQEYGFKVGKDFYLAFSPERVDPGNLIYKTKNTPKVV
CEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCEEEECCCCCHHH
GGVTEKCTLHAKTLYENVLNAEVFTVSSPKEAEMSKILENTFRIVNIGLINEMAILAKKM
CCCCHHHEEHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHEEEEEEHHHHHHHHHHHH
GINIWQVIDAAATKPFGFMPFYPGPGVGGHCIPIDPFYLTYKAREFDYHTRIIELAGEIN
CCHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCEEEEEEECCCHHHHHHHHHHHHHH
DYMPEYVIERLMDILNENKKCLNGSKILMLGVTYKNDIDDLRESPALKVLELLERKGAEV
HCCHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCHHHHHCCCHHHHHHHHHHCCCEE
RIHDPYIKSFSHKGIAYKTVDLTKELLEGSDAVLITTGHKKVDYNFVLENANIVFDTKNV
EEECHHHHHHCCCCCEEEHHHHHHHHHCCCCEEEEEECCCEEEEEEEEECCEEEEECHHH
TKGLREKYPEKVSLL
HHHHHHHCCCCCCCC
>Mature Secondary Structure 
ALLDKIKDKTAKIGVIGLGYVGLPLAVEKAKAGYNVLGFDIQKEKVEKVNKGINYIGDV
CHHHHHHCCHHEEEEEEECCCCCCCEEHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHH
VNSELEKLVDDGYLSATGDYDRIKECDCVTICVPTPLDKYKQPDLSFVVDSTKEVAKRLH
HHHHHHHHHCCCCEECCCCHHHHCCCCEEEEEECCCHHHHCCCCCEEEECCHHHHHHHCC
PEMLIVLESTTYPGTTEEVILPLLQEYGFKVGKDFYLAFSPERVDPGNLIYKTKNTPKVV
CEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCEEEECCCCCHHH
GGVTEKCTLHAKTLYENVLNAEVFTVSSPKEAEMSKILENTFRIVNIGLINEMAILAKKM
CCCCHHHEEHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHEEEEEEHHHHHHHHHHHH
GINIWQVIDAAATKPFGFMPFYPGPGVGGHCIPIDPFYLTYKAREFDYHTRIIELAGEIN
CCHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCEEEEEEECCCHHHHHHHHHHHHHH
DYMPEYVIERLMDILNENKKCLNGSKILMLGVTYKNDIDDLRESPALKVLELLERKGAEV
HCCHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCHHHHHCCCHHHHHHHHHHCCCEE
RIHDPYIKSFSHKGIAYKTVDLTKELLEGSDAVLITTGHKKVDYNFVLENANIVFDTKNV
EEECHHHHHHCCCCCEEEHHHHHHHHHCCCCEEEEEECCCEEEEEEEEECCEEEEECHHH
TKGLREKYPEKVSLL
HHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8248629; 8331073; 11677608; 12644504 [H]