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The map label for this gene is mtaD [H]

Identifier: 160902224

GI number: 160902224

Start: 811019

End: 812347

Strand: Direct

Name: mtaD [H]

Synonym: Pmob_0758

Alternate gene names: 160902224

Gene position: 811019-812347 (Clockwise)

Preceding gene: 160902223

Following gene: 160902225

Centisome position: 37.38

GC content: 36.04

Gene sequence:

>1329_bases
ATGTCTAAAAAGCTTTTGAAGAATGCGTATGTTTTGATAAGTGCTGATGATGATGTAGAAAAATTTGATATATTAATAGA
CGGTGATGAGATCGAAGATTTACTTGCACCAGGTGATTCAACCGAGATGGATTTGGGAGATGTGGACGAGTACGATCTAA
CTGGTAAGCTGATCGTCCCTGGATTTATTAACACCCATAGCCATTCAGTAATGTCTTATTTTAGAGGTATAGCCGATGAT
TTATCGCTTAACGATTGGTTGTTCAAAGAGATGCTGCCAAGAGAGGATTTTTTGGAAAGTGAAATGGCTTACTACGGTGC
CTTAGTTTCTATGTTAGAAATGATTTCCAACGGAATAACAACTTTTGTTGATATGTATATGTTTACTGATGAGATAGCTA
AAGCTTCATACGATTTAGGAATTAGGGCATACATATCAAGAGGGCTCTCTTTTGATACAGATGAGGGTTGGAATAGAAGG
ATAAAAGAAAATATCGAAACGTATGAAAAATACAATGGCTTAGACAATAGGATTTACATAGGCTTTGGACCTCATGCCCC
TTACACCGTTCCAATGGATAAATTGAAAGAAGTAGCGAAAATTGCAAAAAAATACAACACCCACATTCAAATTCATTTGT
TAGAATCTGCAAATGAAAGAAAGCAGTACAATCTTTTAGATGTTGAGAATACAGGTTTATTCGATCTTCCCACGATTGCG
GCGCACTGTGTACATGTGGATGAAAAAGATATAGAGGTTCTTTCGAGAAACGAAGTGAATGTAGCTTATAACCCAATTAG
TAATATGAAGTTGGGCAATGGGATAGCCCCCATAGTCGATATGCTCGATAAGAATATAAACATAACTTTTGGTACGGATG
GTTGTGCTAGCAACAACTCTTTGAATTTTTTCAACGAGATGAAGTTTGGAGGCATATTGCAGAAATACAAGTACGGACCT
GATAGATTTTCAGTCGAACAGATTTTGCGGATGAGCTGGGAGAACGGAGGTTTTGCCTTAGAAACAAATATCGGAAGGTT
AGAACCTGAGTTTAAAGCGGATTTGGTTATTTTAGATATGGATTCCTTTGAGTTTTTACCTAATGATTTATCAAGGTTAA
AGTCTCATATCGTTTATTCTGCAAATCCTAAGAACGTTTTCGCAACGATGGTAGCGGGTAACTTTTTGTACTACGATGGA
AAATTTCTAACTTTAAAAGAGGAAAAGGAGCAAATTTATGAGAAATTCCACAAATTTTACCAAAGAATCGAAGATAAGTA
TAATAATAGCGATTATTCTGATATCCATAACGACGATAGGGATATCTAA

Upstream 100 bases:

>100_bases
TTTTCCGCAATGGTTGATGAATTAGGAAGCTATTGAATCTTTAGCTCAATGGTAGTTCACAGTATAATATTCATTGAAAA
CAACCAAAGGAGTTGTAGAT

Downstream 100 bases:

>100_bases
ACCTATCGATGATTACATAGAGTTTTCTCCTACAGGCTATGAAGAGATAAGTAGGATAGTCACCAGAAATGGGACGATAA
TAAACACAACGGTCCCAGAT

Product: amidohydrolase

Products: NA

Alternate protein names: MTA/SAH deaminase [H]

Number of amino acids: Translated: 442; Mature: 441

Protein sequence:

>442_residues
MSKKLLKNAYVLISADDDVEKFDILIDGDEIEDLLAPGDSTEMDLGDVDEYDLTGKLIVPGFINTHSHSVMSYFRGIADD
LSLNDWLFKEMLPREDFLESEMAYYGALVSMLEMISNGITTFVDMYMFTDEIAKASYDLGIRAYISRGLSFDTDEGWNRR
IKENIETYEKYNGLDNRIYIGFGPHAPYTVPMDKLKEVAKIAKKYNTHIQIHLLESANERKQYNLLDVENTGLFDLPTIA
AHCVHVDEKDIEVLSRNEVNVAYNPISNMKLGNGIAPIVDMLDKNINITFGTDGCASNNSLNFFNEMKFGGILQKYKYGP
DRFSVEQILRMSWENGGFALETNIGRLEPEFKADLVILDMDSFEFLPNDLSRLKSHIVYSANPKNVFATMVAGNFLYYDG
KFLTLKEEKEQIYEKFHKFYQRIEDKYNNSDYSDIHNDDRDI

Sequences:

>Translated_442_residues
MSKKLLKNAYVLISADDDVEKFDILIDGDEIEDLLAPGDSTEMDLGDVDEYDLTGKLIVPGFINTHSHSVMSYFRGIADD
LSLNDWLFKEMLPREDFLESEMAYYGALVSMLEMISNGITTFVDMYMFTDEIAKASYDLGIRAYISRGLSFDTDEGWNRR
IKENIETYEKYNGLDNRIYIGFGPHAPYTVPMDKLKEVAKIAKKYNTHIQIHLLESANERKQYNLLDVENTGLFDLPTIA
AHCVHVDEKDIEVLSRNEVNVAYNPISNMKLGNGIAPIVDMLDKNINITFGTDGCASNNSLNFFNEMKFGGILQKYKYGP
DRFSVEQILRMSWENGGFALETNIGRLEPEFKADLVILDMDSFEFLPNDLSRLKSHIVYSANPKNVFATMVAGNFLYYDG
KFLTLKEEKEQIYEKFHKFYQRIEDKYNNSDYSDIHNDDRDI
>Mature_441_residues
SKKLLKNAYVLISADDDVEKFDILIDGDEIEDLLAPGDSTEMDLGDVDEYDLTGKLIVPGFINTHSHSVMSYFRGIADDL
SLNDWLFKEMLPREDFLESEMAYYGALVSMLEMISNGITTFVDMYMFTDEIAKASYDLGIRAYISRGLSFDTDEGWNRRI
KENIETYEKYNGLDNRIYIGFGPHAPYTVPMDKLKEVAKIAKKYNTHIQIHLLESANERKQYNLLDVENTGLFDLPTIAA
HCVHVDEKDIEVLSRNEVNVAYNPISNMKLGNGIAPIVDMLDKNINITFGTDGCASNNSLNFFNEMKFGGILQKYKYGPD
RFSVEQILRMSWENGGFALETNIGRLEPEFKADLVILDMDSFEFLPNDLSRLKSHIVYSANPKNVFATMVAGNFLYYDGK
FLTLKEEKEQIYEKFHKFYQRIEDKYNNSDYSDIHNDDRDI

Specific function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine. Adenosine-5-monophosphate (AMP) and S-adenosyl-L-methionine (SAM) ar

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTA/SAH deaminase family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=340, Percent_Identity=24.4117647058824, Blast_Score=69, Evalue=9e-12,
Organism=Escherichia coli, GI87082177, Length=420, Percent_Identity=26.4285714285714, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI1789249, Length=336, Percent_Identity=27.0833333333333, Blast_Score=92, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17540282, Length=383, Percent_Identity=25.8485639686684, Blast_Score=85, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6319963, Length=291, Percent_Identity=26.1168384879725, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24643849, Length=377, Percent_Identity=21.2201591511936, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.28 [H]

Molecular weight: Translated: 50750; Mature: 50619

Theoretical pI: Translated: 4.41; Mature: 4.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKLLKNAYVLISADDDVEKFDILIDGDEIEDLLAPGDSTEMDLGDVDEYDLTGKLIVP
CCCCHHCCEEEEEECCCCCEEEEEEECCCHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEC
GFINTHSHSVMSYFRGIADDLSLNDWLFKEMLPREDFLESEMAYYGALVSMLEMISNGIT
CCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHH
TFVDMYMFTDEIAKASYDLGIRAYISRGLSFDTDEGWNRRIKENIETYEKYNGLDNRIYI
HHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEE
GFGPHAPYTVPMDKLKEVAKIAKKYNTHIQIHLLESANERKQYNLLDVENTGLFDLPTIA
EECCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCEEEECCCCCCCHHHHH
AHCVHVDEKDIEVLSRNEVNVAYNPISNMKLGNGIAPIVDMLDKNINITFGTDGCASNNS
HHHEECCCHHHHHHCCCCCEEEECCCCCCCCCCCHHHHHHHHCCCCEEEECCCCCCCCCC
LNFFNEMKFGGILQKYKYGPDRFSVEQILRMSWENGGFALETNIGRLEPEFKADLVILDM
CCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCEEEECCCCCCCCCCCCCEEEEEC
DSFEFLPNDLSRLKSHIVYSANPKNVFATMVAGNFLYYDGKFLTLKEEKEQIYEKFHKFY
CCCCCCHHHHHHHHHCEEECCCCCHHEEHEEECCEEEECCEEEEEHHHHHHHHHHHHHHH
QRIEDKYNNSDYSDIHNDDRDI
HHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SKKLLKNAYVLISADDDVEKFDILIDGDEIEDLLAPGDSTEMDLGDVDEYDLTGKLIVP
CCCHHCCEEEEEECCCCCEEEEEEECCCHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEC
GFINTHSHSVMSYFRGIADDLSLNDWLFKEMLPREDFLESEMAYYGALVSMLEMISNGIT
CCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHH
TFVDMYMFTDEIAKASYDLGIRAYISRGLSFDTDEGWNRRIKENIETYEKYNGLDNRIYI
HHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEE
GFGPHAPYTVPMDKLKEVAKIAKKYNTHIQIHLLESANERKQYNLLDVENTGLFDLPTIA
EECCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCEEEECCCCCCCHHHHH
AHCVHVDEKDIEVLSRNEVNVAYNPISNMKLGNGIAPIVDMLDKNINITFGTDGCASNNS
HHHEECCCHHHHHHCCCCCEEEECCCCCCCCCCCHHHHHHHHCCCCEEEECCCCCCCCCC
LNFFNEMKFGGILQKYKYGPDRFSVEQILRMSWENGGFALETNIGRLEPEFKADLVILDM
CCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCEEEECCCCCCCCCCCCCEEEEEC
DSFEFLPNDLSRLKSHIVYSANPKNVFATMVAGNFLYYDGKFLTLKEEKEQIYEKFHKFY
CCCCCCHHHHHHHHHCEEECCCCCHHEEHEEECCEEEECCEEEEEHHHHHHHHHHHHHHH
QRIEDKYNNSDYSDIHNDDRDI
HHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]