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The map label for this gene is cyoE1 [H]

Identifier: 160877456

GI number: 160877456

Start: 5147402

End: 5148271

Strand: Direct

Name: cyoE1 [H]

Synonym: Sbal195_4354

Alternate gene names: 160877456

Gene position: 5147402-5148271 (Clockwise)

Preceding gene: 160877455

Following gene: 160877462

Centisome position: 96.26

GC content: 51.38

Gene sequence:

>870_bases
GTGACTAAGCCTGGCATCATTTTCGGGAATCTGATTTCCGTTGCTGGCGGTTTTTTATTAGCCGCCAAAGGCGACGTAAA
TCTGGTCTTGATGCTAGCGAGCTTAGTGGGATTGTCCTTGGTCGTAGCCTCGGGTTGCGCAATCAATAACTGTATTGACC
GTGATATCGACGCCAAGATGCAGCGAACCTGCAAACGCGTGACCGTCACGGGCGAAATTGCCGTGGGTAACGTACTCGCG
TTTGGACTCGCCTTAGGCGTGTTGGGCTTTAGCATCTTAGCCTTGTTTACCAATGCATTAGCCCTGCTATTTGCCGTTAT
TGGTTACATAGTATATGTGGGGGTTTATAGCCTCTACATGAAACGTAACTCAGTGTATGGCACTTTGGTTGGCAGCTTCT
CGGGCGCTGTACCGCCCGTGGTTGGCTATTGCAGTGTGACAGGGCAAATGGACATGGGCGCGGCTATTTTGCTGTTGATG
TTCAGTCTATGGCAGATGCCACATTCTTACGCCATCGCGATTTTCCGTTTTAATGACTATGCGGCCGCCAATATTCCTGT
GCTGCCAGTGGCAGAAGGCATGACCAAAGCAAAACTGCATATCGTGCTTTATATTGCCGTGTTCGCCTTAGTCAGTGCAC
TGTTGCCACTCGCGGGCTACACAGGTATCGCCTTTATGGCGGTCACCTGCGCCACCAGCCTGTGGTGGCTTGCCATGGCA
TTAAAAGGTTATCGCCACGGCGTCGACATGCAACGCTGGGCTCGCCAAGTGTTTGGTTTTTCAATCATCACTATTACGGC
GCTCAGTGTGACTATGGCGCTCGACTTCCAAGTCGTGAGTCAGGCGCCACTGCTCACCTTAGTGAAGTAA

Upstream 100 bases:

>100_bases
GAAGCCAACGCTTTGATGATGTAACGAGAAACAGTCTATGCAAATACAAGACAGATTTATGTCACCGCAATGGAAAGCAC
GCTTCAAAGGGTATGTACAG

Downstream 100 bases:

>100_bases
ATCCTAAGCTTTCAGCTAATGGTCTAGTCCTGAAATAAGTTGATAATACAAAAGCGCTAACCTAGATTAGCGCTTTTTTT
CTCCCTTAAAACAGCCCCCT

Product: protoheme IX farnesyltransferase

Products: diphosphate; presqualene diphosphate

Alternate protein names: Heme B farnesyltransferase 1; Heme O synthase 1 [H]

Number of amino acids: Translated: 289; Mature: 288

Protein sequence:

>289_residues
MTKPGIIFGNLISVAGGFLLAAKGDVNLVLMLASLVGLSLVVASGCAINNCIDRDIDAKMQRTCKRVTVTGEIAVGNVLA
FGLALGVLGFSILALFTNALALLFAVIGYIVYVGVYSLYMKRNSVYGTLVGSFSGAVPPVVGYCSVTGQMDMGAAILLLM
FSLWQMPHSYAIAIFRFNDYAAANIPVLPVAEGMTKAKLHIVLYIAVFALVSALLPLAGYTGIAFMAVTCATSLWWLAMA
LKGYRHGVDMQRWARQVFGFSIITITALSVTMALDFQVVSQAPLLTLVK

Sequences:

>Translated_289_residues
MTKPGIIFGNLISVAGGFLLAAKGDVNLVLMLASLVGLSLVVASGCAINNCIDRDIDAKMQRTCKRVTVTGEIAVGNVLA
FGLALGVLGFSILALFTNALALLFAVIGYIVYVGVYSLYMKRNSVYGTLVGSFSGAVPPVVGYCSVTGQMDMGAAILLLM
FSLWQMPHSYAIAIFRFNDYAAANIPVLPVAEGMTKAKLHIVLYIAVFALVSALLPLAGYTGIAFMAVTCATSLWWLAMA
LKGYRHGVDMQRWARQVFGFSIITITALSVTMALDFQVVSQAPLLTLVK
>Mature_288_residues
TKPGIIFGNLISVAGGFLLAAKGDVNLVLMLASLVGLSLVVASGCAINNCIDRDIDAKMQRTCKRVTVTGEIAVGNVLAF
GLALGVLGFSILALFTNALALLFAVIGYIVYVGVYSLYMKRNSVYGTLVGSFSGAVPPVVGYCSVTGQMDMGAAILLLMF
SLWQMPHSYAIAIFRFNDYAAANIPVLPVAEGMTKAKLHIVLYIAVFALVSALLPLAGYTGIAFMAVTCATSLWWLAMAL
KGYRHGVDMQRWARQVFGFSIITITALSVTMALDFQVVSQAPLLTLVK

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group [H]

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI17921982, Length=169, Percent_Identity=32.5443786982249, Blast_Score=81, Evalue=9e-16,
Organism=Escherichia coli, GI1786631, Length=288, Percent_Identity=61.4583333333333, Blast_Score=347, Evalue=4e-97,
Organism=Caenorhabditis elegans, GI71998235, Length=231, Percent_Identity=27.7056277056277, Blast_Score=90, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6325085, Length=211, Percent_Identity=26.5402843601896, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19921064, Length=258, Percent_Identity=28.6821705426357, Blast_Score=89, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006369
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: 2.5.1.21

Molecular weight: Translated: 30739; Mature: 30608

Theoretical pI: Translated: 9.31; Mature: 9.31

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKPGIIFGNLISVAGGFLLAAKGDVNLVLMLASLVGLSLVVASGCAINNCIDRDIDAKM
CCCCCEEHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHH
QRTCKRVTVTGEIAVGNVLAFGLALGVLGFSILALFTNALALLFAVIGYIVYVGVYSLYM
HHHHHHEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KRNSVYGTLVGSFSGAVPPVVGYCSVTGQMDMGAAILLLMFSLWQMPHSYAIAIFRFNDY
HHCCCCEEEHHCCCCCCCCCEEHEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCC
AAANIPVLPVAEGMTKAKLHIVLYIAVFALVSALLPLAGYTGIAFMAVTCATSLWWLAMA
CCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
LKGYRHGVDMQRWARQVFGFSIITITALSVTMALDFQVVSQAPLLTLVK
HHHHHCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCEECC
>Mature Secondary Structure 
TKPGIIFGNLISVAGGFLLAAKGDVNLVLMLASLVGLSLVVASGCAINNCIDRDIDAKM
CCCCEEHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHH
QRTCKRVTVTGEIAVGNVLAFGLALGVLGFSILALFTNALALLFAVIGYIVYVGVYSLYM
HHHHHHEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KRNSVYGTLVGSFSGAVPPVVGYCSVTGQMDMGAAILLLMFSLWQMPHSYAIAIFRFNDY
HHCCCCEEEHHCCCCCCCCCEEHEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCC
AAANIPVLPVAEGMTKAKLHIVLYIAVFALVSALLPLAGYTGIAFMAVTCATSLWWLAMA
CCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
LKGYRHGVDMQRWARQVFGFSIITITALSVTMALDFQVVSQAPLLTLVK
HHHHHCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: farnesyl diphosphate

Specific reaction: 2 farnesyl diphosphate = diphosphate + presqualene diphosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA