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The map label for this gene is tpm [H]

Identifier: 160877014

GI number: 160877014

Start: 4607545

End: 4608201

Strand: Reverse

Name: tpm [H]

Synonym: Sbal195_3910

Alternate gene names: 160877014

Gene position: 4608201-4607545 (Counterclockwise)

Preceding gene: 160877015

Following gene: 160877012

Centisome position: 86.18

GC content: 47.03

Gene sequence:

>657_bases
ATGGAACCCGGTTTTTGGCATGAAAAGTGGCACCAGCAACAAATAGGTTTTCATCAGCAAGACATCAATCCTTTCCTGGT
TAAGTATTGGCAGAAGCTTGGATTACCCGCAGATACGCAGGTTTTTGTGCCCTTATGTGGCAAGTCGCTAGACATGTGTT
TCTTGGCCGAACAAGGGCATCAGGTCATAGGTTGTGAGTTGAATGAATTGGCGGTGCAGCAATTTTTCAGCGATATCCAA
CTCGAGATGACGCAAACGACCGTGGGTGAGCATCAGCATTATCACACTGAGCAGATCAGTTTGTATCAAGGTGATATTTT
CACTTTACCTAAGGCTATCACTCAAGAAGTGACAGCATTTTATGATCGCGCCGCGTTGATCGCATGGCCAGAGTGCATGC
GTGCACAATATGCCAAGCAGCTCGCGAGCTTGTTACCTAGTGGCAGTGTCGGCTTATTAGTGACCTTAGATTATCCGCAG
GAAGCCTTAAGTGGTCCACCTTTCGCCGTATCCCCAACCTGGGTTGAGCAGCATCTGAGTGATGACTTTGACATTGGAGT
ATTAGCCTCCCAAGATGTGTTGGCCGACAATCCCCGCTTTATTAAAAAAGCCGTACCTTGGCTTAATGAAGCCGCCTATT
TGTTGAAACGTAAGTAG

Upstream 100 bases:

>100_bases
GAGTCTTTACATTGCTGAGTTTGTCGAATGGCAGGCAGCTTTGCATCCGCTTTAAAATGTCATTAGAGTAAGGACAACTT
TAGCGAATAGAGATCAACCC

Downstream 100 bases:

>100_bases
GGTTGAAACGTAAGTAGGATTGACTCGAAAGTGGATCTGCAACCCCATTGAATGATCAGTAGTATTAGAGTTCAGTGGGG
ACTTGTCATTAAAACATCAT

Product: thiopurine S-methyltransferase

Products: NA

Alternate protein names: Thiopurine methyltransferase [H]

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MEPGFWHEKWHQQQIGFHQQDINPFLVKYWQKLGLPADTQVFVPLCGKSLDMCFLAEQGHQVIGCELNELAVQQFFSDIQ
LEMTQTTVGEHQHYHTEQISLYQGDIFTLPKAITQEVTAFYDRAALIAWPECMRAQYAKQLASLLPSGSVGLLVTLDYPQ
EALSGPPFAVSPTWVEQHLSDDFDIGVLASQDVLADNPRFIKKAVPWLNEAAYLLKRK

Sequences:

>Translated_218_residues
MEPGFWHEKWHQQQIGFHQQDINPFLVKYWQKLGLPADTQVFVPLCGKSLDMCFLAEQGHQVIGCELNELAVQQFFSDIQ
LEMTQTTVGEHQHYHTEQISLYQGDIFTLPKAITQEVTAFYDRAALIAWPECMRAQYAKQLASLLPSGSVGLLVTLDYPQ
EALSGPPFAVSPTWVEQHLSDDFDIGVLASQDVLADNPRFIKKAVPWLNEAAYLLKRK
>Mature_218_residues
MEPGFWHEKWHQQQIGFHQQDINPFLVKYWQKLGLPADTQVFVPLCGKSLDMCFLAEQGHQVIGCELNELAVQQFFSDIQ
LEMTQTTVGEHQHYHTEQISLYQGDIFTLPKAITQEVTAFYDRAALIAWPECMRAQYAKQLASLLPSGSVGLLVTLDYPQ
EALSGPPFAVSPTWVEQHLSDDFDIGVLASQDVLADNPRFIKKAVPWLNEAAYLLKRK

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. TPMT family [H]

Homologues:

Organism=Homo sapiens, GI4507653, Length=219, Percent_Identity=31.5068493150685, Blast_Score=102, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022474
- InterPro:   IPR008854
- InterPro:   IPR016822 [H]

Pfam domain/function: PF05724 TPMT [H]

EC number: =2.1.1.67 [H]

Molecular weight: Translated: 24776; Mature: 24776

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPGFWHEKWHQQQIGFHQQDINPFLVKYWQKLGLPADTQVFVPLCGKSLDMCFLAEQGH
CCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEECCCCC
QVIGCELNELAVQQFFSDIQLEMTQTTVGEHQHYHTEQISLYQGDIFTLPKAITQEVTAF
EEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHEEEECCCHHHHHHHHHHHHHHH
YDRAALIAWPECMRAQYAKQLASLLPSGSVGLLVTLDYPQEALSGPPFAVSPTWVEQHLS
HHHHHHEECHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHCCCCCCCCHHHHHHHCC
DDFDIGVLASQDVLADNPRFIKKAVPWLNEAAYLLKRK
CCCCEEEEECCCHHCCCCHHHHHHCCHHHHHHHHHCCC
>Mature Secondary Structure
MEPGFWHEKWHQQQIGFHQQDINPFLVKYWQKLGLPADTQVFVPLCGKSLDMCFLAEQGH
CCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEECCCCC
QVIGCELNELAVQQFFSDIQLEMTQTTVGEHQHYHTEQISLYQGDIFTLPKAITQEVTAF
EEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHEEEECCCHHHHHHHHHHHHHHH
YDRAALIAWPECMRAQYAKQLASLLPSGSVGLLVTLDYPQEALSGPPFAVSPTWVEQHLS
HHHHHHEECHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHCCCCCCCCHHHHHHHCC
DDFDIGVLASQDVLADNPRFIKKAVPWLNEAAYLLKRK
CCCCEEEEECCCHHCCCCHHHHHHCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA