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The map label for this gene is melA [H]

Identifier: 160875841

GI number: 160875841

Start: 3235786

End: 3236826

Strand: Direct

Name: melA [H]

Synonym: Sbal195_2729

Alternate gene names: 160875841

Gene position: 3235786-3236826 (Clockwise)

Preceding gene: 160875840

Following gene: 160875843

Centisome position: 60.51

GC content: 44.0

Gene sequence:

>1041_bases
ATGGCAAGCGAACTAAATCCACTGGGCTTATTAGGTATCGAATTCACTGAATTCGCCAGCCCTGATACTGATTTTATGCA
CAAAGTCTTTATAGACTTTGGTTTTTCACTGCTGAAAAAAGCCAAGAACAAAAACATTCTGTACTACAAACAGAATGACA
TTAATTTTCTGCTCAACACTGAGCGCGAAGGTTTCTCTGCTAAGTTTGCTAAATCCCACGGCCCAGCCATTTGTTCTATG
GGCTGGCGGGTAGAAGATGCCGGCTTTGCCTATCGCGTTGCCGTTGAACGTGGTGCAAAACCCGCCGATGATGCCAATAA
AGATCTGCCTTATCCTGCGATTTACGGCATTGGCGACAGCTTGATTTATTTCATCGACACCTTTGGCGCAGATAACAATA
TCTATGCCGCTGATTTTGAAGACTTAGACGAGCAAGTGATCACCCAAGAGAAAGGCTTTATCGAAGTCGATCACTTAACC
AACAACGTTTACAAAGGCACAATGGAACATTGGGCTAACTTCTATAAAAACATTTTTGGTTTTACTGAAGTGCGCTACTT
TGACATCAGCGGCGTACAAACCGCGCTAGTGTCCTACGCCCTGCGTTCGCCCGATGGCAGCTTCTGTATTCCGATTAACG
AAGGTAAAGGCAGCGATAAGAACCAAATCGATGAATACCTGAAGGAATACAATGGCCCAGGTGTGCAGCATTTAGCCTTT
AGAAGTCGCGATATCGTAAAATCTCTGGATGCGATGGAAGGCAGTTCAATCCAATGCTTAGACATTATCCCTGAATACTA
CGACACCATATTTGAGAAGTTACCGCAGGTGACTGAGAATCGTGAGCGCATCAAACATCACCAAATTTTGGTGGATGGCG
ATGAATCCGGTTATTTACTGCAAATTTTCACTAAAAACCTGTTCGGACCGATTTTTATCGAAATCATCCAACGCAAGAAT
AACTTAGGTTTTGGTGAAGGCAACTTTACTGCCCTGTTTGAATCGATTGAGCGGGATCAAATGCGTCGCGGCGTACTGTA
A

Upstream 100 bases:

>100_bases
TAGCCCTAAGCCACCAGCGCACCGAAAAGGTTGCGTATCCCAACGTAATAAAAGGGATAAAGAGTGTCGGCGGTTGAACT
AAAATAATGAGGAAAACATC

Downstream 100 bases:

>100_bases
GTTTTCATCCTGCTAATAAAAAACGGTACGCACTGCGTACCGTTTTTGTTTCTACGACTATCTAAATCGTCATCTAAATC
AGCATCAGCATTGACGCCAA

Product: 4-hydroxyphenylpyruvate dioxygenase

Products: homogentisate; CO2

Alternate protein names: NA

Number of amino acids: Translated: 346; Mature: 345

Protein sequence:

>346_residues
MASELNPLGLLGIEFTEFASPDTDFMHKVFIDFGFSLLKKAKNKNILYYKQNDINFLLNTEREGFSAKFAKSHGPAICSM
GWRVEDAGFAYRVAVERGAKPADDANKDLPYPAIYGIGDSLIYFIDTFGADNNIYAADFEDLDEQVITQEKGFIEVDHLT
NNVYKGTMEHWANFYKNIFGFTEVRYFDISGVQTALVSYALRSPDGSFCIPINEGKGSDKNQIDEYLKEYNGPGVQHLAF
RSRDIVKSLDAMEGSSIQCLDIIPEYYDTIFEKLPQVTENRERIKHHQILVDGDESGYLLQIFTKNLFGPIFIEIIQRKN
NLGFGEGNFTALFESIERDQMRRGVL

Sequences:

>Translated_346_residues
MASELNPLGLLGIEFTEFASPDTDFMHKVFIDFGFSLLKKAKNKNILYYKQNDINFLLNTEREGFSAKFAKSHGPAICSM
GWRVEDAGFAYRVAVERGAKPADDANKDLPYPAIYGIGDSLIYFIDTFGADNNIYAADFEDLDEQVITQEKGFIEVDHLT
NNVYKGTMEHWANFYKNIFGFTEVRYFDISGVQTALVSYALRSPDGSFCIPINEGKGSDKNQIDEYLKEYNGPGVQHLAF
RSRDIVKSLDAMEGSSIQCLDIIPEYYDTIFEKLPQVTENRERIKHHQILVDGDESGYLLQIFTKNLFGPIFIEIIQRKN
NLGFGEGNFTALFESIERDQMRRGVL
>Mature_345_residues
ASELNPLGLLGIEFTEFASPDTDFMHKVFIDFGFSLLKKAKNKNILYYKQNDINFLLNTEREGFSAKFAKSHGPAICSMG
WRVEDAGFAYRVAVERGAKPADDANKDLPYPAIYGIGDSLIYFIDTFGADNNIYAADFEDLDEQVITQEKGFIEVDHLTN
NVYKGTMEHWANFYKNIFGFTEVRYFDISGVQTALVSYALRSPDGSFCIPINEGKGSDKNQIDEYLKEYNGPGVQHLAFR
SRDIVKSLDAMEGSSIQCLDIIPEYYDTIFEKLPQVTENRERIKHHQILVDGDESGYLLQIFTKNLFGPIFIEIIQRKNN
LGFGEGNFTALFESIERDQMRRGVL

Specific function: Unknown

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family [H]

Homologues:

Organism=Homo sapiens, GI285002264, Length=320, Percent_Identity=30.3125, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI4504477, Length=320, Percent_Identity=30.3125, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI14249394, Length=344, Percent_Identity=24.1279069767442, Blast_Score=86, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17555220, Length=203, Percent_Identity=39.9014778325123, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17550752, Length=206, Percent_Identity=37.8640776699029, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI21356105, Length=299, Percent_Identity=33.7792642140468, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24667510, Length=299, Percent_Identity=33.7792642140468, Blast_Score=139, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005956
- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: 1.13.11.27

Molecular weight: Translated: 39339; Mature: 39208

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASELNPLGLLGIEFTEFASPDTDFMHKVFIDFGFSLLKKAKNKNILYYKQNDINFLLNT
CCCCCCCCEEEEEEHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEEC
EREGFSAKFAKSHGPAICSMGWRVEDAGFAYRVAVERGAKPADDANKDLPYPAIYGIGDS
CCCCCCHHHHHCCCCEEEECCCEEECCCEEEEEEECCCCCCCCCCCCCCCCCEEECCCCC
LIYFIDTFGADNNIYAADFEDLDEQVITQEKGFIEVDHLTNNVYKGTMEHWANFYKNIFG
EEEEEECCCCCCCEEECCHHHHHHHHHHHCCCCEEEECHHCHHHHHHHHHHHHHHHHHHC
FTEVRYFDISGVQTALVSYALRSPDGSFCIPINEGKGSDKNQIDEYLKEYNGPGVQHLAF
HHEEEEEECCHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHH
RSRDIVKSLDAMEGSSIQCLDIIPEYYDTIFEKLPQVTENRERIKHHQILVDGDESGYLL
HHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCEEE
QIFTKNLFGPIFIEIIQRKNNLGFGEGNFTALFESIERDQMRRGVL
EEEHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ASELNPLGLLGIEFTEFASPDTDFMHKVFIDFGFSLLKKAKNKNILYYKQNDINFLLNT
CCCCCCCEEEEEEHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEEC
EREGFSAKFAKSHGPAICSMGWRVEDAGFAYRVAVERGAKPADDANKDLPYPAIYGIGDS
CCCCCCHHHHHCCCCEEEECCCEEECCCEEEEEEECCCCCCCCCCCCCCCCCEEECCCCC
LIYFIDTFGADNNIYAADFEDLDEQVITQEKGFIEVDHLTNNVYKGTMEHWANFYKNIFG
EEEEEECCCCCCCEEECCHHHHHHHHHHHCCCCEEEECHHCHHHHHHHHHHHHHHHHHHC
FTEVRYFDISGVQTALVSYALRSPDGSFCIPINEGKGSDKNQIDEYLKEYNGPGVQHLAF
HHEEEEEECCHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHH
RSRDIVKSLDAMEGSSIQCLDIIPEYYDTIFEKLPQVTENRERIKHHQILVDGDESGYLL
HHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCEEE
QIFTKNLFGPIFIEIIQRKNNLGFGEGNFTALFESIERDQMRRGVL
EEEHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-hydroxyphenylpyruvate; O2

Specific reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1756973 [H]