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The map label for this gene is tmk [H]

Identifier: 160875684

GI number: 160875684

Start: 3046220

End: 3046846

Strand: Reverse

Name: tmk [H]

Synonym: Sbal195_2572

Alternate gene names: 160875684

Gene position: 3046846-3046220 (Counterclockwise)

Preceding gene: 160875685

Following gene: 160875683

Centisome position: 56.98

GC content: 49.76

Gene sequence:

>627_bases
ATGTCAGTTTTTGCAAAATTTATCGTTATTGAAGGTTTAGAAGGCGCGGGTAAGTCGAGTGCGATTAACCTTATTCGCGA
CTTTATTGAGAAACATACGGGTAAAGCGCCGATCTGCACTCGCGAGCCGGGTGGCACGCCACTGGCCGAACGTATCCGTG
ATTTGGTCAAAATTGCCGATGCGACCGATCCCCTGTGTGACGAGGCCGAGTGTTTACTTATCTATGCCGCCAGAGCCCAG
TTGGTTGCTAATGTCATTAAGCCCGCGCTTGCGCAGGGTCAATGGGTATTGGGTGACAGACACAATTTATCGTCACTGGC
CTATCAAGGTGGTGGCAGGGGCTTAATGCCGTTAGTGGAAGCGGTGAGCACTGCCACCCTTAAAGGCTTTAAACCCGATC
TCACCTTGTACTTAGATTTAGATCCTAAACTTGGGCTAACCCGCGCAGCTAAACGCGGTGAGCTTGATAGAATCGAGCAA
CAAGCGATTGATTTCTTTGAACGGGCTCGCGCGACTTATCTTAAACTTGCCAGCGAAGATGACAGCATAGTGGTTATCGA
TGCGAGTCAAACCATGGCCGAAGTGCATAAAGATATCTTAGCCGTACTACAGGCGATGGCATGGTAG

Upstream 100 bases:

>100_bases
CTTGAAGCACACAACCAAGCTGTAGATGTGTATCAGCGTAAGAAAAAACCGGCGACGCCAGAAAAATCACCAAAGTAAAA
ATGCAGAGAAAGAAAATCCA

Downstream 100 bases:

>100_bases
CCGAGTCAGGGTTTACAGCTGCGCAATTGCCTTGGCTCGAAGGGCCAAGACAGGCATTTTTAGCGCAACTCACGCGGCAA
AAAATGCCCCATGCACAGCT

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 208; Mature: 207

Protein sequence:

>208_residues
MSVFAKFIVIEGLEGAGKSSAINLIRDFIEKHTGKAPICTREPGGTPLAERIRDLVKIADATDPLCDEAECLLIYAARAQ
LVANVIKPALAQGQWVLGDRHNLSSLAYQGGGRGLMPLVEAVSTATLKGFKPDLTLYLDLDPKLGLTRAAKRGELDRIEQ
QAIDFFERARATYLKLASEDDSIVVIDASQTMAEVHKDILAVLQAMAW

Sequences:

>Translated_208_residues
MSVFAKFIVIEGLEGAGKSSAINLIRDFIEKHTGKAPICTREPGGTPLAERIRDLVKIADATDPLCDEAECLLIYAARAQ
LVANVIKPALAQGQWVLGDRHNLSSLAYQGGGRGLMPLVEAVSTATLKGFKPDLTLYLDLDPKLGLTRAAKRGELDRIEQ
QAIDFFERARATYLKLASEDDSIVVIDASQTMAEVHKDILAVLQAMAW
>Mature_207_residues
SVFAKFIVIEGLEGAGKSSAINLIRDFIEKHTGKAPICTREPGGTPLAERIRDLVKIADATDPLCDEAECLLIYAARAQL
VANVIKPALAQGQWVLGDRHNLSSLAYQGGGRGLMPLVEAVSTATLKGFKPDLTLYLDLDPKLGLTRAAKRGELDRIEQQ
AIDFFERARATYLKLASEDDSIVVIDASQTMAEVHKDILAVLQAMAW

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis [H]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1787340, Length=194, Percent_Identity=55.6701030927835, Blast_Score=210, Evalue=5e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018095
- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 22603; Mature: 22472

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVFAKFIVIEGLEGAGKSSAINLIRDFIEKHTGKAPICTREPGGTPLAERIRDLVKIAD
CCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHC
ATDPLCDEAECLLIYAARAQLVANVIKPALAQGQWVLGDRHNLSSLAYQGGGRGLMPLVE
CCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHCCCCCCHHHHHH
AVSTATLKGFKPDLTLYLDLDPKLGLTRAAKRGELDRIEQQAIDFFERARATYLKLASED
HHHHHHHCCCCCCEEEEEECCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHEECCC
DSIVVIDASQTMAEVHKDILAVLQAMAW
CCEEEEECHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SVFAKFIVIEGLEGAGKSSAINLIRDFIEKHTGKAPICTREPGGTPLAERIRDLVKIAD
CHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHC
ATDPLCDEAECLLIYAARAQLVANVIKPALAQGQWVLGDRHNLSSLAYQGGGRGLMPLVE
CCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHCCCCCCHHHHHH
AVSTATLKGFKPDLTLYLDLDPKLGLTRAAKRGELDRIEQQAIDFFERARATYLKLASED
HHHHHHHCCCCCCEEEEEECCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHEECCC
DSIVVIDASQTMAEVHKDILAVLQAMAW
CCEEEEECHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]