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The map label for this gene is ribA

Identifier: 160874807

GI number: 160874807

Start: 2038339

End: 2038953

Strand: Direct

Name: ribA

Synonym: Sbal195_1690

Alternate gene names: 160874807

Gene position: 2038339-2038953 (Clockwise)

Preceding gene: 160874806

Following gene: 160874808

Centisome position: 38.12

GC content: 45.69

Gene sequence:

>615_bases
ATGTCGATAAAATATGTCGCGACGTCAAAGTTACCCACTCCTTGGGGCGTGTTTGCCATGCATGGTTTTGAAGATACAGA
ATCAGGCAAAGAGCATGTTGCGCTCACATTCGGTACGCTCAGTGCGGATGAACCTGTGTTGGGTCGAATTCATTCCGAGT
GTTTAACTGGCGATGCGTTATTTAGCTTGCGTTGTGACTGTGGTTTTCAGTTACAAGCGGCGATGCAAAATATTGCAGAA
ACGGGCAGTGGCTTTATCCTCTATTTGCGCCAAGAAGGCCGTGGCATTGGTTTGTTGAATAAAATCCGCGCCTACGAGCT
GCAAGATAAAGGTGCCAACACAGTTGAAGCCAACGAGCAACTGGGCTTCGAAGCCGATATGCGTAAATACGACATGATCA
AACCTATGCTGGAACAGATAGGCGTGAAGCATGTGCGTTTGATGACCAATAACCCTCGTAAAGTGAAAGCAATGAAGGAG
TTTGGCATCGAAGTGGTTGAGCGCGTACCGCTGCAAGTTGGTAAGAATCGTTACAACGAAGCCTACTTAAAAACCAAATC
CACTGAGCTTGGACACATGATGTCTGAATATCATTTTATGGATGAAAATAAGTAG

Upstream 100 bases:

>100_bases
ACTTTAGAATAGTGCGCTTAGTTGGCTAAGTGCCTAATCCTCGTTTGTTTCTAGGGATCTTATTCGTCTCATGGAATGAG
AGTTGTCGTTAAGGTTAAGT

Downstream 100 bases:

>100_bases
CTTTGTATTTATGATAGGTCGACCGATTGAGTCAGAAATGAGTAAGGTTTAAGTCAATTGAGCCATTTTTTCAGTCGGTT
GCCATTATGTTTGTCGTTAA

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: GTP cyclohydrolase II

Number of amino acids: Translated: 204; Mature: 203

Protein sequence:

>204_residues
MSIKYVATSKLPTPWGVFAMHGFEDTESGKEHVALTFGTLSADEPVLGRIHSECLTGDALFSLRCDCGFQLQAAMQNIAE
TGSGFILYLRQEGRGIGLLNKIRAYELQDKGANTVEANEQLGFEADMRKYDMIKPMLEQIGVKHVRLMTNNPRKVKAMKE
FGIEVVERVPLQVGKNRYNEAYLKTKSTELGHMMSEYHFMDENK

Sequences:

>Translated_204_residues
MSIKYVATSKLPTPWGVFAMHGFEDTESGKEHVALTFGTLSADEPVLGRIHSECLTGDALFSLRCDCGFQLQAAMQNIAE
TGSGFILYLRQEGRGIGLLNKIRAYELQDKGANTVEANEQLGFEADMRKYDMIKPMLEQIGVKHVRLMTNNPRKVKAMKE
FGIEVVERVPLQVGKNRYNEAYLKTKSTELGHMMSEYHFMDENK
>Mature_203_residues
SIKYVATSKLPTPWGVFAMHGFEDTESGKEHVALTFGTLSADEPVLGRIHSECLTGDALFSLRCDCGFQLQAAMQNIAET
GSGFILYLRQEGRGIGLLNKIRAYELQDKGANTVEANEQLGFEADMRKYDMIKPMLEQIGVKHVRLMTNNPRKVKAMKEF
GIEVVERVPLQVGKNRYNEAYLKTKSTELGHMMSEYHFMDENK

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase II family

Homologues:

Organism=Escherichia coli, GI1787533, Length=196, Percent_Identity=61.2244897959184, Blast_Score=258, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6319438, Length=195, Percent_Identity=40.5128205128205, Blast_Score=130, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RIBA_SHEB2 (B8EF62)

Other databases:

- EMBL:   CP001252
- RefSeq:   YP_002358603.1
- ProteinModelPortal:   B8EF62
- SMR:   B8EF62
- GeneID:   7087069
- GenomeReviews:   CP001252_GR
- KEGG:   sbp:Sbal223_2690
- HOGENOM:   HBG735778
- OMA:   QGFILYL
- ProtClustDB:   PRK00393
- HAMAP:   MF_00179
- InterPro:   IPR000926
- TIGRFAMs:   TIGR00505

Pfam domain/function: PF00925 GTP_cyclohydro2

EC number: =3.5.4.25

Molecular weight: Translated: 23016; Mature: 22885

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: ACT_SITE 126-126 ACT_SITE 128-128 BINDING 70-70 BINDING 114-114 BINDING 149-149 BINDING 154-154

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIKYVATSKLPTPWGVFAMHGFEDTESGKEHVALTFGTLSADEPVLGRIHSECLTGDAL
CCEEEEECCCCCCCCCEEEECCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCE
FSLRCDCGFQLQAAMQNIAETGSGFILYLRQEGRGIGLLNKIRAYELQDKGANTVEANEQ
EEEECCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHEEECCCCCCCCCCCHH
LGFEADMRKYDMIKPMLEQIGVKHVRLMTNNPRKVKAMKEFGIEVVERVPLQVGKNRYNE
CCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCH
AYLKTKSTELGHMMSEYHFMDENK
HHEEECCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SIKYVATSKLPTPWGVFAMHGFEDTESGKEHVALTFGTLSADEPVLGRIHSECLTGDAL
CEEEEECCCCCCCCCEEEECCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCE
FSLRCDCGFQLQAAMQNIAETGSGFILYLRQEGRGIGLLNKIRAYELQDKGANTVEANEQ
EEEECCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHEEECCCCCCCCCCCHH
LGFEADMRKYDMIKPMLEQIGVKHVRLMTNNPRKVKAMKEFGIEVVERVPLQVGKNRYNE
CCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCH
AYLKTKSTELGHMMSEYHFMDENK
HHEEECCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA