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The map label for this gene is lon [H]

Identifier: 160874746

GI number: 160874746

Start: 1968625

End: 1970982

Strand: Direct

Name: lon [H]

Synonym: Sbal195_1629

Alternate gene names: 160874746

Gene position: 1968625-1970982 (Clockwise)

Preceding gene: 160874745

Following gene: 160874747

Centisome position: 36.82

GC content: 47.07

Gene sequence:

>2358_bases
ATGACCCAAGAGCGTGAAGCGCATATCGAACTCCCCGTGCTGCCACTGCGAGATGTGGTGGTCTATCCCCATATGGTAAT
TCCGTTATTTGTCGGACGAGAAAAATCTATTCGATGTCTCGAAACCGCAATGGCGCAGGATAAGCAAATTATTTTAGTGG
CGCAGCGTGATGCCGAACTCGATGAACCATCAAAAGATGACATCTTCGAAGTGGGTACGGTTGCCTCTATTTTACAGTTA
CTTAAGCTGCCAGACGGCACAGTCAAAGTGTTGGTAGAAGGCGGTCGTCGCGCCCGTATTACCCGTTACACCCAAGAAAC
AGAATTCTTTGTGGCTAAGGCTGAGTATCTGGAATCAGAACCGCTGGAAGACAAAGAAGAAGAAGTGTTAGTGCGCAGTG
CTATTGGTCAGTTTGAAGGTTATATCAAGCTGAACAAAAAGATCCCGCCAGAAGTCTTGACCTCTTTATCGGGTATCGAT
GAAGCGGCGCGTCTGGCAGATACTATGGCCGCACACATGCCACTTAAGCTTGAAGATAAGCAATCTGTGCTTGAGATGAT
CAACGTTGGCGAGCGTCTCGAATATTTAATGGCGATGATGGAATCGGAGATCGACCTATTGCAGGTTGAGAAACGTATCC
GTACCCGCGTTAAAAAACAGATGGAAAAAAGTCAGCGTGAGTACTATCTGAACGAACAGATGAAAGCCATCCAGAAAGAA
CTGGGTGACTTAGACGAAGGCCATGACGAGTTTGAAGCCTTAAATCGTAAGATTGAAGAGGCTAACATGCCCGCCGAGGC
GAAAGAAAAAGCCCTGGCTGAGCTTAACAAGCTACGTATGATGTCGCCAATGTCGGCAGAAGCCACAGTTGTTCGCAGCT
ATGTGGATTGGATGACGTCAGTGCCTTGGAGCCAACGCTCTAAAATCAAACGTGATTTAGCGAAAGCCCAAGAAGTGCTC
GATACCGATCATTTTGGTCTGGAAAAAGTTAAAGAACGTATCTTGGAATATTTGGCAGTCCAAAGCCGAGTGCGTCAGCT
TAAAGGGCCAATCCTGTGTCTCGTTGGACCTCCAGGTGTGGGTAAAACTTCCTTGGGTCAATCGATCGCTAAGGCGACCG
GTCGTAAGTATGTGCGTGTTGCTTTAGGCGGCGTGCGTGATGAAGCGGAAATCCGTGGTCATCGCCGTACTTATATTGGT
TCTATGCCAGGTAAAGTCATTCAAAAAATGGCTAAAGTGGGCGTGAAAAACCCATTATTCTTGCTCGATGAAATCGACAA
GATGAGTTCAGACATGCGCGGCGATCCGGCTTCTGCTTTATTAGAAGTGTTAGATCCTGAGCAAAATGCGACCTTTAACG
ATCATTACCTCGAAGTCGATTACGACTTATCCGATGTGATGTTTGTGGCAACGTCTAACTCTATGGACATTCCTGGGCCA
CTACTTGACCGTATGGAAGTGATCCGTTTGTCGGGTTACACCGAAGACGAGAAGCTGAATATTGCTAAGCAACATTTGCT
GAATAAGCAAATTGAGCGCAACGGCTTAAAAGCGGCTGAAATTAAAGTCGAGGATAGCGCTATCGTTGGCATTATCCGCT
ATTACACCCGTGAAGCGGGCGTGCGTTCACTTGAGCGTGAATTGTCTAAGATTTGCCGTAAAGTCGTGAAAATGATTTTG
CTCGATAAATCAGTAAAATCTGTCACTGTGAATCAAGATAATCTTAAGTCATTCCTTGGCGTGCAGCGCTTCGATTACGG
TAAAGCCGAGTCGAAGAACCAAATCGGTCAAGTGACAGGCTTAGCGTGGACACAAGTCGGCGGTGATCTGCTAACGATTG
AAGCAACATCGGTACCAGGTAAAGGTAAATTAACTTATACCGGTTCCCTTGGCGACGTGATGCAAGAGTCGATTCAAGCG
GCGATGACAGTTGTTCGTGCCCGTGCGGAACAATTAGGTATTAATGCGGATTTCTACGAGAAGCGTGATATCCATGTGCA
TGTGCCAGAAGGTGCAACGCCAAAAGATGGGCCATCGGCCGGTGCGGCTATGTGTACCGCTTTAGTATCCAGCTTAACGG
GTAACCCTGTGCGTAGCGACGTGGCCATGACAGGTGAAATAACCTTACGTGGTGAAGTGTTACCTATCGGTGGTTTGAAA
GAAAAACTGCTGGCAGCACACCGCGGCGGCATAAAATTAGTGCTTATACCAAAAGAAAACGAGCGTGATCTGGAAGAAAT
TCCTGCCAATGTGATTGCCGATTTAGAAATTCGTCCCGTGCGTTGGGTCGATGAAGTGTTAAAACTGGCCCTAGAAAGAC
CGGTTGAAGGCTTCGAAGTGGTTAAAAACTTGGCATAA

Upstream 100 bases:

>100_bases
GAGTCCAATGGACTCCTTTTTTCGTATTAGCCATTGAAACTCAATAAAGCGTCCCAATATACTCCAGTATTAATCCATTT
CACCAAAACGGAATCGAACT

Downstream 100 bases:

>100_bases
CGCAAGAAATTGCGCTATCACGTTAAAAAAAATGAAAAAAGGGGCTTAACAAAGCGTAGACCTGTGGTAGCCTAGGTCTG
TGGAGAGCCAACTGCTCCAA

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 785; Mature: 784

Protein sequence:

>785_residues
MTQEREAHIELPVLPLRDVVVYPHMVIPLFVGREKSIRCLETAMAQDKQIILVAQRDAELDEPSKDDIFEVGTVASILQL
LKLPDGTVKVLVEGGRRARITRYTQETEFFVAKAEYLESEPLEDKEEEVLVRSAIGQFEGYIKLNKKIPPEVLTSLSGID
EAARLADTMAAHMPLKLEDKQSVLEMINVGERLEYLMAMMESEIDLLQVEKRIRTRVKKQMEKSQREYYLNEQMKAIQKE
LGDLDEGHDEFEALNRKIEEANMPAEAKEKALAELNKLRMMSPMSAEATVVRSYVDWMTSVPWSQRSKIKRDLAKAQEVL
DTDHFGLEKVKERILEYLAVQSRVRQLKGPILCLVGPPGVGKTSLGQSIAKATGRKYVRVALGGVRDEAEIRGHRRTYIG
SMPGKVIQKMAKVGVKNPLFLLDEIDKMSSDMRGDPASALLEVLDPEQNATFNDHYLEVDYDLSDVMFVATSNSMDIPGP
LLDRMEVIRLSGYTEDEKLNIAKQHLLNKQIERNGLKAAEIKVEDSAIVGIIRYYTREAGVRSLERELSKICRKVVKMIL
LDKSVKSVTVNQDNLKSFLGVQRFDYGKAESKNQIGQVTGLAWTQVGGDLLTIEATSVPGKGKLTYTGSLGDVMQESIQA
AMTVVRARAEQLGINADFYEKRDIHVHVPEGATPKDGPSAGAAMCTALVSSLTGNPVRSDVAMTGEITLRGEVLPIGGLK
EKLLAAHRGGIKLVLIPKENERDLEEIPANVIADLEIRPVRWVDEVLKLALERPVEGFEVVKNLA

Sequences:

>Translated_785_residues
MTQEREAHIELPVLPLRDVVVYPHMVIPLFVGREKSIRCLETAMAQDKQIILVAQRDAELDEPSKDDIFEVGTVASILQL
LKLPDGTVKVLVEGGRRARITRYTQETEFFVAKAEYLESEPLEDKEEEVLVRSAIGQFEGYIKLNKKIPPEVLTSLSGID
EAARLADTMAAHMPLKLEDKQSVLEMINVGERLEYLMAMMESEIDLLQVEKRIRTRVKKQMEKSQREYYLNEQMKAIQKE
LGDLDEGHDEFEALNRKIEEANMPAEAKEKALAELNKLRMMSPMSAEATVVRSYVDWMTSVPWSQRSKIKRDLAKAQEVL
DTDHFGLEKVKERILEYLAVQSRVRQLKGPILCLVGPPGVGKTSLGQSIAKATGRKYVRVALGGVRDEAEIRGHRRTYIG
SMPGKVIQKMAKVGVKNPLFLLDEIDKMSSDMRGDPASALLEVLDPEQNATFNDHYLEVDYDLSDVMFVATSNSMDIPGP
LLDRMEVIRLSGYTEDEKLNIAKQHLLNKQIERNGLKAAEIKVEDSAIVGIIRYYTREAGVRSLERELSKICRKVVKMIL
LDKSVKSVTVNQDNLKSFLGVQRFDYGKAESKNQIGQVTGLAWTQVGGDLLTIEATSVPGKGKLTYTGSLGDVMQESIQA
AMTVVRARAEQLGINADFYEKRDIHVHVPEGATPKDGPSAGAAMCTALVSSLTGNPVRSDVAMTGEITLRGEVLPIGGLK
EKLLAAHRGGIKLVLIPKENERDLEEIPANVIADLEIRPVRWVDEVLKLALERPVEGFEVVKNLA
>Mature_784_residues
TQEREAHIELPVLPLRDVVVYPHMVIPLFVGREKSIRCLETAMAQDKQIILVAQRDAELDEPSKDDIFEVGTVASILQLL
KLPDGTVKVLVEGGRRARITRYTQETEFFVAKAEYLESEPLEDKEEEVLVRSAIGQFEGYIKLNKKIPPEVLTSLSGIDE
AARLADTMAAHMPLKLEDKQSVLEMINVGERLEYLMAMMESEIDLLQVEKRIRTRVKKQMEKSQREYYLNEQMKAIQKEL
GDLDEGHDEFEALNRKIEEANMPAEAKEKALAELNKLRMMSPMSAEATVVRSYVDWMTSVPWSQRSKIKRDLAKAQEVLD
TDHFGLEKVKERILEYLAVQSRVRQLKGPILCLVGPPGVGKTSLGQSIAKATGRKYVRVALGGVRDEAEIRGHRRTYIGS
MPGKVIQKMAKVGVKNPLFLLDEIDKMSSDMRGDPASALLEVLDPEQNATFNDHYLEVDYDLSDVMFVATSNSMDIPGPL
LDRMEVIRLSGYTEDEKLNIAKQHLLNKQIERNGLKAAEIKVEDSAIVGIIRYYTREAGVRSLERELSKICRKVVKMILL
DKSVKSVTVNQDNLKSFLGVQRFDYGKAESKNQIGQVTGLAWTQVGGDLLTIEATSVPGKGKLTYTGSLGDVMQESIQAA
MTVVRARAEQLGINADFYEKRDIHVHVPEGATPKDGPSAGAAMCTALVSSLTGNPVRSDVAMTGEITLRGEVLPIGGLKE
KLLAAHRGGIKLVLIPKENERDLEEIPANVIADLEIRPVRWVDEVLKLALERPVEGFEVVKNLA

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=775, Percent_Identity=39.0967741935484, Blast_Score=528, Evalue=1e-150,
Organism=Homo sapiens, GI21396489, Length=830, Percent_Identity=36.3855421686747, Blast_Score=506, Evalue=1e-143,
Organism=Escherichia coli, GI1786643, Length=781, Percent_Identity=80.921895006402, Blast_Score=1288, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=653, Percent_Identity=41.3476263399694, Blast_Score=499, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI17556486, Length=797, Percent_Identity=34.3789209535759, Blast_Score=437, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6319449, Length=723, Percent_Identity=38.3125864453665, Blast_Score=493, Evalue=1e-140,
Organism=Drosophila melanogaster, GI221513036, Length=629, Percent_Identity=44.3561208267091, Blast_Score=523, Evalue=1e-148,
Organism=Drosophila melanogaster, GI24666867, Length=620, Percent_Identity=44.6774193548387, Blast_Score=523, Evalue=1e-148,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 87646; Mature: 87514

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQEREAHIELPVLPLRDVVVYPHMVIPLFVGREKSIRCLETAMAQDKQIILVAQRDAEL
CCCCCCCCEECCCCCHHHHHHCCHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEEECCCCC
DEPSKDDIFEVGTVASILQLLKLPDGTVKVLVEGGRRARITRYTQETEFFVAKAEYLESE
CCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEEEEHHHHHHHHHHHHHHHCCC
PLEDKEEEVLVRSAIGQFEGYIKLNKKIPPEVLTSLSGIDEAARLADTMAAHMPLKLEDK
CCCCHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHCHHHHHHHHHHHHHHCCCEECHH
QSVLEMINVGERLEYLMAMMESEIDLLQVEKRIRTRVKKQMEKSQREYYLNEQMKAIQKE
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGDLDEGHDEFEALNRKIEEANMPAEAKEKALAELNKLRMMSPMSAEATVVRSYVDWMTS
HCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHC
VPWSQRSKIKRDLAKAQEVLDTDHFGLEKVKERILEYLAVQSRVRQLKGPILCLVGPPGV
CCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCC
GKTSLGQSIAKATGRKYVRVALGGVRDEAEIRGHRRTYIGSMPGKVIQKMAKVGVKNPLF
CHHHHHHHHHHHCCCCEEEEECCCCCCHHHHCCCHHHHCCCCCHHHHHHHHHCCCCCCHH
LLDEIDKMSSDMRGDPASALLEVLDPEQNATFNDHYLEVDYDLSDVMFVATSNSMDIPGP
HHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEEEEEECCCCCCCCH
LLDRMEVIRLSGYTEDEKLNIAKQHLLNKQIERNGLKAAEIKVEDSAIVGIIRYYTREAG
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHH
VRSLERELSKICRKVVKMILLDKSVKSVTVNQDNLKSFLGVQRFDYGKAESKNQIGQVTG
HHHHHHHHHHHHHHHHHHHHHCCCHHEEECCHHHHHHHHHHHHCCCCCCCCCHHHHHHHC
LAWTQVGGDLLTIEATSVPGKGKLTYTGSLGDVMQESIQAAMTVVRARAEQLGINADFYE
CHHHHCCCCEEEEEEECCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
KRDIHVHVPEGATPKDGPSAGAAMCTALVSSLTGNPVRSDVAMTGEITLRGEVLPIGGLK
CCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEECEEEECCCHH
EKLLAAHRGGIKLVLIPKENERDLEEIPANVIADLEIRPVRWVDEVLKLALERPVEGFEV
HHHHHHHCCCEEEEEECCCCCCCHHHCCHHHEECCCCCCHHHHHHHHHHHHHCCCHHHHH
VKNLA
HHHCC
>Mature Secondary Structure 
TQEREAHIELPVLPLRDVVVYPHMVIPLFVGREKSIRCLETAMAQDKQIILVAQRDAEL
CCCCCCCEECCCCCHHHHHHCCHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEEECCCCC
DEPSKDDIFEVGTVASILQLLKLPDGTVKVLVEGGRRARITRYTQETEFFVAKAEYLESE
CCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEEEEHHHHHHHHHHHHHHHCCC
PLEDKEEEVLVRSAIGQFEGYIKLNKKIPPEVLTSLSGIDEAARLADTMAAHMPLKLEDK
CCCCHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHCHHHHHHHHHHHHHHCCCEECHH
QSVLEMINVGERLEYLMAMMESEIDLLQVEKRIRTRVKKQMEKSQREYYLNEQMKAIQKE
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGDLDEGHDEFEALNRKIEEANMPAEAKEKALAELNKLRMMSPMSAEATVVRSYVDWMTS
HCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHC
VPWSQRSKIKRDLAKAQEVLDTDHFGLEKVKERILEYLAVQSRVRQLKGPILCLVGPPGV
CCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCC
GKTSLGQSIAKATGRKYVRVALGGVRDEAEIRGHRRTYIGSMPGKVIQKMAKVGVKNPLF
CHHHHHHHHHHHCCCCEEEEECCCCCCHHHHCCCHHHHCCCCCHHHHHHHHHCCCCCCHH
LLDEIDKMSSDMRGDPASALLEVLDPEQNATFNDHYLEVDYDLSDVMFVATSNSMDIPGP
HHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEEEEEECCCCCCCCH
LLDRMEVIRLSGYTEDEKLNIAKQHLLNKQIERNGLKAAEIKVEDSAIVGIIRYYTREAG
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHH
VRSLERELSKICRKVVKMILLDKSVKSVTVNQDNLKSFLGVQRFDYGKAESKNQIGQVTG
HHHHHHHHHHHHHHHHHHHHHCCCHHEEECCHHHHHHHHHHHHCCCCCCCCCHHHHHHHC
LAWTQVGGDLLTIEATSVPGKGKLTYTGSLGDVMQESIQAAMTVVRARAEQLGINADFYE
CHHHHCCCCEEEEEEECCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
KRDIHVHVPEGATPKDGPSAGAAMCTALVSSLTGNPVRSDVAMTGEITLRGEVLPIGGLK
CCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEECEEEECCCHH
EKLLAAHRGGIKLVLIPKENERDLEEIPANVIADLEIRPVRWVDEVLKLALERPVEGFEV
HHHHHHHCCCEEEEEECCCCCCCHHHCCHHHEECCCCCCHHHHHHHHHHHHHCCCHHHHH
VKNLA
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8981986; 12620739 [H]