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The map label for this gene is clpP

Identifier: 160874744

GI number: 160874744

Start: 1966519

End: 1967127

Strand: Direct

Name: clpP

Synonym: Sbal195_1627

Alternate gene names: 160874744

Gene position: 1966519-1967127 (Clockwise)

Preceding gene: 160874743

Following gene: 160874745

Centisome position: 36.78

GC content: 45.65

Gene sequence:

>609_bases
ATGCATAATGCGTCAGACATACAAAGTGCTTTAGTGCCTATGGTGATCGAACAGACTGCTAAGGGTGAACGCTCATACGA
TATTTATTCTCGTTTGTTGAAAGAGCGGATTATCTTTTTGGTAGGTCAAGTTGAAGAACACATGGCAAACCTTATCGTGG
CGCAACTATTATTCTTAGAATCAGAAAGCCCAGATAAAGATATCTTTTTATACATTAACTCTCCAGGTGGCTCAGTCACC
GCAGGCATGGCGATTTATGATACCATGCAGTTTATCAAACCGAATGTTAGCACTGTCTGTATCGGCCAAGCGGCCAGCAT
GGGCGCTTTCTTATTAGCCGGTGGTGAGAAGGGCAAACGTCACTGTTTACCAAACTCTCGCGTGATGATCCATCAACCAC
TGGGTGGTTTCCAAGGTCAAGCTTCTGACATCGCTATCCATGCCAAAGAAATCTTAGGCATTAAGAATAAGCTTAACCAA
ATGTTAGCCGAGCACACTGGCCAACCGCTCGAAGTGGTTGAACGCGATACCGATCGTGACAACTTCATGAGCGCGACTCA
AGCCGTCGAATATGGCTTAGTTGACTCTGTGATGACGAAACGCGGCTGA

Upstream 100 bases:

>100_bases
GTCGCGCATAAGCTAAGCTTGACTTGATTAGCTGTTCGCCATTTATAATGGCTCGTATGAGGCTCCTCATGCGAGCCATT
TTTATTTAGGGAAGTGAATA

Downstream 100 bases:

>100_bases
TTTTTGCTTTTGACTGAGCTATGCTCTGTAAAGGTTAAGCAAATTTAAGACAGGCAGTAGAGCAGACTGCAAATGAGGTA
ATTAATGGGCGACAACAAAA

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp

Number of amino acids: Translated: 202; Mature: 202

Protein sequence:

>202_residues
MHNASDIQSALVPMVIEQTAKGERSYDIYSRLLKERIIFLVGQVEEHMANLIVAQLLFLESESPDKDIFLYINSPGGSVT
AGMAIYDTMQFIKPNVSTVCIGQAASMGAFLLAGGEKGKRHCLPNSRVMIHQPLGGFQGQASDIAIHAKEILGIKNKLNQ
MLAEHTGQPLEVVERDTDRDNFMSATQAVEYGLVDSVMTKRG

Sequences:

>Translated_202_residues
MHNASDIQSALVPMVIEQTAKGERSYDIYSRLLKERIIFLVGQVEEHMANLIVAQLLFLESESPDKDIFLYINSPGGSVT
AGMAIYDTMQFIKPNVSTVCIGQAASMGAFLLAGGEKGKRHCLPNSRVMIHQPLGGFQGQASDIAIHAKEILGIKNKLNQ
MLAEHTGQPLEVVERDTDRDNFMSATQAVEYGLVDSVMTKRG
>Mature_202_residues
MHNASDIQSALVPMVIEQTAKGERSYDIYSRLLKERIIFLVGQVEEHMANLIVAQLLFLESESPDKDIFLYINSPGGSVT
AGMAIYDTMQFIKPNVSTVCIGQAASMGAFLLAGGEKGKRHCLPNSRVMIHQPLGGFQGQASDIAIHAKEILGIKNKLNQ
MLAEHTGQPLEVVERDTDRDNFMSATQAVEYGLVDSVMTKRG

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=198, Percent_Identity=55.5555555555556, Blast_Score=241, Evalue=4e-64,
Organism=Escherichia coli, GI1786641, Length=192, Percent_Identity=76.5625, Blast_Score=326, Evalue=5e-91,
Organism=Caenorhabditis elegans, GI17538017, Length=200, Percent_Identity=55, Blast_Score=229, Evalue=7e-61,
Organism=Drosophila melanogaster, GI20129427, Length=188, Percent_Identity=55.8510638297872, Blast_Score=229, Evalue=7e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP_SHEB2 (B8E5E9)

Other databases:

- EMBL:   CP001252
- RefSeq:   YP_002358661.1
- ProteinModelPortal:   B8E5E9
- SMR:   B8E5E9
- MEROPS:   S14.001
- GeneID:   7087129
- GenomeReviews:   CP001252_GR
- KEGG:   sbp:Sbal223_2750
- HOGENOM:   HBG558421
- OMA:   SPMEAQD
- ProtClustDB:   PRK00277
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127
- TIGRFAMs:   TIGR00493

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 22138; Mature: 22138

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 106-106 ACT_SITE 131-131

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHNASDIQSALVPMVIEQTAKGERSYDIYSRLLKERIIFLVGQVEEHMANLIVAQLLFLE
CCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SESPDKDIFLYINSPGGSVTAGMAIYDTMQFIKPNVSTVCIGQAASMGAFLLAGGEKGKR
CCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEECCHHCCCEEEEECCCCCCC
HCLPNSRVMIHQPLGGFQGQASDIAIHAKEILGIKNKLNQMLAEHTGQPLEVVERDTDRD
CCCCCCCEEEECCCCCCCCCCCHHEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCHH
NFMSATQAVEYGLVDSVMTKRG
HHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MHNASDIQSALVPMVIEQTAKGERSYDIYSRLLKERIIFLVGQVEEHMANLIVAQLLFLE
CCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SESPDKDIFLYINSPGGSVTAGMAIYDTMQFIKPNVSTVCIGQAASMGAFLLAGGEKGKR
CCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEECCHHCCCEEEEECCCCCCC
HCLPNSRVMIHQPLGGFQGQASDIAIHAKEILGIKNKLNQMLAEHTGQPLEVVERDTDRD
CCCCCCCEEEECCCCCCCCCCCHHEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCHH
NFMSATQAVEYGLVDSVMTKRG
HHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA