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The map label for this gene is dxr [H]

Identifier: 160874604

GI number: 160874604

Start: 1788477

End: 1789667

Strand: Direct

Name: dxr [H]

Synonym: Sbal195_1487

Alternate gene names: 160874604

Gene position: 1788477-1789667 (Clockwise)

Preceding gene: 160874603

Following gene: 160874605

Centisome position: 33.45

GC content: 49.71

Gene sequence:

>1191_bases
ATGCAAAATATGGTGATTTTGGGTGCTACCGGCTCTATAGGTGCCAGTACCTTAAGTGTGATCTCGGCTAATCCATTTGC
TTATAGCGTGTATGGATTAGTGGCCAACGCGAGCGTTGATAAGATGCTTGCACTCTGTGTGGCCCATAAACCGAAAGTGG
CGCATATGGTGGATGAAGCGGCAGCAAAACAGTTGCGTGCCGTTTTACCTGCGACGCTCAATATCCAAGTCACCACTGGC
ATGAACGATTTACTCGGTTTAGTGACCGCTGCCGAAGTGGATACTGTGATGGCGGCGATTGTAGGGGCTGCAGGGCTAGT
ACCGACGCTTGAAGCCGTAAAGGCGGGTAAGCGGGTATTACTGGCCAACAAAGAAGCCTTAGTCATGTCAGGTGAGCTGT
TTATTGAGGCGACTAAGCGCTCTGGCGCAGTGCTCTTGCCTGTGGACAGTGAGCATAATGCCATCTTCCAATGTCTTCCC
CAGGAAGTGCAAGCCAATCTTGGCCGTTGTGACTTAGCGGCATCGGGTATTTCCCATATTCTGTTAACCGGTTCTGGCGG
ACCTTTCCTGCGGTCGGATTTGGCGACACTGGCCGCCATGACGCCTGCCCAAGCCTGTAAACATCCTAATTGGTCCATGG
GACCTAAAATCTCCGTCGACTCCGCCACTATGATGAATAAGGGCTTAGAGTTTATTGAGGCGCGTTGGTTGTTTAACACT
CAGGCTGAGCAACTGAAGGTGGTTATCCATCCGCAAAGCGTGATCCACTCAATGGTGCAGTACCGTGATGGCTCCGTTAT
TGCCCAAATGGGTAACCCAGATATGCGTACGCCTATTGCCCATTGCATGGCTTATCCGCAAAGAATTCATTCTGGCGTTG
AACCTTTAGATTTTTTCAAAGTCGGACAGTTAAGCTTTTATGAACCTGATTTTGAACGTTTCCCCTGCTTGGCTTTGGCA
ATGGAAGCCTGTGCCCAAGGCCAAGAGGCGACAACTGTGTTAAATGCTGCCAATGAGATTGCCGTTGAAGCATTTTTACA
GGGGCAAATTGGCTTTACGCAAATTGCAAAAGTGAACGAAGCTTGTTTAGTGACTGTGCCTAAGCGCCCTATGGGCAGCA
TAGAAGATATTTTAGCCTTAGATGCGCAAACCCGCGTCTATGCGCGTGAGACCTTAGCAAGCATCGCTTAG

Upstream 100 bases:

>100_bases
ATTTTGCCAGGTCACGGCGGCGTGCTCGACCGCATCGACAGCCTGACAGCAGCCTTGCCGGTGTTTACCCTGATCTACAT
TGCATTCTGGATGTAACGCT

Downstream 100 bases:

>100_bases
CAATGGCTGAGTGATTAAATCAATGACGTAAGGAGTGGGATGTTAGATTTTTTATGGAACTTAGGTTCTTTTATCGTTGC
ACTGGGCCTGTTAATCACCG

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MQNMVILGATGSIGASTLSVISANPFAYSVYGLVANASVDKMLALCVAHKPKVAHMVDEAAAKQLRAVLPATLNIQVTTG
MNDLLGLVTAAEVDTVMAAIVGAAGLVPTLEAVKAGKRVLLANKEALVMSGELFIEATKRSGAVLLPVDSEHNAIFQCLP
QEVQANLGRCDLAASGISHILLTGSGGPFLRSDLATLAAMTPAQACKHPNWSMGPKISVDSATMMNKGLEFIEARWLFNT
QAEQLKVVIHPQSVIHSMVQYRDGSVIAQMGNPDMRTPIAHCMAYPQRIHSGVEPLDFFKVGQLSFYEPDFERFPCLALA
MEACAQGQEATTVLNAANEIAVEAFLQGQIGFTQIAKVNEACLVTVPKRPMGSIEDILALDAQTRVYARETLASIA

Sequences:

>Translated_396_residues
MQNMVILGATGSIGASTLSVISANPFAYSVYGLVANASVDKMLALCVAHKPKVAHMVDEAAAKQLRAVLPATLNIQVTTG
MNDLLGLVTAAEVDTVMAAIVGAAGLVPTLEAVKAGKRVLLANKEALVMSGELFIEATKRSGAVLLPVDSEHNAIFQCLP
QEVQANLGRCDLAASGISHILLTGSGGPFLRSDLATLAAMTPAQACKHPNWSMGPKISVDSATMMNKGLEFIEARWLFNT
QAEQLKVVIHPQSVIHSMVQYRDGSVIAQMGNPDMRTPIAHCMAYPQRIHSGVEPLDFFKVGQLSFYEPDFERFPCLALA
MEACAQGQEATTVLNAANEIAVEAFLQGQIGFTQIAKVNEACLVTVPKRPMGSIEDILALDAQTRVYARETLASIA
>Mature_396_residues
MQNMVILGATGSIGASTLSVISANPFAYSVYGLVANASVDKMLALCVAHKPKVAHMVDEAAAKQLRAVLPATLNIQVTTG
MNDLLGLVTAAEVDTVMAAIVGAAGLVPTLEAVKAGKRVLLANKEALVMSGELFIEATKRSGAVLLPVDSEHNAIFQCLP
QEVQANLGRCDLAASGISHILLTGSGGPFLRSDLATLAAMTPAQACKHPNWSMGPKISVDSATMMNKGLEFIEARWLFNT
QAEQLKVVIHPQSVIHSMVQYRDGSVIAQMGNPDMRTPIAHCMAYPQRIHSGVEPLDFFKVGQLSFYEPDFERFPCLALA
MEACAQGQEATTVLNAANEIAVEAFLQGQIGFTQIAKVNEACLVTVPKRPMGSIEDILALDAQTRVYARETLASIA

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=397, Percent_Identity=58.1863979848867, Blast_Score=449, Evalue=1e-127,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 42114; Mature: 42114

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNMVILGATGSIGASTLSVISANPFAYSVYGLVANASVDKMLALCVAHKPKVAHMVDEA
CCCEEEEECCCCCCCHHHHEEECCCCEEEEEHHHCCCCHHHHHHHHHHCCCHHHHHHHHH
AAKQLRAVLPATLNIQVTTGMNDLLGLVTAAEVDTVMAAIVGAAGLVPTLEAVKAGKRVL
HHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCEEE
LANKEALVMSGELFIEATKRSGAVLLPVDSEHNAIFQCLPQEVQANLGRCDLAASGISHI
EECCCEEEEECEEEEEEECCCCEEEEEECCCCCHHHHHCCHHHHCCCCCCHHHHCCCCEE
LLTGSGGPFLRSDLATLAAMTPAQACKHPNWSMGPKISVDSATMMNKGLEFIEARWLFNT
EEECCCCCHHHHHHHHHHHCCCHHHHCCCCCCCCCEEECCHHHHHHHCHHHHHHHHEECC
QAEQLKVVIHPQSVIHSMVQYRDGSVIAQMGNPDMRTPIAHCMAYPQRIHSGVEPLDFFK
CCCEEEEEECCHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCCHHHHE
VGQLSFYEPDFERFPCLALAMEACAQGQEATTVLNAANEIAVEAFLQGQIGFTQIAKVNE
ECCCEECCCCHHHCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCC
ACLVTVPKRPMGSIEDILALDAQTRVYARETLASIA
EEEEEECCCCCCCHHHHHHHCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MQNMVILGATGSIGASTLSVISANPFAYSVYGLVANASVDKMLALCVAHKPKVAHMVDEA
CCCEEEEECCCCCCCHHHHEEECCCCEEEEEHHHCCCCHHHHHHHHHHCCCHHHHHHHHH
AAKQLRAVLPATLNIQVTTGMNDLLGLVTAAEVDTVMAAIVGAAGLVPTLEAVKAGKRVL
HHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCEEE
LANKEALVMSGELFIEATKRSGAVLLPVDSEHNAIFQCLPQEVQANLGRCDLAASGISHI
EECCCEEEEECEEEEEEECCCCEEEEEECCCCCHHHHHCCHHHHCCCCCCHHHHCCCCEE
LLTGSGGPFLRSDLATLAAMTPAQACKHPNWSMGPKISVDSATMMNKGLEFIEARWLFNT
EEECCCCCHHHHHHHHHHHCCCHHHHCCCCCCCCCEEECCHHHHHHHCHHHHHHHHEECC
QAEQLKVVIHPQSVIHSMVQYRDGSVIAQMGNPDMRTPIAHCMAYPQRIHSGVEPLDFFK
CCCEEEEEECCHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCCHHHHE
VGQLSFYEPDFERFPCLALAMEACAQGQEATTVLNAANEIAVEAFLQGQIGFTQIAKVNE
ECCCEECCCCHHHCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCC
ACLVTVPKRPMGSIEDILALDAQTRVYARETLASIA
EEEEEECCCCCCCHHHHHHHCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA