Click here to switch to the map view.

The map label for this gene is hemE [H]

Identifier: 159900063

GI number: 159900063

Start: 4462649

End: 4463671

Strand: Direct

Name: hemE [H]

Synonym: Haur_3546

Alternate gene names: 159900063

Gene position: 4462649-4463671 (Clockwise)

Preceding gene: 159900062

Following gene: 159900064

Centisome position: 70.32

GC content: 51.52

Gene sequence:

>1023_bases
ATGCAAGATCGATTTTTACGGGCCTGTCGGCGCGAAGCTGTGGATGCCACCCCAGTTTGGTTTATGCGTCAGGCTGGCCG
TGCGCTGCCCGAATACCGTGCCATCCGCGAGCAATATGGCTTTATGGATATTTGCTATCAGCCCGAATTGTGTGCTGAAG
TAACTTTGCAGCCAGTGCGCCGTTTGGGTGTTGATGCAGCAATTATGTTTGCCGATATTATGACCCCGTTGATTGCGACT
GGGGTGGGCGTTGATTTGGTTGAAAGCATCGGCCCAGTGGTTGCCAACCCCATTCGCACGATGGCCGATGTTAGCCGCAT
TCGGCCAATTGAGCCAGAAGTTGATGTGCCTTACATTAGCAAATCGATTCATTTGCTCAAAGCTGAGTTGGGCCAAACAC
CCTTAATTGGCTTTGCTGGCGCACCATTTACCTTGGCGGCCTACTTGGTCGAAGGCAAAGGCTCGAAGAATTTTCTGAAT
ACCAAAGCGCTCATGTATGGCAGCCCCAACGTGTGGAATGCCCTGATGGAGCGCTTGGCTGACCTGACGATCAGTTATTT
GCGGGTGAAAATTGCGGCTGGGGTTGATGCGCTACAACTTTTTGATAGTTGGGTCGGCTGTTTAAGCCCCCACGATTATG
CAACCTTTGTGCAACCCTACACCGCCCGCATTTTGAAAACCCTACGCGAAGAAACCAACATTCCATTAATTCACTTTGGC
ACCAACACCACCAATCTTTTGCCGTTGATGCGCAACGATGGTGGCTCAGTGCTCGGAGCCGATTGGCGGATTCCAATCGA
CGAGGCTTGGGAACTAATTGGTGATGACAAAGCCATCCAAGGCAATCTTGATCCGGCGGTTTTGCTGGGGCCATGGGAAT
ATGTTCGCGAACAAGCTGCCGATATTTTGCGCCGCGTCAATCGCCGCCCAGGCCATATTTTCAACCTTGGTCATGGCATT
CACCCACAAACTCCGGTTGCCAATCTCGAACGCTTGGTGGCATTTATTCACGAAAGAGCATAG

Upstream 100 bases:

>100_bases
ATGATTTAGGCGGCAAACCGAGGCAGAATTCAGCTTGAATAGCGATTCTGCCTCGGTTTTGAAATTATTCAGTAAACCAT
ACAAGGACATACCAATAATT

Downstream 100 bases:

>100_bases
ACCATAGAGCATAGACCATAGGATTGAGGACTGGAAATTGGAGAACATAGAGCATAGAACATAAAATAATTCTTCGCGAT
CTTCGTGTTCTTCGCGGTTT

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MQDRFLRACRREAVDATPVWFMRQAGRALPEYRAIREQYGFMDICYQPELCAEVTLQPVRRLGVDAAIMFADIMTPLIAT
GVGVDLVESIGPVVANPIRTMADVSRIRPIEPEVDVPYISKSIHLLKAELGQTPLIGFAGAPFTLAAYLVEGKGSKNFLN
TKALMYGSPNVWNALMERLADLTISYLRVKIAAGVDALQLFDSWVGCLSPHDYATFVQPYTARILKTLREETNIPLIHFG
TNTTNLLPLMRNDGGSVLGADWRIPIDEAWELIGDDKAIQGNLDPAVLLGPWEYVREQAADILRRVNRRPGHIFNLGHGI
HPQTPVANLERLVAFIHERA

Sequences:

>Translated_340_residues
MQDRFLRACRREAVDATPVWFMRQAGRALPEYRAIREQYGFMDICYQPELCAEVTLQPVRRLGVDAAIMFADIMTPLIAT
GVGVDLVESIGPVVANPIRTMADVSRIRPIEPEVDVPYISKSIHLLKAELGQTPLIGFAGAPFTLAAYLVEGKGSKNFLN
TKALMYGSPNVWNALMERLADLTISYLRVKIAAGVDALQLFDSWVGCLSPHDYATFVQPYTARILKTLREETNIPLIHFG
TNTTNLLPLMRNDGGSVLGADWRIPIDEAWELIGDDKAIQGNLDPAVLLGPWEYVREQAADILRRVNRRPGHIFNLGHGI
HPQTPVANLERLVAFIHERA
>Mature_340_residues
MQDRFLRACRREAVDATPVWFMRQAGRALPEYRAIREQYGFMDICYQPELCAEVTLQPVRRLGVDAAIMFADIMTPLIAT
GVGVDLVESIGPVVANPIRTMADVSRIRPIEPEVDVPYISKSIHLLKAELGQTPLIGFAGAPFTLAAYLVEGKGSKNFLN
TKALMYGSPNVWNALMERLADLTISYLRVKIAAGVDALQLFDSWVGCLSPHDYATFVQPYTARILKTLREETNIPLIHFG
TNTTNLLPLMRNDGGSVLGADWRIPIDEAWELIGDDKAIQGNLDPAVLLGPWEYVREQAADILRRVNRRPGHIFNLGHGI
HPQTPVANLERLVAFIHERA

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=348, Percent_Identity=38.2183908045977, Blast_Score=222, Evalue=3e-58,
Organism=Escherichia coli, GI2367337, Length=341, Percent_Identity=41.6422287390029, Blast_Score=267, Evalue=6e-73,
Organism=Saccharomyces cerevisiae, GI6320252, Length=333, Percent_Identity=33.9339339339339, Blast_Score=194, Evalue=2e-50,
Organism=Drosophila melanogaster, GI19921920, Length=343, Percent_Identity=36.1516034985423, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI221330099, Length=343, Percent_Identity=36.1516034985423, Blast_Score=229, Evalue=3e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 37880; Mature: 37880

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDRFLRACRREAVDATPVWFMRQAGRALPEYRAIREQYGFMDICYQPELCAEVTLQPVR
CCHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHCCCEEEECCCHHHHHHHHHHHH
RLGVDAAIMFADIMTPLIATGVGVDLVESIGPVVANPIRTMADVSRIRPIEPEVDVPYIS
HHCCHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHH
KSIHLLKAELGQTPLIGFAGAPFTLAAYLVEGKGSKNFLNTKALMYGSPNVWNALMERLA
HHHHHHHHHHCCCCEEEECCCHHHHHHHHHCCCCCCCHHCCCEEEECCCHHHHHHHHHHH
DLTISYLRVKIAAGVDALQLFDSWVGCLSPHDYATFVQPYTARILKTLREETNIPLIHFG
HHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEC
TNTTNLLPLMRNDGGSVLGADWRIPIDEAWELIGDDKAIQGNLDPAVLLGPWEYVREQAA
CCCCCEEEEEECCCCCEECCCCCCCHHHHHHHHCCCCCEECCCCCEEEECCHHHHHHHHH
DILRRVNRRPGHIFNLGHGIHPQTPVANLERLVAFIHERA
HHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQDRFLRACRREAVDATPVWFMRQAGRALPEYRAIREQYGFMDICYQPELCAEVTLQPVR
CCHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHCCCEEEECCCHHHHHHHHHHHH
RLGVDAAIMFADIMTPLIATGVGVDLVESIGPVVANPIRTMADVSRIRPIEPEVDVPYIS
HHCCHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHH
KSIHLLKAELGQTPLIGFAGAPFTLAAYLVEGKGSKNFLNTKALMYGSPNVWNALMERLA
HHHHHHHHHHCCCCEEEECCCHHHHHHHHHCCCCCCCHHCCCEEEECCCHHHHHHHHHHH
DLTISYLRVKIAAGVDALQLFDSWVGCLSPHDYATFVQPYTARILKTLREETNIPLIHFG
HHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEC
TNTTNLLPLMRNDGGSVLGADWRIPIDEAWELIGDDKAIQGNLDPAVLLGPWEYVREQAA
CCCCCEEEEEECCCCCEECCCCCCCHHHHHHHHCCCCCEECCCCCEEEECCHHHHHHHHH
DILRRVNRRPGHIFNLGHGIHPQTPVANLERLVAFIHERA
HHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA