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The map label for this gene is hemH

Identifier: 159900064

GI number: 159900064

Start: 4463829

End: 4464746

Strand: Direct

Name: hemH

Synonym: Haur_3547

Alternate gene names: 159900064

Gene position: 4463829-4464746 (Clockwise)

Preceding gene: 159900063

Following gene: 159900065

Centisome position: 70.33

GC content: 48.15

Gene sequence:

>918_bases
ATGTCAGCCAAAACAGCTGTCTTGCTGATGGCCTATGGCACACCCAATCGCATCGATGAAGTTGAACAATACTACATCAA
TGTGCGTGGTGGTCGCATGCCAACGCCAGAGCAGGTCGAAAATCTTTCAGCTCGCTATCGAGCAGTTGGTGGTCATACCC
CGCTGACCACATTAACCAAATCGGTGACTGATCAACTGCAAGCCCAACTTGATGCCGAATTTCCTGACCAATATCAGGTT
TACTTTGGAATGAAATATTGGCATCCATTAATTCCCGATGTGGTCAAGCAAATTCATGCCGATGGTATTAGCAAGGTGAT
TGGGCTTGCCCTCGCACCGCATTATTCCAAAATCAGCATCGGCGGCTATCAAAAACAAGTTGATCGCGCTAACGAAGAAT
TTAACACCAACATCGAATTAACCATGATCAATAGCTGGCAAGAGCAGCCAAAGTTTCGCAATTTGATTGCTAACCGCATC
AGCGAGGCCTTAGCTCAATTTCCTGCCGACGTGCGCGATCAAGTAACGGTGTTGTTTAGCGCTCATAGCTTGCCGCAACG
AGTCTTGGCCTGGGGCGATCCCTATCCTGATGAGTTGTTGGGTAGCGCCAAAGGCATTGCCGAAATGCTCGAATTGCCAG
ATTGGCGTTTTACCTATCAAAGCCAAGGTGAAACTGGCGAACCATGGCTTGGGCCTGATGTGCTCGATACCTTGGCTGAA
TTGGCGGCTGAAGGCAAAAAATATGTGCTGCAAGTGCCATTTGGCTTTGTCTGCGACCACCTCGAAATTCTTTACGATAT
TGATATTGAGGGCAAGCACAAAGCCAACGAGTTAGGCTTGCAACTTGAACGCATTCGCTTGCTCAACGATGATCCAGCCT
TCGTCGATTTGCTCAAAACCGTCGTGACTGGCCAATAA

Upstream 100 bases:

>100_bases
AACATAAAATAATTCTTCGCGATCTTCGTGTTCTTCGCGGTTTCAAGCCTTCGGGTTCCTTCGTGCGCTTTGTGGATCAT
TAATAGATAAGAGGTAATCA

Downstream 100 bases:

>100_bases
AGAGGGAGCAGCGGTCAGTAAAGAGGGGATAGGCTACGGCAACCGCAAAGATTAGGAAGAATGCCGCTGGGCAGAACGAT
ACGTGTCAGGTTTATCGAGG

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase

Number of amino acids: Translated: 305; Mature: 304

Protein sequence:

>305_residues
MSAKTAVLLMAYGTPNRIDEVEQYYINVRGGRMPTPEQVENLSARYRAVGGHTPLTTLTKSVTDQLQAQLDAEFPDQYQV
YFGMKYWHPLIPDVVKQIHADGISKVIGLALAPHYSKISIGGYQKQVDRANEEFNTNIELTMINSWQEQPKFRNLIANRI
SEALAQFPADVRDQVTVLFSAHSLPQRVLAWGDPYPDELLGSAKGIAEMLELPDWRFTYQSQGETGEPWLGPDVLDTLAE
LAAEGKKYVLQVPFGFVCDHLEILYDIDIEGKHKANELGLQLERIRLLNDDPAFVDLLKTVVTGQ

Sequences:

>Translated_305_residues
MSAKTAVLLMAYGTPNRIDEVEQYYINVRGGRMPTPEQVENLSARYRAVGGHTPLTTLTKSVTDQLQAQLDAEFPDQYQV
YFGMKYWHPLIPDVVKQIHADGISKVIGLALAPHYSKISIGGYQKQVDRANEEFNTNIELTMINSWQEQPKFRNLIANRI
SEALAQFPADVRDQVTVLFSAHSLPQRVLAWGDPYPDELLGSAKGIAEMLELPDWRFTYQSQGETGEPWLGPDVLDTLAE
LAAEGKKYVLQVPFGFVCDHLEILYDIDIEGKHKANELGLQLERIRLLNDDPAFVDLLKTVVTGQ
>Mature_304_residues
SAKTAVLLMAYGTPNRIDEVEQYYINVRGGRMPTPEQVENLSARYRAVGGHTPLTTLTKSVTDQLQAQLDAEFPDQYQVY
FGMKYWHPLIPDVVKQIHADGISKVIGLALAPHYSKISIGGYQKQVDRANEEFNTNIELTMINSWQEQPKFRNLIANRIS
EALAQFPADVRDQVTVLFSAHSLPQRVLAWGDPYPDELLGSAKGIAEMLELPDWRFTYQSQGETGEPWLGPDVLDTLAEL
AAEGKKYVLQVPFGFVCDHLEILYDIDIEGKHKANELGLQLERIRLLNDDPAFVDLLKTVVTGQ

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Homo sapiens, GI60499025, Length=275, Percent_Identity=31.6363636363636, Blast_Score=142, Evalue=3e-34,
Organism=Homo sapiens, GI60499021, Length=275, Percent_Identity=31.6363636363636, Blast_Score=142, Evalue=4e-34,
Organism=Escherichia coli, GI1786681, Length=227, Percent_Identity=24.2290748898678, Blast_Score=73, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324750, Length=318, Percent_Identity=26.1006289308176, Blast_Score=125, Evalue=1e-29,
Organism=Drosophila melanogaster, GI17864156, Length=320, Percent_Identity=28.4375, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24651774, Length=254, Percent_Identity=26.3779527559055, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI45552018, Length=170, Percent_Identity=33.5294117647059, Blast_Score=95, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH_HERA2 (A9B546)

Other databases:

- EMBL:   CP000875
- RefSeq:   YP_001546311.1
- ProteinModelPortal:   A9B546
- SMR:   A9B546
- GeneID:   5735406
- GenomeReviews:   CP000875_GR
- KEGG:   hau:Haur_3547
- HOGENOM:   HBG697135
- OMA:   LAPHFST
- ProtClustDB:   CLSK973757
- BioCyc:   HAUR316274:HAUR_3547-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- InterPro:   IPR019772
- PANTHER:   PTHR11108
- TIGRFAMs:   TIGR00109

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 34315; Mature: 34184

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAKTAVLLMAYGTPNRIDEVEQYYINVRGGRMPTPEQVENLSARYRAVGGHTPLTTLTK
CCCCEEEEEEECCCCCHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHH
SVTDQLQAQLDAEFPDQYQVYFGMKYWHPLIPDVVKQIHADGISKVIGLALAPHYSKISI
HHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEC
GGYQKQVDRANEEFNTNIELTMINSWQEQPKFRNLIANRISEALAQFPADVRDQVTVLFS
CCHHHHHHHCCHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHEEHHHH
AHSLPQRVLAWGDPYPDELLGSAKGIAEMLELPDWRFTYQSQGETGEPWLGPDVLDTLAE
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCHHHHHHHHH
LAAEGKKYVLQVPFGFVCDHLEILYDIDIEGKHKANELGLQLERIRLLNDDPAFVDLLKT
HHHCCCEEEEECCHHHHHHHHHEEEECCCCCCCCHHHHCHHHHHHHHCCCCHHHHHHHHH
VVTGQ
HHCCC
>Mature Secondary Structure 
SAKTAVLLMAYGTPNRIDEVEQYYINVRGGRMPTPEQVENLSARYRAVGGHTPLTTLTK
CCCEEEEEEECCCCCHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHH
SVTDQLQAQLDAEFPDQYQVYFGMKYWHPLIPDVVKQIHADGISKVIGLALAPHYSKISI
HHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEC
GGYQKQVDRANEEFNTNIELTMINSWQEQPKFRNLIANRISEALAQFPADVRDQVTVLFS
CCHHHHHHHCCHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHEEHHHH
AHSLPQRVLAWGDPYPDELLGSAKGIAEMLELPDWRFTYQSQGETGEPWLGPDVLDTLAE
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCHHHHHHHHH
LAAEGKKYVLQVPFGFVCDHLEILYDIDIEGKHKANELGLQLERIRLLNDDPAFVDLLKT
HHHCCCEEEEECCHHHHHHHHHEEEECCCCCCCCHHHHCHHHHHHHHCCCCHHHHHHHHH
VVTGQ
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA