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The map label for this gene is yngE [H]

Identifier: 159899982

GI number: 159899982

Start: 4362621

End: 4364228

Strand: Direct

Name: yngE [H]

Synonym: Haur_3465

Alternate gene names: 159899982

Gene position: 4362621-4364228 (Clockwise)

Preceding gene: 159899981

Following gene: 159899983

Centisome position: 68.74

GC content: 52.92

Gene sequence:

>1608_bases
ATGTCGATCATTCAGAGTACGCTCGATATCCATAGCCCTGAATTTCGCCAAAATGTTGATTTTCATCGCCAATTAAGCGC
TGAATTGCGCCAAAAGACCCAGCAAATTGCCCAAGGTGGCAGCGCCGAAGCGCGTGCCCGCCACGAACGTCGTGGCAAAT
TACTGGTACGCGATCGGATCGAGCGTTTGCTTGATCCTGGTAGTGCTTGGCTCGAAATCGGCACATTAGCCGCATGGCAA
GTCTACGAAGATGATGTGCCAGCAGCAGGTGTAATTACTGGCATTGGGCGGGTGTCGGGAGTTGAGGTATTAATTGTAGC
CAACGATGCCACGGTCAAAGGTGGCACATACTATCCATTAACTGTCAAAAAACATTTGCGTGCCCAAGAAATCGCGCTGC
AAAACCATTTGCCTTGTATTTACTTGGTCGATAGCGGTGGCGCGTTCTTGCCGTTGCAAGCCGAGGTTTTTCCCGATCGC
GAACATTTTGGGCGGATTTTCTACAATCAAGCGCAAATGTCGGCCTTGGGTATTCCGCAAATCGCGGTGGTAATGGGCAG
TTGTACCGCTGGCGGAGCCTATGTGCCAGCCATGAGCGATGAAGTCGTGATTGTGCGCGAACAAGGCACGATCTTTTTGG
GTGGCCCACCTTTAGTCAAAGCAGCGACCGGCGAGATTGTGAGCGCCGAAGATTTAGGCGGCGCTGATGTGCATACCCGC
TTATCTGGTGTGGCCGACCACTTTGCCGATAACGATGAGCATGCCTTGGCAATCACGCGTTCGATTGTAGCCAATTTGCA
GCATCGCAAAGCTAACCCATGGCCGCTGCGCACGCCCGAGGCGCCACGCTACGATCCTCAAGAATTGTATGGCATTATTC
CCGCCGATACGCGCAAACAATTCGATGTGCGCGAAATTATCGCCCGCATCGTCGATGGCTCGCGCTTGGATGAATTCAAG
GCCCGCTATGGCACAACCTTGGTGACAGGCTTTTCCCACATTTATGGTCATCCAGTCGGCATTTTGGCTAACAACGGCAT
TTTATTTTCCGAGAGTGCCCTCAAGGCAGCGCACTTTATTGAGCTTTGTAACGAACGCGCCATTCCGCTGCTGTTTTTGC
AAAATATCACGGGCTTTATGGTTGGCCGCGAATACGAGCAACGCGGGATTGCCAAAGACGGAGCCAAGATGGTGATGGCG
GTTTCCAATGCGCGTGTGCCAAAATTTACCGTGGTGATTGGCGGCTCGTTTGGCGCTGGCAACTATGGCATGTGTGGCCG
AGCCTATAGCCCGCGCCAACTCTGGATGTGGCCCAACAGTCGCATCTCGGTGATGGGTGGCTCACAGGCTGCCAACGTGC
TGCTAACCGTGCGCCGCGATGGCCTGCAAGCCAAAGGCCAAGACATGAATTTGGCCGAGCAACAAGCCTTTATGCAGCCA
ATTCTCGATAAATACGAGGCTGAGGGCAACCCCTATTATTCCAGTGCTCGCCTGTGGGATGATGGAATTCTTGATCCGGT
TGATACGCGCATGGCTTTGGCGCTGGGTTTATCGGCAGCCGCCAACGCACCATTAGCTGATGTTAAATATGGTGTGTTTC
GAATGTAA

Upstream 100 bases:

>100_bases
CGATTTTCCCTATGGCGAGCAAACGATTCGCGTTGGTTTGTTTTAAGCGCGATCATCGGTATCATGTGCCCAGCGAACGT
CTAGTGATAAGGAACGATCA

Downstream 100 bases:

>100_bases
TGCGCTGAGCCGCCCCCTTGATTCATGGATCGAGGGGGCAATTTGATCCACGAAGGACACGAAGATCACGAAGTGTTGAA
ACCACAAAGAGCGCAAAGGA

Product: propionyl-CoA carboxylase

Products: ADP; phosphate; 3-methylglutaconyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 535; Mature: 534

Protein sequence:

>535_residues
MSIIQSTLDIHSPEFRQNVDFHRQLSAELRQKTQQIAQGGSAEARARHERRGKLLVRDRIERLLDPGSAWLEIGTLAAWQ
VYEDDVPAAGVITGIGRVSGVEVLIVANDATVKGGTYYPLTVKKHLRAQEIALQNHLPCIYLVDSGGAFLPLQAEVFPDR
EHFGRIFYNQAQMSALGIPQIAVVMGSCTAGGAYVPAMSDEVVIVREQGTIFLGGPPLVKAATGEIVSAEDLGGADVHTR
LSGVADHFADNDEHALAITRSIVANLQHRKANPWPLRTPEAPRYDPQELYGIIPADTRKQFDVREIIARIVDGSRLDEFK
ARYGTTLVTGFSHIYGHPVGILANNGILFSESALKAAHFIELCNERAIPLLFLQNITGFMVGREYEQRGIAKDGAKMVMA
VSNARVPKFTVVIGGSFGAGNYGMCGRAYSPRQLWMWPNSRISVMGGSQAANVLLTVRRDGLQAKGQDMNLAEQQAFMQP
ILDKYEAEGNPYYSSARLWDDGILDPVDTRMALALGLSAAANAPLADVKYGVFRM

Sequences:

>Translated_535_residues
MSIIQSTLDIHSPEFRQNVDFHRQLSAELRQKTQQIAQGGSAEARARHERRGKLLVRDRIERLLDPGSAWLEIGTLAAWQ
VYEDDVPAAGVITGIGRVSGVEVLIVANDATVKGGTYYPLTVKKHLRAQEIALQNHLPCIYLVDSGGAFLPLQAEVFPDR
EHFGRIFYNQAQMSALGIPQIAVVMGSCTAGGAYVPAMSDEVVIVREQGTIFLGGPPLVKAATGEIVSAEDLGGADVHTR
LSGVADHFADNDEHALAITRSIVANLQHRKANPWPLRTPEAPRYDPQELYGIIPADTRKQFDVREIIARIVDGSRLDEFK
ARYGTTLVTGFSHIYGHPVGILANNGILFSESALKAAHFIELCNERAIPLLFLQNITGFMVGREYEQRGIAKDGAKMVMA
VSNARVPKFTVVIGGSFGAGNYGMCGRAYSPRQLWMWPNSRISVMGGSQAANVLLTVRRDGLQAKGQDMNLAEQQAFMQP
ILDKYEAEGNPYYSSARLWDDGILDPVDTRMALALGLSAAANAPLADVKYGVFRM
>Mature_534_residues
SIIQSTLDIHSPEFRQNVDFHRQLSAELRQKTQQIAQGGSAEARARHERRGKLLVRDRIERLLDPGSAWLEIGTLAAWQV
YEDDVPAAGVITGIGRVSGVEVLIVANDATVKGGTYYPLTVKKHLRAQEIALQNHLPCIYLVDSGGAFLPLQAEVFPDRE
HFGRIFYNQAQMSALGIPQIAVVMGSCTAGGAYVPAMSDEVVIVREQGTIFLGGPPLVKAATGEIVSAEDLGGADVHTRL
SGVADHFADNDEHALAITRSIVANLQHRKANPWPLRTPEAPRYDPQELYGIIPADTRKQFDVREIIARIVDGSRLDEFKA
RYGTTLVTGFSHIYGHPVGILANNGILFSESALKAAHFIELCNERAIPLLFLQNITGFMVGREYEQRGIAKDGAKMVMAV
SNARVPKFTVVIGGSFGAGNYGMCGRAYSPRQLWMWPNSRISVMGGSQAANVLLTVRRDGLQAKGQDMNLAEQQAFMQPI
LDKYEAEGNPYYSSARLWDDGILDPVDTRMALALGLSAAANAPLADVKYGVFRM

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=528, Percent_Identity=64.3939393939394, Blast_Score=698, Evalue=0.0,
Organism=Homo sapiens, GI119943100, Length=498, Percent_Identity=31.5261044176707, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI295821216, Length=518, Percent_Identity=30.5019305019305, Blast_Score=219, Evalue=5e-57,
Organism=Homo sapiens, GI310133460, Length=138, Percent_Identity=55.7971014492754, Blast_Score=141, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17552936, Length=537, Percent_Identity=59.2178770949721, Blast_Score=664, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147359, Length=511, Percent_Identity=30.7240704500978, Blast_Score=222, Evalue=4e-58,
Organism=Caenorhabditis elegans, GI25147362, Length=511, Percent_Identity=30.7240704500978, Blast_Score=222, Evalue=4e-58,
Organism=Drosophila melanogaster, GI24586065, Length=551, Percent_Identity=62.2504537205082, Blast_Score=707, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.4

Molecular weight: Translated: 58467; Mature: 58335

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIIQSTLDIHSPEFRQNVDFHRQLSAELRQKTQQIAQGGSAEARARHERRGKLLVRDRI
CCHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHH
ERLLDPGSAWLEIGTLAAWQVYEDDVPAAGVITGIGRVSGVEVLIVANDATVKGGTYYPL
HHHHCCCHHHEEECCEEEEEEECCCCCCCHHHHHCCCCCCEEEEEEECCCEECCCEEEEE
TVKKHLRAQEIALQNHLPCIYLVDSGGAFLPLQAEVFPDREHFGRIFYNQAQMSALGIPQ
EHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEEHEECCCHHHHHHHHCCHHHHHHCCCCE
IAVVMGSCTAGGAYVPAMSDEVVIVREQGTIFLGGPPLVKAATGEIVSAEDLGGADVHTR
EEEEEECCCCCCEECCCCCCCEEEEEECCEEEECCCCEEEECCCCEEECCCCCCCHHHHH
LSGVADHFADNDEHALAITRSIVANLQHRKANPWPLRTPEAPRYDPQELYGIIPADTRKQ
HHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHEEECCCCCCCC
FDVREIIARIVDGSRLDEFKARYGTTLVTGFSHIYGHPVGILANNGILFSESALKAAHFI
CCHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHCCCEEEEECCCEEEEHHHHHHHHHH
ELCNERAIPLLFLQNITGFMVGREYEQRGIAKDGAKMVMAVSNARVPKFTVVIGGSFGAG
HHHCCCCCCEEEEHHHHHHHHCCHHHHCCCCCCCCEEEEEECCCCCCEEEEEEECCCCCC
NYGMCGRAYSPRQLWMWPNSRISVMGGSQAANVLLTVRRDGLQAKGQDMNLAEQQAFMQP
CCCCCCCCCCCCEEEECCCCEEEEECCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHH
ILDKYEAEGNPYYSSARLWDDGILDPVDTRMALALGLSAAANAPLADVKYGVFRM
HHHHHCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHCCCCCHHHCCCHHCCC
>Mature Secondary Structure 
SIIQSTLDIHSPEFRQNVDFHRQLSAELRQKTQQIAQGGSAEARARHERRGKLLVRDRI
CHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHH
ERLLDPGSAWLEIGTLAAWQVYEDDVPAAGVITGIGRVSGVEVLIVANDATVKGGTYYPL
HHHHCCCHHHEEECCEEEEEEECCCCCCCHHHHHCCCCCCEEEEEEECCCEECCCEEEEE
TVKKHLRAQEIALQNHLPCIYLVDSGGAFLPLQAEVFPDREHFGRIFYNQAQMSALGIPQ
EHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEEHEECCCHHHHHHHHCCHHHHHHCCCCE
IAVVMGSCTAGGAYVPAMSDEVVIVREQGTIFLGGPPLVKAATGEIVSAEDLGGADVHTR
EEEEEECCCCCCEECCCCCCCEEEEEECCEEEECCCCEEEECCCCEEECCCCCCCHHHHH
LSGVADHFADNDEHALAITRSIVANLQHRKANPWPLRTPEAPRYDPQELYGIIPADTRKQ
HHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHEEECCCCCCCC
FDVREIIARIVDGSRLDEFKARYGTTLVTGFSHIYGHPVGILANNGILFSESALKAAHFI
CCHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHCCCEEEEECCCEEEEHHHHHHHHHH
ELCNERAIPLLFLQNITGFMVGREYEQRGIAKDGAKMVMAVSNARVPKFTVVIGGSFGAG
HHHCCCCCCEEEEHHHHHHHHCCHHHHCCCCCCCCEEEEEECCCCCCEEEEEEECCCCCC
NYGMCGRAYSPRQLWMWPNSRISVMGGSQAANVLLTVRRDGLQAKGQDMNLAEQQAFMQP
CCCCCCCCCCCCEEEECCCCEEEEECCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHH
ILDKYEAEGNPYYSSARLWDDGILDPVDTRMALALGLSAAANAPLADVKYGVFRM
HHHHHCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHCCCCCHHHCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; 3-methylcrotonoyl-CoA; HCO3-

Specific reaction: ATP + 3-methylcrotonoyl-CoA + HCO3- = ADP + phosphate + 3-methylglutaconyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]