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The map label for this gene is hmrR [H]

Identifier: 159899798

GI number: 159899798

Start: 4146633

End: 4147052

Strand: Direct

Name: hmrR [H]

Synonym: Haur_3280

Alternate gene names: 159899798

Gene position: 4146633-4147052 (Clockwise)

Preceding gene: 159899797

Following gene: 159899801

Centisome position: 65.34

GC content: 47.86

Gene sequence:

>420_bases
ATGCCAGGATTATCAATCGGCGAGGTTGCCCAACAAACAGGCCTCCAATCATCAGCAATTCGCTATTACGAGCAGATGGG
CTTAATTCCCAAACCACAACGCCATAACACCCGCCGCCGTTACGATTCCAGCGTGTTGCAATGGATTGATTTGATCAATT
TGGCGCGTAAAGCAGGTTTTTCGATTGCCGAGGTTCAAACATTAATTCATGGATTTAGCGAGGATACGCCGCCATCAGCC
CGTTGGCGAACAATGGCCACCACAAAATTAACCCAAGTTGCCCAACAGATTCAGGATTTGCAGCAAATGCAAGAATTACT
CAATCATGGCTTGCAATGTCAGTGTTTGCGCCTAGAAGATTGTCGGATTAGCAATCAGCAGGGGTGTAGCGAGCAATGCA
ATGGAGCAGATCAGGCCTGA

Upstream 100 bases:

>100_bases
GAAACAATCCTGTAAAAGTTTCATTGAAAACTCCTTTATACGTTGATGCCTTCACGCTATCATGTGAAGTGCACTTTAAG
TCAAGCAGGAGTTTTAGCCA

Downstream 100 bases:

>100_bases
TCTGCTCCATATTGAGTTTATTGAGGAAGTGATGAAGGTTTAGGTTTGTAACGCAATAATCGGGCTGAATTGACCATAAT
GCCTAAATCGGGCAGCGATT

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: Copper efflux regulator; Copper export regulator [H]

Number of amino acids: Translated: 139; Mature: 138

Protein sequence:

>139_residues
MPGLSIGEVAQQTGLQSSAIRYYEQMGLIPKPQRHNTRRRYDSSVLQWIDLINLARKAGFSIAEVQTLIHGFSEDTPPSA
RWRTMATTKLTQVAQQIQDLQQMQELLNHGLQCQCLRLEDCRISNQQGCSEQCNGADQA

Sequences:

>Translated_139_residues
MPGLSIGEVAQQTGLQSSAIRYYEQMGLIPKPQRHNTRRRYDSSVLQWIDLINLARKAGFSIAEVQTLIHGFSEDTPPSA
RWRTMATTKLTQVAQQIQDLQQMQELLNHGLQCQCLRLEDCRISNQQGCSEQCNGADQA
>Mature_138_residues
PGLSIGEVAQQTGLQSSAIRYYEQMGLIPKPQRHNTRRRYDSSVLQWIDLINLARKAGFSIAEVQTLIHGFSEDTPPSAR
WRTMATTKLTQVAQQIQDLQQMQELLNHGLQCQCLRLEDCRISNQQGCSEQCNGADQA

Specific function: Regulates the transcription of actP. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. In the absence of copper, it negatively regulates the transcription of actP [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786695, Length=129, Percent_Identity=34.1085271317829, Blast_Score=68, Evalue=3e-13,
Organism=Escherichia coli, GI1790498, Length=123, Percent_Identity=28.4552845528455, Blast_Score=67, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011789
- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 15689; Mature: 15558

Theoretical pI: Translated: 7.35; Mature: 7.35

Prosite motif: PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
3.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGLSIGEVAQQTGLQSSAIRYYEQMGLIPKPQRHNTRRRYDSSVLQWIDLINLARKAGF
CCCCCHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
SIAEVQTLIHGFSEDTPPSARWRTMATTKLTQVAQQIQDLQQMQELLNHGLQCQCLRLED
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCC
CRISNQQGCSEQCNGADQA
CCCCCCCCCHHHCCCCCCC
>Mature Secondary Structure 
PGLSIGEVAQQTGLQSSAIRYYEQMGLIPKPQRHNTRRRYDSSVLQWIDLINLARKAGF
CCCCHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
SIAEVQTLIHGFSEDTPPSARWRTMATTKLTQVAQQIQDLQQMQELLNHGLQCQCLRLED
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCC
CRISNQQGCSEQCNGADQA
CCCCCCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11936079 [H]