Click here to switch to the map view.

The map label for this gene is era [H]

Identifier: 159899753

GI number: 159899753

Start: 4094880

End: 4096349

Strand: Direct

Name: era [H]

Synonym: Haur_3235

Alternate gene names: 159899753

Gene position: 4094880-4096349 (Clockwise)

Preceding gene: 159899752

Following gene: 159899754

Centisome position: 64.52

GC content: 50.41

Gene sequence:

>1470_bases
ATGTTAGAACTTACTTTTGATGCTGATGCACGGGCGTTATACGCCTACTTTACCGATATTAACGAAGGCGACGATGCCAG
CCAACTGGAAATTCCAGGGGTCTTTTTATTAGATGCTGCTGGGCAGATTGTTGGCGTGCGGTTGCAATTGGCTTCAGCAC
CGAAAAAGAGCTTTTTGCAATATGCCCAAGGCTTTGAAGAATTAAGCTACGACGAGGCAGCCCAGCAATTAACCCTCAGC
TTTGGTCAGCACGTTGTTGCTGCAACCGAAGAGTTGCCCTACGACGCAATTGTTGACCTTGATCGCAAAGGCCGCGCTTT
GGGCCTTGAAGTTCAAGCGATGATCGAATTTGGTCTCAACGAACGCCTTGAAGTGCTCAATCCATGGCTGGTAGCCTTCG
ATGAAGAGTCCGACGACGAGTTTGAGGCTGATGAAGATGCTGACGACGAGCAAGCAGCTGCCAAACTTGAGGTCAAACCT
GAACCCACGGCTGAGGACGAGGACGAAGCTAGACCAGCCGTTCATCAGCCAATCAAACTCAACCCAAACTTGCCCAAGCC
CTTGCTACCGACCGATCAGGAAGTGCATAGCGGTTTTGTGGCCTTGGTTGGCAAGCCCAACGTTGGCAAATCAACGTTAT
TGAATGCCTATCTTGGTCAAAAAGTCTCGATTGTTTCGCCAAAACCGCAAACTACCCGCGTGCCTGTGCGTGGGATTCTC
AACGGCCCCGATGCCCAGATTATTTTTGTGGATACGCCTGGGATTCACAAGCCACGCCATAAGCTTGGTAACTTTATGGT
CGATGTAGCCAAACGTGCCGTACCAAATGCCGATGTGATCTGTTTTATGGTCGATATTACCGTGCCACCCAACCGCATGG
ATCGTGAAATTGCCCAGATGGTCTTGCTCTCACGCAAGCCGCATATTTTGGTGCTCAACAAAGTCGATGCGACTGATGAA
GCCGATAAGCATCTGCAAGAATATCGCGACCTCGCGCCGTGGGAGATGGAAGTGGCGGTTTCGGCCCGTGATAAATTGGG
CATGGAAACCTTGCTGGCCGAAATTGTTCAGCGCTTGCCGGTTGGCCATCGACTCTACCCCGAAGACCAACTTTCCGATG
TGTCCGAGCGCAGTTTGGTTGCCGAGATGATTCGCGAAAAAGTCATGCTCAACACCGAGGAAGAAATTCCCCATTCAATC
GCAGTTGAAGTCGAAGAATGGGAAGATCGCGGCAAGGTTGTTTATATTCGAGCCAATATTTCGGTCGAAAAAGATTCACA
AAAAGGCATCATCATTGGTGCGGGTGGCTCGATGCTACGCAAAATTGGCGCAACCTCACGCTTTGAAATCGAGCGCTCAC
TTGGCCGCCAAATCTATCTCGACCTCTGGATTAAGGTGCGCGAGAATTGGCGACAAAAGCCTAACGAGCTACGTTGGCTC
GGCTACGACGTGAAATTCTTCAGGGATTAA

Upstream 100 bases:

>100_bases
CCAGCGTTGCGCCAACACCAACCAATAGTGGTGGTAGTCTTTCCGGAACCGCTGTTCCAATTAAACCTTAAAGTGCTTAA
CACTAGAATTTGATGGAGTT

Downstream 100 bases:

>100_bases
CCCCTATAGGCTAACCCTTTATGGACAAATGGCGGGGGATATACATCCCCCGTTTGAGGTATTTTATGCCATACTACAAT
GTATGGTATTTTTTTGTAAT

Product: GTP-binding protein Era

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 489; Mature: 489

Protein sequence:

>489_residues
MLELTFDADARALYAYFTDINEGDDASQLEIPGVFLLDAAGQIVGVRLQLASAPKKSFLQYAQGFEELSYDEAAQQLTLS
FGQHVVAATEELPYDAIVDLDRKGRALGLEVQAMIEFGLNERLEVLNPWLVAFDEESDDEFEADEDADDEQAAAKLEVKP
EPTAEDEDEARPAVHQPIKLNPNLPKPLLPTDQEVHSGFVALVGKPNVGKSTLLNAYLGQKVSIVSPKPQTTRVPVRGIL
NGPDAQIIFVDTPGIHKPRHKLGNFMVDVAKRAVPNADVICFMVDITVPPNRMDREIAQMVLLSRKPHILVLNKVDATDE
ADKHLQEYRDLAPWEMEVAVSARDKLGMETLLAEIVQRLPVGHRLYPEDQLSDVSERSLVAEMIREKVMLNTEEEIPHSI
AVEVEEWEDRGKVVYIRANISVEKDSQKGIIIGAGGSMLRKIGATSRFEIERSLGRQIYLDLWIKVRENWRQKPNELRWL
GYDVKFFRD

Sequences:

>Translated_489_residues
MLELTFDADARALYAYFTDINEGDDASQLEIPGVFLLDAAGQIVGVRLQLASAPKKSFLQYAQGFEELSYDEAAQQLTLS
FGQHVVAATEELPYDAIVDLDRKGRALGLEVQAMIEFGLNERLEVLNPWLVAFDEESDDEFEADEDADDEQAAAKLEVKP
EPTAEDEDEARPAVHQPIKLNPNLPKPLLPTDQEVHSGFVALVGKPNVGKSTLLNAYLGQKVSIVSPKPQTTRVPVRGIL
NGPDAQIIFVDTPGIHKPRHKLGNFMVDVAKRAVPNADVICFMVDITVPPNRMDREIAQMVLLSRKPHILVLNKVDATDE
ADKHLQEYRDLAPWEMEVAVSARDKLGMETLLAEIVQRLPVGHRLYPEDQLSDVSERSLVAEMIREKVMLNTEEEIPHSI
AVEVEEWEDRGKVVYIRANISVEKDSQKGIIIGAGGSMLRKIGATSRFEIERSLGRQIYLDLWIKVRENWRQKPNELRWL
GYDVKFFRD
>Mature_489_residues
MLELTFDADARALYAYFTDINEGDDASQLEIPGVFLLDAAGQIVGVRLQLASAPKKSFLQYAQGFEELSYDEAAQQLTLS
FGQHVVAATEELPYDAIVDLDRKGRALGLEVQAMIEFGLNERLEVLNPWLVAFDEESDDEFEADEDADDEQAAAKLEVKP
EPTAEDEDEARPAVHQPIKLNPNLPKPLLPTDQEVHSGFVALVGKPNVGKSTLLNAYLGQKVSIVSPKPQTTRVPVRGIL
NGPDAQIIFVDTPGIHKPRHKLGNFMVDVAKRAVPNADVICFMVDITVPPNRMDREIAQMVLLSRKPHILVLNKVDATDE
ADKHLQEYRDLAPWEMEVAVSARDKLGMETLLAEIVQRLPVGHRLYPEDQLSDVSERSLVAEMIREKVMLNTEEEIPHSI
AVEVEEWEDRGKVVYIRANISVEKDSQKGIIIGAGGSMLRKIGATSRFEIERSLGRQIYLDLWIKVRENWRQKPNELRWL
GYDVKFFRD

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism [H]

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain [H]

Homologues:

Organism=Homo sapiens, GI24307899, Length=297, Percent_Identity=25.2525252525253, Blast_Score=69, Evalue=8e-12,
Organism=Escherichia coli, GI1788919, Length=294, Percent_Identity=36.3945578231293, Blast_Score=174, Evalue=2e-44,
Organism=Escherichia coli, GI87082120, Length=177, Percent_Identity=31.638418079096, Blast_Score=68, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323665, Length=206, Percent_Identity=30.0970873786408, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24646434, Length=310, Percent_Identity=26.4516129032258, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005662
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 54949; Mature: 54949

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLELTFDADARALYAYFTDINEGDDASQLEIPGVFLLDAAGQIVGVRLQLASAPKKSFLQ
CEEEEECCCCCEEEEEEECCCCCCCCCEEECCCEEEEECCCCEEEEEEEECCCCHHHHHH
YAQGFEELSYDEAAQQLTLSFGQHVVAATEELPYDAIVDLDRKGRALGLEVQAMIEFGLN
HHHHHHHCCHHHHHHHHHHHHCCEEEEHHHCCCCHHEEECCCCCCEECEEHHHHHHHCCC
ERLEVLNPWLVAFDEESDDEFEADEDADDEQAAAKLEVKPEPTAEDEDEARPAVHQPIKL
CHHHHCCCEEEEECCCCCCCCCCCCCCCCCHHHEEEEECCCCCCCCCCCCCCCCCCCEEE
NPNLPKPLLPTDQEVHSGFVALVGKPNVGKSTLLNAYLGQKVSIVSPKPQTTRVPVRGIL
CCCCCCCCCCCCHHHHCCEEEEEECCCCCHHHHHHHHHCCEEEEECCCCCCCCCCHHEEC
NGPDAQIIFVDTPGIHKPRHKLGNFMVDVAKRAVPNADVICFMVDITVPPNRMDREIAQM
CCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCHHHHHHHHH
VLLSRKPHILVLNKVDATDEADKHLQEYRDLAPWEMEVAVSARDKLGMETLLAEIVQRLP
HHHCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEECCHHHCCHHHHHHHHHHHCC
VGHRLYPEDQLSDVSERSLVAEMIREKVMLNTEEEIPHSIAVEVEEWEDRGKVVYIRANI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCEEEEEEEHHCCCCCEEEEEEEE
SVEKDSQKGIIIGAGGSMLRKIGATSRFEIERSLGRQIYLDLWIKVRENWRQKPNELRWL
EEECCCCCCEEEECCHHHHHHHCCCCHHHHHHHCCCEEEEHHHHHHHHHHHCCCCCEEEE
GYDVKFFRD
EEEEEEECC
>Mature Secondary Structure
MLELTFDADARALYAYFTDINEGDDASQLEIPGVFLLDAAGQIVGVRLQLASAPKKSFLQ
CEEEEECCCCCEEEEEEECCCCCCCCCEEECCCEEEEECCCCEEEEEEEECCCCHHHHHH
YAQGFEELSYDEAAQQLTLSFGQHVVAATEELPYDAIVDLDRKGRALGLEVQAMIEFGLN
HHHHHHHCCHHHHHHHHHHHHCCEEEEHHHCCCCHHEEECCCCCCEECEEHHHHHHHCCC
ERLEVLNPWLVAFDEESDDEFEADEDADDEQAAAKLEVKPEPTAEDEDEARPAVHQPIKL
CHHHHCCCEEEEECCCCCCCCCCCCCCCCCHHHEEEEECCCCCCCCCCCCCCCCCCCEEE
NPNLPKPLLPTDQEVHSGFVALVGKPNVGKSTLLNAYLGQKVSIVSPKPQTTRVPVRGIL
CCCCCCCCCCCCHHHHCCEEEEEECCCCCHHHHHHHHHCCEEEEECCCCCCCCCCHHEEC
NGPDAQIIFVDTPGIHKPRHKLGNFMVDVAKRAVPNADVICFMVDITVPPNRMDREIAQM
CCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCHHHHHHHHH
VLLSRKPHILVLNKVDATDEADKHLQEYRDLAPWEMEVAVSARDKLGMETLLAEIVQRLP
HHHCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEECCHHHCCHHHHHHHHHHHCC
VGHRLYPEDQLSDVSERSLVAEMIREKVMLNTEEEIPHSIAVEVEEWEDRGKVVYIRANI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCEEEEEEEHHCCCCCEEEEEEEE
SVEKDSQKGIIIGAGGSMLRKIGATSRFEIERSLGRQIYLDLWIKVRENWRQKPNELRWL
EEECCCCCCEEEECCHHHHHHHCCCCHHHHHHHCCCEEEEHHHHHHHHHHHCCCCCEEEE
GYDVKFFRD
EEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA