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The map label for this gene is mutL [H]

Identifier: 159899518

GI number: 159899518

Start: 3787657

End: 3789552

Strand: Direct

Name: mutL [H]

Synonym: Haur_2999

Alternate gene names: 159899518

Gene position: 3787657-3789552 (Clockwise)

Preceding gene: 159899517

Following gene: 159899526

Centisome position: 59.68

GC content: 53.06

Gene sequence:

>1896_bases
ATGCCAATTCGTGTTTTAGACCCAACTTTAGCTGCCCAAATCGCCGCTGGCGAGGTGGTTGAACGCCCAGCCTCGGTCGT
CAAAGAATTAATCGAAAATTCGGTCGATGCTGGCGCTACCGAGATTCGGGTCGAGGCACGCGAGGGCGGCAAACGCGAGT
TGCGCATCCAAGATAATGGCTGTGGCATTGCCAGCGATGAGGTTGAAACGGCATTTTTGCGCCATGCCACCAGTAAAGTA
ACCGAAATTGAAGACCTATTTTCGATTCGCACACTGGGTTTTCGTGGCGAAGCCTTGCCTTCCATTGCCTCAGTTGCTCA
AGTAACATGCCTTACCCGCACTGCCGCCGATGAAGTTGGTACTGAATTGCGGATCGCTGGTGGCGAAATTCAGGCTAAAA
CGCCGCGTGGCTGCTCGGTCGGCACAACCTTCACGATTCGCAATTTGTTTTATAACACCCCAGCACGGCTCAAATTTATG
CGCTCCGATGCCACCGAAATGAGCCAAATTAGCACAATCGTGACCCAATATGCCTTGGCCTACCCCAACATTCGCTGGAC
CTTGCTGCTCGATGGCAAGCTGGCCTTACAAACCCCAGGCAATGGGCGTTTGCTCGATGCCTTGATTGAATTGTATGGGA
TTGATGTTGGCCGCGAGATGATCAGCGTTGATCGGACCTCGGAAGCCGAAGATGAAACTGTGCGCGTTCATGGCTTTGTC
AGCCAACCTTCGACCTTTCGCGCTGCCCGTTCGTATATGCACTTATTCGTCAATCAGCGTTGGATCAAGCCGCAAGGCAA
TTTGGTCTATATGATCGAAGAGGCCTACCATACCTTATTGATGAAGGGTCGGCATCCGATTGTGGCCTTGAATATTGAGC
TTGAGCCAGAAGCGGTTGATGTGAATGTGCACCCAACCAAGAGCGAGGTCAAATTTCGCAATCAATCGCATGTCTATGGC
GCATTGACCAAAGCAGTACGCGAAGCCTTGGCTGCTCAAAGCACTATTCGGGCTTGGACAGGCTTTGGAGCCAACGAAAG
TGTCAATCGGCGGGTCGAATTACGCTCGCCCAATGGCGAACGACGTGGCTCAAGCAATGATGCACCCTTGTTTGATGATG
CACCAGCAGCGCCACGCCCTCAGGTCAATAATTATCCTGATGACGATTTTGATTCGACCGTGAATTTGCCGCCAATTGCT
AAACAAGCGCGGTTTGAAACCCCAACCACCAGCCAAACCAGCAGTTTCTTGCCGCCGCAGCAACAAGCTTTTGATCCGGC
GTATGCACCGAGCATGCCAGCTCCAGGCGAGGCCAAATTGCCGATGTTACGGGTGGTTGGCCAAGTTAACGAAACCTATA
TTGTGGCCGAAAGCAGCGATGGTATGTATTTGGTCGATCAGCATGCGGCCCACGAACGGGTGGTGTATGAGCGCTTGATG
GCCGAACATCAGGATGTGCCAATTGAACGCCAAACCCTGATGTTAGCCCAACCGATTGAACTACCACCAGCCGTCACCCG
TTTGCTCAGCGCTCACTTGGCCGATTTGGAGCAATGGGGCTTTGAGGCCGAGGAATTTGGCGAAGGCACATTAATGTTGC
GAGCTGTGCCAAGTGGCTTGCACGTTGGCCAAATTGCCACCGCCTTGATGGAAATCGCTGATCATTTGAGTTATGAAGGC
GGGGCCACTAGCGACGATCGGCGTGAAAAAATGTTGACCACGATCGCCTGCCATAGCTCAATTCGCGCGGGCAAAACCCT
GACCCACGAAGAGATGCGCCAGCTTTTGCAACAACTTGAGCGCTGCGAAATGCCGCGCACCTGCCCGCATGGCCGCCCAA
CCATGCTCCAAATTACGCAAGGCCAAATCGAACGCCAATTTGGGCGCAAAGGCTAG

Upstream 100 bases:

>100_bases
GTGCTCCCGATCTCCATCCCAAACTAGCTCATTTATGCTAAAAAGCCCAATTTATGCTACAATAGCAGGGCAGAATGTGT
ATCTACGAGGAGCCTGAGCA

Downstream 100 bases:

>100_bases
GGATCAGGGATCGGTTGTTAGGGGCTGGGGATCAGGATTTAACACAGAGGCACAGAGACGATTTAAGGGTTAGGGGCCAG
CGATCAGGACTCAGGATTGA

Product: DNA mismatch repair protein MutL

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 631; Mature: 630

Protein sequence:

>631_residues
MPIRVLDPTLAAQIAAGEVVERPASVVKELIENSVDAGATEIRVEAREGGKRELRIQDNGCGIASDEVETAFLRHATSKV
TEIEDLFSIRTLGFRGEALPSIASVAQVTCLTRTAADEVGTELRIAGGEIQAKTPRGCSVGTTFTIRNLFYNTPARLKFM
RSDATEMSQISTIVTQYALAYPNIRWTLLLDGKLALQTPGNGRLLDALIELYGIDVGREMISVDRTSEAEDETVRVHGFV
SQPSTFRAARSYMHLFVNQRWIKPQGNLVYMIEEAYHTLLMKGRHPIVALNIELEPEAVDVNVHPTKSEVKFRNQSHVYG
ALTKAVREALAAQSTIRAWTGFGANESVNRRVELRSPNGERRGSSNDAPLFDDAPAAPRPQVNNYPDDDFDSTVNLPPIA
KQARFETPTTSQTSSFLPPQQQAFDPAYAPSMPAPGEAKLPMLRVVGQVNETYIVAESSDGMYLVDQHAAHERVVYERLM
AEHQDVPIERQTLMLAQPIELPPAVTRLLSAHLADLEQWGFEAEEFGEGTLMLRAVPSGLHVGQIATALMEIADHLSYEG
GATSDDRREKMLTTIACHSSIRAGKTLTHEEMRQLLQQLERCEMPRTCPHGRPTMLQITQGQIERQFGRKG

Sequences:

>Translated_631_residues
MPIRVLDPTLAAQIAAGEVVERPASVVKELIENSVDAGATEIRVEAREGGKRELRIQDNGCGIASDEVETAFLRHATSKV
TEIEDLFSIRTLGFRGEALPSIASVAQVTCLTRTAADEVGTELRIAGGEIQAKTPRGCSVGTTFTIRNLFYNTPARLKFM
RSDATEMSQISTIVTQYALAYPNIRWTLLLDGKLALQTPGNGRLLDALIELYGIDVGREMISVDRTSEAEDETVRVHGFV
SQPSTFRAARSYMHLFVNQRWIKPQGNLVYMIEEAYHTLLMKGRHPIVALNIELEPEAVDVNVHPTKSEVKFRNQSHVYG
ALTKAVREALAAQSTIRAWTGFGANESVNRRVELRSPNGERRGSSNDAPLFDDAPAAPRPQVNNYPDDDFDSTVNLPPIA
KQARFETPTTSQTSSFLPPQQQAFDPAYAPSMPAPGEAKLPMLRVVGQVNETYIVAESSDGMYLVDQHAAHERVVYERLM
AEHQDVPIERQTLMLAQPIELPPAVTRLLSAHLADLEQWGFEAEEFGEGTLMLRAVPSGLHVGQIATALMEIADHLSYEG
GATSDDRREKMLTTIACHSSIRAGKTLTHEEMRQLLQQLERCEMPRTCPHGRPTMLQITQGQIERQFGRKG
>Mature_630_residues
PIRVLDPTLAAQIAAGEVVERPASVVKELIENSVDAGATEIRVEAREGGKRELRIQDNGCGIASDEVETAFLRHATSKVT
EIEDLFSIRTLGFRGEALPSIASVAQVTCLTRTAADEVGTELRIAGGEIQAKTPRGCSVGTTFTIRNLFYNTPARLKFMR
SDATEMSQISTIVTQYALAYPNIRWTLLLDGKLALQTPGNGRLLDALIELYGIDVGREMISVDRTSEAEDETVRVHGFVS
QPSTFRAARSYMHLFVNQRWIKPQGNLVYMIEEAYHTLLMKGRHPIVALNIELEPEAVDVNVHPTKSEVKFRNQSHVYGA
LTKAVREALAAQSTIRAWTGFGANESVNRRVELRSPNGERRGSSNDAPLFDDAPAAPRPQVNNYPDDDFDSTVNLPPIAK
QARFETPTTSQTSSFLPPQQQAFDPAYAPSMPAPGEAKLPMLRVVGQVNETYIVAESSDGMYLVDQHAAHERVVYERLMA
EHQDVPIERQTLMLAQPIELPPAVTRLLSAHLADLEQWGFEAEEFGEGTLMLRAVPSGLHVGQIATALMEIADHLSYEGG
ATSDDRREKMLTTIACHSSIRAGKTLTHEEMRQLLQQLERCEMPRTCPHGRPTMLQITQGQIERQFGRKG

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=343, Percent_Identity=35.2769679300292, Blast_Score=209, Evalue=6e-54,
Organism=Homo sapiens, GI310128478, Length=349, Percent_Identity=30.945558739255, Blast_Score=155, Evalue=9e-38,
Organism=Homo sapiens, GI4505913, Length=349, Percent_Identity=30.945558739255, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI4505911, Length=323, Percent_Identity=31.5789473684211, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI189458898, Length=323, Percent_Identity=31.5789473684211, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI189458896, Length=316, Percent_Identity=29.746835443038, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI310128480, Length=314, Percent_Identity=28.6624203821656, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI263191589, Length=249, Percent_Identity=29.3172690763052, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI91992162, Length=403, Percent_Identity=23.5732009925558, Blast_Score=102, Evalue=8e-22,
Organism=Homo sapiens, GI91992160, Length=403, Percent_Identity=23.5732009925558, Blast_Score=102, Evalue=9e-22,
Organism=Escherichia coli, GI1790612, Length=338, Percent_Identity=40.8284023668639, Blast_Score=228, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI71991825, Length=320, Percent_Identity=32.1875, Blast_Score=165, Evalue=7e-41,
Organism=Caenorhabditis elegans, GI17562796, Length=364, Percent_Identity=28.5714285714286, Blast_Score=144, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6323819, Length=345, Percent_Identity=33.3333333333333, Blast_Score=184, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6324247, Length=336, Percent_Identity=29.4642857142857, Blast_Score=136, Evalue=8e-33,
Organism=Saccharomyces cerevisiae, GI6323063, Length=210, Percent_Identity=29.5238095238095, Blast_Score=87, Evalue=7e-18,
Organism=Drosophila melanogaster, GI17136968, Length=618, Percent_Identity=29.2880258899676, Blast_Score=221, Evalue=1e-57,
Organism=Drosophila melanogaster, GI17136970, Length=358, Percent_Identity=26.8156424581006, Blast_Score=135, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 69787; Mature: 69656

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIRVLDPTLAAQIAAGEVVERPASVVKELIENSVDAGATEIRVEAREGGKRELRIQDNG
CCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEEEECCC
CGIASDEVETAFLRHATSKVTEIEDLFSIRTLGFRGEALPSIASVAQVTCLTRTAADEVG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
TELRIAGGEIQAKTPRGCSVGTTFTIRNLFYNTPARLKFMRSDATEMSQISTIVTQYALA
CEEEEECCEEEECCCCCCCCCCEEEEHHHHHCCCHHEEEECCCHHHHHHHHHHHHHHHHH
YPNIRWTLLLDGKLALQTPGNGRLLDALIELYGIDVGREMISVDRTSEAEDETVRVHGFV
CCCEEEEEEECCEEEEECCCCCHHHHHHHHHHCCHHCHHHHHCCCCCCCCCCEEEEEEEC
SQPSTFRAARSYMHLFVNQRWIKPQGNLVYMIEEAYHTLLMKGRHPIVALNIELEPEAVD
CCCHHHHHHHHHHHHHHHCEEECCCCCEEEEEHHHHHHHHHCCCCCEEEEEEEECCCEEE
VNVHPTKSEVKFRNQSHVYGALTKAVREALAAQSTIRAWTGFGANESVNRRVELRSPNGE
EEECCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCC
RRGSSNDAPLFDDAPAAPRPQVNNYPDDDFDSTVNLPPIAKQARFETPTTSQTSSFLPPQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCH
QQAFDPAYAPSMPAPGEAKLPMLRVVGQVNETYIVAESSDGMYLVDQHAAHERVVYERLM
HHHCCCCCCCCCCCCCCCCCHHHHHHCCCCCEEEEEECCCCEEEEECHHHHHHHHHHHHH
AEHQDVPIERQTLMLAQPIELPPAVTRLLSAHLADLEQWGFEAEEFGEGTLMLRAVPSGL
HHHCCCCCCHHHEEEECCCCCCHHHHHHHHHHHHHHHHHCCCHHHHCCCEEEEEECCCCC
HVGQIATALMEIADHLSYEGGATSDDRREKMLTTIACHSSIRAGKTLTHEEMRQLLQQLE
CHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
RCEMPRTCPHGRPTMLQITQGQIERQFGRKG
HCCCCCCCCCCCCEEEEEHHHHHHHHHCCCC
>Mature Secondary Structure 
PIRVLDPTLAAQIAAGEVVERPASVVKELIENSVDAGATEIRVEAREGGKRELRIQDNG
CCEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEEEECCC
CGIASDEVETAFLRHATSKVTEIEDLFSIRTLGFRGEALPSIASVAQVTCLTRTAADEVG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
TELRIAGGEIQAKTPRGCSVGTTFTIRNLFYNTPARLKFMRSDATEMSQISTIVTQYALA
CEEEEECCEEEECCCCCCCCCCEEEEHHHHHCCCHHEEEECCCHHHHHHHHHHHHHHHHH
YPNIRWTLLLDGKLALQTPGNGRLLDALIELYGIDVGREMISVDRTSEAEDETVRVHGFV
CCCEEEEEEECCEEEEECCCCCHHHHHHHHHHCCHHCHHHHHCCCCCCCCCCEEEEEEEC
SQPSTFRAARSYMHLFVNQRWIKPQGNLVYMIEEAYHTLLMKGRHPIVALNIELEPEAVD
CCCHHHHHHHHHHHHHHHCEEECCCCCEEEEEHHHHHHHHHCCCCCEEEEEEEECCCEEE
VNVHPTKSEVKFRNQSHVYGALTKAVREALAAQSTIRAWTGFGANESVNRRVELRSPNGE
EEECCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCC
RRGSSNDAPLFDDAPAAPRPQVNNYPDDDFDSTVNLPPIAKQARFETPTTSQTSSFLPPQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCH
QQAFDPAYAPSMPAPGEAKLPMLRVVGQVNETYIVAESSDGMYLVDQHAAHERVVYERLM
HHHCCCCCCCCCCCCCCCCCHHHHHHCCCCCEEEEEECCCCEEEEECHHHHHHHHHHHHH
AEHQDVPIERQTLMLAQPIELPPAVTRLLSAHLADLEQWGFEAEEFGEGTLMLRAVPSGL
HHHCCCCCCHHHEEEECCCCCCHHHHHHHHHHHHHHHHHCCCHHHHCCCEEEEEECCCCC
HVGQIATALMEIADHLSYEGGATSDDRREKMLTTIACHSSIRAGKTLTHEEMRQLLQQLE
CHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
RCEMPRTCPHGRPTMLQITQGQIERQFGRKG
HCCCCCCCCCCCCEEEEEHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA