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The map label for this gene is pyrE [H]

Identifier: 159899407

GI number: 159899407

Start: 3659069

End: 3659722

Strand: Direct

Name: pyrE [H]

Synonym: Haur_2888

Alternate gene names: 159899407

Gene position: 3659069-3659722 (Clockwise)

Preceding gene: 159899403

Following gene: 159899409

Centisome position: 57.65

GC content: 52.75

Gene sequence:

>654_bases
ATGAAACATTCTTCAACCGCGATCGCCCAACTGTTGCTCGAGGCCGGAGCGGTGGTGCTTTCGCCTGATCGACCGTTTCG
CTTTGCATCGGGCATTCTTTCGCCAATTTATTGCGATAATCGTTTGTTGTTGGCCCAAGTTAGCGCCCGCCGCACCATCA
CTGAAGCTATGTGCCAACAAATTAGCGATGAATTATTGAACACCGAAGTAATTGCTGGAACGGCCACTGCTGGCGTGCCA
TGGGCGGCGTGGGTTGCCCATGAATTAAGTTTGCCAATGGCCTATGTTCGTTCAGGAGCCAAAAAATATGGCCGTGGTCA
GCAGGTTGAAGGCGGGGTGCAAGCCAATCAGCGGGTCGTCGTGATCGAAGATCTGATCAGCACGGGCGGTAGCTCGCTCG
ATGCCGTGGCAGGGTTACGTCAGATTAACGCACTTGTGGCCGATTGTTTTGCGATCTTTACCTATGAGATGGAAGAATCG
AAGCAGCGCTTTAATGCTGCTGGCGTGCGCTTGATGACCTTGACCAATCTTTCGACTTTGTTGGATGTTGCGGCCCAACA
AAACTACATTCGGGCCGAACATCGCAGCTTAATCAGCGATTGGGCCAGTGATCCGGCTGGTTGGGCTGATCGGGCTGGAA
TTAGCGCTGAGTAA

Upstream 100 bases:

>100_bases
ATCGCATTAGGCCTCTCATCGTGGGGGACCTCCCCAAACTAGGCGGTAATGAGCGCCGTCAATTAAGCTATTCGCGCTAT
TGTACCAGATAGGAGCTAGT

Downstream 100 bases:

>100_bases
TTATCGCCACTTACAGATAAACTTCAGAGCACGAAACCTAGTTCGTGCTCTTTTTAATTAACTGGTTGTCCAAGGCATTA
ATGTCGCAATCACCCGCTCG

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase [H]

Number of amino acids: Translated: 217; Mature: 217

Protein sequence:

>217_residues
MKHSSTAIAQLLLEAGAVVLSPDRPFRFASGILSPIYCDNRLLLAQVSARRTITEAMCQQISDELLNTEVIAGTATAGVP
WAAWVAHELSLPMAYVRSGAKKYGRGQQVEGGVQANQRVVVIEDLISTGGSSLDAVAGLRQINALVADCFAIFTYEMEES
KQRFNAAGVRLMTLTNLSTLLDVAAQQNYIRAEHRSLISDWASDPAGWADRAGISAE

Sequences:

>Translated_217_residues
MKHSSTAIAQLLLEAGAVVLSPDRPFRFASGILSPIYCDNRLLLAQVSARRTITEAMCQQISDELLNTEVIAGTATAGVP
WAAWVAHELSLPMAYVRSGAKKYGRGQQVEGGVQANQRVVVIEDLISTGGSSLDAVAGLRQINALVADCFAIFTYEMEES
KQRFNAAGVRLMTLTNLSTLLDVAAQQNYIRAEHRSLISDWASDPAGWADRAGISAE
>Mature_217_residues
MKHSSTAIAQLLLEAGAVVLSPDRPFRFASGILSPIYCDNRLLLAQVSARRTITEAMCQQISDELLNTEVIAGTATAGVP
WAAWVAHELSLPMAYVRSGAKKYGRGQQVEGGVQANQRVVVIEDLISTGGSSLDAVAGLRQINALVADCFAIFTYEMEES
KQRFNAAGVRLMTLTNLSTLLDVAAQQNYIRAEHRSLISDWASDPAGWADRAGISAE

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507835, Length=168, Percent_Identity=26.7857142857143, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17554964, Length=157, Percent_Identity=35.031847133758, Blast_Score=94, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17508631, Length=180, Percent_Identity=26.6666666666667, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17933654, Length=157, Percent_Identity=28.6624203821656, Blast_Score=72, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004467
- InterPro:   IPR023031
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.10 [H]

Molecular weight: Translated: 23367; Mature: 23367

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHSSTAIAQLLLEAGAVVLSPDRPFRFASGILSPIYCDNRLLLAQVSARRTITEAMCQQ
CCCCHHHHHHHHHHCCCEEECCCCCHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHH
ISDELLNTEVIAGTATAGVPWAAWVAHELSLPMAYVRSGAKKYGRGQQVEGGVQANQRVV
HHHHHHCHHHEECCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCEEE
VIEDLISTGGSSLDAVAGLRQINALVADCFAIFTYEMEESKQRFNAAGVRLMTLTNLSTL
EHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEHHHHHHHH
LDVAAQQNYIRAEHRSLISDWASDPAGWADRAGISAE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCCC
>Mature Secondary Structure
MKHSSTAIAQLLLEAGAVVLSPDRPFRFASGILSPIYCDNRLLLAQVSARRTITEAMCQQ
CCCCHHHHHHHHHHCCCEEECCCCCHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHH
ISDELLNTEVIAGTATAGVPWAAWVAHELSLPMAYVRSGAKKYGRGQQVEGGVQANQRVV
HHHHHHCHHHEECCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCEEE
VIEDLISTGGSSLDAVAGLRQINALVADCFAIFTYEMEESKQRFNAAGVRLMTLTNLSTL
EHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEHHHHHHHH
LDVAAQQNYIRAEHRSLISDWASDPAGWADRAGISAE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]