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The map label for this gene is gcvT

Identifier: 159899387

GI number: 159899387

Start: 3639257

End: 3640342

Strand: Direct

Name: gcvT

Synonym: Haur_2868

Alternate gene names: 159899387

Gene position: 3639257-3640342 (Clockwise)

Preceding gene: 159899386

Following gene: 159899388

Centisome position: 57.34

GC content: 52.3

Gene sequence:

>1086_bases
ATGAAACAAACACCACTCAATGCACGCCATCGCGCCCTTGGAGCCAGAATGGTCGAGTTCGGCGGCTGGGACATGCCAGT
CCAATATGCGGGCATCATCGCTGAACACAAGGCAACCCGCGAAGGCGCTGGCCTGTTCGATATTAGCCATATGGCGCGAT
TTTGGGTCACTGGCCCCGATAGCGAACGCTTTATTCAGTTGATCGATACCTTTGATATTAGCAAAACCGCGATCGGCCAA
TCCGATTATGGGATTATGTGCTACGAAGATGGCGGGATTGTTGACGATATTTTCACCTATCATCTTGGCCCCGACGAATG
GATGGTTGTGGCCAACGCTGGCAACGCCGAAAAAGATTGGGCTTGGCTCAATCAACATACTGCTGGCTACGACGTGGTGC
TAACTGATCGCTCTCAAGAGTTGGCGATGATCGCATTGCAAGGGCCAAAAGCTGAAAGCCTGTTGGCTCCCTTGACTGAT
GCTGATGTGGTCAATTTGGCGTTCCATGGCATCACCAAGGCTACAGTTGAGGGCGCTGCTGGTTATATTTCGCGCACTGG
CTACACTGGCGAAGATGGCTTCGAATTGTTCTTGCCTGCTGGCGAGATCGAACGAATCTGGGATCGTTTGTTGGAAGTTG
GGGCTACGCCGATTGGATTGGGTGCTCGTGATAGCCTGCGTTTCGAGCCAGGTTTGGCGCTTTATGGCCATGAAATTGAG
CGCGATATTAATCCTTATGAAGCCAAATTGGGCTGGGTGGTCAAGCTCGATAAAGGCCCATTCATCGGCTCAGAAGCCTT
GCACGATATCAAGGCCAATGGTCCAGTCCGCACTCTAGTTGGCTTAGAAATGACTGGCCGCGGGATTGCCCGTCAAGGCT
ACCCGGTTGTGGCGCTCGATGGCAGTGAATTGGGCGTTGTAACGACTGGCATGCCTAGCCCAAGCTTGGGCAAAAATCTG
GCCTATGCCTTGGTTAAGGCTGGTAGCCTCAAAATTGGCGCTGAAGTCGATGTGCTGATTCGCGAAAAGCCAGTGCGGGC
AACCGTAGTCAAAACGCCGTTTTACAAAGCACGCTACAAAAAATAG

Upstream 100 bases:

>100_bases
TGACTGAGCAAGAGCTGGCCACAGCTGAGCGCTTGCGCCATGAACGCTATACCAACCCTGAATGGTTACAACGACGCTAA
GTGATTTACGAGGTTTTTTG

Downstream 100 bases:

>100_bases
CCTGCTGCTCTTGCATAAAAAGCCGCTTTGCTTGATAGTAGCGCCTAACAATCTATGCTGATTGTGTGCTGTTTTGGCGT
TATTGAAGGAGGACCACCGA

Product: glycine cleavage system T protein

Products: NA

Alternate protein names: Glycine cleavage system T protein

Number of amino acids: Translated: 361; Mature: 361

Protein sequence:

>361_residues
MKQTPLNARHRALGARMVEFGGWDMPVQYAGIIAEHKATREGAGLFDISHMARFWVTGPDSERFIQLIDTFDISKTAIGQ
SDYGIMCYEDGGIVDDIFTYHLGPDEWMVVANAGNAEKDWAWLNQHTAGYDVVLTDRSQELAMIALQGPKAESLLAPLTD
ADVVNLAFHGITKATVEGAAGYISRTGYTGEDGFELFLPAGEIERIWDRLLEVGATPIGLGARDSLRFEPGLALYGHEIE
RDINPYEAKLGWVVKLDKGPFIGSEALHDIKANGPVRTLVGLEMTGRGIARQGYPVVALDGSELGVVTTGMPSPSLGKNL
AYALVKAGSLKIGAEVDVLIREKPVRATVVKTPFYKARYKK

Sequences:

>Translated_361_residues
MKQTPLNARHRALGARMVEFGGWDMPVQYAGIIAEHKATREGAGLFDISHMARFWVTGPDSERFIQLIDTFDISKTAIGQ
SDYGIMCYEDGGIVDDIFTYHLGPDEWMVVANAGNAEKDWAWLNQHTAGYDVVLTDRSQELAMIALQGPKAESLLAPLTD
ADVVNLAFHGITKATVEGAAGYISRTGYTGEDGFELFLPAGEIERIWDRLLEVGATPIGLGARDSLRFEPGLALYGHEIE
RDINPYEAKLGWVVKLDKGPFIGSEALHDIKANGPVRTLVGLEMTGRGIARQGYPVVALDGSELGVVTTGMPSPSLGKNL
AYALVKAGSLKIGAEVDVLIREKPVRATVVKTPFYKARYKK
>Mature_361_residues
MKQTPLNARHRALGARMVEFGGWDMPVQYAGIIAEHKATREGAGLFDISHMARFWVTGPDSERFIQLIDTFDISKTAIGQ
SDYGIMCYEDGGIVDDIFTYHLGPDEWMVVANAGNAEKDWAWLNQHTAGYDVVLTDRSQELAMIALQGPKAESLLAPLTD
ADVVNLAFHGITKATVEGAAGYISRTGYTGEDGFELFLPAGEIERIWDRLLEVGATPIGLGARDSLRFEPGLALYGHEIE
RDINPYEAKLGWVVKLDKGPFIGSEALHDIKANGPVRTLVGLEMTGRGIARQGYPVVALDGSELGVVTTGMPSPSLGKNL
AYALVKAGSLKIGAEVDVLIREKPVRATVVKTPFYKARYKK

Specific function: The glycine cleavage system catalyzes the degradation of glycine

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family

Homologues:

Organism=Homo sapiens, GI44662838, Length=370, Percent_Identity=34.3243243243243, Blast_Score=182, Evalue=3e-46,
Organism=Homo sapiens, GI257796258, Length=338, Percent_Identity=34.6153846153846, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI257796254, Length=365, Percent_Identity=32.0547945205479, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI257796256, Length=318, Percent_Identity=32.7044025157233, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI24797151, Length=330, Percent_Identity=28.1818181818182, Blast_Score=132, Evalue=7e-31,
Organism=Homo sapiens, GI197927446, Length=324, Percent_Identity=26.8518518518519, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI21361378, Length=324, Percent_Identity=26.8518518518519, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI194306651, Length=374, Percent_Identity=24.0641711229947, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI1789272, Length=362, Percent_Identity=38.121546961326, Blast_Score=230, Evalue=9e-62,
Organism=Caenorhabditis elegans, GI17560118, Length=376, Percent_Identity=36.7021276595745, Blast_Score=205, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI71994045, Length=343, Percent_Identity=26.8221574344023, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI71994052, Length=343, Percent_Identity=26.8221574344023, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI32563613, Length=349, Percent_Identity=22.6361031518625, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320222, Length=390, Percent_Identity=34.1025641025641, Blast_Score=189, Evalue=4e-49,
Organism=Drosophila melanogaster, GI20129441, Length=377, Percent_Identity=35.8090185676393, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI20130091, Length=351, Percent_Identity=23.9316239316239, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI28571104, Length=280, Percent_Identity=25.7142857142857, Blast_Score=86, Evalue=6e-17,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): GCST_HERA2 (A9B2Q5)

Other databases:

- EMBL:   CP000875
- RefSeq:   YP_001545634.1
- ProteinModelPortal:   A9B2Q5
- SMR:   A9B2Q5
- GeneID:   5734739
- GenomeReviews:   CP000875_GR
- KEGG:   hau:Haur_2868
- HOGENOM:   HBG299834
- OMA:   GARIVEF
- ProtClustDB:   CLSK973608
- BioCyc:   HAUR316274:HAUR_2868-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00259
- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903
- PIRSF:   PIRSF006487
- TIGRFAMs:   TIGR00528

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C

EC number: =2.1.2.10

Molecular weight: Translated: 39308; Mature: 39308

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQTPLNARHRALGARMVEFGGWDMPVQYAGIIAEHKATREGAGLFDISHMARFWVTGPD
CCCCCCCHHHHHHHHEEEECCCCCCCHHHHHHHHHCCCCCCCCCEEEHHHHEEEEEECCC
SERFIQLIDTFDISKTAIGQSDYGIMCYEDGGIVDDIFTYHLGPDEWMVVANAGNAEKDW
HHHHHHHHHHCCCCHHHCCCCCCEEEEEECCCCEEHHEEEECCCCCEEEEEECCCCCCCH
AWLNQHTAGYDVVLTDRSQELAMIALQGPKAESLLAPLTDADVVNLAFHGITKATVEGAA
HHHHCCCCCEEEEEECCCCCEEEEEECCCCCHHHCCCCCCCCEEEHHHHCCHHHHHCCCC
GYISRTGYTGEDGFELFLPAGEIERIWDRLLEVGATPIGLGARDSLRFEPGLALYGHEIE
CEEECCCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCEECCCEEEECCHHH
RDINPYEAKLGWVVKLDKGPFIGSEALHDIKANGPVRTLVGLEMTGRGIARQGYPVVALD
CCCCCCEEEEEEEEEECCCCCCCHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCEEEEEC
GSELGVVTTGMPSPSLGKNLAYALVKAGSLKIGAEVDVLIREKPVRATVVKTPFYKARYK
CCCEEEEEECCCCCCCCHHHHHHHHCCCCEEECCEEEEEEECCCCEEEEEECCCHHHCCC
K
C
>Mature Secondary Structure
MKQTPLNARHRALGARMVEFGGWDMPVQYAGIIAEHKATREGAGLFDISHMARFWVTGPD
CCCCCCCHHHHHHHHEEEECCCCCCCHHHHHHHHHCCCCCCCCCEEEHHHHEEEEEECCC
SERFIQLIDTFDISKTAIGQSDYGIMCYEDGGIVDDIFTYHLGPDEWMVVANAGNAEKDW
HHHHHHHHHHCCCCHHHCCCCCCEEEEEECCCCEEHHEEEECCCCCEEEEEECCCCCCCH
AWLNQHTAGYDVVLTDRSQELAMIALQGPKAESLLAPLTDADVVNLAFHGITKATVEGAA
HHHHCCCCCEEEEEECCCCCEEEEEECCCCCHHHCCCCCCCCEEEHHHHCCHHHHHCCCC
GYISRTGYTGEDGFELFLPAGEIERIWDRLLEVGATPIGLGARDSLRFEPGLALYGHEIE
CEEECCCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCEECCCEEEECCHHH
RDINPYEAKLGWVVKLDKGPFIGSEALHDIKANGPVRTLVGLEMTGRGIARQGYPVVALD
CCCCCCEEEEEEEEEECCCCCCCHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCEEEEEC
GSELGVVTTGMPSPSLGKNLAYALVKAGSLKIGAEVDVLIREKPVRATVVKTPFYKARYK
CCCEEEEEECCCCCCCCHHHHHHHHCCCCEEECCEEEEEEECCCCEEEEEECCCHHHCCC
K
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA