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The map label for this gene is treA [H]

Identifier: 159899351

GI number: 159899351

Start: 3599922

End: 3601127

Strand: Direct

Name: treA [H]

Synonym: Haur_2832

Alternate gene names: 159899351

Gene position: 3599922-3601127 (Clockwise)

Preceding gene: 159899345

Following gene: 159899353

Centisome position: 56.72

GC content: 52.24

Gene sequence:

>1206_bases
ATGCGACAGCCTGCAATCACGCAGTATATCGATGCTTATTGGGACAAACTTGTTCGTCAACAGCCGGAAGATCAAAAAAC
CTTAATTGGCTTGCCCCATCAATTTATGGTGCCAACCCACGACCCTACCTTTCAAGAGATGTTTTATTGGGATAGTTTTT
TCATTGCGCTGGGGTTGGGTGGCACGCGCTACGAAGCGGTAATCGAGGGCATGGCCGAAAACATGGCCTATCTCTACCAG
CGCTTCGGGGTGATTCCTAACGCTAGCCGTTATTATTTTCTTTCGCGCAGCCAACCACCTTTCTGGACTCAATTGATTTG
GCTGGCCTACCAAACCAAACAGGCCGCTGGCGATCCTGATAGCGCTGCTTGGTTACAACGCCTGATGGCACTCGCTGAGC
AGGAGCATGCCAGTGTTTGGCTGGCTACCACCCATCCGCATCAGCGCCAAGTGCATCGCGGGTTGTCGCGCTATTTCGAT
ATTAACTATTTGGATACCCTGGCCTGTTGCGAAAGTGGCTGGGATCATTCAACCCGCTGCAATGGCCAATGGATGAGCCA
TTTGCCAGTTGATTTGAATAGCATTTTGTATCTGCGTGAGTGCGATTTTGCCCAAGCCGCCCGTGTGCGCGACGATCACG
CGGCTGCCGAGCAATGGCAATCCTGCGCCGATCAACGCGCCGAAACCATGCAAGCAGTTTTTTGGGATGCCGCTAGTGGC
TTTTTCTATGATTACAATTATCTCAATGAAGTGGCTGACCTAGATAACCCTTCGTTGGCCGGATTTTACCCCTTGTGGGC
TGGTTGGGCGACCGAAGTTCAGGCGGCGCAGGTGGTCGAGCAATGGTTGCCAAGCTTTATGCGAGTTGGTGGTTTGGTGA
CAACGCTCAAAACCCATGCTAGCTATCAATGGGCTAGCCCCAACGGCTGGGCACCATTGCAATGGATTGTCGTCGAGGGT
TTGTTACGCTACGGCTATCAATCCCAAGCGCGTGAGGTCATGCAAGCATGGTGTACGCTCAACGAAACTGTCTTCGAGCG
AACCAACGCCATGTGGGAAAAATATAACGTGGTTGACCCAACGGGCGAAGTTGAGGGCGGCAAATATGGCTCGTTGCCAG
GCTTTGGCTGGTCGAATGCGGTTTATCTCGATTTCAAGCGCCGCTTAGCCCAACCAACTATCGAACGCTGGAAGCTTGGC
GAATAA

Upstream 100 bases:

>100_bases
CATACAAACGCGCTCCGAACGGATAATCGAGCGCGGTGGTACGTGCGGCATCGCGATCATACTACAGCACACGGTAGAAG
TCAAAAAGAACAGGAAGCGT

Downstream 100 bases:

>100_bases
CGCTTAACTAAATCAATCTACTTGATGGTGAGGAGCTTACGAGGGTGGTTTTCCGCTATGAACCACGGAATCGGTGGTTC
ATGAGTGGATGCTTGATCAC

Product: alpha,alpha-trehalase

Products: NA

Alternate protein names: Alpha,alpha-trehalase; Alpha,alpha-trehalose glucohydrolase [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MRQPAITQYIDAYWDKLVRQQPEDQKTLIGLPHQFMVPTHDPTFQEMFYWDSFFIALGLGGTRYEAVIEGMAENMAYLYQ
RFGVIPNASRYYFLSRSQPPFWTQLIWLAYQTKQAAGDPDSAAWLQRLMALAEQEHASVWLATTHPHQRQVHRGLSRYFD
INYLDTLACCESGWDHSTRCNGQWMSHLPVDLNSILYLRECDFAQAARVRDDHAAAEQWQSCADQRAETMQAVFWDAASG
FFYDYNYLNEVADLDNPSLAGFYPLWAGWATEVQAAQVVEQWLPSFMRVGGLVTTLKTHASYQWASPNGWAPLQWIVVEG
LLRYGYQSQAREVMQAWCTLNETVFERTNAMWEKYNVVDPTGEVEGGKYGSLPGFGWSNAVYLDFKRRLAQPTIERWKLG
E

Sequences:

>Translated_401_residues
MRQPAITQYIDAYWDKLVRQQPEDQKTLIGLPHQFMVPTHDPTFQEMFYWDSFFIALGLGGTRYEAVIEGMAENMAYLYQ
RFGVIPNASRYYFLSRSQPPFWTQLIWLAYQTKQAAGDPDSAAWLQRLMALAEQEHASVWLATTHPHQRQVHRGLSRYFD
INYLDTLACCESGWDHSTRCNGQWMSHLPVDLNSILYLRECDFAQAARVRDDHAAAEQWQSCADQRAETMQAVFWDAASG
FFYDYNYLNEVADLDNPSLAGFYPLWAGWATEVQAAQVVEQWLPSFMRVGGLVTTLKTHASYQWASPNGWAPLQWIVVEG
LLRYGYQSQAREVMQAWCTLNETVFERTNAMWEKYNVVDPTGEVEGGKYGSLPGFGWSNAVYLDFKRRLAQPTIERWKLG
E
>Mature_401_residues
MRQPAITQYIDAYWDKLVRQQPEDQKTLIGLPHQFMVPTHDPTFQEMFYWDSFFIALGLGGTRYEAVIEGMAENMAYLYQ
RFGVIPNASRYYFLSRSQPPFWTQLIWLAYQTKQAAGDPDSAAWLQRLMALAEQEHASVWLATTHPHQRQVHRGLSRYFD
INYLDTLACCESGWDHSTRCNGQWMSHLPVDLNSILYLRECDFAQAARVRDDHAAAEQWQSCADQRAETMQAVFWDAASG
FFYDYNYLNEVADLDNPSLAGFYPLWAGWATEVQAAQVVEQWLPSFMRVGGLVTTLKTHASYQWASPNGWAPLQWIVVEG
LLRYGYQSQAREVMQAWCTLNETVFERTNAMWEKYNVVDPTGEVEGGKYGSLPGFGWSNAVYLDFKRRLAQPTIERWKLG
E

Specific function: Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system [H]

COG id: COG1626

COG function: function code G; Neutral trehalase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyl hydrolase 37 family [H]

Homologues:

Organism=Homo sapiens, GI116284412, Length=420, Percent_Identity=29.2857142857143, Blast_Score=130, Evalue=2e-30,
Organism=Escherichia coli, GI1787447, Length=417, Percent_Identity=30.4556354916067, Blast_Score=172, Evalue=3e-44,
Organism=Escherichia coli, GI1789936, Length=426, Percent_Identity=28.8732394366197, Blast_Score=167, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17542196, Length=427, Percent_Identity=29.7423887587822, Blast_Score=165, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI25148109, Length=433, Percent_Identity=27.9445727482679, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17565078, Length=419, Percent_Identity=28.1622911694511, Blast_Score=138, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI25141398, Length=430, Percent_Identity=25.3488372093023, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71987755, Length=423, Percent_Identity=24.822695035461, Blast_Score=103, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6320204, Length=436, Percent_Identity=30.045871559633, Blast_Score=159, Evalue=9e-40,
Organism=Saccharomyces cerevisiae, GI6319473, Length=432, Percent_Identity=29.3981481481481, Blast_Score=152, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24656685, Length=431, Percent_Identity=26.2180974477958, Blast_Score=121, Evalue=7e-28,
Organism=Drosophila melanogaster, GI24656661, Length=430, Percent_Identity=26.2790697674419, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI17933716, Length=430, Percent_Identity=26.2790697674419, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24656670, Length=430, Percent_Identity=26.2790697674419, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24656680, Length=430, Percent_Identity=26.2790697674419, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24656675, Length=430, Percent_Identity=26.2790697674419, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI22024178, Length=450, Percent_Identity=23.5555555555556, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI45551104, Length=371, Percent_Identity=22.6415094339623, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008928
- InterPro:   IPR001661
- InterPro:   IPR018232 [H]

Pfam domain/function: PF01204 Trehalase [H]

EC number: =3.2.1.28 [H]

Molecular weight: Translated: 46325; Mature: 46325

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQPAITQYIDAYWDKLVRQQPEDQKTLIGLPHQFMVPTHDPTFQEMFYWDSFFIALGLG
CCCCHHHHHHHHHHHHHHHCCCCCCHHEECCCCCEECCCCCCHHHHHHHHHHHHHHHCCC
GTRYEAVIEGMAENMAYLYQRFGVIPNASRYYFLSRSQPPFWTQLIWLAYQTKQAAGDPD
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCC
SAAWLQRLMALAEQEHASVWLATTHPHQRQVHRGLSRYFDINYLDTLACCESGWDHSTRC
HHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCC
NGQWMSHLPVDLNSILYLRECDFAQAARVRDDHAAAEQWQSCADQRAETMQAVFWDAASG
CCCHHCCCCCCHHHEEEEECCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
FFYDYNYLNEVADLDNPSLAGFYPLWAGWATEVQAAQVVEQWLPSFMRVGGLVTTLKTHA
CEEEHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SYQWASPNGWAPLQWIVVEGLLRYGYQSQAREVMQAWCTLNETVFERTNAMWEKYNVVDP
CEEECCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
TGEVEGGKYGSLPGFGWSNAVYLDFKRRLAQPTIERWKLGE
CCCCCCCCCCCCCCCCCCCCEEEHHHHHHCCCCHHHCCCCC
>Mature Secondary Structure
MRQPAITQYIDAYWDKLVRQQPEDQKTLIGLPHQFMVPTHDPTFQEMFYWDSFFIALGLG
CCCCHHHHHHHHHHHHHHHCCCCCCHHEECCCCCEECCCCCCHHHHHHHHHHHHHHHCCC
GTRYEAVIEGMAENMAYLYQRFGVIPNASRYYFLSRSQPPFWTQLIWLAYQTKQAAGDPD
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCC
SAAWLQRLMALAEQEHASVWLATTHPHQRQVHRGLSRYFDINYLDTLACCESGWDHSTRC
HHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCC
NGQWMSHLPVDLNSILYLRECDFAQAARVRDDHAAAEQWQSCADQRAETMQAVFWDAASG
CCCHHCCCCCCHHHEEEEECCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
FFYDYNYLNEVADLDNPSLAGFYPLWAGWATEVQAAQVVEQWLPSFMRVGGLVTTLKTHA
CEEEHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SYQWASPNGWAPLQWIVVEGLLRYGYQSQAREVMQAWCTLNETVFERTNAMWEKYNVVDP
CEEECCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
TGEVEGGKYGSLPGFGWSNAVYLDFKRRLAQPTIERWKLGE
CCCCCCCCCCCCCCCCCCCCEEEHHHHHHCCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]