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The map label for this gene is sumT [H]

Identifier: 159898268

GI number: 159898268

Start: 2030562

End: 2031353

Strand: Reverse

Name: sumT [H]

Synonym: Haur_1744

Alternate gene names: 159898268

Gene position: 2031353-2030562 (Counterclockwise)

Preceding gene: 159898269

Following gene: 159898265

Centisome position: 32.01

GC content: 53.41

Gene sequence:

>792_bases
ATGACACGCGAAGGATTTGTTGCATTAGTCGGGGCTGGTCCAGGCTCCGCCGATTTAATTACCGTCAAAGGGTTGCGCCG
TTTGCAAAGTGCCGATGTCGTGGTATTCGATGCCTTGGTGTTGCCCGAATTATTGGCCGAAGCTCGTAGCGATGCCGAGT
TGATTCCGGCTGGCAAGCGTGGCGGCCAACATTCCGTCAGCCAAGATTGGATCAACGCAACCTTGATTGAGCACGCTCAG
CAAGGTAAATTGGTGGTTCGACTCAAAGGCGGCGATCCATTTGTATTTGGGCGCGGTGGCGAGGAAGCTGCTGCCTTGAG
CGCTGCCGGAATTGCATGGGAAGTTGTGCCCGGCATTTCTTCGGCGATTGCGGCCCCTGCCTATGCGGGCATTCCAGTGA
CTCATCGCGATGTGGCTTCATCGGTTGTCTTTGTGACAGGTCATGAAGATCCAACCAAGCCAACCAGCCGCATCAATTGG
CAAGCCTTGGCCCAAGGTGTTGATACCTTGGTCTTTTTGATGGGAATTACGCGAATCAACCACACAGTTGCCAGTTTGAT
TGCCAATGGTCGCCCTGCCGATACTCCAACGGCGGTGATTCGCTGGGGCACAACTGCTGATCAAAAAACGGTGGTCGCAC
CACTTGATCAAATTGAGGCTGCGGTTAAAGCGGCTGGCATCGGCGCACCAGCGATTTTAATTGTGGGCGAAGTTGTGGCG
TTGCGTGAACAACTTAATTGGTTTGAATCGACAGTGCTTGAAATGCCCGAAGTTGTCCGAGCATTTGCCTAA

Upstream 100 bases:

>100_bases
CGACACTAACCACGACAGAACGTGAGCAATATTTTGATCAATTGCTGGTTGAATTAGCCCAACAGCCGCCGACGCTCAAT
CACTTGCCAACGGAGGATCT

Downstream 100 bases:

>100_bases
GCAAGAGCATAGAGCAAAGAACATTGAACATAGCGATCGGGCTAGCAATAGCCTGATCTTTTTTTAACGCAGGGGATACA
TGGCTAGTGGCTGAAGGCTC

Product: uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM [H]

Number of amino acids: Translated: 263; Mature: 262

Protein sequence:

>263_residues
MTREGFVALVGAGPGSADLITVKGLRRLQSADVVVFDALVLPELLAEARSDAELIPAGKRGGQHSVSQDWINATLIEHAQ
QGKLVVRLKGGDPFVFGRGGEEAAALSAAGIAWEVVPGISSAIAAPAYAGIPVTHRDVASSVVFVTGHEDPTKPTSRINW
QALAQGVDTLVFLMGITRINHTVASLIANGRPADTPTAVIRWGTTADQKTVVAPLDQIEAAVKAAGIGAPAILIVGEVVA
LREQLNWFESTVLEMPEVVRAFA

Sequences:

>Translated_263_residues
MTREGFVALVGAGPGSADLITVKGLRRLQSADVVVFDALVLPELLAEARSDAELIPAGKRGGQHSVSQDWINATLIEHAQ
QGKLVVRLKGGDPFVFGRGGEEAAALSAAGIAWEVVPGISSAIAAPAYAGIPVTHRDVASSVVFVTGHEDPTKPTSRINW
QALAQGVDTLVFLMGITRINHTVASLIANGRPADTPTAVIRWGTTADQKTVVAPLDQIEAAVKAAGIGAPAILIVGEVVA
LREQLNWFESTVLEMPEVVRAFA
>Mature_262_residues
TREGFVALVGAGPGSADLITVKGLRRLQSADVVVFDALVLPELLAEARSDAELIPAGKRGGQHSVSQDWINATLIEHAQQ
GKLVVRLKGGDPFVFGRGGEEAAALSAAGIAWEVVPGISSAIAAPAYAGIPVTHRDVASSVVFVTGHEDPTKPTSRINWQ
ALAQGVDTLVFLMGITRINHTVASLIANGRPADTPTAVIRWGTTADQKTVVAPLDQIEAAVKAAGIGAPAILIVGEVVAL
REQLNWFESTVLEMPEVVRAFA

Specific function: Catalyzes both methylations at C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin [H]

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=250, Percent_Identity=46.4, Blast_Score=226, Evalue=8e-61,
Organism=Saccharomyces cerevisiae, GI6322922, Length=264, Percent_Identity=35.2272727272727, Blast_Score=134, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR003043 [H]

Pfam domain/function: PF00590 TP_methylase [H]

EC number: =2.1.1.107 [H]

Molecular weight: Translated: 27488; Mature: 27357

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS00839 SUMT_1 ; PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTREGFVALVGAGPGSADLITVKGLRRLQSADVVVFDALVLPELLAEARSDAELIPAGKR
CCCCCEEEEEECCCCCCCEEEHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEECCCCCC
GGQHSVSQDWINATLIEHAQQGKLVVRLKGGDPFVFGRGGEEAAALSAAGIAWEVVPGIS
CCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCEEEEECCCCHHHHHHHCCCEEEECCCCH
SAIAAPAYAGIPVTHRDVASSVVFVTGHEDPTKPTSRINWQALAQGVDTLVFLMGITRIN
HHHHCCCCCCCCCCHHHHHCCEEEEECCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHH
HTVASLIANGRPADTPTAVIRWGTTADQKTVVAPLDQIEAAVKAAGIGAPAILIVGEVVA
HHHHHHHHCCCCCCCCCEEEEECCCCCCCEEECCHHHHHHHHHHCCCCCCHHHHHHHHHH
LREQLNWFESTVLEMPEVVRAFA
HHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TREGFVALVGAGPGSADLITVKGLRRLQSADVVVFDALVLPELLAEARSDAELIPAGKR
CCCCEEEEEECCCCCCCEEEHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEECCCCCC
GGQHSVSQDWINATLIEHAQQGKLVVRLKGGDPFVFGRGGEEAAALSAAGIAWEVVPGIS
CCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCEEEEECCCCHHHHHHHCCCEEEECCCCH
SAIAAPAYAGIPVTHRDVASSVVFVTGHEDPTKPTSRINWQALAQGVDTLVFLMGITRIN
HHHHCCCCCCCCCCHHHHHCCEEEEECCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHH
HTVASLIANGRPADTPTAVIRWGTTADQKTVVAPLDQIEAAVKAAGIGAPAILIVGEVVA
HHHHHHHHCCCCCCCCCEEEEECCCCCCCEEECCHHHHHHHHHHCCCCCCHHHHHHHHHH
LREQLNWFESTVLEMPEVVRAFA
HHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]