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The map label for this gene is cooH [H]

Identifier: 159898164

GI number: 159898164

Start: 1897808

End: 1898914

Strand: Reverse

Name: cooH [H]

Synonym: Haur_1640

Alternate gene names: 159898164

Gene position: 1898914-1897808 (Counterclockwise)

Preceding gene: 159898165

Following gene: 159898163

Centisome position: 29.92

GC content: 54.11

Gene sequence:

>1107_bases
ATGGTTCGTGATCTGTGTGAGGCATTGAGTTTGAGCTACGTTTTACCGCTTGGCCCGTTTCACCCCGACTGGCAAACCCC
GATGCGCATGGTCTTACGGGTTGAGGGCGAACAGATTGCTGATGTTGAATTTCGTGATGGCTACACCAATCGCGGCATTA
GCGAGCGTTTGACGCGCACCACCATTCCTCAGGGATTACACCTTGTGAGCCATATTTGTGCCGCTGATAGCCATGCCCAC
TCATTGGGTTTTTGCTTGGCACTCGAACAATTGCTTAAAATTAATGCTTCGGAGCGAGCTGCTGCCTTACGCTTGCTCGC
CTGCGAAGTCGAACGCGCCACCGTCCATCTCAGCACGATGAAAGAAGTGCTGACAATTTTGGGCTTGCAACGCGATGCTG
AGCATGTGCAAAAACTGCATCATGGCTTATTTGAAGTCATGCAACACTTATGCGGCACGAGTTCGCCGCCCAACTATATT
GTGCCAGGTGGCGTGCGCCAAGATCTCAGCAGCACCGAACAAGAATCGATGGCGTTGCAATTTCGTCGCCTCGAACGCTT
GATGTATCGCTTCGTTGATCGCTTTATCGATCATCGCGGGGTTTTGCGGCGCTGTGTGGGTGTTGGCGTGCTCAGTCGCG
AGGCTGCCGAACAATTCGGGGTGCGTGGGCCAATGGCGCGAGCCGCAGGCATCGGCTTTGATGCCCGAATTGATCGCGCC
TATGGTGCTTATGCGCAATTTCCACCCAGCCGTGTAACCCAAGAGCGTGGCGACGTTTATGCCCGATTGGTGATTTTCTC
GCTAGAAGCCTTTGAAAGCCTTAAATTGGCAATTCGGGTGCTGGCCAATTTGCCTAGCGGCGATTGGGCTGGCAACGCGC
CCGATAGCGTACCTCAAGGCAGCGTCACCTCGAATATCGAATCGGCGCGGGGCACGCTACGCTATACCGTCCAAAGCAAC
GGGGTCAAATTAACCAGTGTGCGGATTGACGCACCACGCCAATTTGATCGCTTGATTGCCCGCACCATCTTGGCCGGAAT
GAACATCGACGACGCACCCTTAATTATCGCCTCGGCTAGTGCTTGCACTGCCTGTAGCGAAGAATAA

Upstream 100 bases:

>100_bases
CCCTTAGCTTAATTGCAATGGCGCTGTTGTTGCGGCAGGAGCGCCATTTGCCAAACAATTCCACAGTATCGAGAAGCCTA
TGCTATAATCGGCAGGGTTG

Downstream 100 bases:

>100_bases
CGCATGAACGGACAAACACTCCTCACCCTTGCGCCCTTTGGGCTGATGATGATCATCGCTTTGGTCAGTTGGTTGACTGG
TCAGCGTTTGCGCACGCGCT

Product: NADH-ubiquinone oxidoreductase subunit 49kDa

Products: NAD+; ubiquinol

Alternate protein names: NA

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MVRDLCEALSLSYVLPLGPFHPDWQTPMRMVLRVEGEQIADVEFRDGYTNRGISERLTRTTIPQGLHLVSHICAADSHAH
SLGFCLALEQLLKINASERAAALRLLACEVERATVHLSTMKEVLTILGLQRDAEHVQKLHHGLFEVMQHLCGTSSPPNYI
VPGGVRQDLSSTEQESMALQFRRLERLMYRFVDRFIDHRGVLRRCVGVGVLSREAAEQFGVRGPMARAAGIGFDARIDRA
YGAYAQFPPSRVTQERGDVYARLVIFSLEAFESLKLAIRVLANLPSGDWAGNAPDSVPQGSVTSNIESARGTLRYTVQSN
GVKLTSVRIDAPRQFDRLIARTILAGMNIDDAPLIIASASACTACSEE

Sequences:

>Translated_368_residues
MVRDLCEALSLSYVLPLGPFHPDWQTPMRMVLRVEGEQIADVEFRDGYTNRGISERLTRTTIPQGLHLVSHICAADSHAH
SLGFCLALEQLLKINASERAAALRLLACEVERATVHLSTMKEVLTILGLQRDAEHVQKLHHGLFEVMQHLCGTSSPPNYI
VPGGVRQDLSSTEQESMALQFRRLERLMYRFVDRFIDHRGVLRRCVGVGVLSREAAEQFGVRGPMARAAGIGFDARIDRA
YGAYAQFPPSRVTQERGDVYARLVIFSLEAFESLKLAIRVLANLPSGDWAGNAPDSVPQGSVTSNIESARGTLRYTVQSN
GVKLTSVRIDAPRQFDRLIARTILAGMNIDDAPLIIASASACTACSEE
>Mature_368_residues
MVRDLCEALSLSYVLPLGPFHPDWQTPMRMVLRVEGEQIADVEFRDGYTNRGISERLTRTTIPQGLHLVSHICAADSHAH
SLGFCLALEQLLKINASERAAALRLLACEVERATVHLSTMKEVLTILGLQRDAEHVQKLHHGLFEVMQHLCGTSSPPNYI
VPGGVRQDLSSTEQESMALQFRRLERLMYRFVDRFIDHRGVLRRCVGVGVLSREAAEQFGVRGPMARAAGIGFDARIDRA
YGAYAQFPPSRVTQERGDVYARLVIFSLEAFESLKLAIRVLANLPSGDWAGNAPDSVPQGSVTSNIESARGTLRYTVQSN
GVKLTSVRIDAPRQFDRLIARTILAGMNIDDAPLIIASASACTACSEE

Specific function: The carbon monoxide dehydrogenase (CODH) oxidizes carbon monoxide coupled, via CooF, to the reduction of a hydrogen cation by a hydrogenase (probably CooH) [H]

COG id: COG3261

COG function: function code C; Ni,Fe-hydrogenase III large subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To E.coli formate hydrogenlyase hydrogenase isozyme 3 and to bovine mitochondrial NADH-ubiquinone oxidoreductase [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=275, Percent_Identity=25.4545454545455, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI260898743, Length=275, Percent_Identity=25.4545454545455, Blast_Score=96, Evalue=5e-20,
Organism=Escherichia coli, GI1789076, Length=361, Percent_Identity=28.2548476454294, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1788832, Length=366, Percent_Identity=25.6830601092896, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI145693162, Length=296, Percent_Identity=25, Blast_Score=88, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17555284, Length=324, Percent_Identity=25.9259259259259, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17568379, Length=328, Percent_Identity=26.219512195122, Blast_Score=98, Evalue=6e-21,
Organism=Drosophila melanogaster, GI221459469, Length=275, Percent_Identity=25.4545454545455, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24638644, Length=346, Percent_Identity=23.4104046242775, Blast_Score=88, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001135
- InterPro:   IPR001501 [H]

Pfam domain/function: PF00346 Complex1_49kDa; PF00374 NiFeSe_Hases [H]

EC number: 1.6.5.3

Molecular weight: Translated: 40609; Mature: 40609

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRDLCEALSLSYVLPLGPFHPDWQTPMRMVLRVEGEQIADVEFRDGYTNRGISERLTRT
CHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCEECEEECCCCCCCCHHHHHHHH
TIPQGLHLVSHICAADSHAHSLGFCLALEQLLKINASERAAALRLLACEVERATVHLSTM
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
KEVLTILGLQRDAEHVQKLHHGLFEVMQHLCGTSSPPNYIVPGGVRQDLSSTEQESMALQ
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCHHHHHHHHHHHHHHH
FRRLERLMYRFVDRFIDHRGVLRRCVGVGVLSREAAEQFGVRGPMARAAGIGFDARIDRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHCCCCHHHHHHH
YGAYAQFPPSRVTQERGDVYARLVIFSLEAFESLKLAIRVLANLPSGDWAGNAPDSVPQG
HCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
SVTSNIESARGTLRYTVQSNGVKLTSVRIDAPRQFDRLIARTILAGMNIDDAPLIIASAS
CHHHHHHHHCCEEEEEEECCCEEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCEEEECCC
ACTACSEE
HHHCCCCC
>Mature Secondary Structure
MVRDLCEALSLSYVLPLGPFHPDWQTPMRMVLRVEGEQIADVEFRDGYTNRGISERLTRT
CHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCEECEEECCCCCCCCHHHHHHHH
TIPQGLHLVSHICAADSHAHSLGFCLALEQLLKINASERAAALRLLACEVERATVHLSTM
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
KEVLTILGLQRDAEHVQKLHHGLFEVMQHLCGTSSPPNYIVPGGVRQDLSSTEQESMALQ
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCHHHHHHHHHHHHHHH
FRRLERLMYRFVDRFIDHRGVLRRCVGVGVLSREAAEQFGVRGPMARAAGIGFDARIDRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHCCCCHHHHHHH
YGAYAQFPPSRVTQERGDVYARLVIFSLEAFESLKLAIRVLANLPSGDWAGNAPDSVPQG
HCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
SVTSNIESARGTLRYTVQSNGVKLTSVRIDAPRQFDRLIARTILAGMNIDDAPLIIASAS
CHHHHHHHHCCEEEEEEECCCEEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCEEEECCC
ACTACSEE
HHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; H+; ubiquinone

Specific reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8626276; 1644755 [H]