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The map label for this gene is polC [H]

Identifier: 159897533

GI number: 159897533

Start: 1149318

End: 1150166

Strand: Reverse

Name: polC [H]

Synonym: Haur_1004

Alternate gene names: 159897533

Gene position: 1150166-1149318 (Counterclockwise)

Preceding gene: 159897534

Following gene: 159897532

Centisome position: 18.12

GC content: 49.0

Gene sequence:

>849_bases
ATGTTTCCCACGTTGGGAACTAGAAATGAAGCACGCATGTATACTCTCCTTGATCGTCCGTTGCACACCATTCCGTTTGT
GTTGTTCGATATGGAAAGCACTGGCTTAGATGTTCAAATTGGGCATCGCATTTGTGAAATGGCGGCAATGCGCATTCAAG
GTCGCGAGATTATTGATCGCTGTGAGTTTTTGGTAAATCCACAACGCGAAATTGATCCCGCTGCGTTTGCGGTAAACGGT
ATTAGTGCCGAAATGGTTGCCAATGCACCATCATTTGGCGAAATTTGGCCTAAAGTCAATAAATTATTTCATGAGGCAGT
TTTAGTTGCGCATAACGCCTATTTTGATATTGGCTTTTTGACCAGCGAATTAAGCCGAATTGATTTACCACCTCTTGAAA
CACCTGTCATCGATACATTGGCGTTGGCGCGGCGCTACATCACTGCACGCCGCTACAATTTGACCTCGCTCGCAACCAAT
TTGGGTGAAAAAGCACCTTCGCATCGTGCGATGAGCGACGTTGTGGCCTTACGCCCAGTTTTTGAGCACTTGCTCGATAT
TTTGTATCGCAAAGGGGTGCATACCTTGGCCGATTTGCTGCGAGCACAGCGCGGCCTGTTGCCTGGCGACGAAGAAAGCC
CTTTGATTCAAGAAATTTCGACGGCGATGACTAGCCGCCAATCGTTGATGATCTCCTATCGCACTGCTGGCGGTGATCCG
GTTGAGCGGCGCGTGCTGCCGATGGGCTTGACAGTCGAGGGTAAACGTCACATTTTGCACGCCTACTGCTATTTGCGCAA
TGCTCAGCGCATGTTCGCGCTCGACCGACTATCGATTGTCGAATTGTAA

Upstream 100 bases:

>100_bases
TTAACAATGACAAATATTGACACATAGGCGTGTTAGACTGACAATCAGTAACGACAAACCTTGCAAGCTCTTTGCCCGGA
TTGTCGAGCGATGTTGTTAA

Downstream 100 bases:

>100_bases
TTCGTTACTCTTGGTCGCCTGACTGTCAACAAACTGGCTTGGCTTGACCTTTTATGGCTAGGGTGTTGACAGTTTGCAAT
TAGGAGGAACGATGAGCAAC

Product: DNA polymerase III subunit epsilon

Products: NA

Alternate protein names: PolIII [H]

Number of amino acids: Translated: 282; Mature: 282

Protein sequence:

>282_residues
MFPTLGTRNEARMYTLLDRPLHTIPFVLFDMESTGLDVQIGHRICEMAAMRIQGREIIDRCEFLVNPQREIDPAAFAVNG
ISAEMVANAPSFGEIWPKVNKLFHEAVLVAHNAYFDIGFLTSELSRIDLPPLETPVIDTLALARRYITARRYNLTSLATN
LGEKAPSHRAMSDVVALRPVFEHLLDILYRKGVHTLADLLRAQRGLLPGDEESPLIQEISTAMTSRQSLMISYRTAGGDP
VERRVLPMGLTVEGKRHILHAYCYLRNAQRMFALDRLSIVEL

Sequences:

>Translated_282_residues
MFPTLGTRNEARMYTLLDRPLHTIPFVLFDMESTGLDVQIGHRICEMAAMRIQGREIIDRCEFLVNPQREIDPAAFAVNG
ISAEMVANAPSFGEIWPKVNKLFHEAVLVAHNAYFDIGFLTSELSRIDLPPLETPVIDTLALARRYITARRYNLTSLATN
LGEKAPSHRAMSDVVALRPVFEHLLDILYRKGVHTLADLLRAQRGLLPGDEESPLIQEISTAMTSRQSLMISYRTAGGDP
VERRVLPMGLTVEGKRHILHAYCYLRNAQRMFALDRLSIVEL
>Mature_282_residues
MFPTLGTRNEARMYTLLDRPLHTIPFVLFDMESTGLDVQIGHRICEMAAMRIQGREIIDRCEFLVNPQREIDPAAFAVNG
ISAEMVANAPSFGEIWPKVNKLFHEAVLVAHNAYFDIGFLTSELSRIDLPPLETPVIDTLALARRYITARRYNLTSLATN
LGEKAPSHRAMSDVVALRPVFEHLLDILYRKGVHTLADLLRAQRGLLPGDEESPLIQEISTAMTSRQSLMISYRTAGGDP
VERRVLPMGLTVEGKRHILHAYCYLRNAQRMFALDRLSIVEL

Specific function: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG0847

COG function: function code L; DNA polymerase III, epsilon subunit and related 3'-5' exonucleases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 exonuclease domain [H]

Homologues:

Organism=Escherichia coli, GI1786409, Length=168, Percent_Identity=33.3333333333333, Blast_Score=84, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011708
- InterPro:   IPR006054
- InterPro:   IPR006055
- InterPro:   IPR013520
- InterPro:   IPR016027
- InterPro:   IPR004365
- InterPro:   IPR004013
- InterPro:   IPR003141
- InterPro:   IPR016195
- InterPro:   IPR006308
- InterPro:   IPR012337 [H]

Pfam domain/function: PF07733 DNA_pol3_alpha; PF00929 Exonuc_X-T; PF02811 PHP; PF01336 tRNA_anti [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 31809; Mature: 31809

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFPTLGTRNEARMYTLLDRPLHTIPFVLFDMESTGLDVQIGHRICEMAAMRIQGREIIDR
CCCCCCCCCCHHHHHHHHCCHHHHCEEEEECCCCCCCHHHHHHHHHHHHHHHCCHHHHHH
CEFLVNPQREIDPAAFAVNGISAEMVANAPSFGEIWPKVNKLFHEAVLVAHNAYFDIGFL
HHHHCCCCHHCCHHHEEECCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEHHHH
TSELSRIDLPPLETPVIDTLALARRYITARRYNLTSLATNLGEKAPSHRAMSDVVALRPV
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHH
FEHLLDILYRKGVHTLADLLRAQRGLLPGDEESPLIQEISTAMTSRQSLMISYRTAGGDP
HHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHEEEEEECCCCCH
VERRVLPMGLTVEGKRHILHAYCYLRNAQRMFALDRLSIVEL
HHHEEEECCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFPTLGTRNEARMYTLLDRPLHTIPFVLFDMESTGLDVQIGHRICEMAAMRIQGREIIDR
CCCCCCCCCCHHHHHHHHCCHHHHCEEEEECCCCCCCHHHHHHHHHHHHHHHCCHHHHHH
CEFLVNPQREIDPAAFAVNGISAEMVANAPSFGEIWPKVNKLFHEAVLVAHNAYFDIGFL
HHHHCCCCHHCCHHHEEECCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEHHHH
TSELSRIDLPPLETPVIDTLALARRYITARRYNLTSLATNLGEKAPSHRAMSDVVALRPV
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHH
FEHLLDILYRKGVHTLADLLRAQRGLLPGDEESPLIQEISTAMTSRQSLMISYRTAGGDP
HHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHEEEEEECCCCCH
VERRVLPMGLTVEGKRHILHAYCYLRNAQRMFALDRLSIVEL
HHHEEEECCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376 [H]