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The map label for this gene is aroA

Identifier: 159897499

GI number: 159897499

Start: 1112376

End: 1113671

Strand: Direct

Name: aroA

Synonym: Haur_0970

Alternate gene names: 159897499

Gene position: 1112376-1113671 (Clockwise)

Preceding gene: 159897498

Following gene: 159897500

Centisome position: 17.53

GC content: 54.78

Gene sequence:

>1296_bases
ATGAAACAGACAGTTAGTCATGCCAAGCGCCTGCGCGGGGCAATTAGCGTCCCAGGTGATAAATCGATCTCGCATCGCTC
GGTGTTATTTAATGCTTTAGCCGAGGGCAACGCCGAAATTACGGGGTTCTTGCCAGGCGCTGATTGTCTTTCGTCAATCG
CTTGTTTGCGCCAAATGGGCGTTGAAATTGAACACAGCGACGATAAGGTACGGGTGTTCGGGCGGGGTTTGCGTGGCCTG
CGTGAGCCAAGCGACGTTTTAGATTGTGGTAATTCGGGTACAACGCTCCGTTTGTTGGCAGGTTTATTGGCTGGTCAGCC
ATTTTTGAGCGTGCTAACTGGCGATGCGTCGTTGCGTTCACGCCCTCAGAAACGCATTGTTGAACCATTACGCCAACTAG
GAGCCAAGCTCGATGGCCGCGATAACGGCAACCGTGCACCCTTGGTGATTCGTGGCACAACCATTCATGGTGGCAACTAT
GAATTGCCGATCGCCAGTGCTCAAGTTAAATCGGCCTTGCTCTTGGCTGGTTTAACTGGCGATGCGCCAATGCGTTTATC
GGGCAAAATCGTTAGCCGCGACCATACCGAGCGCATGTTGATCGCCATGGGAATTGATCTCACCGTTAAAGATGATGAGA
TTGTGCTCTATCCACCGAGCCATCCGGTTTTCCCCTATCCGCTTTCGTTGCATGTTCCAGGCGATCCTTCGTCGGCAACC
TTTTGGTGGGTAGCCGCAGCGATTCACCCCGATGCCGAAATTACCACCTTGGGCGTTGGATTAAACCCCAGTCGCACTGG
AGCGCTCGATGTGCTCAAGGCCATGGGCGCTGATATTACGATCAGCAATGAGCGCAATGAAGGTGCAGAGCCTGTTGGCG
ATGTAACCGTGCGTGGCGGTGGCTTACGAGGCACACGCATCGATGGCGATTTAATTCCGCGTTTGATCGATGAAATTCCG
GTGCTGGCGGTGGCGGCAGCCTGTGCAGTTGGCGAAACCGTGGTTGCCGATGCCGAAGAACTGCGGGCCAAAGAAACCGA
TCGGGTAGCCACAGTGGTTAGCGAACTAACAGCCATGGGTGCGACCCTCGAAGCCACACCCGATGGCATGATCATCGCTG
GTGGTGGCGAACTCCAAGGCGCTCACGTTCAATCGCATGGTGATCATCGCATCGCGATGGCCTTGGCGGTGGCTGGCTTA
GTGGCCGAAGGCGAAACGATTATCGACGAAGCTGAAGCCGTGACCGTCTCGTACCCAACATTCTGGCAGCATTACGCGCA
GATCAAAGAAGCCTGA

Upstream 100 bases:

>100_bases
CTAACCAGCGCTGTGCGCCAAGAACAATTGGTTGCCGCCCTCGCCCGCTTTGAACAGCATATGGGGCTGCCCCCCGCTGC
GCTACAGGAGTCAACGCCCG

Downstream 100 bases:

>100_bases
TCGCGCCGATAGCCCAACAAGGAGGTTGTGCATGTTTCGTTCAGATCTGCTCAAAGACAAAGTGATCATCATCACTGGTG
GGGGTTCGGGCTTGGGGCGT

Product: 3-phosphoshikimate 1-carboxyvinyltransferase

Products: NA

Alternate protein names: 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MKQTVSHAKRLRGAISVPGDKSISHRSVLFNALAEGNAEITGFLPGADCLSSIACLRQMGVEIEHSDDKVRVFGRGLRGL
REPSDVLDCGNSGTTLRLLAGLLAGQPFLSVLTGDASLRSRPQKRIVEPLRQLGAKLDGRDNGNRAPLVIRGTTIHGGNY
ELPIASAQVKSALLLAGLTGDAPMRLSGKIVSRDHTERMLIAMGIDLTVKDDEIVLYPPSHPVFPYPLSLHVPGDPSSAT
FWWVAAAIHPDAEITTLGVGLNPSRTGALDVLKAMGADITISNERNEGAEPVGDVTVRGGGLRGTRIDGDLIPRLIDEIP
VLAVAAACAVGETVVADAEELRAKETDRVATVVSELTAMGATLEATPDGMIIAGGGELQGAHVQSHGDHRIAMALAVAGL
VAEGETIIDEAEAVTVSYPTFWQHYAQIKEA

Sequences:

>Translated_431_residues
MKQTVSHAKRLRGAISVPGDKSISHRSVLFNALAEGNAEITGFLPGADCLSSIACLRQMGVEIEHSDDKVRVFGRGLRGL
REPSDVLDCGNSGTTLRLLAGLLAGQPFLSVLTGDASLRSRPQKRIVEPLRQLGAKLDGRDNGNRAPLVIRGTTIHGGNY
ELPIASAQVKSALLLAGLTGDAPMRLSGKIVSRDHTERMLIAMGIDLTVKDDEIVLYPPSHPVFPYPLSLHVPGDPSSAT
FWWVAAAIHPDAEITTLGVGLNPSRTGALDVLKAMGADITISNERNEGAEPVGDVTVRGGGLRGTRIDGDLIPRLIDEIP
VLAVAAACAVGETVVADAEELRAKETDRVATVVSELTAMGATLEATPDGMIIAGGGELQGAHVQSHGDHRIAMALAVAGL
VAEGETIIDEAEAVTVSYPTFWQHYAQIKEA
>Mature_431_residues
MKQTVSHAKRLRGAISVPGDKSISHRSVLFNALAEGNAEITGFLPGADCLSSIACLRQMGVEIEHSDDKVRVFGRGLRGL
REPSDVLDCGNSGTTLRLLAGLLAGQPFLSVLTGDASLRSRPQKRIVEPLRQLGAKLDGRDNGNRAPLVIRGTTIHGGNY
ELPIASAQVKSALLLAGLTGDAPMRLSGKIVSRDHTERMLIAMGIDLTVKDDEIVLYPPSHPVFPYPLSLHVPGDPSSAT
FWWVAAAIHPDAEITTLGVGLNPSRTGALDVLKAMGADITISNERNEGAEPVGDVTVRGGGLRGTRIDGDLIPRLIDEIP
VLAVAAACAVGETVVADAEELRAKETDRVATVVSELTAMGATLEATPDGMIIAGGGELQGAHVQSHGDHRIAMALAVAGL
VAEGETIIDEAEAVTVSYPTFWQHYAQIKEA

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; sixth step. [C]

COG id: COG0128

COG function: function code E; 5-enolpyruvylshikimate-3-phosphate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family

Homologues:

Organism=Escherichia coli, GI1787137, Length=439, Percent_Identity=29.8405466970387, Blast_Score=138, Evalue=8e-34,
Organism=Saccharomyces cerevisiae, GI6320332, Length=431, Percent_Identity=28.538283062645, Blast_Score=112, Evalue=9e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROA_HERA2 (A9AZ72)

Other databases:

- EMBL:   CP000875
- RefSeq:   YP_001543746.1
- ProteinModelPortal:   A9AZ72
- SMR:   A9AZ72
- GeneID:   5732856
- GenomeReviews:   CP000875_GR
- KEGG:   hau:Haur_0970
- HOGENOM:   HBG646626
- OMA:   LSRNHTE
- ProtClustDB:   PRK02427
- BioCyc:   HAUR316274:HAUR_0970-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00210
- InterPro:   IPR001986
- InterPro:   IPR006264
- InterPro:   IPR023193
- InterPro:   IPR013792
- Gene3D:   G3DSA:3.65.10.10
- PIRSF:   PIRSF000505
- TIGRFAMs:   TIGR01356

Pfam domain/function: PF00275 EPSP_synthase; SSF55205 RNA3'_cycl/enolpyr_transf_A/B

EC number: =2.5.1.19

Molecular weight: Translated: 45381; Mature: 45381

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS00104 EPSP_SYNTHASE_1; PS00885 EPSP_SYNTHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQTVSHAKRLRGAISVPGDKSISHRSVLFNALAEGNAEITGFLPGADCLSSIACLRQMG
CCCHHHHHHHHCCCEECCCCCCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHC
VEIEHSDDKVRVFGRGLRGLREPSDVLDCGNSGTTLRLLAGLLAGQPFLSVLTGDASLRS
CEEECCCCEEEEEEHHHHCCCCCHHHHHCCCCCCHHHHHHHHHCCCCHHHHEECCHHHHC
RPQKRIVEPLRQLGAKLDGRDNGNRAPLVIRGTTIHGGNYELPIASAQVKSALLLAGLTG
CCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEECCCEECCCCHHHHHHEEEEEECCC
DAPMRLSGKIVSRDHTERMLIAMGIDLTVKDDEIVLYPPSHPVFPYPLSLHVPGDPSSAT
CCCCEECCEEECCCCCCEEEEEECCEEEEECCEEEEECCCCCCCCCCEEEECCCCCCCCE
FWWVAAAIHPDAEITTLGVGLNPSRTGALDVLKAMGADITISNERNEGAEPVGDVTVRGG
EEEEEEEECCCCCEEEEEECCCCCCCHHHHHHHHCCCCEEEECCCCCCCCCCCCEEEECC
GLRGTRIDGDLIPRLIDEIPVLAVAAACAVGETVVADAEELRAKETDRVATVVSELTAMG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHCC
ATLEATPDGMIIAGGGELQGAHVQSHGDHRIAMALAVAGLVAEGETIIDEAEAVTVSYPT
CEEEECCCCEEEECCCCCCCCEECCCCCCHHHHHHHHHHHHHCCCHHHCCCCEEEEECCH
FWQHYAQIKEA
HHHHHHHHHCC
>Mature Secondary Structure
MKQTVSHAKRLRGAISVPGDKSISHRSVLFNALAEGNAEITGFLPGADCLSSIACLRQMG
CCCHHHHHHHHCCCEECCCCCCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHC
VEIEHSDDKVRVFGRGLRGLREPSDVLDCGNSGTTLRLLAGLLAGQPFLSVLTGDASLRS
CEEECCCCEEEEEEHHHHCCCCCHHHHHCCCCCCHHHHHHHHHCCCCHHHHEECCHHHHC
RPQKRIVEPLRQLGAKLDGRDNGNRAPLVIRGTTIHGGNYELPIASAQVKSALLLAGLTG
CCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEECCCEECCCCHHHHHHEEEEEECCC
DAPMRLSGKIVSRDHTERMLIAMGIDLTVKDDEIVLYPPSHPVFPYPLSLHVPGDPSSAT
CCCCEECCEEECCCCCCEEEEEECCEEEEECCEEEEECCCCCCCCCCEEEECCCCCCCCE
FWWVAAAIHPDAEITTLGVGLNPSRTGALDVLKAMGADITISNERNEGAEPVGDVTVRGG
EEEEEEEECCCCCEEEEEECCCCCCCHHHHHHHHCCCCEEEECCCCCCCCCCCCEEEECC
GLRGTRIDGDLIPRLIDEIPVLAVAAACAVGETVVADAEELRAKETDRVATVVSELTAMG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHCC
ATLEATPDGMIIAGGGELQGAHVQSHGDHRIAMALAVAGLVAEGETIIDEAEAVTVSYPT
CEEEECCCCEEEECCCCCCCCEECCCCCCHHHHHHHHHHHHHCCCHHHCCCCEEEEECCH
FWQHYAQIKEA
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA