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The map label for this gene is tdcB [H]

Identifier: 159897481

GI number: 159897481

Start: 1092070

End: 1093317

Strand: Reverse

Name: tdcB [H]

Synonym: Haur_0952

Alternate gene names: 159897481

Gene position: 1093317-1092070 (Counterclockwise)

Preceding gene: 159897482

Following gene: 159897480

Centisome position: 17.23

GC content: 53.12

Gene sequence:

>1248_bases
ATGGTAGAAAAGTCTATGCCAACGATTGATGACATTTATGCCGCAGCCCATGTTTTAGGCTCGATTATCACCCAAACGCC
GCTCTTGCCAGCTGAACAACTGAGCCAAGAGCTTGGTGGCCAAATTATTTACAAAGCCGAAAATACTCAACGTGCTGGTT
CGTTCAAAGTGCGTGGAGCGTATACCAAAATCAATTCGCTCTCCGATGAAGAAAAAGCCCGTGGCGTAATTACCCATTCG
GCAGGCAACCATGCCCAAGGCGTGGCCCTCGCTGCTCAATTGAATGGCATTAAAGCTACCGTCGTGATGCCGGAATTTGC
CCCATTGGCCAAAATTACGTCGGCCCAACGTATGGGTGCAGAGGTTATTTTGCATGGAGCTTCGTTTGATGATGCTGGGT
CGTATGCCCGCGAACTGCAAGCCCAAACTGGCGCAACCTATGTCCATGCCTTCGACGATCCCTTTACAATTGCTGGCCAA
GGCACGCTCGGCTTAGAAATTGCCGACCAACTGCCCGACCAAGGCGGCACGGTCGTCGTACCAATCGGCGGTGGCGGGAT
GATGGCAGGGATTGCCCTGGCCTTGCGTTCGCTGCGCCCCAATGTGCGATTGATTGGGGTGCAGGCAGCAGGCTGCCCAT
CGATGATCGCCTCGCAGCAAGCAGGCAAGCCAATTGCTGTGCCCCATGCCGCGACCATCTGTGATGGAATTGCGGTCAAA
CGCCCAGGCGAATTGACCTTGCCGATTATCAATCAATTAGTTGATGATATTGTAACGGTTGATGACGATGCAGCAGCGCG
GGGCTTAGTGCATATTTTGCAATATAGCCGCATGGTGGTCGAGGGAGCAGGAGCAGTTGGCGTGGCCGCCTTGCTTGAAG
GCGCAATTCGCTTGCGACCAAATGAGCCAACGTTGGTAGTGCTCAGCGGTGGCAATATCGATGGCAACTTCCTTGCTCGA
ATTATTGAGCAAGTTTTGGTCAAACAAGGTCGCTATTTACGCGTTCGGACTAGTGTTCCTGATCGTCCGGGAAATCTCGC
TCCCTTAGTTAATGCGATTGCCCAGGCTGGGGCGAATGTGATCGATATTAGCCATCGGCGGGCAGTGTGGCAACTCCCGC
TTGATCGGGTGGGAATAGAGATGATTCTCGAAGTGCGCGATGAAGCGCATGGCCAATCTATCATTGACATGTTGGAAACA
CACGGCTATCACATCGAGCGTTTTGGCCAGCGTGTGTGGCCGGTGTAA

Upstream 100 bases:

>100_bases
TTTACCAACTAGCCAAAAATCCAAAGTGGCTATGGTACAATAGCCCCATTGACTCGCAACGATGCGGGTCAATCCTCATT
GTGGAGGATTTGAACTCACC

Downstream 100 bases:

>100_bases
TCGATGGTTGATGCGAATGCTCGCATGAACTATCTACGGTAGGGCTTATGCCAATTCGAATGATTGCAACCGATATTGAC
CTTACCCTGCTTGATGACCG

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MVEKSMPTIDDIYAAAHVLGSIITQTPLLPAEQLSQELGGQIIYKAENTQRAGSFKVRGAYTKINSLSDEEKARGVITHS
AGNHAQGVALAAQLNGIKATVVMPEFAPLAKITSAQRMGAEVILHGASFDDAGSYARELQAQTGATYVHAFDDPFTIAGQ
GTLGLEIADQLPDQGGTVVVPIGGGGMMAGIALALRSLRPNVRLIGVQAAGCPSMIASQQAGKPIAVPHAATICDGIAVK
RPGELTLPIINQLVDDIVTVDDDAAARGLVHILQYSRMVVEGAGAVGVAALLEGAIRLRPNEPTLVVLSGGNIDGNFLAR
IIEQVLVKQGRYLRVRTSVPDRPGNLAPLVNAIAQAGANVIDISHRRAVWQLPLDRVGIEMILEVRDEAHGQSIIDMLET
HGYHIERFGQRVWPV

Sequences:

>Translated_415_residues
MVEKSMPTIDDIYAAAHVLGSIITQTPLLPAEQLSQELGGQIIYKAENTQRAGSFKVRGAYTKINSLSDEEKARGVITHS
AGNHAQGVALAAQLNGIKATVVMPEFAPLAKITSAQRMGAEVILHGASFDDAGSYARELQAQTGATYVHAFDDPFTIAGQ
GTLGLEIADQLPDQGGTVVVPIGGGGMMAGIALALRSLRPNVRLIGVQAAGCPSMIASQQAGKPIAVPHAATICDGIAVK
RPGELTLPIINQLVDDIVTVDDDAAARGLVHILQYSRMVVEGAGAVGVAALLEGAIRLRPNEPTLVVLSGGNIDGNFLAR
IIEQVLVKQGRYLRVRTSVPDRPGNLAPLVNAIAQAGANVIDISHRRAVWQLPLDRVGIEMILEVRDEAHGQSIIDMLET
HGYHIERFGQRVWPV
>Mature_415_residues
MVEKSMPTIDDIYAAAHVLGSIITQTPLLPAEQLSQELGGQIIYKAENTQRAGSFKVRGAYTKINSLSDEEKARGVITHS
AGNHAQGVALAAQLNGIKATVVMPEFAPLAKITSAQRMGAEVILHGASFDDAGSYARELQAQTGATYVHAFDDPFTIAGQ
GTLGLEIADQLPDQGGTVVVPIGGGGMMAGIALALRSLRPNVRLIGVQAAGCPSMIASQQAGKPIAVPHAATICDGIAVK
RPGELTLPIINQLVDDIVTVDDDAAARGLVHILQYSRMVVEGAGAVGVAALLEGAIRLRPNEPTLVVLSGGNIDGNFLAR
IIEQVLVKQGRYLRVRTSVPDRPGNLAPLVNAIAQAGANVIDISHRRAVWQLPLDRVGIEMILEVRDEAHGQSIIDMLET
HGYHIERFGQRVWPV

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=296, Percent_Identity=37.1621621621622, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI19923959, Length=296, Percent_Identity=31.4189189189189, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI33469958, Length=312, Percent_Identity=26.2820512820513, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1789505, Length=314, Percent_Identity=43.9490445859873, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI1790207, Length=397, Percent_Identity=36.272040302267, Blast_Score=207, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI71991565, Length=386, Percent_Identity=39.119170984456, Blast_Score=246, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI17537387, Length=382, Percent_Identity=34.5549738219895, Blast_Score=191, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI17508781, Length=318, Percent_Identity=29.559748427673, Blast_Score=146, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6320930, Length=352, Percent_Identity=34.6590909090909, Blast_Score=188, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6322631, Length=317, Percent_Identity=36.5930599369085, Blast_Score=180, Evalue=4e-46,
Organism=Saccharomyces cerevisiae, GI6319788, Length=284, Percent_Identity=25.3521126760563, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21355833, Length=392, Percent_Identity=34.6938775510204, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24645328, Length=297, Percent_Identity=32.6599326599327, Blast_Score=138, Evalue=6e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 43904; Mature: 43904

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEKSMPTIDDIYAAAHVLGSIITQTPLLPAEQLSQELGGQIIYKAENTQRAGSFKVRGA
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCEEEEEECCCCCCCCEEEEEE
YTKINSLSDEEKARGVITHSAGNHAQGVALAAQLNGIKATVVMPEFAPLAKITSAQRMGA
HHHHCCCCCHHHHCEEEEECCCCCCCCEEEEEECCCEEEEEECCCCCHHHHHHHHHHCCC
EVILHGASFDDAGSYARELQAQTGATYVHAFDDPFTIAGQGTLGLEIADQLPDQGGTVVV
EEEEECCCCCCHHHHHHHHHHHCCCEEEEECCCCEEEECCCCCCEEEHHCCCCCCCEEEE
PIGGGGMMAGIALALRSLRPNVRLIGVQAAGCPSMIASQQAGKPIAVPHAATICDGIAVK
EECCCHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHCCCCEECCCHHHHHCCCEEC
RPGELTLPIINQLVDDIVTVDDDAAARGLVHILQYSRMVVEGAGAVGVAALLEGAIRLRP
CCCCEEHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCEEECC
NEPTLVVLSGGNIDGNFLARIIEQVLVKQGRYLRVRTSVPDRPGNLAPLVNAIAQAGANV
CCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHCCCCE
IDISHRRAVWQLPLDRVGIEMILEVRDEAHGQSIIDMLETHGYHIERFGQRVWPV
EEECCCCEEEECCHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCHHHHHHHHHCCC
>Mature Secondary Structure
MVEKSMPTIDDIYAAAHVLGSIITQTPLLPAEQLSQELGGQIIYKAENTQRAGSFKVRGA
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCEEEEEECCCCCCCCEEEEEE
YTKINSLSDEEKARGVITHSAGNHAQGVALAAQLNGIKATVVMPEFAPLAKITSAQRMGA
HHHHCCCCCHHHHCEEEEECCCCCCCCEEEEEECCCEEEEEECCCCCHHHHHHHHHHCCC
EVILHGASFDDAGSYARELQAQTGATYVHAFDDPFTIAGQGTLGLEIADQLPDQGGTVVV
EEEEECCCCCCHHHHHHHHHHHCCCEEEEECCCCEEEECCCCCCEEEHHCCCCCCCEEEE
PIGGGGMMAGIALALRSLRPNVRLIGVQAAGCPSMIASQQAGKPIAVPHAATICDGIAVK
EECCCHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHCCCCEECCCHHHHHCCCEEC
RPGELTLPIINQLVDDIVTVDDDAAARGLVHILQYSRMVVEGAGAVGVAALLEGAIRLRP
CCCCEEHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCEEECC
NEPTLVVLSGGNIDGNFLARIIEQVLVKQGRYLRVRTSVPDRPGNLAPLVNAIAQAGANV
CCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHCCCCE
IDISHRRAVWQLPLDRVGIEMILEVRDEAHGQSIIDMLETHGYHIERFGQRVWPV
EEECCCCEEEECCHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA