Click here to switch to the map view.

The map label for this gene is envZ [H]

Identifier: 159046587

GI number: 159046587

Start: 108530

End: 109996

Strand: Direct

Name: envZ [H]

Synonym: Dshi_4049

Alternate gene names: 159046587

Gene position: 108530-109996 (Clockwise)

Preceding gene: 159046586

Following gene: 159046588

Centisome position: 85.93

GC content: 59.51

Gene sequence:

>1467_bases
ATGCGCCGTGCGATGAGATCTCTGAGCGGCCAATTGATCCTGCTTGTGGTCGCGGCACTTGTCGTGGCCCAGGTGATCAG
CCTGTTCCTGTTCGCCGACGAGCGCAGCCTTGCGATCCGTGCAGCTTTAGGATTCGAGGCCGCGGGTCGCGCAGCGAATG
TCGCGCGGTTGATCGAAGAGGCCCCGCTGGATCTGCAGGACTCGATCCTTCGCGCGGCAAATTCGCCTCTGATCCGGTTC
GATCTGTCGGACGCTCCGATCGTGGATCACACCGGTCATTCGGACGGCGGCATCGTGGAAGCGCGCATACGCGCCCTGAT
GGATGACAGCTACAGCCGGGATATTCGCGTTGAATTGCACGAGGTCGAGGGCGAGTTGCGGCCTCTTCCCAATCTCTCGG
ACGAGATGACAGAAATGCATCTCGCGATGATGCGCGGAGAGTTGACAGCGGTTGAAATGAACCTGTCCATCGCCATCAAG
GGAGCGCGTTGGCTGAATGTCGGAACGCGGTTCGAGCGACCGCCGATCCAATGGCCTTTCTATTCGATGCTGACCTTCGG
GATTTCCGCCGGACTGCTTCTGGTGGCGATCTTCTGGTTTGTAATGACGCGCCTGACGCGTCCTTTGCGGCACCTGTCGA
AGGCCGCGGACCATCTTGGCCGGGGCGAAGATGTGGGCGAATTGGCGGTCACAGGGCCGACCGAGGTCAGAGATCTGACC
GTCGCATTCAACCGCATGCAACGACGGCTGACCCGGTTTGTCAGTGATCGTACACGTATGCTCGCAGCCCTTGGCCACGA
TTTACGCTCGCCGTTGACTGCCATGCGTGTCCGCGCGGAGCTGGTTGACGAAGAAGAGACGCGGGACAGCCTCATCGCAT
CGGTCGAAGAGATGCAGAGTATGGTCGAAGCGACGCTCACCTTTGCACGCGGCCTTACCGGATCCGAAGGTGCCGAAGTG
GTCGATCTGCGCAATTTTCTGGACAGCTTGTGCAGCGATATGGCGGCACACTGCACCTTTGCCCCGAGTGATGATGTTGC
CGTGCGGCTTCGACCCAACGCGTTCCGAAGGGCACTGAGGAACTTGCTTGAGAACGCCGTTCGCTACGGTGGTGCCGCAA
AAGTCAGCTGGGCGACCCACGGTTCGAACCTCGTACTCAACATCGATGACAATGGGCCCGGCATTCCCGTCGACCAGTTG
GAAAAGGTCTTCGATCCGTTCTATCGCCTCGAGCAATCGAGGTCTCTGGAAACGGGCGGTTATGGGCTTGGGCTCTCAAT
CGCGAGGACAATCGTCCAATCCCATGGCGGCGATATCCAGCTGGTCAATCAGAACAGCGCGGGTTTGCGCGCTGTTGTCA
CCATCCCGTTGGATGAAACCGAACTGATCGAAGGAGAAACAGATGAAACTGAACGCGTTGATCCTGCCGTTGCTGGCCAG
CTTGCCCGCCAGCATGGCGCAGGCTGA

Upstream 100 bases:

>100_bases
TCCGCCGCAAAATCGAGCCGGATGTACTTAGGCCCAGTGTCATCAAAACGGTGCGGAACGGCGGATACTGTCTGGCTGCC
GATGTCGAGGATGCGCCGTG

Downstream 100 bases:

>100_bases
TGGACCAGGCTCCTGGACGGGGCACATGTGGGGCAGTGGCTATGGCTTTATGGGCGGCTTCATGATGCTCGCCTTCTGGG
GTGCGCTGATCGCATTGGTG

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 488; Mature: 488

Protein sequence:

>488_residues
MRRAMRSLSGQLILLVVAALVVAQVISLFLFADERSLAIRAALGFEAAGRAANVARLIEEAPLDLQDSILRAANSPLIRF
DLSDAPIVDHTGHSDGGIVEARIRALMDDSYSRDIRVELHEVEGELRPLPNLSDEMTEMHLAMMRGELTAVEMNLSIAIK
GARWLNVGTRFERPPIQWPFYSMLTFGISAGLLLVAIFWFVMTRLTRPLRHLSKAADHLGRGEDVGELAVTGPTEVRDLT
VAFNRMQRRLTRFVSDRTRMLAALGHDLRSPLTAMRVRAELVDEEETRDSLIASVEEMQSMVEATLTFARGLTGSEGAEV
VDLRNFLDSLCSDMAAHCTFAPSDDVAVRLRPNAFRRALRNLLENAVRYGGAAKVSWATHGSNLVLNIDDNGPGIPVDQL
EKVFDPFYRLEQSRSLETGGYGLGLSIARTIVQSHGGDIQLVNQNSAGLRAVVTIPLDETELIEGETDETERVDPAVAGQ
LARQHGAG

Sequences:

>Translated_488_residues
MRRAMRSLSGQLILLVVAALVVAQVISLFLFADERSLAIRAALGFEAAGRAANVARLIEEAPLDLQDSILRAANSPLIRF
DLSDAPIVDHTGHSDGGIVEARIRALMDDSYSRDIRVELHEVEGELRPLPNLSDEMTEMHLAMMRGELTAVEMNLSIAIK
GARWLNVGTRFERPPIQWPFYSMLTFGISAGLLLVAIFWFVMTRLTRPLRHLSKAADHLGRGEDVGELAVTGPTEVRDLT
VAFNRMQRRLTRFVSDRTRMLAALGHDLRSPLTAMRVRAELVDEEETRDSLIASVEEMQSMVEATLTFARGLTGSEGAEV
VDLRNFLDSLCSDMAAHCTFAPSDDVAVRLRPNAFRRALRNLLENAVRYGGAAKVSWATHGSNLVLNIDDNGPGIPVDQL
EKVFDPFYRLEQSRSLETGGYGLGLSIARTIVQSHGGDIQLVNQNSAGLRAVVTIPLDETELIEGETDETERVDPAVAGQ
LARQHGAG
>Mature_488_residues
MRRAMRSLSGQLILLVVAALVVAQVISLFLFADERSLAIRAALGFEAAGRAANVARLIEEAPLDLQDSILRAANSPLIRF
DLSDAPIVDHTGHSDGGIVEARIRALMDDSYSRDIRVELHEVEGELRPLPNLSDEMTEMHLAMMRGELTAVEMNLSIAIK
GARWLNVGTRFERPPIQWPFYSMLTFGISAGLLLVAIFWFVMTRLTRPLRHLSKAADHLGRGEDVGELAVTGPTEVRDLT
VAFNRMQRRLTRFVSDRTRMLAALGHDLRSPLTAMRVRAELVDEEETRDSLIASVEEMQSMVEATLTFARGLTGSEGAEV
VDLRNFLDSLCSDMAAHCTFAPSDDVAVRLRPNAFRRALRNLLENAVRYGGAAKVSWATHGSNLVLNIDDNGPGIPVDQL
EKVFDPFYRLEQSRSLETGGYGLGLSIARTIVQSHGGDIQLVNQNSAGLRAVVTIPLDETELIEGETDETERVDPAVAGQ
LARQHGAG

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=334, Percent_Identity=31.1377245508982, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI1790346, Length=267, Percent_Identity=29.9625468164794, Blast_Score=118, Evalue=7e-28,
Organism=Escherichia coli, GI1786783, Length=288, Percent_Identity=29.1666666666667, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1787894, Length=264, Percent_Identity=29.5454545454545, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI87082128, Length=299, Percent_Identity=26.0869565217391, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI1788393, Length=272, Percent_Identity=27.9411764705882, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI1786912, Length=219, Percent_Identity=34.703196347032, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1790551, Length=294, Percent_Identity=29.5918367346939, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1786600, Length=279, Percent_Identity=26.8817204301075, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1789403, Length=307, Percent_Identity=29.3159609120521, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1788279, Length=251, Percent_Identity=27.0916334661355, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI87081816, Length=336, Percent_Identity=26.1904761904762, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1790861, Length=493, Percent_Identity=26.1663286004057, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1788713, Length=251, Percent_Identity=22.3107569721116, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI145693157, Length=221, Percent_Identity=23.0769230769231, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1787374, Length=278, Percent_Identity=25.5395683453237, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI48994928, Length=252, Percent_Identity=25, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1790436, Length=246, Percent_Identity=24.7967479674797, Blast_Score=66, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 53595; Mature: 53595

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRAMRSLSGQLILLVVAALVVAQVISLFLFADERSLAIRAALGFEAAGRAANVARLIEE
CCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHCCHHHHHHHHHHH
APLDLQDSILRAANSPLIRFDLSDAPIVDHTGHSDGGIVEARIRALMDDSYSRDIRVELH
CCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEEE
EVEGELRPLPNLSDEMTEMHLAMMRGELTAVEMNLSIAIKGARWLNVGTRFERPPIQWPF
ECCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEEEEEECCEEEECCCCCCCCCCCCCH
YSMLTFGISAGLLLVAIFWFVMTRLTRPLRHLSKAADHLGRGEDVGELAVTGPTEVRDLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCHHHHHH
VAFNRMQRRLTRFVSDRTRMLAALGHDLRSPLTAMRVRAELVDEEETRDSLIASVEEMQS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
MVEATLTFARGLTGSEGAEVVDLRNFLDSLCSDMAAHCTFAPSDDVAVRLRPNAFRRALR
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHH
NLLENAVRYGGAAKVSWATHGSNLVLNIDDNGPGIPVDQLEKVFDPFYRLEQSRSLETGG
HHHHHHHHCCCCEEEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCC
YGLGLSIARTIVQSHGGDIQLVNQNSAGLRAVVTIPLDETELIEGETDETERVDPAVAGQ
CCCHHHHHHHHHHCCCCCEEEEECCCCCEEEEEEECCCCHHHCCCCCCCCHHCCHHHHHH
LARQHGAG
HHHHCCCC
>Mature Secondary Structure
MRRAMRSLSGQLILLVVAALVVAQVISLFLFADERSLAIRAALGFEAAGRAANVARLIEE
CCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHCCHHHHHHHHHHH
APLDLQDSILRAANSPLIRFDLSDAPIVDHTGHSDGGIVEARIRALMDDSYSRDIRVELH
CCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEEE
EVEGELRPLPNLSDEMTEMHLAMMRGELTAVEMNLSIAIKGARWLNVGTRFERPPIQWPF
ECCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEEEEEECCEEEECCCCCCCCCCCCCH
YSMLTFGISAGLLLVAIFWFVMTRLTRPLRHLSKAADHLGRGEDVGELAVTGPTEVRDLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCHHHHHH
VAFNRMQRRLTRFVSDRTRMLAALGHDLRSPLTAMRVRAELVDEEETRDSLIASVEEMQS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
MVEATLTFARGLTGSEGAEVVDLRNFLDSLCSDMAAHCTFAPSDDVAVRLRPNAFRRALR
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHH
NLLENAVRYGGAAKVSWATHGSNLVLNIDDNGPGIPVDQLEKVFDPFYRLEQSRSLETGG
HHHHHHHHCCCCEEEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCC
YGLGLSIARTIVQSHGGDIQLVNQNSAGLRAVVTIPLDETELIEGETDETERVDPAVAGQ
CCCHHHHHHHHHHCCCCCEEEEECCCCCEEEEEEECCCCHHHCCCCCCCCHHCCHHHHHH
LARQHGAG
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]