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The map label for this gene is ppi [H]

Identifier: 158423948

GI number: 158423948

Start: 2647922

End: 2648380

Strand: Reverse

Name: ppi [H]

Synonym: AZC_2324

Alternate gene names: 158423948

Gene position: 2648380-2647922 (Counterclockwise)

Preceding gene: 158423949

Following gene: 158423941

Centisome position: 49.32

GC content: 64.05

Gene sequence:

>459_bases
ATGGCTGAAGAACTGCTCGTCCTCGAAACCACCAAGGGCGACGTGACCATCAAGTTCCGCCCCGATCTCGCCCCGAACCA
CGTGGCGCGCATCAAGGAGCTGGTGAACGAAGGCTTCTACAACAACGTCCCGTTCCACCGCGTCATCGAGGGCTTCATGG
CCCAGACCGGCGACGGCCAGTATGGCAACGGCATGGGCGGCTCCGGCAAGAAGCTGAAGGCCGAGTTCAATGCGGAGCCG
CACGTGCGCGGCACCTGCTCCATGGCCCGCGCCCAGAACCCGGACAGCGGTGACAGCCAGTTCTTCATCTGCTTCACCGA
CGCCCGCTTCCTCGACCGCCAGTACACGGTGTGGGGGCAGGTGGTGTCCGGCATGGAGAATGTGGACAAGATCAAACGCG
GCGAGCCCGTGCAGGATCCCGACAAGATCGTGACGGCCAAGCTCGTCGCCGCCGAGTGA

Upstream 100 bases:

>100_bases
GGAAGCCAATGGCGCGGTGCCCAATCCCGACCGCATCGTGAAGATGCAGGTCGCGGCCGACGTGAAGTGATCCATTCCAA
CAATCATCAGGAGAGGCCCA

Downstream 100 bases:

>100_bases
TCGGCGCGCCGCTGGCGTTCTGAAGACAACGGCCCCTGTTTCCAAGCGGAACCGGGGCCGTTTCATTATCTGGCGGCACC
ACCTGCGGGATGATCAAGCA

Product: peptidyl prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 152; Mature: 151

Protein sequence:

>152_residues
MAEELLVLETTKGDVTIKFRPDLAPNHVARIKELVNEGFYNNVPFHRVIEGFMAQTGDGQYGNGMGGSGKKLKAEFNAEP
HVRGTCSMARAQNPDSGDSQFFICFTDARFLDRQYTVWGQVVSGMENVDKIKRGEPVQDPDKIVTAKLVAAE

Sequences:

>Translated_152_residues
MAEELLVLETTKGDVTIKFRPDLAPNHVARIKELVNEGFYNNVPFHRVIEGFMAQTGDGQYGNGMGGSGKKLKAEFNAEP
HVRGTCSMARAQNPDSGDSQFFICFTDARFLDRQYTVWGQVVSGMENVDKIKRGEPVQDPDKIVTAKLVAAE
>Mature_151_residues
AEELLVLETTKGDVTIKFRPDLAPNHVARIKELVNEGFYNNVPFHRVIEGFMAQTGDGQYGNGMGGSGKKLKAEFNAEPH
VRGTCSMARAQNPDSGDSQFFICFTDARFLDRQYTVWGQVVSGMENVDKIKRGEPVQDPDKIVTAKLVAAE

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI19557636, Length=133, Percent_Identity=37.593984962406, Blast_Score=84, Evalue=3e-17,
Organism=Homo sapiens, GI24308049, Length=130, Percent_Identity=40.7692307692308, Blast_Score=80, Evalue=8e-16,
Organism=Homo sapiens, GI7706339, Length=130, Percent_Identity=33.0769230769231, Blast_Score=77, Evalue=6e-15,
Organism=Homo sapiens, GI22547215, Length=132, Percent_Identity=37.8787878787879, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI22547212, Length=132, Percent_Identity=37.8787878787879, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI7657473, Length=132, Percent_Identity=37.8787878787879, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI64276486, Length=122, Percent_Identity=36.8852459016393, Blast_Score=70, Evalue=6e-13,
Organism=Homo sapiens, GI5031987, Length=127, Percent_Identity=37.7952755905512, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI10863927, Length=128, Percent_Identity=36.71875, Blast_Score=66, Evalue=1e-11,
Organism=Homo sapiens, GI4758950, Length=114, Percent_Identity=39.4736842105263, Blast_Score=65, Evalue=2e-11,
Organism=Homo sapiens, GI169164185, Length=117, Percent_Identity=36.7521367521368, Blast_Score=64, Evalue=5e-11,
Organism=Homo sapiens, GI169163623, Length=117, Percent_Identity=36.7521367521368, Blast_Score=64, Evalue=5e-11,
Organism=Homo sapiens, GI169163387, Length=117, Percent_Identity=36.7521367521368, Blast_Score=64, Evalue=6e-11,
Organism=Escherichia coli, GI1786736, Length=137, Percent_Identity=40.8759124087591, Blast_Score=93, Evalue=9e-21,
Organism=Escherichia coli, GI1789763, Length=134, Percent_Identity=39.5522388059701, Blast_Score=87, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI71980594, Length=132, Percent_Identity=38.6363636363636, Blast_Score=80, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71980590, Length=132, Percent_Identity=38.6363636363636, Blast_Score=80, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17506311, Length=134, Percent_Identity=37.3134328358209, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17539496, Length=133, Percent_Identity=33.8345864661654, Blast_Score=73, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17532641, Length=124, Percent_Identity=36.2903225806452, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17539498, Length=140, Percent_Identity=36.4285714285714, Blast_Score=69, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17565860, Length=157, Percent_Identity=35.6687898089172, Blast_Score=69, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17559074, Length=109, Percent_Identity=38.5321100917431, Blast_Score=66, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17506307, Length=119, Percent_Identity=38.655462184874, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17566266, Length=92, Percent_Identity=42.3913043478261, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17552780, Length=128, Percent_Identity=35.15625, Blast_Score=63, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6320359, Length=147, Percent_Identity=37.4149659863946, Blast_Score=73, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323562, Length=97, Percent_Identity=41.2371134020619, Blast_Score=64, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17986117, Length=157, Percent_Identity=39.4904458598726, Blast_Score=94, Evalue=4e-20,
Organism=Drosophila melanogaster, GI17647301, Length=128, Percent_Identity=39.84375, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI19922376, Length=143, Percent_Identity=34.965034965035, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24664125, Length=127, Percent_Identity=37.7952755905512, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI21357783, Length=127, Percent_Identity=37.7952755905512, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI45549139, Length=143, Percent_Identity=34.965034965035, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19922912, Length=132, Percent_Identity=41.6666666666667, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21357249, Length=122, Percent_Identity=34.4262295081967, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24652460, Length=132, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI20130249, Length=141, Percent_Identity=35.4609929078014, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 16809; Mature: 16678

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEELLVLETTKGDVTIKFRPDLAPNHVARIKELVNEGFYNNVPFHRVIEGFMAQTGDGQ
CCCCEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCC
YGNGMGGSGKKLKAEFNAEPHVRGTCSMARAQNPDSGDSQFFICFTDARFLDRQYTVWGQ
CCCCCCCCCCEEEEECCCCCCCCCCHHHHHCCCCCCCCCEEEEEEECCHHHCCHHHHHHH
VVSGMENVDKIKRGEPVQDPDKIVTAKLVAAE
HHHHHHHHHHHHCCCCCCCCHHEEEEEEEECC
>Mature Secondary Structure 
AEELLVLETTKGDVTIKFRPDLAPNHVARIKELVNEGFYNNVPFHRVIEGFMAQTGDGQ
CCCEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCC
YGNGMGGSGKKLKAEFNAEPHVRGTCSMARAQNPDSGDSQFFICFTDARFLDRQYTVWGQ
CCCCCCCCCCEEEEECCCCCCCCCCHHHHHCCCCCCCCCEEEEEEECCHHHCCHHHHHHH
VVSGMENVDKIKRGEPVQDPDKIVTAKLVAAE
HHHHHHHHHHHHCCCCCCCCHHEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA