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The map label for this gene is purL

Identifier: 158423855

GI number: 158423855

Start: 2550717

End: 2552924

Strand: Direct

Name: purL

Synonym: AZC_2231

Alternate gene names: 158423855

Gene position: 2550717-2552924 (Clockwise)

Preceding gene: 158423854

Following gene: 158423856

Centisome position: 47.5

GC content: 67.8

Gene sequence:

>2208_bases
GTGATCCCGAACACCCCCAGCATCACCCCGGAACTCGTCGCTGAGCACGGCCTGAAGCCGGACGAATACCAGCGCTTCGT
GGAGCTGATCGGGCGCGAGCCGACCATCACGGAGCTCGGCATCGTTTCCGCCATGTGGAACGAGCACTGCTCCTACAAGT
CCTCCAAGGTCTGGCTGCGCACGCTGCCCACCAAGGGCCCGCGCGTCATCCAGGGGCCGGGCGAGAATGCCGGCGTCGTG
GACATCGGCGACGGTCTGGCCGTGGTCTTCAAGATGGAGAGCCACAACCACCCGTCCTTCATCGAGCCTTATCAGGGCGC
GGGCACGGGCGTGGGTGGCATCCTGCGCGACGTCTTCACCATGGGTGCGCGCCCCATTGCGGCCCTGAACGCCCTGCGCT
TCGGCGACCCCCACCATCCGCGCACCCGCCGCCTGCTGGCGGGCGTGGTGGCCGGCATCGGCGGCTACGGCAATTCCTTC
GGCGTGCCCACTGTGGGCGGCTCCGTGGGCTTCCACGAGCGCTACAACGGCAACATCCTCGTCAACGCCATGGCGGTCGG
CCTCGCGAAGACGGATGAGATCTTCTATGCGGCGGCGGCCGGCGTCGGCCGCTCCATCGTCTATCTCGGCTCCAAGACCG
GCCGCGACGGCATCCACGGCGCCACCATGGCCTCCGCCGAATTCGGCGCGGACGCCGAGGAAAAGCGACCCACCGTGCAG
GTGGGCGACCCCTTCGCCGAGAAGCTGCTGCTGGAAGCCTGCCTCGAGATCATGCAGGCGGGCTGCGTGGTGGCGATCCA
GGACATGGGCGCCGCCGGCCTCACCTGCTCGGCGGTCGAGATGGGCGCCAAGGGCGACCTCGGCGTGGAACTGGACCTCA
ACGCCGTGCCGTGCCGCGAAACCGGCATGACCGCTTATGAGATGATGCTGTCCGAGAGCCAGGAGCGCATGCTCATGGTG
ATCGCGGACGGCAAGGAAGATCAGGCCGAGGCCATCTTCCGCAAGTGGGGTCTGGACTTCGCCATCATCGGCAAGACCAC
CGATACGCTCCGTTTCGTCGTGAAGCACGACGGCGACGTGAAGGCTGACCTGCCCATCAAGGAACTGGGCGACGAGGCGC
CGGAATATTACCGCCCCTTCACCGAGACGCCGCCGCGCCCCGTGCTCGGCCCGTCCGACGTGAATCATGCGGTGTCCGTC
GCCGACGCGCTGGAGCGCCTCATCGCCTCGCCGGACCTGTGCTCCAAGCGCTGGGTCTGGGAGCAGTATGACCACCTCAT
CCTCGGCAACACCGTGCAGCGCCCGGGCGGCGATGCGGCCGTGGTGCGTGTGAACGAAGGCCCGAAGGCGTTGGCGCTGA
CCACCGACGTGACGCCCCGCTATTGCGAGGCCGATCCCTTCGAGGGCGGCAAGCAGGCGGTCGCCGAGGCGTGGCGCAAT
CTCACCGCCGTGGGTGCCACCCCCATCGCCGTGACCGACAACCTCAATTTTGGCAATCCCGAGAAGCCCGAGATCATGGG
CCAGTTCGTGGGCTGCGTGAAAGGCATCGGCGCGGCCTGCGAGGCGCTCGACTTCCCGGTCGTCTCCGGCAACGTCAGTC
TCTACAACGAGACCAACGGGCAGGGCATCCTGCCCACCCCCACCATCGGTGGCGTCGGCCTTATCGACGATGTGGAGCAG
AGCATGACGCTCGCCTTCAAGGCGGCGGGCGAGGCCATCTTCGTGGTCGGCAAGACGGACGGCTGGCTCGGCTCCTCCGC
TTATCTCTACACCGTCTGCGACCGCGAGGACGGCGCTCCGCCGCCGGTGGATCTGGTGGCCGAGAAGCGCAACGGTGACT
TCGTGCGCGGCCTCATCAAGGACGACTTCATCACCGCCGCCCATGACGTCTCCGACGGCGGCCTGCTCGTCGCCATCGCC
GAGATGGCCATGGCGGGCCGCATCGGCGCGTCGGTGGATGGCGTGCCCGCGGGCATGCCGGCCCATTCCTTCTGGTTCGG
CGAGGATCAGGCCCGCTATGTGGTGACGCTCCCGGCCAATCAGGCCGCCGAGATGGTGCGCCGGGCGGAAGCGGCGGGCG
TGCCCGTGACCAAGCTCGGCAAGACCGGCGGCGACAAGATCACGCTGGCCAACGAGCGGCCGATCTTCGTCGAAGGTCTG
CGCGATCGCCACGACAGCTGGCTGCCCATCTATATGGGCGCCAACTAA

Upstream 100 bases:

>100_bases
GAAAGCCTTGCCGGCGCGCTCAAGGCGGCCTGACGCGCCTGCGGCGCGCTTCCGCGCCCGGCGCCTTTCCCAAAGACCTG
GATTGATCGGACGGACGAAC

Downstream 100 bases:

>100_bases
AGGTCTGATCTCAGAGGCGGGGCCGCGCGCCCCGCCCGGAAACGAGGAACAACGCCATGGCCATGGACGCCGGTGACATC
GAGCGCCTCATCAAGGCGGC

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II

Number of amino acids: Translated: 735; Mature: 735

Protein sequence:

>735_residues
MIPNTPSITPELVAEHGLKPDEYQRFVELIGREPTITELGIVSAMWNEHCSYKSSKVWLRTLPTKGPRVIQGPGENAGVV
DIGDGLAVVFKMESHNHPSFIEPYQGAGTGVGGILRDVFTMGARPIAALNALRFGDPHHPRTRRLLAGVVAGIGGYGNSF
GVPTVGGSVGFHERYNGNILVNAMAVGLAKTDEIFYAAAAGVGRSIVYLGSKTGRDGIHGATMASAEFGADAEEKRPTVQ
VGDPFAEKLLLEACLEIMQAGCVVAIQDMGAAGLTCSAVEMGAKGDLGVELDLNAVPCRETGMTAYEMMLSESQERMLMV
IADGKEDQAEAIFRKWGLDFAIIGKTTDTLRFVVKHDGDVKADLPIKELGDEAPEYYRPFTETPPRPVLGPSDVNHAVSV
ADALERLIASPDLCSKRWVWEQYDHLILGNTVQRPGGDAAVVRVNEGPKALALTTDVTPRYCEADPFEGGKQAVAEAWRN
LTAVGATPIAVTDNLNFGNPEKPEIMGQFVGCVKGIGAACEALDFPVVSGNVSLYNETNGQGILPTPTIGGVGLIDDVEQ
SMTLAFKAAGEAIFVVGKTDGWLGSSAYLYTVCDREDGAPPPVDLVAEKRNGDFVRGLIKDDFITAAHDVSDGGLLVAIA
EMAMAGRIGASVDGVPAGMPAHSFWFGEDQARYVVTLPANQAAEMVRRAEAAGVPVTKLGKTGGDKITLANERPIFVEGL
RDRHDSWLPIYMGAN

Sequences:

>Translated_735_residues
MIPNTPSITPELVAEHGLKPDEYQRFVELIGREPTITELGIVSAMWNEHCSYKSSKVWLRTLPTKGPRVIQGPGENAGVV
DIGDGLAVVFKMESHNHPSFIEPYQGAGTGVGGILRDVFTMGARPIAALNALRFGDPHHPRTRRLLAGVVAGIGGYGNSF
GVPTVGGSVGFHERYNGNILVNAMAVGLAKTDEIFYAAAAGVGRSIVYLGSKTGRDGIHGATMASAEFGADAEEKRPTVQ
VGDPFAEKLLLEACLEIMQAGCVVAIQDMGAAGLTCSAVEMGAKGDLGVELDLNAVPCRETGMTAYEMMLSESQERMLMV
IADGKEDQAEAIFRKWGLDFAIIGKTTDTLRFVVKHDGDVKADLPIKELGDEAPEYYRPFTETPPRPVLGPSDVNHAVSV
ADALERLIASPDLCSKRWVWEQYDHLILGNTVQRPGGDAAVVRVNEGPKALALTTDVTPRYCEADPFEGGKQAVAEAWRN
LTAVGATPIAVTDNLNFGNPEKPEIMGQFVGCVKGIGAACEALDFPVVSGNVSLYNETNGQGILPTPTIGGVGLIDDVEQ
SMTLAFKAAGEAIFVVGKTDGWLGSSAYLYTVCDREDGAPPPVDLVAEKRNGDFVRGLIKDDFITAAHDVSDGGLLVAIA
EMAMAGRIGASVDGVPAGMPAHSFWFGEDQARYVVTLPANQAAEMVRRAEAAGVPVTKLGKTGGDKITLANERPIFVEGL
RDRHDSWLPIYMGAN
>Mature_735_residues
MIPNTPSITPELVAEHGLKPDEYQRFVELIGREPTITELGIVSAMWNEHCSYKSSKVWLRTLPTKGPRVIQGPGENAGVV
DIGDGLAVVFKMESHNHPSFIEPYQGAGTGVGGILRDVFTMGARPIAALNALRFGDPHHPRTRRLLAGVVAGIGGYGNSF
GVPTVGGSVGFHERYNGNILVNAMAVGLAKTDEIFYAAAAGVGRSIVYLGSKTGRDGIHGATMASAEFGADAEEKRPTVQ
VGDPFAEKLLLEACLEIMQAGCVVAIQDMGAAGLTCSAVEMGAKGDLGVELDLNAVPCRETGMTAYEMMLSESQERMLMV
IADGKEDQAEAIFRKWGLDFAIIGKTTDTLRFVVKHDGDVKADLPIKELGDEAPEYYRPFTETPPRPVLGPSDVNHAVSV
ADALERLIASPDLCSKRWVWEQYDHLILGNTVQRPGGDAAVVRVNEGPKALALTTDVTPRYCEADPFEGGKQAVAEAWRN
LTAVGATPIAVTDNLNFGNPEKPEIMGQFVGCVKGIGAACEALDFPVVSGNVSLYNETNGQGILPTPTIGGVGLIDDVEQ
SMTLAFKAAGEAIFVVGKTDGWLGSSAYLYTVCDREDGAPPPVDLVAEKRNGDFVRGLIKDDFITAAHDVSDGGLLVAIA
EMAMAGRIGASVDGVPAGMPAHSFWFGEDQARYVVTLPANQAAEMVRRAEAAGVPVTKLGKTGGDKITLANERPIFVEGL
RDRHDSWLPIYMGAN

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family

Homologues:

Organism=Homo sapiens, GI31657129, Length=694, Percent_Identity=25.6484149855908, Blast_Score=113, Evalue=8e-25,
Organism=Escherichia coli, GI48994899, Length=816, Percent_Identity=25, Blast_Score=144, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17553022, Length=651, Percent_Identity=23.0414746543779, Blast_Score=105, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6321498, Length=739, Percent_Identity=23.4100135317997, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24582111, Length=740, Percent_Identity=24.8648648648649, Blast_Score=107, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24582109, Length=740, Percent_Identity=24.8648648648649, Blast_Score=107, Evalue=4e-23,
Organism=Drosophila melanogaster, GI17137292, Length=740, Percent_Identity=24.8648648648649, Blast_Score=107, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURL_AZOC5 (A8I8B0)

Other databases:

- EMBL:   AP009384
- RefSeq:   YP_001525147.1
- ProteinModelPortal:   A8I8B0
- SMR:   A8I8B0
- GeneID:   5689460
- GenomeReviews:   AP009384_GR
- KEGG:   azc:AZC_2231
- HOGENOM:   HBG311214
- OMA:   YGNSFGV
- ProtClustDB:   PRK01213
- BioCyc:   ACAU438753:AZC_2231-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00420
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188
- TIGRFAMs:   TIGR01736

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.5.3

Molecular weight: Translated: 78146; Mature: 78146

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPNTPSITPELVAEHGLKPDEYQRFVELIGREPTITELGIVSAMWNEHCSYKSSKVWLR
CCCCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEE
TLPTKGPRVIQGPGENAGVVDIGDGLAVVFKMESHNHPSFIEPYQGAGTGVGGILRDVFT
ECCCCCCEEEECCCCCCCEEECCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHH
MGARPIAALNALRFGDPHHPRTRRLLAGVVAGIGGYGNSFGVPTVGGSVGFHERYNGNIL
HCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEECCCCEE
VNAMAVGLAKTDEIFYAAAAGVGRSIVYLGSKTGRDGIHGATMASAEFGADAEEKRPTVQ
EEEEEECCCCCCCEEEEECCCCCCEEEEECCCCCCCCCCCCEECCHHCCCCHHHCCCEEE
VGDPFAEKLLLEACLEIMQAGCVVAIQDMGAAGLTCSAVEMGAKGDLGVELDLNAVPCRE
ECCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEHHEECCCCCCCCEEEECCCCCCCC
TGMTAYEMMLSESQERMLMVIADGKEDQAEAIFRKWGLDFAIIGKTTDTLRFVVKHDGDV
CCCHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHCCCEEEECCCCCCEEEEEECCCCC
KADLPIKELGDEAPEYYRPFTETPPRPVLGPSDVNHAVSVADALERLIASPDLCSKRWVW
EECCCHHHHCCCCHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHCCCCH
EQYDHLILGNTVQRPGGDAAVVRVNEGPKALALTTDVTPRYCEADPFEGGKQAVAEAWRN
HHHCCEEECCCCCCCCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHC
LTAVGATPIAVTDNLNFGNPEKPEIMGQFVGCVKGIGAACEALDFPVVSGNVSLYNETNG
EEECCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCEEEEECCCC
QGILPTPTIGGVGLIDDVEQSMTLAFKAAGEAIFVVGKTDGWLGSSAYLYTVCDREDGAP
CEECCCCCCCCCCCHHHHHHHHEEEEEECCCEEEEEECCCCCCCCCEEEEEEECCCCCCC
PPVDLVAEKRNGDFVRGLIKDDFITAAHDVSDGGLLVAIAEMAMAGRIGASVDGVPAGMP
CCHHEEEECCCCCEEEHHHHHCCEEHHCCCCCCCEEHHHHHHHHHCCCCCCCCCCCCCCC
AHSFWFGEDQARYVVTLPANQAAEMVRRAEAAGVPVTKLGKTGGDKITLANERPIFVEGL
CCCEECCCCCCCEEEEECCHHHHHHHHHHHHCCCCHHHHCCCCCCEEEEECCCCEEEECH
RDRHDSWLPIYMGAN
HCCCCCEEEEEECCC
>Mature Secondary Structure
MIPNTPSITPELVAEHGLKPDEYQRFVELIGREPTITELGIVSAMWNEHCSYKSSKVWLR
CCCCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEE
TLPTKGPRVIQGPGENAGVVDIGDGLAVVFKMESHNHPSFIEPYQGAGTGVGGILRDVFT
ECCCCCCEEEECCCCCCCEEECCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHH
MGARPIAALNALRFGDPHHPRTRRLLAGVVAGIGGYGNSFGVPTVGGSVGFHERYNGNIL
HCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEECCCCEE
VNAMAVGLAKTDEIFYAAAAGVGRSIVYLGSKTGRDGIHGATMASAEFGADAEEKRPTVQ
EEEEEECCCCCCCEEEEECCCCCCEEEEECCCCCCCCCCCCEECCHHCCCCHHHCCCEEE
VGDPFAEKLLLEACLEIMQAGCVVAIQDMGAAGLTCSAVEMGAKGDLGVELDLNAVPCRE
ECCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEHHEECCCCCCCCEEEECCCCCCCC
TGMTAYEMMLSESQERMLMVIADGKEDQAEAIFRKWGLDFAIIGKTTDTLRFVVKHDGDV
CCCHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHCCCEEEECCCCCCEEEEEECCCCC
KADLPIKELGDEAPEYYRPFTETPPRPVLGPSDVNHAVSVADALERLIASPDLCSKRWVW
EECCCHHHHCCCCHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHCCCCH
EQYDHLILGNTVQRPGGDAAVVRVNEGPKALALTTDVTPRYCEADPFEGGKQAVAEAWRN
HHHCCEEECCCCCCCCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHC
LTAVGATPIAVTDNLNFGNPEKPEIMGQFVGCVKGIGAACEALDFPVVSGNVSLYNETNG
EEECCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCEEEEECCCC
QGILPTPTIGGVGLIDDVEQSMTLAFKAAGEAIFVVGKTDGWLGSSAYLYTVCDREDGAP
CEECCCCCCCCCCCHHHHHHHHEEEEEECCCEEEEEECCCCCCCCCEEEEEEECCCCCCC
PPVDLVAEKRNGDFVRGLIKDDFITAAHDVSDGGLLVAIAEMAMAGRIGASVDGVPAGMP
CCHHEEEECCCCCEEEHHHHHCCEEHHCCCCCCCEEHHHHHHHHHCCCCCCCCCCCCCCC
AHSFWFGEDQARYVVTLPANQAAEMVRRAEAAGVPVTKLGKTGGDKITLANERPIFVEGL
CCCEECCCCCCCEEEEECCHHHHHHHHHHHHCCCCHHHHCCCCCCEEEEECCCCEEEECH
RDRHDSWLPIYMGAN
HCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA