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The map label for this gene is lrgA [H]

Identifier: 158423806

GI number: 158423806

Start: 2499121

End: 2499516

Strand: Direct

Name: lrgA [H]

Synonym: AZC_2182

Alternate gene names: 158423806

Gene position: 2499121-2499516 (Clockwise)

Preceding gene: 158423804

Following gene: 158423807

Centisome position: 46.54

GC content: 67.93

Gene sequence:

>396_bases
ATGCCCCGTTCCCTCAGTACCCGCCTCTCCATGCTGCACCGCACTCGCCCGGTGCAGATCGCCGTTCTCGGCGCCTTCTG
GTTCTTCGGCGACACGGCCGCGCGCGCCATGGGCCTGCCCATTCCCGGCGGCGTCATCGGCATGCTGGCGCTGCTCACGC
TGCTCGGCACCGGCCTGATGAAGGTGACGAGCGTCGGCGGCGGCGCGAAGGTGCTGCTGGCGGAAATGCTGCTCTTCTTC
GTGCCGTCCGTTCTCGCCGTGCTCGACCACCGCGAGTTCATCGGTGCCGTCGGTCTCAAGATCGCCGCCGTGATCTTCGT
CGGCACGGTCATGGTGATGGTGGTCACGGCCCTCACCGTGGACCTCTGCTACCGCTGGCAGGCCCGTCATGCCTGA

Upstream 100 bases:

>100_bases
AATAAATTCGTCCAATTCATTTTACGCATGATGCGTTGCAACGTAAAGTGCAAGGCAAGTCGGATGAACCGGCGCCTTCC
AGCATTTACATGGTTTTCCC

Downstream 100 bases:

>100_bases
TGCCTTGCAGAGCCTTCTGGGCGCGCTGTTCTGGTCGCTGGTGACCATCGGCTGCTACGCGCTGGCGCGGCTCATCAATC
AGAAGGCGCGGGCCTGGTGG

Product: effector of murein hydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 131; Mature: 130

Protein sequence:

>131_residues
MPRSLSTRLSMLHRTRPVQIAVLGAFWFFGDTAARAMGLPIPGGVIGMLALLTLLGTGLMKVTSVGGGAKVLLAEMLLFF
VPSVLAVLDHREFIGAVGLKIAAVIFVGTVMVMVVTALTVDLCYRWQARHA

Sequences:

>Translated_131_residues
MPRSLSTRLSMLHRTRPVQIAVLGAFWFFGDTAARAMGLPIPGGVIGMLALLTLLGTGLMKVTSVGGGAKVLLAEMLLFF
VPSVLAVLDHREFIGAVGLKIAAVIFVGTVMVMVVTALTVDLCYRWQARHA
>Mature_130_residues
PRSLSTRLSMLHRTRPVQIAVLGAFWFFGDTAARAMGLPIPGGVIGMLALLTLLGTGLMKVTSVGGGAKVLLAEMLLFFV
PSVLAVLDHREFIGAVGLKIAAVIFVGTVMVMVVTALTVDLCYRWQARHA

Specific function: Increases the activity of extracellular murein hydrolases possibly by mediating their export via hole formation. Inhibited by the antiholin-like proteins LrgAB. In an unstressed cell, the LrgAB products probably inhibit the function of the CidA protein. W

COG id: COG1380

COG function: function code R; Putative effector of murein hydrolase LrgA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CidA/LrgA family. CidA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005538 [H]

Pfam domain/function: PF03788 LrgA [H]

EC number: NA

Molecular weight: Translated: 13965; Mature: 13834

Theoretical pI: Translated: 11.42; Mature: 11.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
6.1 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRSLSTRLSMLHRTRPVQIAVLGAFWFFGDTAARAMGLPIPGGVIGMLALLTLLGTGLM
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
KVTSVGGGAKVLLAEMLLFFVPSVLAVLDHREFIGAVGLKIAAVIFVGTVMVMVVTALTV
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLCYRWQARHA
HHHHHHHHCCC
>Mature Secondary Structure 
PRSLSTRLSMLHRTRPVQIAVLGAFWFFGDTAARAMGLPIPGGVIGMLALLTLLGTGLM
CCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
KVTSVGGGAKVLLAEMLLFFVPSVLAVLDHREFIGAVGLKIAAVIFVGTVMVMVVTALTV
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLCYRWQARHA
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]