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The map label for this gene is aphA [H]

Identifier: 158423673

GI number: 158423673

Start: 2362875

End: 2363906

Strand: Direct

Name: aphA [H]

Synonym: AZC_2049

Alternate gene names: 158423673

Gene position: 2362875-2363906 (Clockwise)

Preceding gene: 158423672

Following gene: 158423675

Centisome position: 44.0

GC content: 67.25

Gene sequence:

>1032_bases
ATGAAGTTCATTTTCGATCCGCGCCAGCTGCTGCATGACCCGGAACTCTATTTCCGCCGTGGCGCCTTCATTCCCCATCC
CGAACAGCCCCAGCGCGCCATTCTCGTGCGCGATGCGCTGCTTGCGGCCGCCCATGAGATGGAGGCGCCGCGCGACCACG
GCATCGCACCGGTGAAGGCGGTGCATGACGAGGGCTATGTGGACTTCCTGCTCACCGGCTGGCCGGAATGGGTGAAGGCC
ACCGGCACCACCGTGCCCGCTGTGCCGAACTATCACACGGACCGGCGCACCTGGCGCGTGCCGAAGGGCGTCATCGGCAA
GCTCGGCTATTATTCCACCGACACGTCCTGTCCGCTCGTGGAAGGCACAGCCACTGCCATCTACTGGTCGGCCCAGACGG
CCATCGAGGCGGCCGAGCGGGTGCGCACGGGCGAGACGGACCACATCTATGCCCTGTGCCGTCCGCCCGGCCACCATGCG
GTGCAGGACGCGAGCTGGGGCTTCTGCTTCTTCAACAATGCGGCGGTGGCGGCCCAGCATCTGCGCGGGCGCTTCGGCAA
GGTGGCGATCCTCGACGTGGATACGCACGCCGGCAACGGCACGCAGGACATCTTCTATGAGCGTGGCGACGTGCTCTATG
TCTCCATTCACACTGATCCCAGCGACTATACCCCCTTCTTCCTCGGCTATGAGGATGAGACCGGGCGAGGGGAGGGCGCG
GGCGCGACCCGCAATCTCGTGCTCCCGGTTGGCGCGGGCGTGGAGGACATTCTCGCGCGCTATGACGCGGCGGTGGAGAT
CATCCGCGCGTCCGGCGTCGAGGCGCTGGTGCTCTCCCTCGGCCTCGACATGTCGAAGGACGATCCGCTCTCCCTCGTGG
GCATGACCACGGAGGGCTTCCGCATCGGCGCGGCGAAGCTCGCAGCGCTCGGCCTGCCGACGGTCATCGTCCAGGAGGGC
GGCTATCTCGGGCCGTCCCTGTCGGACAATGCCGTCGCCTTCCTCGGCGCCTTCGAGGCGGCGCGGACGTAG

Upstream 100 bases:

>100_bases
CGGCGGTCTGACGAGCGCGGGCTGCCCGCCACGGCGGCGGGCGGACCGCCTTGCGCACGGCAGCAAGTTTCCGCCGTGCG
ATGAGAGCACGAGGACTGTG

Downstream 100 bases:

>100_bases
CATCCGGATGGACGAAAGGCTCCCCGGCGGGCATCCGCGACGCCGGGGAGCCGAACGTCAGCCGCGTGCGGCACCGCGCA
GGGTGGGCAGGCCGATGCCG

Product: histone deacetylase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MKFIFDPRQLLHDPELYFRRGAFIPHPEQPQRAILVRDALLAAAHEMEAPRDHGIAPVKAVHDEGYVDFLLTGWPEWVKA
TGTTVPAVPNYHTDRRTWRVPKGVIGKLGYYSTDTSCPLVEGTATAIYWSAQTAIEAAERVRTGETDHIYALCRPPGHHA
VQDASWGFCFFNNAAVAAQHLRGRFGKVAILDVDTHAGNGTQDIFYERGDVLYVSIHTDPSDYTPFFLGYEDETGRGEGA
GATRNLVLPVGAGVEDILARYDAAVEIIRASGVEALVLSLGLDMSKDDPLSLVGMTTEGFRIGAAKLAALGLPTVIVQEG
GYLGPSLSDNAVAFLGAFEAART

Sequences:

>Translated_343_residues
MKFIFDPRQLLHDPELYFRRGAFIPHPEQPQRAILVRDALLAAAHEMEAPRDHGIAPVKAVHDEGYVDFLLTGWPEWVKA
TGTTVPAVPNYHTDRRTWRVPKGVIGKLGYYSTDTSCPLVEGTATAIYWSAQTAIEAAERVRTGETDHIYALCRPPGHHA
VQDASWGFCFFNNAAVAAQHLRGRFGKVAILDVDTHAGNGTQDIFYERGDVLYVSIHTDPSDYTPFFLGYEDETGRGEGA
GATRNLVLPVGAGVEDILARYDAAVEIIRASGVEALVLSLGLDMSKDDPLSLVGMTTEGFRIGAAKLAALGLPTVIVQEG
GYLGPSLSDNAVAFLGAFEAART
>Mature_343_residues
MKFIFDPRQLLHDPELYFRRGAFIPHPEQPQRAILVRDALLAAAHEMEAPRDHGIAPVKAVHDEGYVDFLLTGWPEWVKA
TGTTVPAVPNYHTDRRTWRVPKGVIGKLGYYSTDTSCPLVEGTATAIYWSAQTAIEAAERVRTGETDHIYALCRPPGHHA
VQDASWGFCFFNNAAVAAQHLRGRFGKVAILDVDTHAGNGTQDIFYERGDVLYVSIHTDPSDYTPFFLGYEDETGRGEGA
GATRNLVLPVGAGVEDILARYDAAVEIIRASGVEALVLSLGLDMSKDDPLSLVGMTTEGFRIGAAKLAALGLPTVIVQEG
GYLGPSLSDNAVAFLGAFEAART

Specific function: Acts on many types of acetylpolyamines has high affinity towards acetylputrescine, acetylcadaverine, acetylspermidine, and acetylspermine [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI13128864, Length=222, Percent_Identity=36.036036036036, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI148539870, Length=232, Percent_Identity=32.7586206896552, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI169234807, Length=232, Percent_Identity=32.7586206896552, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI153085395, Length=227, Percent_Identity=33.920704845815, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI17158039, Length=115, Percent_Identity=42.6086956521739, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI30795204, Length=115, Percent_Identity=42.6086956521739, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI30795202, Length=115, Percent_Identity=42.6086956521739, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI20070354, Length=208, Percent_Identity=34.1346153846154, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI62750349, Length=106, Percent_Identity=41.5094339622642, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI62750347, Length=106, Percent_Identity=41.5094339622642, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI226529806, Length=137, Percent_Identity=37.956204379562, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI8923769, Length=171, Percent_Identity=31.5789473684211, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI13128860, Length=307, Percent_Identity=23.4527687296417, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI262073088, Length=171, Percent_Identity=30.4093567251462, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI293336691, Length=284, Percent_Identity=23.5915492957746, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI262073092, Length=111, Percent_Identity=33.3333333333333, Blast_Score=68, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17540332, Length=198, Percent_Identity=38.3838383838384, Blast_Score=111, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI193206283, Length=198, Percent_Identity=38.3838383838384, Blast_Score=110, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI17540334, Length=198, Percent_Identity=38.3838383838384, Blast_Score=110, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI193209491, Length=295, Percent_Identity=31.864406779661, Blast_Score=107, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI17537347, Length=192, Percent_Identity=34.8958333333333, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17534739, Length=309, Percent_Identity=24.9190938511327, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17508561, Length=308, Percent_Identity=25, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17561978, Length=218, Percent_Identity=27.0642201834862, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI25154020, Length=213, Percent_Identity=26.2910798122066, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI25154022, Length=100, Percent_Identity=35, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6324307, Length=334, Percent_Identity=29.6407185628743, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6323999, Length=218, Percent_Identity=27.5229357798165, Blast_Score=80, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6321244, Length=313, Percent_Identity=22.0447284345048, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI281360799, Length=229, Percent_Identity=34.061135371179, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI281360899, Length=319, Percent_Identity=31.974921630094, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24641720, Length=229, Percent_Identity=34.061135371179, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI281360801, Length=229, Percent_Identity=34.061135371179, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24642144, Length=239, Percent_Identity=35.9832635983264, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24642142, Length=239, Percent_Identity=35.9832635983264, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24642146, Length=239, Percent_Identity=35.9832635983264, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24657891, Length=309, Percent_Identity=24.2718446601942, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24644244, Length=309, Percent_Identity=23.3009708737864, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 37193; Mature: 37193

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFIFDPRQLLHDPELYFRRGAFIPHPEQPQRAILVRDALLAAAHEMEAPRDHGIAPVKA
CCCEECHHHHHCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHCCCCCEEE
VHDEGYVDFLLTGWPEWVKATGTTVPAVPNYHTDRRTWRVPKGVIGKLGYYSTDTSCPLV
ECCCCCEEEEECCCHHHHHHCCCCCCCCCCCCCCCEEEECCHHHHHCCCCCCCCCCCCEE
EGTATAIYWSAQTAIEAAERVRTGETDHIYALCRPPGHHAVQDASWGFCFFNNAAVAAQH
CCCEEEEEEEHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCEEEECCHHHHHHH
LRGRFGKVAILDVDTHAGNGTQDIFYERGDVLYVSIHTDPSDYTPFFLGYEDETGRGEGA
HHCCCCEEEEEEEECCCCCCCHHHEEECCCEEEEEEECCCCCCCCEEEEECCCCCCCCCC
GATRNLVLPVGAGVEDILARYDAAVEIIRASGVEALVLSLGLDMSKDDPLSLVGMTTEGF
CCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCHHEEHHHHCCCCCCCCCEEEEEECCCCE
RIGAAKLAALGLPTVIVQEGGYLGPSLSDNAVAFLGAFEAART
EECHHHHHHHCCCEEEEECCCCCCCCCCCCCEEEEEHHHHHCC
>Mature Secondary Structure
MKFIFDPRQLLHDPELYFRRGAFIPHPEQPQRAILVRDALLAAAHEMEAPRDHGIAPVKA
CCCEECHHHHHCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHCCCCCEEE
VHDEGYVDFLLTGWPEWVKATGTTVPAVPNYHTDRRTWRVPKGVIGKLGYYSTDTSCPLV
ECCCCCEEEEECCCHHHHHHCCCCCCCCCCCCCCCEEEECCHHHHHCCCCCCCCCCCCEE
EGTATAIYWSAQTAIEAAERVRTGETDHIYALCRPPGHHAVQDASWGFCFFNNAAVAAQH
CCCEEEEEEEHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCEEEECCHHHHHHH
LRGRFGKVAILDVDTHAGNGTQDIFYERGDVLYVSIHTDPSDYTPFFLGYEDETGRGEGA
HHCCCCEEEEEEEECCCCCCCHHHEEECCCEEEEEEECCCCCCCCEEEEECCCCCCCCCC
GATRNLVLPVGAGVEDILARYDAAVEIIRASGVEALVLSLGLDMSKDDPLSLVGMTTEGF
CCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCHHEEHHHHCCCCCCCCCEEEEEECCCCE
RIGAAKLAALGLPTVIVQEGGYLGPSLSDNAVAFLGAFEAART
EECHHHHHHHCCCEEEEECCCCCCCCCCCCCEEEEEHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8824626; 3207420 [H]