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The map label for this gene is rnc

Identifier: 158423628

GI number: 158423628

Start: 2310474

End: 2311181

Strand: Direct

Name: rnc

Synonym: AZC_2004

Alternate gene names: 158423628

Gene position: 2310474-2311181 (Clockwise)

Preceding gene: 158423627

Following gene: 158423629

Centisome position: 43.03

GC content: 70.34

Gene sequence:

>708_bases
ATGAGCGAGACGCAGGATTTCGCCGCGCTGGAGGCGCGGCTCGGGCACAGCTTCGCCGACCGCAGCCATCTCGTGCTCGC
GCTGACTCATATCAGCTCGGTTAAGGGGCAGGCGGTGCGCGTGCGCTCCTACCAGCGGCTGGAATTCCTCGGCGACCACG
TGCTTGGCAGCGTGGTTTCGCATATGCTTTACGCTGCGTTCCCCAAGGCGGAGGAGGGTGAACTGTCCCGCCGCCTCGCG
GAACTGGTGCGCGAGGAGGCCTGCGCCGAGGTGGCACAGGACATGGGCCTCGGGCCCTATCTGCGGCTCGGCCCCGGCGA
GGCCCAGTCCGGCGCCCGCCAGCGCCGGGCCATTCTGGCCGACGTGGCCGAGGCGGTGGTGGCGGCGGTCTATCTGGACG
GCGGCTATGAGGCGGCTTCCGCCTTGGTGGAGCGCTTCTGGCGCGGTCGCCTGGAAGCGCCCCGGCGCCCGCTGCGCGAC
CCGAAGACGGTGTTGCAGGAATGGGCGCAAGCCCGCGGCCTGCCGCCACCGGTCTATCGGGACGTGGAGCGCTCCGGACC
CGACCATGCGCCGCGCTTCCGCGTGGCGGTGGATCTGCCGGGGCTGGAATGCGCCGAGGCTGAGGGCGGATCGAAACAGA
CAGCGCAGAAGGCTGCGGCCTCTGCATTTCTCGCCCGCGAGGGCGTCGTGACGGAGAGTGGTGAATGA

Upstream 100 bases:

>100_bases
CGCAGATGATCTTCTTCTCCATCGATGAGCACACCCCGGCCTGGCAGGTGTGGAACTGGCCCTGGACCGTGCGTTGGACC
CGCATCTTCAGCATGGTGCG

Downstream 100 bases:

>100_bases
ACGGATTGGAGCGGGCGGAAGCGGAGGGCGCGGAGCCGACGCGGTGCGGTTTCGTGGCCTTGCTGGGCGCCCCCAATGCG
GGCAAGTCCACCCTCACCAA

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III

Number of amino acids: Translated: 235; Mature: 234

Protein sequence:

>235_residues
MSETQDFAALEARLGHSFADRSHLVLALTHISSVKGQAVRVRSYQRLEFLGDHVLGSVVSHMLYAAFPKAEEGELSRRLA
ELVREEACAEVAQDMGLGPYLRLGPGEAQSGARQRRAILADVAEAVVAAVYLDGGYEAASALVERFWRGRLEAPRRPLRD
PKTVLQEWAQARGLPPPVYRDVERSGPDHAPRFRVAVDLPGLECAEAEGGSKQTAQKAAASAFLAREGVVTESGE

Sequences:

>Translated_235_residues
MSETQDFAALEARLGHSFADRSHLVLALTHISSVKGQAVRVRSYQRLEFLGDHVLGSVVSHMLYAAFPKAEEGELSRRLA
ELVREEACAEVAQDMGLGPYLRLGPGEAQSGARQRRAILADVAEAVVAAVYLDGGYEAASALVERFWRGRLEAPRRPLRD
PKTVLQEWAQARGLPPPVYRDVERSGPDHAPRFRVAVDLPGLECAEAEGGSKQTAQKAAASAFLAREGVVTESGE
>Mature_234_residues
SETQDFAALEARLGHSFADRSHLVLALTHISSVKGQAVRVRSYQRLEFLGDHVLGSVVSHMLYAAFPKAEEGELSRRLAE
LVREEACAEVAQDMGLGPYLRLGPGEAQSGARQRRAILADVAEAVVAAVYLDGGYEAASALVERFWRGRLEAPRRPLRDP
KTVLQEWAQARGLPPPVYRDVERSGPDHAPRFRVAVDLPGLECAEAEGGSKQTAQKAAASAFLAREGVVTESGE

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain

Homologues:

Organism=Homo sapiens, GI155030236, Length=223, Percent_Identity=28.6995515695067, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI155030234, Length=223, Percent_Identity=28.6995515695067, Blast_Score=79, Evalue=5e-15,
Organism=Escherichia coli, GI1788920, Length=195, Percent_Identity=40, Blast_Score=141, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI17506883, Length=227, Percent_Identity=30.8370044052863, Blast_Score=80, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI193202651, Length=227, Percent_Identity=30.8370044052863, Blast_Score=80, Evalue=6e-16,
Organism=Drosophila melanogaster, GI17137682, Length=219, Percent_Identity=33.7899543378995, Blast_Score=81, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNC_AZOC5 (A8I3B5)

Other databases:

- EMBL:   AP009384
- RefSeq:   YP_001524920.1
- ProteinModelPortal:   A8I3B5
- SMR:   A8I3B5
- GeneID:   5689508
- GenomeReviews:   AP009384_GR
- KEGG:   azc:AZC_2004
- HOGENOM:   HBG744556
- OMA:   ALTHKSF
- ProtClustDB:   CLSK980124
- BioCyc:   ACAU438753:AZC_2004-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00104
- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907
- Gene3D:   G3DSA:3.30.160.20
- Gene3D:   G3DSA:1.10.1520.10
- SMART:   SM00358
- SMART:   SM00535
- TIGRFAMs:   TIGR02191

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3; SSF69065 RNase_III

EC number: =3.1.26.3

Molecular weight: Translated: 25499; Mature: 25368

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS50137 DS_RBD; PS00517 RNASE_3_1; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSETQDFAALEARLGHSFADRSHLVLALTHISSVKGQAVRVRSYQRLEFLGDHVLGSVVS
CCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
HMLYAAFPKAEEGELSRRLAELVREEACAEVAQDMGLGPYLRLGPGEAQSGARQRRAILA
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHH
DVAEAVVAAVYLDGGYEAASALVERFWRGRLEAPRRPLRDPKTVLQEWAQARGLPPPVYR
HHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHH
DVERSGPDHAPRFRVAVDLPGLECAEAEGGSKQTAQKAAASAFLAREGVVTESGE
HHHHCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SETQDFAALEARLGHSFADRSHLVLALTHISSVKGQAVRVRSYQRLEFLGDHVLGSVVS
CCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
HMLYAAFPKAEEGELSRRLAELVREEACAEVAQDMGLGPYLRLGPGEAQSGARQRRAILA
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHH
DVAEAVVAAVYLDGGYEAASALVERFWRGRLEAPRRPLRDPKTVLQEWAQARGLPPPVYR
HHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHH
DVERSGPDHAPRFRVAVDLPGLECAEAEGGSKQTAQKAAASAFLAREGVVTESGE
HHHHCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA