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The map label for this gene is era [H]

Identifier: 158423629

GI number: 158423629

Start: 2311178

End: 2312113

Strand: Direct

Name: era [H]

Synonym: AZC_2005

Alternate gene names: 158423629

Gene position: 2311178-2312113 (Clockwise)

Preceding gene: 158423628

Following gene: 158423630

Centisome position: 43.04

GC content: 65.6

Gene sequence:

>936_bases
ATGAACGGATTGGAGCGGGCGGAAGCGGAGGGCGCGGAGCCGACGCGGTGCGGTTTCGTGGCCTTGCTGGGCGCCCCCAA
TGCGGGCAAGTCCACCCTCACCAACCAGTTGGTCGGCACCAAGGTCTCCATCGTCTCGCACAAGGTGCAGACGACCCGCG
CGATCGTGCGTGGCATCGCGCTGGAAGGCCCGTCTCAGGTCATTCTCGTGGACACCCCCGGCATCTTCTCGCCCAAGCGG
CGGCTGGAGCGGGCCATGGTGAACACCGCCTGGACCAGCGCCTCTGACGCGGACGTGGTGGCTCTCCTCGTGGATGCCAA
CCGGGGCATCGACGAGAACGTGGAATCGATCCTGAAGCCCCTCGCGGAGGTGAAGCGCCCGCGCGCGCTCATCCTGAACA
AGATCGACATGATCCGCCGCGACACGCTGCTGGAGCTGGCGCAGAAGCTCACCGAGCGCCTGTCTTTCGAGCGCGTGTTC
ATGGTCTCCGCGCTCAAGGGCGACGGCGTGGACGATGTGCGCACGTGGTTCGCCGAGAAGGTGCCGTTCGGCCCCTGGCT
CTATCCCGAGGACCAGATCTCGGACGCGCCCATGCGCATGCTGGCGGCGGAGATCACCCGCGAGAAGCTGTTCCTGCGCC
TGCACGACGAACTGCCCTATCGCTCCACGGTCGAGACCGATTCGTGGAAGGAGCTGCGCGACAAGTCCGTGCGCATCGAG
CAGACCATCTTCGTGGAGCGGGAAAGCCAGCGGAAGATCGTGCTCGGCAAGGCGGGGGCGACCATCAAGGCCATCTCGTC
CGAATCGCGGGCGGAGATTTCCGAGATCATCGAGGCCCCGGTGCATCTCTTCCTGTTCGTGAAGGTGCGCGAGAACTGGG
CCGATGATCCGGAGCGCTATCGCGAGATGGGGCTCGAATTCCCGCACGGAGACTGA

Upstream 100 bases:

>100_bases
TGGAATGCGCCGAGGCTGAGGGCGGATCGAAACAGACAGCGCAGAAGGCTGCGGCCTCTGCATTTCTCGCCCGCGAGGGC
GTCGTGACGGAGAGTGGTGA

Downstream 100 bases:

>100_bases
CACCGCCGTGGAATGGACCGACGCGGGCATCGTTCTTGGCGTGCGTCGCCACGGGGAAACGAGTGCCATCGTCGATCTGA
TGACGCGGGAGCGGGGCCGT

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MNGLERAEAEGAEPTRCGFVALLGAPNAGKSTLTNQLVGTKVSIVSHKVQTTRAIVRGIALEGPSQVILVDTPGIFSPKR
RLERAMVNTAWTSASDADVVALLVDANRGIDENVESILKPLAEVKRPRALILNKIDMIRRDTLLELAQKLTERLSFERVF
MVSALKGDGVDDVRTWFAEKVPFGPWLYPEDQISDAPMRMLAAEITREKLFLRLHDELPYRSTVETDSWKELRDKSVRIE
QTIFVERESQRKIVLGKAGATIKAISSESRAEISEIIEAPVHLFLFVKVRENWADDPERYREMGLEFPHGD

Sequences:

>Translated_311_residues
MNGLERAEAEGAEPTRCGFVALLGAPNAGKSTLTNQLVGTKVSIVSHKVQTTRAIVRGIALEGPSQVILVDTPGIFSPKR
RLERAMVNTAWTSASDADVVALLVDANRGIDENVESILKPLAEVKRPRALILNKIDMIRRDTLLELAQKLTERLSFERVF
MVSALKGDGVDDVRTWFAEKVPFGPWLYPEDQISDAPMRMLAAEITREKLFLRLHDELPYRSTVETDSWKELRDKSVRIE
QTIFVERESQRKIVLGKAGATIKAISSESRAEISEIIEAPVHLFLFVKVRENWADDPERYREMGLEFPHGD
>Mature_311_residues
MNGLERAEAEGAEPTRCGFVALLGAPNAGKSTLTNQLVGTKVSIVSHKVQTTRAIVRGIALEGPSQVILVDTPGIFSPKR
RLERAMVNTAWTSASDADVVALLVDANRGIDENVESILKPLAEVKRPRALILNKIDMIRRDTLLELAQKLTERLSFERVF
MVSALKGDGVDDVRTWFAEKVPFGPWLYPEDQISDAPMRMLAAEITREKLFLRLHDELPYRSTVETDSWKELRDKSVRIE
QTIFVERESQRKIVLGKAGATIKAISSESRAEISEIIEAPVHLFLFVKVRENWADDPERYREMGLEFPHGD

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism [H]

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain [H]

Homologues:

Organism=Homo sapiens, GI24307899, Length=327, Percent_Identity=32.7217125382263, Blast_Score=139, Evalue=4e-33,
Organism=Escherichia coli, GI1788919, Length=294, Percent_Identity=41.156462585034, Blast_Score=208, Evalue=3e-55,
Organism=Escherichia coli, GI87082120, Length=160, Percent_Identity=30.625, Blast_Score=69, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24646434, Length=315, Percent_Identity=26.6666666666667, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005662
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 34918; Mature: 34918

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGLERAEAEGAEPTRCGFVALLGAPNAGKSTLTNQLVGTKVSIVSHKVQTTRAIVRGIA
CCCCCHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHC
LEGPSQVILVDTPGIFSPKRRLERAMVNTAWTSASDADVVALLVDANRGIDENVESILKP
CCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCHHHHHHHHHH
LAEVKRPRALILNKIDMIRRDTLLELAQKLTERLSFERVFMVSALKGDGVDDVRTWFAEK
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHC
VPFGPWLYPEDQISDAPMRMLAAEITREKLFLRLHDELPYRSTVETDSWKELRDKSVRIE
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCEEE
QTIFVERESQRKIVLGKAGATIKAISSESRAEISEIIEAPVHLFLFVKVRENWADDPERY
HEEEEEECCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHEEEEEECCCCCCCHHHH
REMGLEFPHGD
HHCCCCCCCCC
>Mature Secondary Structure
MNGLERAEAEGAEPTRCGFVALLGAPNAGKSTLTNQLVGTKVSIVSHKVQTTRAIVRGIA
CCCCCHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHC
LEGPSQVILVDTPGIFSPKRRLERAMVNTAWTSASDADVVALLVDANRGIDENVESILKP
CCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCHHHHHHHHHH
LAEVKRPRALILNKIDMIRRDTLLELAQKLTERLSFERVFMVSALKGDGVDDVRTWFAEK
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHC
VPFGPWLYPEDQISDAPMRMLAAEITREKLFLRLHDELPYRSTVETDSWKELRDKSVRIE
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCEEE
QTIFVERESQRKIVLGKAGATIKAISSESRAEISEIIEAPVHLFLFVKVRENWADDPERY
HEEEEEECCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHEEEEEECCCCCCCHHHH
REMGLEFPHGD
HHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12597275; 9870699 [H]