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The map label for this gene is hom [H]

Identifier: 158423472

GI number: 158423472

Start: 2113733

End: 2115043

Strand: Direct

Name: hom [H]

Synonym: AZC_1848

Alternate gene names: 158423472

Gene position: 2113733-2115043 (Clockwise)

Preceding gene: 158423471

Following gene: 158423473

Centisome position: 39.36

GC content: 69.95

Gene sequence:

>1311_bases
ATGAGCCAGTTGAAGATTGGTCTGGCCGGCCTCGGCACGGTCGGCGCCGCCGTGGTTGGGATGCTGGAGCGCCGCGCCGG
CGAGATCGCGGCCCGCACCGGCCGTACCGTCAAGGTGGTCGCCGTCTCCGCCCGCTCGAAGTCCAAGGACCGCGGCGTCG
ATCTCTCCGCCGTGCGCTGGTATGACGACCCGGTGGAACTCGCCCGCGACCCGGACATCGACGTCTTCGTCGAGCTGATG
GGCGGCGAGGGCGATCCGGCCAGGGCGGCGGTTACCGCCGCGCTTCAGGCCGGCCGCGCGGTCGTAACCGCCAACAAGGC
GCTGCTTGCCCGCCACGGCCTTGAGCTGGCGAAGATCGCCGAAGCCTCCGGTGGCAGCCTGCATTTCGAGGCGGCGGTGG
CCGGCGGTATCCCCATCGTGAAGACGCTGCGCGAGGCGCTGGGCGGCAATCGCATCGGCCGCGTGTCCGGCATCCTCAAC
GGCACCTGCAACTACATTCTCACCCGCATGGCGGACGAGAAGCTGGCCTTCGACACCTGCCTGTCGGAAGCCCAGCGCCT
CGGCTATGCGGAGGCCGATCCCACCTTCGACATCGACGGCCACGACACCGCCCACAAGCTGGCGCTGCTCACGAGCCTCG
CCTTCGGCACGCAGGTGGACGCCGATTCCATCTATGTGGAGGGCATCCGCTCCCTGACCCTGGCCGATCTGGAAGCGGCC
GACGAACTCGGCTTCAACGTGAAGCTGCTGGGCGTTGCCGTGCGCACGGACGAAGGCATCGAGCAGCGCGTGCATCCGAC
CATGGTGCCCAAGGGCTGGCCCATCGCGCAGGTCTCCGGCGTCACCAATGCGGTGGCGGTGGATGGGGACGCGGTGAACC
TCACCCTTGTCGGTCCCGGTGCCGGCGGCGCGGCCACCGCTTCTGCCGTGGTGGGTGATCTCATCGATGTGGCCAAGGGC
AACCGGGGCTTTGCCTTCGGCCTGCCGGTTTCGGCGCTTGAGCCCTGCGAGCGCGCGCCCATGCAGCGCCACGGCGGGGG
CTACTACATCCGCCTGGCCGCCGTGAACAAGCCGGGCACCGCCGCCACCATCGCCGGCCGTATGGCGGAGGAGGGCATCT
CGCTCGCCTCCATCGTGCAGCGCCAGCCGGCCCGGGCCGCCGGCGCCAAGACGGTGGGGCCCGAGGACGTGGCGGTGATC
CTCATCACCTACGCCACCACCGAGGATGCCGTGCGCAAGGCCATCGACGCCATAGAGGCGGACGGGGTCATCGTCGGCCG
CCCGCAGGTGATCCGCATCGAGAAGGACTGA

Upstream 100 bases:

>100_bases
CCCACAGGGCGTCCCGTGCCAGCCTCGCGCTGGCACCGTGTCTATGATCCCGCCGCGGCCGTGAAGGTCGCGGCTTTCTC
ACAGGACATATGTTCGTTCC

Downstream 100 bases:

>100_bases
CGTCTCCATGTCCCGTGTCCCGCCCCAGCTCGACCGCCGTCTCGCCCTCGAACTCGCCCGCGTGACCGAGCGCGCGGCGG
TGGCGGCGGCCGTCTATCGC

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 436; Mature: 435

Protein sequence:

>436_residues
MSQLKIGLAGLGTVGAAVVGMLERRAGEIAARTGRTVKVVAVSARSKSKDRGVDLSAVRWYDDPVELARDPDIDVFVELM
GGEGDPARAAVTAALQAGRAVVTANKALLARHGLELAKIAEASGGSLHFEAAVAGGIPIVKTLREALGGNRIGRVSGILN
GTCNYILTRMADEKLAFDTCLSEAQRLGYAEADPTFDIDGHDTAHKLALLTSLAFGTQVDADSIYVEGIRSLTLADLEAA
DELGFNVKLLGVAVRTDEGIEQRVHPTMVPKGWPIAQVSGVTNAVAVDGDAVNLTLVGPGAGGAATASAVVGDLIDVAKG
NRGFAFGLPVSALEPCERAPMQRHGGGYYIRLAAVNKPGTAATIAGRMAEEGISLASIVQRQPARAAGAKTVGPEDVAVI
LITYATTEDAVRKAIDAIEADGVIVGRPQVIRIEKD

Sequences:

>Translated_436_residues
MSQLKIGLAGLGTVGAAVVGMLERRAGEIAARTGRTVKVVAVSARSKSKDRGVDLSAVRWYDDPVELARDPDIDVFVELM
GGEGDPARAAVTAALQAGRAVVTANKALLARHGLELAKIAEASGGSLHFEAAVAGGIPIVKTLREALGGNRIGRVSGILN
GTCNYILTRMADEKLAFDTCLSEAQRLGYAEADPTFDIDGHDTAHKLALLTSLAFGTQVDADSIYVEGIRSLTLADLEAA
DELGFNVKLLGVAVRTDEGIEQRVHPTMVPKGWPIAQVSGVTNAVAVDGDAVNLTLVGPGAGGAATASAVVGDLIDVAKG
NRGFAFGLPVSALEPCERAPMQRHGGGYYIRLAAVNKPGTAATIAGRMAEEGISLASIVQRQPARAAGAKTVGPEDVAVI
LITYATTEDAVRKAIDAIEADGVIVGRPQVIRIEKD
>Mature_435_residues
SQLKIGLAGLGTVGAAVVGMLERRAGEIAARTGRTVKVVAVSARSKSKDRGVDLSAVRWYDDPVELARDPDIDVFVELMG
GEGDPARAAVTAALQAGRAVVTANKALLARHGLELAKIAEASGGSLHFEAAVAGGIPIVKTLREALGGNRIGRVSGILNG
TCNYILTRMADEKLAFDTCLSEAQRLGYAEADPTFDIDGHDTAHKLALLTSLAFGTQVDADSIYVEGIRSLTLADLEAAD
ELGFNVKLLGVAVRTDEGIEQRVHPTMVPKGWPIAQVSGVTNAVAVDGDAVNLTLVGPGAGGAATASAVVGDLIDVAKGN
RGFAFGLPVSALEPCERAPMQRHGGGYYIRLAAVNKPGTAATIAGRMAEEGISLASIVQRQPARAAGAKTVGPEDVAVIL
ITYATTEDAVRKAIDAIEADGVIVGRPQVIRIEKD

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1790376, Length=358, Percent_Identity=26.536312849162, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1786183, Length=249, Percent_Identity=29.718875502008, Blast_Score=73, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6322599, Length=159, Percent_Identity=26.4150943396226, Blast_Score=68, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 45094; Mature: 44963

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQLKIGLAGLGTVGAAVVGMLERRAGEIAARTGRTVKVVAVSARSKSKDRGVDLSAVRW
CCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCEEEEEE
YDDPVELARDPDIDVFVELMGGEGDPARAAVTAALQAGRAVVTANKALLARHGLELAKIA
CCCHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCEEEEECHHHHHHCCCHHHHHH
EASGGSLHFEAAVAGGIPIVKTLREALGGNRIGRVSGILNGTCNYILTRMADEKLAFDTC
CCCCCCEEEEEEECCCCHHHHHHHHHHCCCCEEHHHHHHCCHHHHHHHHHHHHHHHHHHH
LSEAQRLGYAEADPTFDIDGHDTAHKLALLTSLAFGTQVDADSIYVEGIRSLTLADLEAA
HHHHHHCCCCCCCCCEECCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
DELGFNVKLLGVAVRTDEGIEQRVHPTMVPKGWPIAQVSGVTNAVAVDGDAVNLTLVGPG
HHCCCCEEEEEEEEECCCCHHHCCCCCCCCCCCCCCEECCCCEEEEECCCEEEEEEECCC
AGGAATASAVVGDLIDVAKGNRGFAFGLPVSALEPCERAPMQRHGGGYYIRLAAVNKPGT
CCCHHHHHHHHHHHHHHHCCCCCEEECCCHHHHCHHHHCCHHHCCCCEEEEEEEECCCCC
AATIAGRMAEEGISLASIVQRQPARAAGAKTVGPEDVAVILITYATTEDAVRKAIDAIEA
HHHHHHHHHHHCCHHHHHHHCCCCHHCCCCCCCCCCEEEEEEEEECCHHHHHHHHHHHCC
DGVIVGRPQVIRIEKD
CCEEECCCEEEEEECC
>Mature Secondary Structure 
SQLKIGLAGLGTVGAAVVGMLERRAGEIAARTGRTVKVVAVSARSKSKDRGVDLSAVRW
CCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCEEEEEE
YDDPVELARDPDIDVFVELMGGEGDPARAAVTAALQAGRAVVTANKALLARHGLELAKIA
CCCHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCEEEEECHHHHHHCCCHHHHHH
EASGGSLHFEAAVAGGIPIVKTLREALGGNRIGRVSGILNGTCNYILTRMADEKLAFDTC
CCCCCCEEEEEEECCCCHHHHHHHHHHCCCCEEHHHHHHCCHHHHHHHHHHHHHHHHHHH
LSEAQRLGYAEADPTFDIDGHDTAHKLALLTSLAFGTQVDADSIYVEGIRSLTLADLEAA
HHHHHHCCCCCCCCCEECCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
DELGFNVKLLGVAVRTDEGIEQRVHPTMVPKGWPIAQVSGVTNAVAVDGDAVNLTLVGPG
HHCCCCEEEEEEEEECCCCHHHCCCCCCCCCCCCCCEECCCCEEEEECCCEEEEEEECCC
AGGAATASAVVGDLIDVAKGNRGFAFGLPVSALEPCERAPMQRHGGGYYIRLAAVNKPGT
CCCHHHHHHHHHHHHHHHCCCCCEEECCCHHHHCHHHHCCHHHCCCCEEEEEEEECCCCC
AATIAGRMAEEGISLASIVQRQPARAAGAKTVGPEDVAVILITYATTEDAVRKAIDAIEA
HHHHHHHHHHHCCHHHHHHHCCCCHHCCCCCCCCCCEEEEEEEEECCHHHHHHHHHHHCC
DGVIVGRPQVIRIEKD
CCEEECCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]