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The map label for this gene is livM [H]

Identifier: 158423384

GI number: 158423384

Start: 2012363

End: 2013487

Strand: Direct

Name: livM [H]

Synonym: AZC_1760

Alternate gene names: 158423384

Gene position: 2012363-2013487 (Clockwise)

Preceding gene: 158423383

Following gene: 158423385

Centisome position: 37.48

GC content: 66.4

Gene sequence:

>1125_bases
ATGCGCGGCTCAGGCATTCTCGATCGCCGCGGGGCGATCTTCATCATCCTCGTGCTGGCGGCGGGCGTGCTGGTGCCGGC
CGGCAATCTGCTGGCGCCCGTCGGCAGCCCCTTCCATGTCTCGGACTATCTGGTGCCGCTGCTGGGCAAGTATCTGTGCT
ACGCGCTGCTGGCCGTGGCGGTGGATCTGGTCTGGGGCTATTGCGGCGTGCTCTCGCTCGGCCACGGCGCCTTCTTTGCG
CTCGGCGGCTATGCCATGGGCATGTATCTCATGCGCCAGATCGGCCCGCGCGGCGTCTATGGCAATCCCGTCCTGCCCGA
CTTCATGGTGTTCCTGAACTACAAGGAACTTCCCTGGTTCTGGCTGGGCTTCAACCATTTCCCCTTCGCCGCGCTGATGG
TGCTTGTGGTGCCGGGGCTGCTGGCCTTCGCCTTCGGCTGGTTCGCCTTCCGCTCGCGCGTTACGGGCGTCTATCTGTCC
ATCATCACGCAGGCCATGACCTTCGCGCTCATGCTCGCCTTCTTCCGCAATGACATGGGTTTCGGCGGCAACAACGGCCT
CACCGATTTCAAGGACATCCTCGGCTATTCCATCACCGCCGGCACGACCCGCGGGGCGCTGTTCTTCGCCTCTGCCGTGG
CGCTGGTGCTGGGCTATCTCATCTGCCGGGCGCTGGTCGTCTCGAAATACGGCAAGGTGCTGGTGGCGGTGCGCGATGCG
GAAAGCCGCACCCGCTTCCTCGGCTACAAGGTGGCCAACTACAAGCTCGTCGCCTGGACGCTCTCCGCCATGCTGGCCGG
TGTCGCCGGTGCGCTCTACGTGCCGCAGGTGGGCATCATCAATCCGGGCGAGTTCGCGCCGGCCAATTCCATCGAGACGG
TGATCTGGGTGGCGGTGGGCGGTCGCGGCACGCTGGTGGGCGCGGCGCTCGGCGCGCTGGTGGTGAATGCGGGCAAGACT
TGGTTCACAGGCGCACTGCCCGAGGCGTGGCTGTTTGCCCTCGGTGCGCTGTTCGTGGTGGTGACGCTGTTCCTGCCGCG
CGGCATCATCGGCCTGTGGGGGGATCTCTCCTCCCGCTTGCGCAAGTCCGCCGGCCCCGTGCCCGCGCCCAAGCCTGCGG
AGTGA

Upstream 100 bases:

>100_bases
TCGGCAAGATCGCGCTCCTCGTCTTCATCATCCTCTTCATCCAGAAGCGCCCGCGCGGCCTGTTCGCGCTCAAGGGCCGG
GCGGTGGAAGCGTGAACATC

Downstream 100 bases:

>100_bases
GACGACATGGAACCCGTCACCCAGTCGCTGCTCTATCTCGACAACATCTCCGTGGTGTTCGACGGTTTCCGGGCGCTCAA
CAAGCTCTCGCTGACCATCG

Product: ABC transporter permease

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein M [H]

Number of amino acids: Translated: 374; Mature: 374

Protein sequence:

>374_residues
MRGSGILDRRGAIFIILVLAAGVLVPAGNLLAPVGSPFHVSDYLVPLLGKYLCYALLAVAVDLVWGYCGVLSLGHGAFFA
LGGYAMGMYLMRQIGPRGVYGNPVLPDFMVFLNYKELPWFWLGFNHFPFAALMVLVVPGLLAFAFGWFAFRSRVTGVYLS
IITQAMTFALMLAFFRNDMGFGGNNGLTDFKDILGYSITAGTTRGALFFASAVALVLGYLICRALVVSKYGKVLVAVRDA
ESRTRFLGYKVANYKLVAWTLSAMLAGVAGALYVPQVGIINPGEFAPANSIETVIWVAVGGRGTLVGAALGALVVNAGKT
WFTGALPEAWLFALGALFVVVTLFLPRGIIGLWGDLSSRLRKSAGPVPAPKPAE

Sequences:

>Translated_374_residues
MRGSGILDRRGAIFIILVLAAGVLVPAGNLLAPVGSPFHVSDYLVPLLGKYLCYALLAVAVDLVWGYCGVLSLGHGAFFA
LGGYAMGMYLMRQIGPRGVYGNPVLPDFMVFLNYKELPWFWLGFNHFPFAALMVLVVPGLLAFAFGWFAFRSRVTGVYLS
IITQAMTFALMLAFFRNDMGFGGNNGLTDFKDILGYSITAGTTRGALFFASAVALVLGYLICRALVVSKYGKVLVAVRDA
ESRTRFLGYKVANYKLVAWTLSAMLAGVAGALYVPQVGIINPGEFAPANSIETVIWVAVGGRGTLVGAALGALVVNAGKT
WFTGALPEAWLFALGALFVVVTLFLPRGIIGLWGDLSSRLRKSAGPVPAPKPAE
>Mature_374_residues
MRGSGILDRRGAIFIILVLAAGVLVPAGNLLAPVGSPFHVSDYLVPLLGKYLCYALLAVAVDLVWGYCGVLSLGHGAFFA
LGGYAMGMYLMRQIGPRGVYGNPVLPDFMVFLNYKELPWFWLGFNHFPFAALMVLVVPGLLAFAFGWFAFRSRVTGVYLS
IITQAMTFALMLAFFRNDMGFGGNNGLTDFKDILGYSITAGTTRGALFFASAVALVLGYLICRALVVSKYGKVLVAVRDA
ESRTRFLGYKVANYKLVAWTLSAMLAGVAGALYVPQVGIINPGEFAPANSIETVIWVAVGGRGTLVGAALGALVVNAGKT
WFTGALPEAWLFALGALFVVVTLFLPRGIIGLWGDLSSRLRKSAGPVPAPKPAE

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=337, Percent_Identity=24.9258160237389, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 39898; Mature: 39898

Theoretical pI: Translated: 10.01; Mature: 10.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGSGILDRRGAIFIILVLAAGVLVPAGNLLAPVGSPFHVSDYLVPLLGKYLCYALLAVA
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
VDLVWGYCGVLSLGHGAFFALGGYAMGMYLMRQIGPRGVYGNPVLPDFMVFLNYKELPWF
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEE
WLGFNHFPFAALMVLVVPGLLAFAFGWFAFRSRVTGVYLSIITQAMTFALMLAFFRNDMG
EECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
FGGNNGLTDFKDILGYSITAGTTRGALFFASAVALVLGYLICRALVVSKYGKVLVAVRDA
CCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECC
ESRTRFLGYKVANYKLVAWTLSAMLAGVAGALYVPQVGIINPGEFAPANSIETVIWVAVG
HHHHHHHEEEECCEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEEC
GRGTLVGAALGALVVNAGKTWFTGALPEAWLFALGALFVVVTLFLPRGIIGLWGDLSSRL
CCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
RKSAGPVPAPKPAE
HHHCCCCCCCCCCC
>Mature Secondary Structure
MRGSGILDRRGAIFIILVLAAGVLVPAGNLLAPVGSPFHVSDYLVPLLGKYLCYALLAVA
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
VDLVWGYCGVLSLGHGAFFALGGYAMGMYLMRQIGPRGVYGNPVLPDFMVFLNYKELPWF
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEE
WLGFNHFPFAALMVLVVPGLLAFAFGWFAFRSRVTGVYLSIITQAMTFALMLAFFRNDMG
EECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
FGGNNGLTDFKDILGYSITAGTTRGALFFASAVALVLGYLICRALVVSKYGKVLVAVRDA
CCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECC
ESRTRFLGYKVANYKLVAWTLSAMLAGVAGALYVPQVGIINPGEFAPANSIETVIWVAVG
HHHHHHHEEEECCEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEEC
GRGTLVGAALGALVVNAGKTWFTGALPEAWLFALGALFVVVTLFLPRGIIGLWGDLSSRL
CCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
RKSAGPVPAPKPAE
HHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]