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The map label for this gene is livH [H]

Identifier: 158423166

GI number: 158423166

Start: 1753600

End: 1754934

Strand: Reverse

Name: livH [H]

Synonym: AZC_1542

Alternate gene names: 158423166

Gene position: 1754934-1753600 (Counterclockwise)

Preceding gene: 158423167

Following gene: 158423165

Centisome position: 32.68

GC content: 72.36

Gene sequence:

>1335_bases
GTGACACCGGCGGCGCGCCTTCCGCTTTGCCTCTGGCCGTTGCTCGCGCTGCTGTGCGCGGGCTGCGGTTCGGTGGTGGA
CGTGGATCAGGCGCGCCTGTGCGAGCGGGTGCTGCCAGCGCTCCTGCCGGACGGCACCCGCATCGAGCGGGTGGAGAGCC
GGCCGGCCGAGGCTGGATCGAGCGGCGTCACTCTCGCCTATTTCGCCCGCACCCCAGAGGATACGGCCGCCCGGCCGGAC
CGCATCACCTGCCGCTTCGCCGCCCCAACCGGGCCGGGGCGGCTTGATTTGGTGGGCGTCACCACCATCGAGGGCGATCT
CGGCGAGGCTCGCCTGTTCATCCTCAAGCGCTGGTGGCTGGAGGCGGGCGGGGGCGCGGGCTTCCCTGCCCATTCCGCTC
TCTTTCGCCTTCCGACGCCATGGGCCTACGGGCTCCAGCAGGCGCTGAACGCTTTGCCGAACATGACAGCCTATGCGGCG
CTCGCCGCCGCTTTCACCCTCATCCATGGGCTGACGGGACGGATCATTCTCGCCATGGGCGAGATCGCTGTGGCCGGCGG
CGGCGCCATGCTGGCGGTGGCCGCTCTCGCTCCGGCGACCGGCGCCTTCACGCTGGCCCATCTCCTGCTCGGGCTAGTGG
CGGGCACCGCCACGGGCGGTCTCTGGATGCTCACCTTCGGCCGCCTTGTCCTGCGACGGATGGCGGAGCGGCGAGAGGCC
TCGCAGGCGGTCATCATCGCCAGCATCGGTCTGGCCCTGGTGCTGCGCGAGGCCATGACGCTGGCCCAGAGCGGGTCCGG
CCTCTGGCTCCCGCGCCTCGTTCACACCCCGATCCCGCTCGCCGGCAGTGCCGCCTTCACGGCCACGGTGACGCCCGCCA
TGATCGGCGGCGCGCTGGCCTCCGGCTGCGGCGTGGCCGGCGTGCTCGCTCTGCTGCGCTTCAGCCGCTTCGGACGGGGC
TGGCGGGCCTTCCGCGACGATCCTCTGATGGCCTCGCTGTGTGCCGTGGCACCAAGCCGGCTGCTCGGGGCCACCTTCCT
CCTCGCCGGTGCCCTGTCGGGGCTCGCGGGCGCCAGCCTCGTGCTCGTCTTCGGCAATGTGGACGCGGCCCTCGGCCTGC
CGCTGACCCTGAAAACGCTGGCCGGCGCCATCCTCGGCGGCGTCGGTTCAGTCGGCGGGGCGGCGGCCGGCGGCCTGCTT
GTCGGGGCGCTGGAGGGCGGCTGGTCTTCGGTCTGGGACATCGCCTGGCGCGACGTGGCGATCTATGGGCTCCTCATTCT
TGGGCTCGTGGCGCGGCCGGAGGGCCTGTTCGGCTCCGGCACGCGGAATCTTTAG

Upstream 100 bases:

>100_bases
GCGTGGTGGAGGAGAGCCTCATCGCCTTCAAGCGGGCGGGTGCCGACGGCATCCTCACCTACTTCGCCCCGCGCGTGGCC
GAGCGGCTCGCCGCCGGCGC

Downstream 100 bases:

>100_bases
GTCCCGCGCGCCTGCGCTTCGGGCGCCGTGCCTTGCGCCTGCCGCACGGCACCACCACCTTTGTGCCCGAGGAGGCGGAA
GCCATGAGCTACACTTCGCA

Product: branched-chain amino acid ABC transporter permease

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MTPAARLPLCLWPLLALLCAGCGSVVDVDQARLCERVLPALLPDGTRIERVESRPAEAGSSGVTLAYFARTPEDTAARPD
RITCRFAAPTGPGRLDLVGVTTIEGDLGEARLFILKRWWLEAGGGAGFPAHSALFRLPTPWAYGLQQALNALPNMTAYAA
LAAAFTLIHGLTGRIILAMGEIAVAGGGAMLAVAALAPATGAFTLAHLLLGLVAGTATGGLWMLTFGRLVLRRMAERREA
SQAVIIASIGLALVLREAMTLAQSGSGLWLPRLVHTPIPLAGSAAFTATVTPAMIGGALASGCGVAGVLALLRFSRFGRG
WRAFRDDPLMASLCAVAPSRLLGATFLLAGALSGLAGASLVLVFGNVDAALGLPLTLKTLAGAILGGVGSVGGAAAGGLL
VGALEGGWSSVWDIAWRDVAIYGLLILGLVARPEGLFGSGTRNL

Sequences:

>Translated_444_residues
MTPAARLPLCLWPLLALLCAGCGSVVDVDQARLCERVLPALLPDGTRIERVESRPAEAGSSGVTLAYFARTPEDTAARPD
RITCRFAAPTGPGRLDLVGVTTIEGDLGEARLFILKRWWLEAGGGAGFPAHSALFRLPTPWAYGLQQALNALPNMTAYAA
LAAAFTLIHGLTGRIILAMGEIAVAGGGAMLAVAALAPATGAFTLAHLLLGLVAGTATGGLWMLTFGRLVLRRMAERREA
SQAVIIASIGLALVLREAMTLAQSGSGLWLPRLVHTPIPLAGSAAFTATVTPAMIGGALASGCGVAGVLALLRFSRFGRG
WRAFRDDPLMASLCAVAPSRLLGATFLLAGALSGLAGASLVLVFGNVDAALGLPLTLKTLAGAILGGVGSVGGAAAGGLL
VGALEGGWSSVWDIAWRDVAIYGLLILGLVARPEGLFGSGTRNL
>Mature_443_residues
TPAARLPLCLWPLLALLCAGCGSVVDVDQARLCERVLPALLPDGTRIERVESRPAEAGSSGVTLAYFARTPEDTAARPDR
ITCRFAAPTGPGRLDLVGVTTIEGDLGEARLFILKRWWLEAGGGAGFPAHSALFRLPTPWAYGLQQALNALPNMTAYAAL
AAAFTLIHGLTGRIILAMGEIAVAGGGAMLAVAALAPATGAFTLAHLLLGLVAGTATGGLWMLTFGRLVLRRMAERREAS
QAVIIASIGLALVLREAMTLAQSGSGLWLPRLVHTPIPLAGSAAFTATVTPAMIGGALASGCGVAGVLALLRFSRFGRGW
RAFRDDPLMASLCAVAPSRLLGATFLLAGALSGLAGASLVLVFGNVDAALGLPLTLKTLAGAILGGVGSVGGAAAGGLLV
GALEGGWSSVWDIAWRDVAIYGLLILGLVARPEGLFGSGTRNL

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=310, Percent_Identity=28.7096774193548, Blast_Score=105, Evalue=5e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 45364; Mature: 45233

Theoretical pI: Translated: 9.16; Mature: 9.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPAARLPLCLWPLLALLCAGCGSVVDVDQARLCERVLPALLPDGTRIERVESRPAEAGS
CCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCC
SGVTLAYFARTPEDTAARPDRITCRFAAPTGPGRLDLVGVTTIEGDLGEARLFILKRWWL
CCCEEEEEECCCCCCCCCCCCEEEEEECCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHH
EAGGGAGFPAHSALFRLPTPWAYGLQQALNALPNMTAYAALAAAFTLIHGLTGRIILAMG
HCCCCCCCCHHHHHEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEEC
EIAVAGGGAMLAVAALAPATGAFTLAHLLLGLVAGTATGGLWMLTFGRLVLRRMAERREA
CEEEECCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
SQAVIIASIGLALVLREAMTLAQSGSGLWLPRLVHTPIPLAGSAAFTATVTPAMIGGALA
CCEEHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCEEEEECCHHHHHHHHH
SGCGVAGVLALLRFSRFGRGWRAFRDDPLMASLCAVAPSRLLGATFLLAGALSGLAGASL
HCCCHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
VLVFGNVDAALGLPLTLKTLAGAILGGVGSVGGAAAGGLLVGALEGGWSSVWDIAWRDVA
EEEEECCCHHHCCCCHHHHHHHHHHHCCCCCCCHHHCCCEEEECCCCCHHHHHHHHHHHH
IYGLLILGLVARPEGLFGSGTRNL
HHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
TPAARLPLCLWPLLALLCAGCGSVVDVDQARLCERVLPALLPDGTRIERVESRPAEAGS
CCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCC
SGVTLAYFARTPEDTAARPDRITCRFAAPTGPGRLDLVGVTTIEGDLGEARLFILKRWWL
CCCEEEEEECCCCCCCCCCCCEEEEEECCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHH
EAGGGAGFPAHSALFRLPTPWAYGLQQALNALPNMTAYAALAAAFTLIHGLTGRIILAMG
HCCCCCCCCHHHHHEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEEC
EIAVAGGGAMLAVAALAPATGAFTLAHLLLGLVAGTATGGLWMLTFGRLVLRRMAERREA
CEEEECCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
SQAVIIASIGLALVLREAMTLAQSGSGLWLPRLVHTPIPLAGSAAFTATVTPAMIGGALA
CCEEHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCEEEEECCHHHHHHHHH
SGCGVAGVLALLRFSRFGRGWRAFRDDPLMASLCAVAPSRLLGATFLLAGALSGLAGASL
HCCCHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
VLVFGNVDAALGLPLTLKTLAGAILGGVGSVGGAAAGGLLVGALEGGWSSVWDIAWRDVA
EEEEECCCHHHCCCCHHHHHHHHHHHCCCCCCCHHHCCCEEEECCCCCHHHHHHHHHHHH
IYGLLILGLVARPEGLFGSGTRNL
HHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]