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The map label for this gene is pepD [H]

Identifier: 157962908

GI number: 157962908

Start: 3794531

End: 3795991

Strand: Direct

Name: pepD [H]

Synonym: Spea_3091

Alternate gene names: 157962908

Gene position: 3794531-3795991 (Clockwise)

Preceding gene: 157962899

Following gene: 157962924

Centisome position: 73.33

GC content: 47.43

Gene sequence:

>1461_bases
GTGACCACTCTTAGTCAGTTACAACCACAAGCACTTTGGCAATGGTTCGAACAGATCTGTGCCATTCCGCATCCATCTAA
ACACGAGCAAGCTTTGAGTGCTCATATTCAGGCTTGGGCTAAAGATAAACAACTCTGTGTCGTTGAAGACAAGGTCGGGA
ACCTGATCATCAAAAAACCGGCAACTGCGGGTATGGAAGACCGTAAGATTGTCGTACTTCAAGCCCATATCGATATGGTG
CCGCAGAAGAACGCTGATAAAGTCCATGATTTTGAAAAAGACCCAATTGAAGCTTATGTCGACGGTGACTGGGTTAAAGC
CAAAGGCACCACATTAGGTGCTGATAACGGTATTGGTATGGCGTCTGCGCTTGCCATTTTAGGTGCCGATGATATTCCTC
ATGGGCCACTAGAAGTGCTACTTACCATTGATGAAGAAGCCGGTATGACTGGTGCATTTGGCCTAGAGGCCGGTATGCTT
GATGCTGAAATCCTGATCAACACCGACTCAGAGCAGGAAGGTGAGATCTACATGGGTTGTGCTGGCGGCGTTGATGCGCA
GTTAAGCGTACCTATGGTTTGGCAATCTCCTGAGCCAACAAACGCCAGTTATAAACTGTCGCTCTCTGGGCTTAAAGGTG
GTCACTCAGGCGTTAACATTCACTTGGGTCGTGGTAACGCTAATAAACTATTAGCTCGCTTCCTGGTTGAGCATGGCGAC
GAACTAGCGATTGAGTTAACTCAATTTGTTGGTGGTTCACTGCGTAACGCCATCCCGCGTGAAGCCGAAATCAACTTTAT
GCTACCGCCAGAGAACTTAACACTGTTACAGACGCGTATTGCTGAGTTTCAGGCTCTAGTGCGTGAAGAGCTAGCGATTG
CCGATCCAGATACGGTGTTAACATTGGCTGAAATTCCAGCTGAAAAGCAAGTGATGAGCGAAGATTCACAGCAGATCTTA
ATTGACCTGCTAAATGCTTGCCCTAACGGCGTCATTCGCATGAGTGATGAAGTCGAAGGCGTGACTGAGACTTCGCTTAA
CGTGGGTGTAATTAGCACCGATGATAACGGCGTGCAAATACTTTGCCTTATCCGTTCACTGATCGACTCTGGTCGCAGTG
AAGTTGAAGGCGTATTGACCTCGCTTGCTAATCTTGCTGGTGCAAATGTTGAATTCAGCGGTGCTTATCCTGGCTGGAAG
CCGGACAATAGCTCACCAGTAATGGCAAGTGTGCGTGAAACCTACGAGGCGATTTACGATAAAGAGCCTACTATCATGGT
GATCCACGCTGGTCTTGAATGTGGTCTATTTAAGAAGCCATACCCAGAGATGGATATGGTGTCTATTGGTCCGACTATTC
GTTACCCACACAGCCCTGATGAAAAAGTTAACATCACCACAGTCGGCCAATACTGGAAGCTGTTATTAGCGGTACTAGAG
CGTACACCAGTTAAAGGCTAA

Upstream 100 bases:

>100_bases
AACGACTCCGCGGCGCAGTAAGACTATGCTAGACTGTCTGCAATTTCTGCCTCAGTGGCAGCCGCGCGCTATAGATATTA
CTCGAATAGGGGATTTTTAA

Downstream 100 bases:

>100_bases
TACTCTCTTAACTTCAAAGTAAAACCTAAAAGGCCACTTAGCTATTAATTAGCAGTAAGTGGCCTTTGTTTTTTCTAACG
AGCCATTTCTGGCTATACAC

Product: aminoacyl-histidine dipeptidase

Products: NA

Alternate protein names: Beta-alanyl-histidine dipeptidase; Carnosinase; Cysteinylglycinase; Peptidase D; Xaa-His dipeptidase; X-His dipeptidase [H]

Number of amino acids: Translated: 486; Mature: 485

Protein sequence:

>486_residues
MTTLSQLQPQALWQWFEQICAIPHPSKHEQALSAHIQAWAKDKQLCVVEDKVGNLIIKKPATAGMEDRKIVVLQAHIDMV
PQKNADKVHDFEKDPIEAYVDGDWVKAKGTTLGADNGIGMASALAILGADDIPHGPLEVLLTIDEEAGMTGAFGLEAGML
DAEILINTDSEQEGEIYMGCAGGVDAQLSVPMVWQSPEPTNASYKLSLSGLKGGHSGVNIHLGRGNANKLLARFLVEHGD
ELAIELTQFVGGSLRNAIPREAEINFMLPPENLTLLQTRIAEFQALVREELAIADPDTVLTLAEIPAEKQVMSEDSQQIL
IDLLNACPNGVIRMSDEVEGVTETSLNVGVISTDDNGVQILCLIRSLIDSGRSEVEGVLTSLANLAGANVEFSGAYPGWK
PDNSSPVMASVRETYEAIYDKEPTIMVIHAGLECGLFKKPYPEMDMVSIGPTIRYPHSPDEKVNITTVGQYWKLLLAVLE
RTPVKG

Sequences:

>Translated_486_residues
MTTLSQLQPQALWQWFEQICAIPHPSKHEQALSAHIQAWAKDKQLCVVEDKVGNLIIKKPATAGMEDRKIVVLQAHIDMV
PQKNADKVHDFEKDPIEAYVDGDWVKAKGTTLGADNGIGMASALAILGADDIPHGPLEVLLTIDEEAGMTGAFGLEAGML
DAEILINTDSEQEGEIYMGCAGGVDAQLSVPMVWQSPEPTNASYKLSLSGLKGGHSGVNIHLGRGNANKLLARFLVEHGD
ELAIELTQFVGGSLRNAIPREAEINFMLPPENLTLLQTRIAEFQALVREELAIADPDTVLTLAEIPAEKQVMSEDSQQIL
IDLLNACPNGVIRMSDEVEGVTETSLNVGVISTDDNGVQILCLIRSLIDSGRSEVEGVLTSLANLAGANVEFSGAYPGWK
PDNSSPVMASVRETYEAIYDKEPTIMVIHAGLECGLFKKPYPEMDMVSIGPTIRYPHSPDEKVNITTVGQYWKLLLAVLE
RTPVKG
>Mature_485_residues
TTLSQLQPQALWQWFEQICAIPHPSKHEQALSAHIQAWAKDKQLCVVEDKVGNLIIKKPATAGMEDRKIVVLQAHIDMVP
QKNADKVHDFEKDPIEAYVDGDWVKAKGTTLGADNGIGMASALAILGADDIPHGPLEVLLTIDEEAGMTGAFGLEAGMLD
AEILINTDSEQEGEIYMGCAGGVDAQLSVPMVWQSPEPTNASYKLSLSGLKGGHSGVNIHLGRGNANKLLARFLVEHGDE
LAIELTQFVGGSLRNAIPREAEINFMLPPENLTLLQTRIAEFQALVREELAIADPDTVLTLAEIPAEKQVMSEDSQQILI
DLLNACPNGVIRMSDEVEGVTETSLNVGVISTDDNGVQILCLIRSLIDSGRSEVEGVLTSLANLAGANVEFSGAYPGWKP
DNSSPVMASVRETYEAIYDKEPTIMVIHAGLECGLFKKPYPEMDMVSIGPTIRYPHSPDEKVNITTVGQYWKLLLAVLER
TPVKG

Specific function: Dipeptidase with broad substrate specificity. Requires dipeptide substrates with an unblocked N-terminus and the amino group in the alpha or beta position. Non-protein amino acids and proline are not accepted in the C-terminal position, whereas some dipep

COG id: COG2195

COG function: function code E; Di- and tripeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20C family [H]

Homologues:

Organism=Escherichia coli, GI1786432, Length=485, Percent_Identity=59.1752577319588, Blast_Score=593, Evalue=1e-171,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002933
- InterPro:   IPR011650
- InterPro:   IPR001160 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.4.13.3 [H]

Molecular weight: Translated: 52660; Mature: 52529

Theoretical pI: Translated: 4.35; Mature: 4.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTLSQLQPQALWQWFEQICAIPHPSKHEQALSAHIQAWAKDKQLCVVEDKVGNLIIKKP
CCCHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEECC
ATAGMEDRKIVVLQAHIDMVPQKNADKVHDFEKDPIEAYVDGDWVKAKGTTLGADNGIGM
CCCCCCCCEEEEEEEEECCCCCCCCCHHHCCCCCCCEEEECCCEEEECCCEECCCCCCCH
ASALAILGADDIPHGPLEVLLTIDEEAGMTGAFGLEAGMLDAEILINTDSEQEGEIYMGC
HHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEE
AGGVDAQLSVPMVWQSPEPTNASYKLSLSGLKGGHSGVNIHLGRGNANKLLARFLVEHGD
CCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCCCCCEEEEECCCCHHHHHHHHHHHCCC
ELAIELTQFVGGSLRNAIPREAEINFMLPPENLTLLQTRIAEFQALVREELAIADPDTVL
HHEEHHHHHHCCHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEE
TLAEIPAEKQVMSEDSQQILIDLLNACPNGVIRMSDEVEGVTETSLNVGVISTDDNGVQI
EEECCCCHHHHHHCCHHHHHHHHHHHCCCCEEEECCCCCCCEECCEEEEEEEECCCCCCH
LCLIRSLIDSGRSEVEGVLTSLANLAGANVEFSGAYPGWKPDNSSPVMASVRETYEAIYD
HHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHC
KEPTIMVIHAGLECGLFKKPYPEMDMVSIGPTIRYPHSPDEKVNITTVGQYWKLLLAVLE
CCCCEEEEECCCCCCCCCCCCCCCCEEECCCEEECCCCCCCEEEEEEHHHHHHHHHHHHH
RTPVKG
HCCCCC
>Mature Secondary Structure 
TTLSQLQPQALWQWFEQICAIPHPSKHEQALSAHIQAWAKDKQLCVVEDKVGNLIIKKP
CCHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEECC
ATAGMEDRKIVVLQAHIDMVPQKNADKVHDFEKDPIEAYVDGDWVKAKGTTLGADNGIGM
CCCCCCCCEEEEEEEEECCCCCCCCCHHHCCCCCCCEEEECCCEEEECCCEECCCCCCCH
ASALAILGADDIPHGPLEVLLTIDEEAGMTGAFGLEAGMLDAEILINTDSEQEGEIYMGC
HHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEE
AGGVDAQLSVPMVWQSPEPTNASYKLSLSGLKGGHSGVNIHLGRGNANKLLARFLVEHGD
CCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCCCCCEEEEECCCCHHHHHHHHHHHCCC
ELAIELTQFVGGSLRNAIPREAEINFMLPPENLTLLQTRIAEFQALVREELAIADPDTVL
HHEEHHHHHHCCHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEE
TLAEIPAEKQVMSEDSQQILIDLLNACPNGVIRMSDEVEGVTETSLNVGVISTDDNGVQI
EEECCCCHHHHHHCCHHHHHHHHHHHCCCCEEEECCCCCCCEECCEEEEEEEECCCCCCH
LCLIRSLIDSGRSEVEGVLTSLANLAGANVEFSGAYPGWKPDNSSPVMASVRETYEAIYD
HHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHC
KEPTIMVIHAGLECGLFKKPYPEMDMVSIGPTIRYPHSPDEKVNITTVGQYWKLLLAVLE
CCCCEEEEECCCCCCCCCCCCCCCCEEECCCEEECCCCCCCEEEEEEHHHHHHHHHHHHH
RTPVKG
HCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1695895; 9278503; 2651887 [H]