Click here to switch to the map view.

The map label for this gene is hns [H]

Identifier: 157962675

GI number: 157962675

Start: 3487541

End: 3487933

Strand: Direct

Name: hns [H]

Synonym: Spea_2856

Alternate gene names: 157962675

Gene position: 3487541-3487933 (Clockwise)

Preceding gene: 157962671

Following gene: 157962676

Centisome position: 67.4

GC content: 40.97

Gene sequence:

>393_bases
ATGAGCGATTTTCTTGAAATATTGACACATGGTCGTCGTTTTAAAGCTGCAGTGAAAGACTTGTCACTAAATGATTTAAA
AGAACTATCAGTGAAGTTAGAAAAAATCATTGAAGAAAAATCTTCTCAAGATGCTGCAGAACAAGAAGCGATGGCTGAGC
GTAATGCTAAAATCGAAGAGATCCGTAAGCAAATGGAAGCTATCGGTTTATCTGTTGACGATATTGGTGGCGCTGCCGTT
AAAGCCGCTCCTAAGAAGCGTGCTCCTCGTCCAGCTAAATATCAAATTGAAGTTGATGGCGAAATGGTACAGTGGACTGG
TCAAGGCCGTATGCCAACTGTATTTAAGAACCAACTTGAGAACGGCCGTACAATGGAAGACTTCTTGATCTAA

Upstream 100 bases:

>100_bases
AATAATTCAAAAATAATATTTGATCCTTATCCAAATAGTTTCTATTATTTAAGCCAATAGAGTTATTACCTATCTTATTC
TTAATTGGACCTAAATAATT

Downstream 100 bases:

>100_bases
TATCGAGTCATCCAAACTAAGAGCCCTGCGATTGCGGGGCTTTTTCATTTTAGGTTAAAATTTTCACATTGGTCGTTACA
ATTACTGCTTAGTCATTGTT

Product: histone family protein nucleoid-structuring protein H-NS

Products: NA

Alternate protein names: Histone-like protein HLP-II [H]

Number of amino acids: Translated: 130; Mature: 129

Protein sequence:

>130_residues
MSDFLEILTHGRRFKAAVKDLSLNDLKELSVKLEKIIEEKSSQDAAEQEAMAERNAKIEEIRKQMEAIGLSVDDIGGAAV
KAAPKKRAPRPAKYQIEVDGEMVQWTGQGRMPTVFKNQLENGRTMEDFLI

Sequences:

>Translated_130_residues
MSDFLEILTHGRRFKAAVKDLSLNDLKELSVKLEKIIEEKSSQDAAEQEAMAERNAKIEEIRKQMEAIGLSVDDIGGAAV
KAAPKKRAPRPAKYQIEVDGEMVQWTGQGRMPTVFKNQLENGRTMEDFLI
>Mature_129_residues
SDFLEILTHGRRFKAAVKDLSLNDLKELSVKLEKIIEEKSSQDAAEQEAMAERNAKIEEIRKQMEAIGLSVDDIGGAAVK
AAPKKRAPRPAKYQIEVDGEMVQWTGQGRMPTVFKNQLENGRTMEDFLI

Specific function: H-NS binds tightly to ds-DNA, increases its thermal stability and inhibits transcription. It also binds to ss-DNA and RNA but with a much lower affinity. H-NS has possible histone-like function. May be a global transcriptional regulator through its abilit

COG id: COG2916

COG function: function code R; DNA-binding protein H-NS

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone-like protein H-NS family [H]

Homologues:

Organism=Escherichia coli, GI1789023, Length=134, Percent_Identity=36.5671641791045, Blast_Score=80, Evalue=3e-17,
Organism=Escherichia coli, GI1787489, Length=135, Percent_Identity=37.7777777777778, Blast_Score=75, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001801 [H]

Pfam domain/function: PF00816 Histone_HNS [H]

EC number: NA

Molecular weight: Translated: 14618; Mature: 14487

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDFLEILTHGRRFKAAVKDLSLNDLKELSVKLEKIIEEKSSQDAAEQEAMAERNAKIEE
CHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHH
IRKQMEAIGLSVDDIGGAAVKAAPKKRAPRPAKYQIEVDGEMVQWTGQGRMPTVFKNQLE
HHHHHHHHCCCCCCCCCHHHCCCCHHCCCCCCCEEEEECCEEEEEECCCCCCHHHHHHHC
NGRTMEDFLI
CCCCHHHHCC
>Mature Secondary Structure 
SDFLEILTHGRRFKAAVKDLSLNDLKELSVKLEKIIEEKSSQDAAEQEAMAERNAKIEE
HHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHH
IRKQMEAIGLSVDDIGGAAVKAAPKKRAPRPAKYQIEVDGEMVQWTGQGRMPTVFKNQLE
HHHHHHHHCCCCCCCCCHHHCCCCHHCCCCCCCEEEEECCEEEEEECCCCCCHHHHHHHC
NGRTMEDFLI
CCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2494066 [H]