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The map label for this gene is ribA [H]

Identifier: 157962437

GI number: 157962437

Start: 3185955

End: 3186584

Strand: Reverse

Name: ribA [H]

Synonym: Spea_2616

Alternate gene names: 157962437

Gene position: 3186584-3185955 (Counterclockwise)

Preceding gene: 157962438

Following gene: 157962436

Centisome position: 61.58

GC content: 43.49

Gene sequence:

>630_bases
ATGTCGATTAAATACATCGCGTCTTCAAAATTACCAACCCCTTGGGGTGTTTTCGAAATGCATGGTTTTGAAGATAGTGA
GACGGGTAAAGAGCATGTAGCGCTTACCTTTGGCACATTTACCCCAGATGCACCAATCCTTGGACGTATCCATTCAGAAT
GTTTAACTGGCGATGCATTGTTTAGTTTGCGCTGTGATTGTGGTTTTCAACTGCAAACCGCGATGCAGAATATTGCCGAA
GAAGGTCAAGGATTTATCCTCTACTTGCGCCAAGAAGGTCGTGGTATCGGTCTGCTTAATAAGATCCGTGCTTATGAGCT
ACAAGATCAAGGTGCTAATACGGTAGAAGCTAACGAACGTTTAGGTTTTGAAGCCGATATGCGTAAATACGATATGATCA
TCCCTATGATGGAGAAGATTGGTGTCGATAAAGTGCGTTTAATGACCAATAATCCCCGTAAGGTTAAAGCGATGCAAAGC
TTTGGATTGGAAGTTGTCGAACGTGTGCCACTGCAAGTGGGCAAAAATCGCTATAACGAAGGTTACCTCAAGACTAAGTC
GACCCAGCTTGGACACATGATGTCTGAGCATCACTTCACTGAAACCGATCCCGAAGTTGATAAAGACTAA

Upstream 100 bases:

>100_bases
TGGGTCATAGGGCTAGCAAGAGTATCGTCTCAAGCAATTTATTTTCTTTATCAGGATGTTTGCAGTCTCAAGGAGTGAGA
GTTGTCGTTAAGGTTTTTTC

Downstream 100 bases:

>100_bases
TCTACTCAGGGAAAAGCCTTAATTTCTTTGGCTTTTCCCATGCTATAACGCTATATTCGGGCTATCTATTAGAGTTTAAT
TAAGTTTAAAGTCGATTTAT

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: GTP cyclohydrolase II [H]

Number of amino acids: Translated: 209; Mature: 208

Protein sequence:

>209_residues
MSIKYIASSKLPTPWGVFEMHGFEDSETGKEHVALTFGTFTPDAPILGRIHSECLTGDALFSLRCDCGFQLQTAMQNIAE
EGQGFILYLRQEGRGIGLLNKIRAYELQDQGANTVEANERLGFEADMRKYDMIIPMMEKIGVDKVRLMTNNPRKVKAMQS
FGLEVVERVPLQVGKNRYNEGYLKTKSTQLGHMMSEHHFTETDPEVDKD

Sequences:

>Translated_209_residues
MSIKYIASSKLPTPWGVFEMHGFEDSETGKEHVALTFGTFTPDAPILGRIHSECLTGDALFSLRCDCGFQLQTAMQNIAE
EGQGFILYLRQEGRGIGLLNKIRAYELQDQGANTVEANERLGFEADMRKYDMIIPMMEKIGVDKVRLMTNNPRKVKAMQS
FGLEVVERVPLQVGKNRYNEGYLKTKSTQLGHMMSEHHFTETDPEVDKD
>Mature_208_residues
SIKYIASSKLPTPWGVFEMHGFEDSETGKEHVALTFGTFTPDAPILGRIHSECLTGDALFSLRCDCGFQLQTAMQNIAEE
GQGFILYLRQEGRGIGLLNKIRAYELQDQGANTVEANERLGFEADMRKYDMIIPMMEKIGVDKVRLMTNNPRKVKAMQSF
GLEVVERVPLQVGKNRYNEGYLKTKSTQLGHMMSEHHFTETDPEVDKD

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=196, Percent_Identity=59.1836734693878, Blast_Score=254, Evalue=4e-69,
Organism=Saccharomyces cerevisiae, GI6319438, Length=204, Percent_Identity=40.6862745098039, Blast_Score=131, Evalue=7e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000926 [H]

Pfam domain/function: PF00925 GTP_cyclohydro2 [H]

EC number: =3.5.4.25 [H]

Molecular weight: Translated: 23641; Mature: 23510

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIKYIASSKLPTPWGVFEMHGFEDSETGKEHVALTFGTFTPDAPILGRIHSECLTGDAL
CCEEEEECCCCCCCCCEEEECCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHCCCCE
FSLRCDCGFQLQTAMQNIAEEGQGFILYLRQEGRGIGLLNKIRAYELQDQGANTVEANER
EEEECCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHEEECCCCCCEECCCHH
LGFEADMRKYDMIIPMMEKIGVDKVRLMTNNPRKVKAMQSFGLEVVERVPLQVGKNRYNE
CCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHCHHHHHHHHHHHCCCCCCC
GYLKTKSTQLGHMMSEHHFTETDPEVDKD
CEEEECCHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SIKYIASSKLPTPWGVFEMHGFEDSETGKEHVALTFGTFTPDAPILGRIHSECLTGDAL
CEEEEECCCCCCCCCEEEECCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHCCCCE
FSLRCDCGFQLQTAMQNIAEEGQGFILYLRQEGRGIGLLNKIRAYELQDQGANTVEANER
EEEECCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHEEECCCCCCEECCCHH
LGFEADMRKYDMIIPMMEKIGVDKVRLMTNNPRKVKAMQSFGLEVVERVPLQVGKNRYNE
CCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHCHHHHHHHHHHHCCCCCCC
GYLKTKSTQLGHMMSEHHFTETDPEVDKD
CEEEECCHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA