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The map label for this gene is upp [H]

Identifier: 157962397

GI number: 157962397

Start: 3135588

End: 3136214

Strand: Reverse

Name: upp [H]

Synonym: Spea_2576

Alternate gene names: 157962397

Gene position: 3136214-3135588 (Counterclockwise)

Preceding gene: 157962400

Following gene: 157962395

Centisome position: 60.61

GC content: 44.66

Gene sequence:

>627_bases
ATGAAAGTCGTTGAAGTTAAACATCCTTTAGTCCGTCATAAAATTGGATTAATGCGCGAAGGTAACATCAGTACCAAACG
TTTTCGCGAATTAGCGGCAGAAGTGGGCAGTTTACTGACTTATGAAGCGACGGCTGACTTTGAAACTGAAAAGGTAACGA
TTGATGGTTGGAATGGTCCTGTTGAAATTGAACAGATCAAAGGTAAGAAGGTAACAGTAGTACCAATCTTACGTGCGGGT
CTTGGCATGATGGATGGCGTTCTTGAGCACGTACCAAGTGCGCGTATCTCTGTTGTGGGTATTTACCGTGACGAAGAGAC
ACTTGAGCCAGTGCCTTACTTTGAAAAGCTAGCCAGTGACATGCCTTCACGTATTGCCTTGGTTGTAGATCCAATGCTTG
CGACTGGCGGCTCGATGATTTCAACTATCGACCTACTAAAAGAGCGCGGTTGTACTGCTATTAAAGCACTTGTGCTTGTA
GCGGCTCCAGAAGGTGTTGCTGCTCTAGAGAAAGCTCATCCAGATATCGAGCTTTATACTGCGTCAATCGATGACTGCCT
AAATGAGCAAGGTTATATCCTGCCAGGTCTTGGTGATGCGGGTGATAAGATTTTTGGTACTAAATAA

Upstream 100 bases:

>100_bases
TTACCGTCTTTTTGAAACTTTAAGTTTTCCTAAATGAACAAATCTACTAAAATCGTTAAAATTTACCGTAAAAAATACGT
TAGAAAATCAGGAGAACAAG

Downstream 100 bases:

>100_bases
CCTTTTTATTGATTGGTATTAGTCTAAATTCTATTGTAAAAAAGGAGCCAAATGGCTCCTTTTTTGTTTTCATTTTTCTA
GAATCTAGAGCACCATAGCG

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MKVVEVKHPLVRHKIGLMREGNISTKRFRELAAEVGSLLTYEATADFETEKVTIDGWNGPVEIEQIKGKKVTVVPILRAG
LGMMDGVLEHVPSARISVVGIYRDEETLEPVPYFEKLASDMPSRIALVVDPMLATGGSMISTIDLLKERGCTAIKALVLV
AAPEGVAALEKAHPDIELYTASIDDCLNEQGYILPGLGDAGDKIFGTK

Sequences:

>Translated_208_residues
MKVVEVKHPLVRHKIGLMREGNISTKRFRELAAEVGSLLTYEATADFETEKVTIDGWNGPVEIEQIKGKKVTVVPILRAG
LGMMDGVLEHVPSARISVVGIYRDEETLEPVPYFEKLASDMPSRIALVVDPMLATGGSMISTIDLLKERGCTAIKALVLV
AAPEGVAALEKAHPDIELYTASIDDCLNEQGYILPGLGDAGDKIFGTK
>Mature_208_residues
MKVVEVKHPLVRHKIGLMREGNISTKRFRELAAEVGSLLTYEATADFETEKVTIDGWNGPVEIEQIKGKKVTVVPILRAG
LGMMDGVLEHVPSARISVVGIYRDEETLEPVPYFEKLASDMPSRIALVVDPMLATGGSMISTIDLLKERGCTAIKALVLV
AAPEGVAALEKAHPDIELYTASIDDCLNEQGYILPGLGDAGDKIFGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=142, Percent_Identity=29.5774647887324, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI57863312, Length=142, Percent_Identity=29.5774647887324, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI87082118, Length=208, Percent_Identity=83.6538461538462, Blast_Score=365, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17539892, Length=201, Percent_Identity=23.8805970149254, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17539894, Length=201, Percent_Identity=23.8805970149254, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6321920, Length=138, Percent_Identity=39.8550724637681, Blast_Score=102, Evalue=6e-23,
Organism=Drosophila melanogaster, GI28573516, Length=195, Percent_Identity=27.1794871794872, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28573514, Length=195, Percent_Identity=27.1794871794872, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28573512, Length=195, Percent_Identity=27.1794871794872, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45550449, Length=195, Percent_Identity=27.1794871794872, Blast_Score=76, Evalue=2e-14,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 22513; Mature: 22513

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVVEVKHPLVRHKIGLMREGNISTKRFRELAAEVGSLLTYEATADFETEKVTIDGWNGP
CCEEECCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHEEEECCCCCCCCEEEEECCCCC
VEIEQIKGKKVTVVPILRAGLGMMDGVLEHVPSARISVVGIYRDEETLEPVPYFEKLASD
EEEEEECCCEEEEEHHHHHCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCHHHHHHHC
MPSRIALVVDPMLATGGSMISTIDLLKERGCTAIKALVLVAAPEGVAALEKAHPDIELYT
CCCEEEEEECHHHHCCCHHHHHHHHHHHCCCHHHHHHHHEECCCCHHHHHHCCCCEEEEE
ASIDDCLNEQGYILPGLGDAGDKIFGTK
ECHHHHCCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MKVVEVKHPLVRHKIGLMREGNISTKRFRELAAEVGSLLTYEATADFETEKVTIDGWNGP
CCEEECCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHEEEECCCCCCCCEEEEECCCCC
VEIEQIKGKKVTVVPILRAGLGMMDGVLEHVPSARISVVGIYRDEETLEPVPYFEKLASD
EEEEEECCCEEEEEHHHHHCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCHHHHHHHC
MPSRIALVVDPMLATGGSMISTIDLLKERGCTAIKALVLVAAPEGVAALEKAHPDIELYT
CCCEEEEEECHHHHCCCHHHHHHHHHHHCCCHHHHHHHHEECCCCHHHHHHCCCCEEEEE
ASIDDCLNEQGYILPGLGDAGDKIFGTK
ECHHHHCCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA