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The map label for this gene is ahpC [C]

Identifier: 157962395

GI number: 157962395

Start: 3133262

End: 3133867

Strand: Reverse

Name: ahpC [C]

Synonym: Spea_2574

Alternate gene names: 157962395

Gene position: 3133867-3133262 (Counterclockwise)

Preceding gene: 157962397

Following gene: 157962391

Centisome position: 60.56

GC content: 47.19

Gene sequence:

>606_bases
ATGAGCGTATTAGTCGGCCGTCCGGCCCCTGATTTTACTGCAGCTGCGGTACTAGGTAATGGTGAGATTGTTGATACCTT
CAACCTATCTGAAGCAATTAAAGGAAAGACTGCCGTAGTATTCTTCTACCCACTTGACTTCACTTTCGTGTGTCCATCAG
AGCTGATTGCTTTTGATCACCGCATGGATGAGTTCAAGAAGCGTGGCGTTGAAGTGATCGGTGTTTCAATCGATTCTCAG
TTCACTCACAACGCATGGCGTAACACGCCAGTAGACAAGGGCGGTATTGGCCAAGTTCAATACACGCTAGTTGCTGACGT
TAAGCATGAGATCTGTAAAGCATACGATGTTGAGCATCCAGAAGCGGGTGTTGCATTCCGTGGTTCTTTCCTAATCGACA
AAGAAGGTCAAGTTCGTCACCAAGTGGTTAATGACTTGCCACTAGGTCGTAACGTTGATGAAATGATCCGTATGGTTGAT
GCACTTCACTTCCACGAAGAGCACGGTGACGTATGTCCAGCGGGTTGGGAAAAGGGTGACAAAGGGATGGACGCAAGCCC
AGCAGGTGTTGCTTCTTACCTAACTGACAATGCTGATTCACTATAA

Upstream 100 bases:

>100_bases
ATTGTTTTCAAATTGCTTGTGCAAAGAAAAACACTGCCTATAATGCCTTTAGATTTAAAACGAAACAGCGTTTTTAGCAA
TCCATAGATGGAGAAATAAA

Downstream 100 bases:

>100_bases
TTTCTAATGAATTTATAAGTTGTTGTCTAGTCCTAAAATAGGTTGACGGTTTTTATTAAGCCAGTTGGAACTCCCGACTG
GCTTTTTTATGTACTTCATT

Product: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen

Products: NA

Alternate protein names: Thioredoxin reductase [H]

Number of amino acids: Translated: 201; Mature: 200

Protein sequence:

>201_residues
MSVLVGRPAPDFTAAAVLGNGEIVDTFNLSEAIKGKTAVVFFYPLDFTFVCPSELIAFDHRMDEFKKRGVEVIGVSIDSQ
FTHNAWRNTPVDKGGIGQVQYTLVADVKHEICKAYDVEHPEAGVAFRGSFLIDKEGQVRHQVVNDLPLGRNVDEMIRMVD
ALHFHEEHGDVCPAGWEKGDKGMDASPAGVASYLTDNADSL

Sequences:

>Translated_201_residues
MSVLVGRPAPDFTAAAVLGNGEIVDTFNLSEAIKGKTAVVFFYPLDFTFVCPSELIAFDHRMDEFKKRGVEVIGVSIDSQ
FTHNAWRNTPVDKGGIGQVQYTLVADVKHEICKAYDVEHPEAGVAFRGSFLIDKEGQVRHQVVNDLPLGRNVDEMIRMVD
ALHFHEEHGDVCPAGWEKGDKGMDASPAGVASYLTDNADSL
>Mature_200_residues
SVLVGRPAPDFTAAAVLGNGEIVDTFNLSEAIKGKTAVVFFYPLDFTFVCPSELIAFDHRMDEFKKRGVEVIGVSIDSQF
THNAWRNTPVDKGGIGQVQYTLVADVKHEICKAYDVEHPEAGVAFRGSFLIDKEGQVRHQVVNDLPLGRNVDEMIRMVDA
LHFHEEHGDVCPAGWEKGDKGMDASPAGVASYLTDNADSL

Specific function: Directly Reduces Organic Hydroperoxides In Its Reduced Dithiol Form. [C]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI32189392, Length=175, Percent_Identity=52.5714285714286, Blast_Score=196, Evalue=2e-50,
Organism=Homo sapiens, GI4505591, Length=175, Percent_Identity=52.5714285714286, Blast_Score=194, Evalue=6e-50,
Organism=Homo sapiens, GI32455266, Length=175, Percent_Identity=52.5714285714286, Blast_Score=194, Evalue=6e-50,
Organism=Homo sapiens, GI32455264, Length=175, Percent_Identity=52.5714285714286, Blast_Score=194, Evalue=6e-50,
Organism=Homo sapiens, GI5453549, Length=190, Percent_Identity=45.7894736842105, Blast_Score=184, Evalue=5e-47,
Organism=Homo sapiens, GI5802974, Length=190, Percent_Identity=45.2631578947368, Blast_Score=174, Evalue=4e-44,
Organism=Homo sapiens, GI32483377, Length=186, Percent_Identity=45.6989247311828, Blast_Score=174, Evalue=6e-44,
Organism=Homo sapiens, GI33188454, Length=82, Percent_Identity=58.5365853658537, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI4758638, Length=190, Percent_Identity=28.9473684210526, Blast_Score=68, Evalue=6e-12,
Organism=Escherichia coli, GI1786822, Length=168, Percent_Identity=32.7380952380952, Blast_Score=110, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI32565831, Length=176, Percent_Identity=50, Blast_Score=182, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI193204376, Length=176, Percent_Identity=50, Blast_Score=182, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17554494, Length=180, Percent_Identity=45.5555555555556, Blast_Score=169, Evalue=8e-43,
Organism=Caenorhabditis elegans, GI25153706, Length=189, Percent_Identity=26.4550264550265, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323613, Length=179, Percent_Identity=41.8994413407821, Blast_Score=152, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6320661, Length=179, Percent_Identity=39.1061452513966, Blast_Score=140, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6319407, Length=180, Percent_Identity=27.7777777777778, Blast_Score=84, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24656348, Length=194, Percent_Identity=49.4845360824742, Blast_Score=193, Evalue=6e-50,
Organism=Drosophila melanogaster, GI17864676, Length=194, Percent_Identity=49.4845360824742, Blast_Score=193, Evalue=6e-50,
Organism=Drosophila melanogaster, GI17157991, Length=188, Percent_Identity=48.4042553191489, Blast_Score=184, Evalue=4e-47,
Organism=Drosophila melanogaster, GI24641739, Length=188, Percent_Identity=48.4042553191489, Blast_Score=184, Evalue=4e-47,
Organism=Drosophila melanogaster, GI17738015, Length=186, Percent_Identity=45.1612903225806, Blast_Score=179, Evalue=1e-45,
Organism=Drosophila melanogaster, GI21357347, Length=190, Percent_Identity=42.1052631578947, Blast_Score=168, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24581278, Length=185, Percent_Identity=30.2702702702703, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17975518, Length=189, Percent_Identity=28.042328042328, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24652434, Length=189, Percent_Identity=28.042328042328, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24652436, Length=189, Percent_Identity=28.042328042328, Blast_Score=73, Evalue=1e-13,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR019479
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 22022; Mature: 21891

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVLVGRPAPDFTAAAVLGNGEIVDTFNLSEAIKGKTAVVFFYPLDFTFVCPSELIAFDH
CCEECCCCCCCCEEEEEECCCCEEEECCHHHHHCCCEEEEEEEECCEEEECHHHHHHHHH
RMDEFKKRGVEVIGVSIDSQFTHNAWRNTPVDKGGIGQVQYTLVADVKHEICKAYDVEHP
HHHHHHHCCEEEEEEEECCCHHHHCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHCCCCC
EAGVAFRGSFLIDKEGQVRHQVVNDLPLGRNVDEMIRMVDALHFHEEHGDVCPAGWEKGD
CCCEEEECEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
KGMDASPAGVASYLTDNADSL
CCCCCCCCHHHHHHCCCCCCC
>Mature Secondary Structure 
SVLVGRPAPDFTAAAVLGNGEIVDTFNLSEAIKGKTAVVFFYPLDFTFVCPSELIAFDH
CEECCCCCCCCEEEEEECCCCEEEECCHHHHHCCCEEEEEEEECCEEEECHHHHHHHHH
RMDEFKKRGVEVIGVSIDSQFTHNAWRNTPVDKGGIGQVQYTLVADVKHEICKAYDVEHP
HHHHHHHCCEEEEEEEECCCHHHHCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHCCCCC
EAGVAFRGSFLIDKEGQVRHQVVNDLPLGRNVDEMIRMVDALHFHEEHGDVCPAGWEKGD
CCCEEEECEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
KGMDASPAGVASYLTDNADSL
CCCCCCCCHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12522265 [H]