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The map label for this gene is csrD [H]

Identifier: 157962173

GI number: 157962173

Start: 2867204

End: 2869120

Strand: Direct

Name: csrD [H]

Synonym: Spea_2352

Alternate gene names: 157962173

Gene position: 2867204-2869120 (Clockwise)

Preceding gene: 157962171

Following gene: 157962174

Centisome position: 55.41

GC content: 40.11

Gene sequence:

>1917_bases
ATGACAACCTCTAAACTTTTCCAGTTGTTTTTAGTTTTACTTTTTTCAGGACTCACCTTTTTAAGTTACCAAGATGAAAA
GCTAAAATTATCGACTCAAGCTCAACTGCAACTTGATCAATACGCCAATACCATCAAGCAACAGCAGCAATGGCAAGGAA
AAGGTGAAGCGCTTTTTGACACCCTCACACAACAATTTAACTTTCAATTTTTCCAATATATCGATACGTCGGATAGCGGT
AATAATTTCACTCATGGCCAATTAGCTCCAACAGAGAAAGTAAATTTAGCTAAATTTTTTTCCCTTCAATCACCACACAC
TCAGGCTTTAGATGCTGGGAGATTACAAGTTAAACTATCTAACCTAGCGACAATTGATAGCACTGTGGCCCGGTTTCAAA
ATGTCCTGTTTATCATTTGGACGACATTCCTACTGATTAGTGTCACTTACCTACTATTAACCATGAGACAAAAAAGAAGT
ATTCGCTATATTTCAATGTGTGTTGAAAATTTAGCTAAGCTCTCTTTCGGTGCAATTGAAAATTCACGTATAAAAGGCGA
ATTTAAAAGCATAGGAGTCACGTTCGATAACAGTAAACAGCTTTTAAAAGCCAAAATCGATGGATTCCATAAAACCCATG
AACGACTAAGCAAAACCGCTTTTCATGATCCGATCACAGGTTTTGGTACTCGAGCTCTATTTACCGAAAAACTTGATGAA
ATAGGAAAACCCGAACACAAAGGCAAAGGTGTTTTGATGGTTATTAGGGCGACGGAACTCGCCTCTATCAATCAGATGCA
TGGTAGAGAAGCGGGGGATGATTATCTTACTCGCATTGCTAATGAGATTAAGTGTGCATTTAATGAAATTCCTCAAGCAC
AGTTTTATCGGATCTCAACTGCCGACTTTGCCATTGTTATTGCCGATATAGCTATCAAGCAAGCCACCGGAATAGCCGAT
GCTCTTAAGACAGCATTTAATGAATATCAACAGCAAGTTGGCACTCCAGCTATTGGTCATACCGGCTTAGTGCCCTACCT
TCAAGATAGCGACCCAGTCTCTTTAATGACACTGGCTGATACCGCCGTCAGTATTGCTCAAACATTAGGCCCTAACAGCT
ACCATATCCAGGAAAAGCTAACAGGCGGTGAGCTTTTTGGTGAGAGTCGCTGGAAAGTGGCGATCAACGACCTTTTAAGA
CGAAAAGCGATAAGGTTCTACATTCAACCTATTCGTCCATGTCGACATAATGTCGAATTCTATCGAGAGCTACTATCACG
CTTTTATAATAGCCAAGGAAAACTATTACCCACAGCAACAGTCATCGCGATGGCAGAACGTCACGGCATGAGCGAAGAAC
TCGATAAGCTAATCGTTTTGAATACACTTCGCATGCTTATCCAGTCACCGAATCTAGACGGGCTTATAGGTATCAACATC
AGTGCTGCCTCTGCTACCAATAAATCGTTTGTTTCTTGGTTAAAAAACATACTCAGCAGGCAGAGACAAATCGCAGCTAG
ATTAGTATTTGAGGTGAGTGAGTCTGGTATGCAGGCAAATCTTAGTGCCACCTACCATTTTATTAATGAACTCCATAGTG
TCGGTTCACGGATCTCTATCGAACGATTTGGTTTAGGCTTTACTTCATTTAAACTTTTTAAAGAAGTTCGCCCTGACTAT
ATCAAGTTAGATCCTAGTTACACTCAAGAAATAACCCAAGATCCACACAATAAATTTTTCGTTAAAATGATCATAGATAT
CGCCCGAAAACTCGGGATAAAAGTAATTGCAACTGGAGTAGAAAAGCAGCAAGACAAGTTGGCAATGGAGCAACTGCTCA
TTGATGGCTTACAAGGCTACTATATTTCGGAACCTAGCCCGTTAAAAAAGGAAGAAAAGTCGCTTACTACTGCTTAA

Upstream 100 bases:

>100_bases
TACGCTGCAATAAACCCCTAAATCTGTTTATAATGCCTCCAATTAAACCAGTGTTACTCGAACAAATTCGAGTTATGACG
TGCGTTGAACGGACTCTCTT

Downstream 100 bases:

>100_bases
TACTGACTATTTATAAAGCAAACTTTTTATCCTTGCTTTCTATGTGTTGTTAATGGCTTAGGAAAAGCCGATAATGGAAC
ATATTCTGTCTAAAAAAATT

Product: diguanylate cyclase/phosphodiesterase

Products: NA

Alternate protein names: Regulator of CsrB and CsrC decay CsrD [H]

Number of amino acids: Translated: 638; Mature: 637

Protein sequence:

>638_residues
MTTSKLFQLFLVLLFSGLTFLSYQDEKLKLSTQAQLQLDQYANTIKQQQQWQGKGEALFDTLTQQFNFQFFQYIDTSDSG
NNFTHGQLAPTEKVNLAKFFSLQSPHTQALDAGRLQVKLSNLATIDSTVARFQNVLFIIWTTFLLISVTYLLLTMRQKRS
IRYISMCVENLAKLSFGAIENSRIKGEFKSIGVTFDNSKQLLKAKIDGFHKTHERLSKTAFHDPITGFGTRALFTEKLDE
IGKPEHKGKGVLMVIRATELASINQMHGREAGDDYLTRIANEIKCAFNEIPQAQFYRISTADFAIVIADIAIKQATGIAD
ALKTAFNEYQQQVGTPAIGHTGLVPYLQDSDPVSLMTLADTAVSIAQTLGPNSYHIQEKLTGGELFGESRWKVAINDLLR
RKAIRFYIQPIRPCRHNVEFYRELLSRFYNSQGKLLPTATVIAMAERHGMSEELDKLIVLNTLRMLIQSPNLDGLIGINI
SAASATNKSFVSWLKNILSRQRQIAARLVFEVSESGMQANLSATYHFINELHSVGSRISIERFGLGFTSFKLFKEVRPDY
IKLDPSYTQEITQDPHNKFFVKMIIDIARKLGIKVIATGVEKQQDKLAMEQLLIDGLQGYYISEPSPLKKEEKSLTTA

Sequences:

>Translated_638_residues
MTTSKLFQLFLVLLFSGLTFLSYQDEKLKLSTQAQLQLDQYANTIKQQQQWQGKGEALFDTLTQQFNFQFFQYIDTSDSG
NNFTHGQLAPTEKVNLAKFFSLQSPHTQALDAGRLQVKLSNLATIDSTVARFQNVLFIIWTTFLLISVTYLLLTMRQKRS
IRYISMCVENLAKLSFGAIENSRIKGEFKSIGVTFDNSKQLLKAKIDGFHKTHERLSKTAFHDPITGFGTRALFTEKLDE
IGKPEHKGKGVLMVIRATELASINQMHGREAGDDYLTRIANEIKCAFNEIPQAQFYRISTADFAIVIADIAIKQATGIAD
ALKTAFNEYQQQVGTPAIGHTGLVPYLQDSDPVSLMTLADTAVSIAQTLGPNSYHIQEKLTGGELFGESRWKVAINDLLR
RKAIRFYIQPIRPCRHNVEFYRELLSRFYNSQGKLLPTATVIAMAERHGMSEELDKLIVLNTLRMLIQSPNLDGLIGINI
SAASATNKSFVSWLKNILSRQRQIAARLVFEVSESGMQANLSATYHFINELHSVGSRISIERFGLGFTSFKLFKEVRPDY
IKLDPSYTQEITQDPHNKFFVKMIIDIARKLGIKVIATGVEKQQDKLAMEQLLIDGLQGYYISEPSPLKKEEKSLTTA
>Mature_637_residues
TTSKLFQLFLVLLFSGLTFLSYQDEKLKLSTQAQLQLDQYANTIKQQQQWQGKGEALFDTLTQQFNFQFFQYIDTSDSGN
NFTHGQLAPTEKVNLAKFFSLQSPHTQALDAGRLQVKLSNLATIDSTVARFQNVLFIIWTTFLLISVTYLLLTMRQKRSI
RYISMCVENLAKLSFGAIENSRIKGEFKSIGVTFDNSKQLLKAKIDGFHKTHERLSKTAFHDPITGFGTRALFTEKLDEI
GKPEHKGKGVLMVIRATELASINQMHGREAGDDYLTRIANEIKCAFNEIPQAQFYRISTADFAIVIADIAIKQATGIADA
LKTAFNEYQQQVGTPAIGHTGLVPYLQDSDPVSLMTLADTAVSIAQTLGPNSYHIQEKLTGGELFGESRWKVAINDLLRR
KAIRFYIQPIRPCRHNVEFYRELLSRFYNSQGKLLPTATVIAMAERHGMSEELDKLIVLNTLRMLIQSPNLDGLIGINIS
AASATNKSFVSWLKNILSRQRQIAARLVFEVSESGMQANLSATYHFINELHSVGSRISIERFGLGFTSFKLFKEVRPDYI
KLDPSYTQEITQDPHNKFFVKMIIDIARKLGIKVIATGVEKQQDKLAMEQLLIDGLQGYYISEPSPLKKEEKSLTTA

Specific function: Serves as a specificity factor required for RNase E- mediated decay of the small global regulatory RNAs CsrB and CsrC, it is probably not a nuclease. Nor does its activity involve c-di- GMP, despite its domain composition. Positively modulates motility ge

COG id: COG2200

COG function: function code T; FOG: EAL domain

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GGDEF domain [H]

Homologues:

Organism=Escherichia coli, GI1789650, Length=441, Percent_Identity=23.1292517006803, Blast_Score=125, Evalue=1e-29,
Organism=Escherichia coli, GI1788849, Length=222, Percent_Identity=28.8288288288288, Blast_Score=96, Evalue=9e-21,
Organism=Escherichia coli, GI87081845, Length=237, Percent_Identity=29.1139240506329, Blast_Score=94, Evalue=4e-20,
Organism=Escherichia coli, GI1787541, Length=424, Percent_Identity=22.1698113207547, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI87081980, Length=242, Percent_Identity=27.2727272727273, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1786507, Length=240, Percent_Identity=26.6666666666667, Blast_Score=89, Evalue=1e-18,
Organism=Escherichia coli, GI87082096, Length=224, Percent_Identity=26.3392857142857, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1790496, Length=234, Percent_Identity=25.2136752136752, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1787055, Length=231, Percent_Identity=29.4372294372294, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI87081921, Length=437, Percent_Identity=19.6796338672769, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1788502, Length=152, Percent_Identity=28.2894736842105, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI87081743, Length=237, Percent_Identity=22.7848101265823, Blast_Score=66, Evalue=7e-12,
Organism=Escherichia coli, GI226510982, Length=162, Percent_Identity=23.4567901234568, Blast_Score=64, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF [H]

EC number: NA

Molecular weight: Translated: 71950; Mature: 71819

Theoretical pI: Translated: 9.56; Mature: 9.56

Prosite motif: PS50883 EAL ; PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTSKLFQLFLVLLFSGLTFLSYQDEKLKLSTQAQLQLDQYANTIKQQQQWQGKGEALFD
CCHHHHHHHHHHHHHHCCHHEECCCCCEEECHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
TLTQQFNFQFFQYIDTSDSGNNFTHGQLAPTEKVNLAKFFSLQSPHTQALDAGRLQVKLS
HHHHHHCCHHEEEECCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCHHHCCCCEEEEEEC
NLATIDSTVARFQNVLFIIWTTFLLISVTYLLLTMRQKRSIRYISMCVENLAKLSFGAIE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
NSRIKGEFKSIGVTFDNSKQLLKAKIDGFHKTHERLSKTAFHDPITGFGTRALFTEKLDE
CCCCCCHHHHEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
IGKPEHKGKGVLMVIRATELASINQMHGREAGDDYLTRIANEIKCAFNEIPQAQFYRIST
CCCCCCCCCCEEEEEEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEC
ADFAIVIADIAIKQATGIADALKTAFNEYQQQVGTPAIGHTGLVPYLQDSDPVSLMTLAD
CCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEHHH
TAVSIAQTLGPNSYHIQEKLTGGELFGESRWKVAINDLLRRKAIRFYIQPIRPCRHNVEF
HHHHHHHHCCCCCEEHHHHCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHCCHHH
YRELLSRFYNSQGKLLPTATVIAMAERHGMSEELDKLIVLNTLRMLIQSPNLDGLIGINI
HHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEE
SAASATNKSFVSWLKNILSRQRQIAARLVFEVSESGMQANLSATYHFINELHSVGSRISI
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECHHHHHHHHHHHHHCCCCEEH
ERFGLGFTSFKLFKEVRPDYIKLDPSYTQEITQDPHNKFFVKMIIDIARKLGIKVIATGV
HHHCCCHHHHHHHHHCCCCEEEECCHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEECCC
EKQQDKLAMEQLLIDGLQGYYISEPSPLKKEEKSLTTA
HHHHHHHHHHHHHHHCCCCCEECCCCCCCHHHHCCCCC
>Mature Secondary Structure 
TTSKLFQLFLVLLFSGLTFLSYQDEKLKLSTQAQLQLDQYANTIKQQQQWQGKGEALFD
CHHHHHHHHHHHHHHCCHHEECCCCCEEECHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
TLTQQFNFQFFQYIDTSDSGNNFTHGQLAPTEKVNLAKFFSLQSPHTQALDAGRLQVKLS
HHHHHHCCHHEEEECCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCHHHCCCCEEEEEEC
NLATIDSTVARFQNVLFIIWTTFLLISVTYLLLTMRQKRSIRYISMCVENLAKLSFGAIE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
NSRIKGEFKSIGVTFDNSKQLLKAKIDGFHKTHERLSKTAFHDPITGFGTRALFTEKLDE
CCCCCCHHHHEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
IGKPEHKGKGVLMVIRATELASINQMHGREAGDDYLTRIANEIKCAFNEIPQAQFYRIST
CCCCCCCCCCEEEEEEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEC
ADFAIVIADIAIKQATGIADALKTAFNEYQQQVGTPAIGHTGLVPYLQDSDPVSLMTLAD
CCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEHHH
TAVSIAQTLGPNSYHIQEKLTGGELFGESRWKVAINDLLRRKAIRFYIQPIRPCRHNVEF
HHHHHHHHCCCCCEEHHHHCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHCCHHH
YRELLSRFYNSQGKLLPTATVIAMAERHGMSEELDKLIVLNTLRMLIQSPNLDGLIGINI
HHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEE
SAASATNKSFVSWLKNILSRQRQIAARLVFEVSESGMQANLSATYHFINELHSVGSRISI
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECHHHHHHHHHHHHHCCCCEEH
ERFGLGFTSFKLFKEVRPDYIKLDPSYTQEITQDPHNKFFVKMIIDIARKLGIKVIATGV
HHHCCCHHHHHHHHHCCCCEEEECCHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEECCC
EKQQDKLAMEQLLIDGLQGYYISEPSPLKKEEKSLTTA
HHHHHHHHHHHHHHHCCCCCEECCCCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503; 3049542 [H]