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The map label for this gene is apr [H]

Identifier: 157962121

GI number: 157962121

Start: 2792348

End: 2794168

Strand: Direct

Name: apr [H]

Synonym: Spea_2300

Alternate gene names: 157962121

Gene position: 2792348-2794168 (Clockwise)

Preceding gene: 157962120

Following gene: 157962123

Centisome position: 53.96

GC content: 48.87

Gene sequence:

>1821_bases
ATGAGAAAAACAACTAAAACCCTTATCGCCCTGAGTATAGGCTTGTCCTTTGCAACTCAGGCAGCGGATCAACGCTATAT
CATCCAAGTTGATGAGGGACACAAGGGATTAGTCAAAGCCCTAGCTAAAAAGGTAGGTGGCGAGCTTAACGTAGACGGCA
GCGGCTTTATCGCAGCAACATTTTCAGGCAAAGACCTCAGCACAGTTAAAGGCTTGCTCAATAATCCACATGTTAAGCTT
GTAGAAGAAGATCAACGCCGCGTACCGCTGTCGCTATACAGCGATGACATTGGCGATCCATCCGTCACACAGCTAACACC
CTATGCAGTCTATCAATCACAAGCTGACCAACTCACATTAAACCCCAGTGCAGGCACTAAGGTGTGTGTAATTGATTCAG
GGCTGGATCAATCTAATCCCGATTTTGTATGGTCATCTATTACAGGTGACAGTGACTCGGGCACCGGCAACTGGTATGAA
CATGGTGGCCCCCATGGCACCCACGTAGCCGGAACCATAGGCGCAGCTGACAATGACTTTGGCGTGATTGGCATGGCGCC
AGGTGTCGATATGCATATCATTAAAGTCTTTAATGCCAGTGGCTGGGGTTATTCATCAGATTTAGCCCACGCCGCTAGCC
TTTGTAGCGCAGCAGGCGCGAACATTATTAGCATGAGTCTAGGTGGCGGCTCGCCAAATACCACCGAAGAGAACGCCTTT
AAATCCTTCACCTCTGACGGTGGCTTAGTCATCGCGGCTGCAGGTAACAGCGGTAATAATGTGCGAACTTACCCAGCAGG
CTATACCTCGGTGATGATGGTAGGCGCAAATGATGCTGACAATAATATTGCCGTATTCTCACAATTCCCCGCCTGCTCAA
CCTTTTCTACCGGCAAAGGCAAAAAAAGCAAAACTGAGATTATTGACGGCAGTTGCGTAGAGATCACCGCTGGCGGCGTG
AGTACCCTATCGACATACCCTCAAGGCATGGCGGTTAATTCCAACCTTGAAGCAGACGGACAAAGCATCGCCTCTTCGGC
AATGGAGAACGCCGGTATCGTAACAGCCGAGTCGTACTTTATGGGAACAGCCGAGGCAATAGATGCAAGCGCTAATGGTA
AAGTTTGTCTTATCGATCGAGGCGTTATCTCATTCCACGATAAGGTTAAAAACTGTGAAGCTTCAGGCGGTTTAGGCGCT
GTTATCGTTAACAATGTCGATGGCATGCTATATGGAACATTGGGGGATGCCAATATCACTGAAATTCCAGCCGTAGGAGC
CGCATTAGCCGATAGAGGCGCTTTACATGCCGCAACACAGATGACAGTTAAAATTGCCGCCAGCGACTATGGTTTCATGA
GCGGAACTTCAATGGCGACCCCAGCGGTCTCAGGATTAGCAGCGCTGTTATGGTCAAACCATAGCGGTTGTACTGGTACA
GATATCCGAGAGGCGCTAAAGGCCTCTGCATTTGACGCTGGAGAATCGGGCCGCGACGATTACTTTGGCTACGGTATCGC
CAAGGTCGCCGACGCCAGTGCTTATCTCGATAACATGGGTTGTAACACCACTGAGCCGTTAGAAGATATCGAGCTCAGCG
CGACAACATCATTTTCAAAGGGTAAGGATAGAGTGAGCTTAACTTGGTCTGGCGCTAGCAGCAGTCGAGTCGATGTTTAT
CGTAACGGCCTTATCCAAACCACAACAAGTAATGACGGCAGCCACGAAGATACATTAAGAAATGCTTACGGCATTTACAC
TTACAGTGTTTGTAATGCAGGTACCAACCATTGCTCTAGCAATGTCAGCGTCAACTTTTAA

Upstream 100 bases:

>100_bases
ATGGCAGTCGCTTTATTTCAAATGCCCAGTTTTTTGAAGCTTATCAGCAATATTCAAATAGACATATTTAATAAGAATCA
TAAATAAATGGAGTGTATTA

Downstream 100 bases:

>100_bases
TTTATTTGATTGATTGATGCTTGTTAGTCGCAAACAATCAACAAAAATAGCCTAAAAAGCCGCATTCGCGGCTTTTTTAA
TTAATGTGCTTATCAACTCT

Product: peptidase S8/S53 subtilisin kexin sedolisin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 606; Mature: 606

Protein sequence:

>606_residues
MRKTTKTLIALSIGLSFATQAADQRYIIQVDEGHKGLVKALAKKVGGELNVDGSGFIAATFSGKDLSTVKGLLNNPHVKL
VEEDQRRVPLSLYSDDIGDPSVTQLTPYAVYQSQADQLTLNPSAGTKVCVIDSGLDQSNPDFVWSSITGDSDSGTGNWYE
HGGPHGTHVAGTIGAADNDFGVIGMAPGVDMHIIKVFNASGWGYSSDLAHAASLCSAAGANIISMSLGGGSPNTTEENAF
KSFTSDGGLVIAAAGNSGNNVRTYPAGYTSVMMVGANDADNNIAVFSQFPACSTFSTGKGKKSKTEIIDGSCVEITAGGV
STLSTYPQGMAVNSNLEADGQSIASSAMENAGIVTAESYFMGTAEAIDASANGKVCLIDRGVISFHDKVKNCEASGGLGA
VIVNNVDGMLYGTLGDANITEIPAVGAALADRGALHAATQMTVKIAASDYGFMSGTSMATPAVSGLAALLWSNHSGCTGT
DIREALKASAFDAGESGRDDYFGYGIAKVADASAYLDNMGCNTTEPLEDIELSATTSFSKGKDRVSLTWSGASSSRVDVY
RNGLIQTTTSNDGSHEDTLRNAYGIYTYSVCNAGTNHCSSNVSVNF

Sequences:

>Translated_606_residues
MRKTTKTLIALSIGLSFATQAADQRYIIQVDEGHKGLVKALAKKVGGELNVDGSGFIAATFSGKDLSTVKGLLNNPHVKL
VEEDQRRVPLSLYSDDIGDPSVTQLTPYAVYQSQADQLTLNPSAGTKVCVIDSGLDQSNPDFVWSSITGDSDSGTGNWYE
HGGPHGTHVAGTIGAADNDFGVIGMAPGVDMHIIKVFNASGWGYSSDLAHAASLCSAAGANIISMSLGGGSPNTTEENAF
KSFTSDGGLVIAAAGNSGNNVRTYPAGYTSVMMVGANDADNNIAVFSQFPACSTFSTGKGKKSKTEIIDGSCVEITAGGV
STLSTYPQGMAVNSNLEADGQSIASSAMENAGIVTAESYFMGTAEAIDASANGKVCLIDRGVISFHDKVKNCEASGGLGA
VIVNNVDGMLYGTLGDANITEIPAVGAALADRGALHAATQMTVKIAASDYGFMSGTSMATPAVSGLAALLWSNHSGCTGT
DIREALKASAFDAGESGRDDYFGYGIAKVADASAYLDNMGCNTTEPLEDIELSATTSFSKGKDRVSLTWSGASSSRVDVY
RNGLIQTTTSNDGSHEDTLRNAYGIYTYSVCNAGTNHCSSNVSVNF
>Mature_606_residues
MRKTTKTLIALSIGLSFATQAADQRYIIQVDEGHKGLVKALAKKVGGELNVDGSGFIAATFSGKDLSTVKGLLNNPHVKL
VEEDQRRVPLSLYSDDIGDPSVTQLTPYAVYQSQADQLTLNPSAGTKVCVIDSGLDQSNPDFVWSSITGDSDSGTGNWYE
HGGPHGTHVAGTIGAADNDFGVIGMAPGVDMHIIKVFNASGWGYSSDLAHAASLCSAAGANIISMSLGGGSPNTTEENAF
KSFTSDGGLVIAAAGNSGNNVRTYPAGYTSVMMVGANDADNNIAVFSQFPACSTFSTGKGKKSKTEIIDGSCVEITAGGV
STLSTYPQGMAVNSNLEADGQSIASSAMENAGIVTAESYFMGTAEAIDASANGKVCLIDRGVISFHDKVKNCEASGGLGA
VIVNNVDGMLYGTLGDANITEIPAVGAALADRGALHAATQMTVKIAASDYGFMSGTSMATPAVSGLAALLWSNHSGCTGT
DIREALKASAFDAGESGRDDYFGYGIAKVADASAYLDNMGCNTTEPLEDIELSATTSFSKGKDRVSLTWSGASSSRVDVY
RNGLIQTTTSNDGSHEDTLRNAYGIYTYSVCNAGTNHCSSNVSVNF

Specific function: Subtilisin is an extracellular alkaline serine protease, it catalyzes the hydrolysis of proteins and peptide amides [H]

COG id: COG1404

COG function: function code O; Subtilisin-like serine proteases

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S8 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000209
- InterPro:   IPR022398
- InterPro:   IPR015500 [H]

Pfam domain/function: PF00082 Peptidase_S8 [H]

EC number: =3.4.21.62 [H]

Molecular weight: Translated: 62559; Mature: 62559

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: PS00136 SUBTILASE_ASP ; PS00137 SUBTILASE_HIS ; PS00138 SUBTILASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKTTKTLIALSIGLSFATQAADQRYIIQVDEGHKGLVKALAKKVGGELNVDGSGFIAAT
CCCHHHEEEEEECCHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCCCEEEECCCCEEEEE
FSGKDLSTVKGLLNNPHVKLVEEDQRRVPLSLYSDDIGDPSVTQLTPYAVYQSQADQLTL
ECCCCHHHHHHHHCCCCEEEEECCCCCCCEEEECCCCCCCCHHEECCHHHCCCCCCEEEE
NPSAGTKVCVIDSGLDQSNPDFVWSSITGDSDSGTGNWYEHGGPHGTHVAGTIGAADNDF
CCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCCCCCCHHCCCCCCCEEEEEECCCCCCC
GVIGMAPGVDMHIIKVFNASGWGYSSDLAHAASLCSAAGANIISMSLGGGSPNTTEENAF
EEEEECCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHH
KSFTSDGGLVIAAAGNSGNNVRTYPAGYTSVMMVGANDADNNIAVFSQFPACSTFSTGKG
HHHCCCCCEEEEEECCCCCCEEECCCCCEEEEEEECCCCCCCEEEEECCCCCCCCCCCCC
KKSKTEIIDGSCVEITAGGVSTLSTYPQGMAVNSNLEADGQSIASSAMENAGIVTAESYF
CCCCCEEECCCEEEEECCCCHHHHCCCCCEEECCCCCCCHHHHHHHHHHCCCEEEEHHHH
MGTAEAIDASANGKVCLIDRGVISFHDKVKNCEASGGLGAVIVNNVDGMLYGTLGDANIT
CCCHHHHCCCCCCCEEEEECCCHHHHHHHCCCCCCCCEEEEEEECCCCEEEEECCCCCCC
EIPAVGAALADRGALHAATQMTVKIAASDYGFMSGTSMATPAVSGLAALLWSNHSGCTGT
CCCCHHHHHHCCCCCEEEEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCH
DIREALKASAFDAGESGRDDYFGYGIAKVADASAYLDNMGCNTTEPLEDIELSATTSFSK
HHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHCEEEEECCCCC
GKDRVSLTWSGASSSRVDVYRNGLIQTTTSNDGSHEDTLRNAYGIYTYSVCNAGTNHCSS
CCCEEEEEECCCCCCEEEEECCCEEEEECCCCCCCHHHHHHHCCEEEEEEECCCCCCCCC
NVSVNF
CCEEEC
>Mature Secondary Structure
MRKTTKTLIALSIGLSFATQAADQRYIIQVDEGHKGLVKALAKKVGGELNVDGSGFIAAT
CCCHHHEEEEEECCHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCCCEEEECCCCEEEEE
FSGKDLSTVKGLLNNPHVKLVEEDQRRVPLSLYSDDIGDPSVTQLTPYAVYQSQADQLTL
ECCCCHHHHHHHHCCCCEEEEECCCCCCCEEEECCCCCCCCHHEECCHHHCCCCCCEEEE
NPSAGTKVCVIDSGLDQSNPDFVWSSITGDSDSGTGNWYEHGGPHGTHVAGTIGAADNDF
CCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCCCCCCHHCCCCCCCEEEEEECCCCCCC
GVIGMAPGVDMHIIKVFNASGWGYSSDLAHAASLCSAAGANIISMSLGGGSPNTTEENAF
EEEEECCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHH
KSFTSDGGLVIAAAGNSGNNVRTYPAGYTSVMMVGANDADNNIAVFSQFPACSTFSTGKG
HHHCCCCCEEEEEECCCCCCEEECCCCCEEEEEEECCCCCCCEEEEECCCCCCCCCCCCC
KKSKTEIIDGSCVEITAGGVSTLSTYPQGMAVNSNLEADGQSIASSAMENAGIVTAESYF
CCCCCEEECCCEEEEECCCCHHHHCCCCCEEECCCCCCCHHHHHHHHHHCCCEEEEHHHH
MGTAEAIDASANGKVCLIDRGVISFHDKVKNCEASGGLGAVIVNNVDGMLYGTLGDANIT
CCCHHHHCCCCCCCEEEEECCCHHHHHHHCCCCCCCCEEEEEEECCCCEEEEECCCCCCC
EIPAVGAALADRGALHAATQMTVKIAASDYGFMSGTSMATPAVSGLAALLWSNHSGCTGT
CCCCHHHHHHCCCCCEEEEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCH
DIREALKASAFDAGESGRDDYFGYGIAKVADASAYLDNMGCNTTEPLEDIELSATTSFSK
HHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHCEEEEECCCCC
GKDRVSLTWSGASSSRVDVYRNGLIQTTTSNDGSHEDTLRNAYGIYTYSVCNAGTNHCSS
CCCEEEEEECCCCCCEEEEECCCEEEEECCCCCCCHHHHHHHCCEEEEEEECCCCCCCCC
NVSVNF
CCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6420308; 9826175 [H]